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As thousands of expression traits are typically analyzed, this can reduce power because of the need to correct for the number of hypothesis tests performed. In addition, gene expression traits exhibit a complex correlation structure, which is ignored when analyzing traits individually.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>To address these issues, we applied two different multivariate dimension reduction techniques, the Singular Value Decomposition (SVD) and Independent Component Analysis (ICA) to gene expression traits derived from a cross between two strains of <jats:italic>Saccharomyces cerevisiae<\/jats:italic>. Both methods decompose the data into a set of meta-traits, which are linear combinations of all the expression traits. The meta-traits were enriched for several Gene Ontology categories including metabolic pathways, stress response, RNA processing, ion transport, retro-transposition and telomeric maintenance. Genome-wide linkage analysis was performed on the top 20 meta-traits from both techniques. In total, 21 eQTL were found, of which 11 are novel. Interestingly, both <jats:italic>cis<\/jats:italic> and <jats:italic>trans<\/jats:italic>-linkages to the meta-traits were observed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These results demonstrate that dimension reduction methods are a useful and complementary approach for probing the genetic architecture of gene expression variation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-9-244","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T16:50:06Z","timestamp":1211388606000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis"],"prefix":"10.1186","volume":"9","author":[{"given":"Shameek","family":"Biswas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D","family":"Storey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M","family":"Akey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,5,20]]},"reference":[{"key":"2229_CR1","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1126\/science.1069516","volume":"296","author":"RB Brem","year":"2002","unstructured":"Brem RB, Yvert G, Clinton R, Kruglyak L: Genetic dissection of transcriptional regulation in budding yeast. 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