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Therefore, it is desirable to expand these interactomes with ortholog-based and other methods.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Orthologous pairs of 18 eukaryotic species were expanded and merged with experimental PPI datasets. The contributions of interologs from each species were evaluated. The expanded orthologous pairs enable the inference of interologs for various species. For example, more than 32,000 human interactions can be predicted. The same dataset has also been applied to the prediction of host-pathogen interactions. PPIs between <jats:italic>P. falciparum<\/jats:italic> calmodulin and several <jats:italic>H. sapiens<\/jats:italic> proteins are predicted, and these interactions may contribute to the maintenance of host cell Ca<jats:sup>2+<\/jats:sup> concentration. Using comparisons with Bayesian and structure-based approaches, interactions between putative HSP40 homologs of <jats:italic>P. falciparum<\/jats:italic> and the <jats:italic>H. sapiens<\/jats:italic> TNF receptor associated factor family are revealed, suggesting a role for these interactions in the interference of the human immune response to <jats:italic>P. falciparum<\/jats:italic>.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The PPI datasets are available from POINT <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/point.bioinformatics.tw\/\" ext-link-type=\"uri\">http:\/\/point.bioinformatics.tw\/<\/jats:ext-link> and POINeT <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/poinet.bioinformatics.tw\/\" ext-link-type=\"uri\">http:\/\/poinet.bioinformatics.tw\/<\/jats:ext-link>. Further development of methods to predict host-pathogen interactions should incorporate multiple approaches in order to improve sensitivity, and should facilitate the identification of targets for drug discovery and design.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-9-s12-s11","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T19:13:59Z","timestamp":1229109239000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Ortholog-based protein-protein interaction prediction and its application to inter-species interactions"],"prefix":"10.1186","volume":"9","author":[{"given":"Sheng-An","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-hsiung","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Hung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Mei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Yan","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Ying F","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,12,12]]},"reference":[{"key":"2716_CR1","doi-asserted-by":"publisher","first-page":"D535","DOI":"10.1093\/nar\/gkj109","volume":"34","author":"C Stark","year":"2006","unstructured":"Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M: BioGRID: a general repository for interaction datasets. 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