{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:16:37Z","timestamp":1773868597808,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,1,7]],"date-time":"2008-01-07T00:00:00Z","timestamp":1199664000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1186\/1471-2105-9-7","type":"journal-article","created":{"date-parts":[[2008,1,8]],"date-time":"2008-01-08T07:23:55Z","timestamp":1199777035000},"source":"Crossref","is-referenced-by-count":18,"title":["A PATO-compliant zebrafish screening database (MODB): management of morpholino knockdown screen information"],"prefix":"10.1186","volume":"9","author":[{"given":"Michelle N","family":"Knowlton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongliang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent R","family":"Bill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda BM","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C","family":"Ekker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,1,7]]},"reference":[{"issue":"3","key":"1992_CR1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/aja.1002030302","volume":"203","author":"CB Kimmel","year":"1995","unstructured":"Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF: Stages of embryonic development of the zebrafish. Dev Dyn 1995, 203(3):253\u2013310.","journal-title":"Dev Dyn"},{"issue":"1","key":"1992_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1471-2164-8-11","volume":"8","author":"R Geisler","year":"2007","unstructured":"Geisler R, Rauch GJ, Geiger-Rudolph S, Albrecht A, van Bebber F, Berger A, Busch-Nentwich E, Dahm R, Dekens MP, Dooley C, et al.: Large-scale mapping of mutations affecting zebrafish development. BMC Genomics 2007, 8(1):11. 10.1186\/1471-2164-8-11","journal-title":"BMC Genomics"},{"key":"1992_CR3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0091-679X(04)77005-3","volume":"77","author":"BW Draper","year":"2004","unstructured":"Draper BW, McCallum CM, Stout JL, Slade AJ, Moens CB: A high-throughput method for identifying N-ethyl-N-nitrosourea (ENU)-induced point mutations in zebrafish. Methods Cell Biol 2004, 77: 91\u2013112.","journal-title":"Methods Cell Biol"},{"issue":"12","key":"1992_CR4","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1101\/gr.1725103","volume":"13","author":"E Wienholds","year":"2003","unstructured":"Wienholds E, van Eeden F, Kosters M, Mudde J, Plasterk RH, Cuppen E: Efficient target-selected mutagenesis in zebrafish. Genome Res 2003, 13(12):2700\u20132707. 10.1101\/gr.1725103","journal-title":"Genome Res"},{"issue":"20","key":"1992_CR5","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1101\/gad.13.20.2713","volume":"13","author":"A Amsterdam","year":"1999","unstructured":"Amsterdam A, Burgess S, Golling G, Chen W, Sun Z, Townsend K, Farrington S, Haldi M, Hopkins N: A large-scale insertional mutagenesis screen in zebrafish. Genes Dev 1999, 13(20):2713\u20132724. 10.1101\/gad.13.20.2713","journal-title":"Genes Dev"},{"issue":"5","key":"1992_CR6","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/j.1600-0749.2004.00189.x","volume":"17","author":"MA Pickart","year":"2004","unstructured":"Pickart MA, Sivasubbu S, Nielsen AL, Shriram S, King RA, Ekker SC: Functional genomics tools for the analysis of zebrafish pigment. Pigment Cell Res 2004, 17(5):461\u2013470. 10.1111\/j.1600-0749.2004.00189.x","journal-title":"Pigment Cell Res"},{"issue":"1","key":"1992_CR7","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1534\/genetics.104.036434","volume":"170","author":"MR Taylor","year":"2005","unstructured":"Taylor MR, Kikkawa S, Diez-Juan A, Ramamurthy V, Kawakami K, Carmeliet P, Brockerhoff SE: The zebrafish pob gene encodes a novel protein required for survival of red cone photoreceptor cells. Genetics 2005, 170(1):263\u2013273. 