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However, whether topological information reaped from these experimentally-measured sub-networks can be extrapolated to complete protein-protein interaction networks is unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>By analyzing various experimental protein-protein interaction datasets, we found that they are not random samples of the parent networks. Based on the experimental bait-prey behaviors, our computer simulations show that these non-random sampling features may affect the topological information. We tested the hypothesis that a core sub-network exists within the experimentally sampled network that better maintains the topological characteristics of the parent protein-protein interaction network. We developed a method to filter the experimentally sampled network to result in a core sub-network that more accurately reflects the topology of the parent network. These findings have fundamental implications for large-scale protein interaction studies and for our understanding of the behavior of cellular networks.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The topological information from experimental measured networks network <jats:italic>as is<\/jats:italic> may not be the correct source for topological information about the parent protein-protein interaction network. We define a core sub-network that more accurately reflects the topology of the parent network.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-9-301","type":"journal-article","created":{"date-parts":[[2008,7,4]],"date-time":"2008-07-04T06:13:33Z","timestamp":1215152013000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Deducing topology of protein-protein interaction networks from experimentally measured sub-networks"],"prefix":"10.1186","volume":"9","author":[{"given":"Ling","family":"Yang","sequence":"first","affiliation":[]},{"given":"Thomas M","family":"Vondriska","sequence":"additional","affiliation":[]},{"given":"Zhangang","family":"Han","sequence":"additional","affiliation":[]},{"given":"W Robb","family":"MacLellan","sequence":"additional","affiliation":[]},{"given":"James N","family":"Weiss","sequence":"additional","affiliation":[]},{"given":"Zhilin","family":"Qu","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,7,3]]},"reference":[{"issue":"6794","key":"2286_CR1","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/35019019","volume":"406","author":"R Albert","year":"2000","unstructured":"Albert R, Jeong H, Barabasi AL: Error and attack tolerance of complex networks. 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