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While Verprolin has been shown to be important for somatic muscle cell fusion, the function of this protein in visceral muscle fusion has not been determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Verprolin is specifically expressed in the fusion competent myoblasts of the visceral mesoderm, suggesting a role in visceral mesoderm fusion. We here describe a novel Verprolin mutant allele which displays subtle visceral mesoderm fusion defects in the form of mislocalization of the immunoglobulin superfamily molecule Duf\/Kirre, which is required on the myoblast cell surface to facilitate attachment between cells that are about to fuse, indicating a function for Verprolin in visceral mesoderm fusion. We further show that Verprolin mutant cells are capable of both migrating and fusing and that the WASP-binding domain of Verprolin is required for rescue of the Verprolin mutant phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Verprolin is expressed in the visceral mesoderm and plays a role in visceral muscle fusion as shown by mislocalization of Duf\/Kirre in the<jats:italic>Verprolin<\/jats:italic>mutant, however it is not absolutely required for myoblast fusion in either the visceral or the somatic mesoderm.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-213x-10-86","type":"journal-article","created":{"date-parts":[[2010,8,11]],"date-time":"2010-08-11T20:40:47Z","timestamp":1281559247000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characterisation of the role of Vrp1 in cell fusion during the development of visceral muscle of Drosophila melanogaster"],"prefix":"10.1186","volume":"10","author":[{"given":"Therese","family":"Eriksson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Varshney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pontus","family":"Aspenstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth H","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,8,11]]},"reference":[{"key":"563_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0925-4773(01)00567-6","volume":"110","author":"R Klapper","year":"2002","unstructured":"Klapper R, Stute C, Schomaker O, Strasser T, Janning W, Renkawitz-Pohl R, Holz A: The formation of syncytia within the visceral musculature of the Drosophila midgut is dependent on duf, sns and mbc. 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