10.1534\/genetics.104.036434","journal-title":"Genetics"},{"issue":"8","key":"1992_CR8","doi-asserted-by":"publisher","first-page":"e254","DOI":"10.1371\/journal.pbio.0030254","volume":"3","author":"CE Eckfeldt","year":"2005","unstructured":"Eckfeldt CE, Mendenhall EM, Flynn CM, Wang TF, Pickart MA, Grindle SM, Ekker SC, Verfaillie CM: Functional analysis of human hematopoietic stem cell gene expression using zebrafish. PLoS Biol 2005, 3(8):e254. 10.1371\/journal.pbio.0030254","journal-title":"PLoS Biol"},{"issue":"1","key":"1992_CR9","doi-asserted-by":"publisher","first-page":"e104","DOI":"10.1371\/journal.pone.0000104","volume":"1","author":"A Michael","year":"2006","unstructured":"Michael A, Pickart EWK, Nielsen AubreyL, Sivasubbu Sridhar, Mendenhall EricM, Bill BrentR, Chen Eleanor, Eckfeldt CraigE, Knowlton Michelle, Robu MaraE, Larson JonD, Deng Yun, Schimmenti LisaA, Ellis LyndaBM, Verfaillie CatherineM, Hammerschmidt Matthias, Farber StevenA, Ekker StephenC: Genome-Wide Reverse Genetics Framework to Identify Novel Functions of the Vertebrate Secretome. PLoS One 2006, 1(1):e104. 10.1371\/journal.pone.0000104","journal-title":"PLoS One"},{"key":"1992_CR10","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/1471-2105-6-256","volume":"6","author":"EW Klee","year":"2005","unstructured":"Klee EW, Ellis LBM: Evaluating eukaryotic secreted protein prediction. BMC Bioinformatics 2005, 6: 256. 10.1186\/1471-2105-6-256","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"1992_CR11","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/dvdy.10279","volume":"227","author":"VS Sadl","year":"2003","unstructured":"Sadl VS, Sing A, Mar L, Jin F, Cordes SP: Analysis of hindbrain patterning defects caused by the kreisler(enu) mutation reveals multiple roles of Kreisler in hindbrain segmentation. Dev Dyn 2003, 227(1):134\u2013142. 10.1002\/dvdy.10279","journal-title":"Dev Dyn"},{"key":"1992_CR12","doi-asserted-by":"crossref","unstructured":"Klee EW, Shim KJ, Pickart MA, Ekker SC, Ellis LB: AMOD: a morpholino oligonucleotide selection tool. Nucleic Acids Res 2005, (33 Web Server):W506\u2013511. 10.1093\/nar\/gki453","DOI":"10.1093\/nar\/gki453"},{"issue":"1","key":"1992_CR13","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1006\/dbio.1999.9384","volume":"214","author":"V Miller-Bertoglio","year":"1999","unstructured":"Miller-Bertoglio V, Carmany-Rampey A, Furthauer M, Gonzalez EM, Thisse C, Thisse B, Halpern ME, Solnica-Krezel L: Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signaling. Dev Biol 1999, 214(1):72\u201386. 10.1006\/dbio.1999.9384","journal-title":"Dev Biol"},{"key":"1992_CR14","series-title":"Nucleic Acids Res","volume-title":"The Zebrafish Information Network: the zebrafish model organism database","author":"J Sprague","year":"2006","unstructured":"Sprague J, Bayraktaroglu L, Clements D, Conlin T, Fashena D, Frazer K, Haendel M, Howe DG, Mani P, Ramachandran S, et al.: The Zebrafish Information Network: the zebrafish model organism database. Nucleic Acids Res 2006, (34 Database):D581\u2013585. 10.1093\/nar\/gkj086"},{"key":"1992_CR15","unstructured":"Mouse Phenome Database[ http:\/\/phenome.jax.org\/pub-cgi\/phenome\/mpdcgi?rtn=docs\/home ]"},{"key":"1992_CR16","series-title":"Nucleic Acids Res","first-page":"D643","volume-title":"Mouse Phenome Database (MPD).","author":"MA Bogue","year":"2007","unstructured":"Bogue MA, Grubb SC, Maddatu TP, Bult CJ: Mouse Phenome Database (MPD). Nucleic Acids Res 2007, (35 Database):D643\u2013649. 10.1093\/nar\/gkl1049"},{"key":"1992_CR17","series-title":"Nucleic Acids Res","first-page":"D492","volume-title":"GenomeRNAi: a database for cell-based RNAi phenotypes","author":"T Horn","year":"2007","unstructured":"Horn T, Arziman Z, Berger J, Boutros M: GenomeRNAi: a database for cell-based RNAi phenotypes. Nucleic Acids Res 2007, (35 Database):D492\u2013497. 10.1093\/nar\/gkl906"},{"key":"1992_CR18","unstructured":"GenomeRNA i[ http:\/\/www.dkfz.de\/signaling2\/rnai\/ernai.html ]"},{"key":"1992_CR19","unstructured":"Xenopus tropicalis Morpholino Screen[ http:\/\/www.gurdon.cam.ac.uk\/~smithlab\/screens\/Xenopus-morpholino-pilot\/morpholino-screen-lists.html#synphenotypes ]"},{"issue":"11","key":"1992_CR20","doi-asserted-by":"publisher","first-page":"e193","DOI":"10.1371\/journal.pgen.0020193","volume":"2","author":"AA Rana","year":"2006","unstructured":"Rana AA, Collart C, Gilchrist MJ, Smith JC: Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides. PLoS Genet 2006, 2(11):e193. 10.1371\/journal.pgen.0020193","journal-title":"PLoS Genet"},{"key":"1992_CR21","unstructured":"Apache Web Server[ http:\/\/www.apache.org ]"},{"issue":"2","key":"1992_CR22","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/79951","volume":"26","author":"A Nasevicius","year":"2000","unstructured":"Nasevicius A, Ekker SC: Effective targeted gene 'knockdown' in zebrafish. Nat Genet 2000, 26(2):216\u2013220. 10.1038\/79951","journal-title":"Nat Genet"},{"key":"1992_CR23","unstructured":"Smarty[ http:\/\/smarty.php.net ]"},{"key":"1992_CR24","unstructured":"GD Graphics[ http:\/\/www.boutell.com\/gd\/ ]"},{"issue":"3","key":"1992_CR25","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ: Basic local alignment search tool. J Mol Biol 1990, 215(3):403\u2013410.","journal-title":"J Mol Biol"},{"key":"1992_CR26","unstructured":"ZFIN Anatomy Ontology[ http:\/\/www.geneontology.org\/GO.format.shtml ]"},{"key":"1992_CR27","unstructured":"The Institute for Genomic Research (TIGR)[ http:\/\/www.tigr.org ]"},{"key":"1992_CR28","unstructured":"GenBank[ http:\/\/www.ncbi.nlm.nih.gov\/Genbank\/index.html ]"},{"key":"1992_CR29","unstructured":"WormBase[ http:\/\/www.wormbase.org\/ ]"},{"key":"1992_CR30","unstructured":"National Center for Biomedical Ontology (NCBO)[ http:\/\/www.bioontology.org\/ ]"},{"issue":"1","key":"1992_CR31","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/bfgp\/ell008","volume":"5","author":"A Amsterdam","year":"2006","unstructured":"Amsterdam A: Insertional mutagenesis in zebrafish: genes for development, genes for disease. Brief Funct Genomic Proteomic 2006, 5(1):19\u201323. 10.1093\/bfgp\/ell008","journal-title":"Brief Funct Genomic Proteomic"},{"issue":"9","key":"1992_CR32","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.tig.2006.06.011","volume":"22","author":"A Amsterdam","year":"2006","unstructured":"Amsterdam A, Hopkins N: Mutagenesis strategies in zebrafish for identifying genes involved in development and disease. Trends Genet 2006, 22(9):473\u2013478. 10.1016\/j.tig.2006.06.011","journal-title":"Trends Genet"},{"issue":"4","key":"1992_CR33","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s10126-006-5139-0","volume":"8","author":"R Dahm","year":"2006","unstructured":"Dahm R, Geisler R: Learning from small fry: the zebrafish as a genetic model organism for aquaculture fish species. Mar Biotechnol (NY) 2006, 8(4):329\u2013345. 10.1007\/s10126-006-5139-0","journal-title":"Mar Biotechnol (NY)"},{"key":"1992_CR34","unstructured":"Gene Tools[ http:\/\/www.gene-tools.com\/ ]"},{"key":"1992_CR35","unstructured":"Open Biosystems[ http:\/\/www.openbiosystems.com\/ ]"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-9-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2105-9-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-9-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T17:12:06Z","timestamp":1557162726000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-9-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,7]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["1992"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-9-7","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,7]]},"article-number":"7"}}