{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:20:53Z","timestamp":1787019653447,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:00:00Z","timestamp":1357776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"},{"start":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:00:00Z","timestamp":1357776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Dev Biol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The members of the protein kinase C (PKC) family consist of serine\/threonine kinases classified according to their regulatory domain. Those that belong to the novel PKC subfamily, such as PKC\u03b4, are dependent on diacylglycerol but not Calcium when considering their catalytic activity. Although several studies have shown the importance of PKC\u03b4 in different cellular events in health and disease, the overall in vivo distribution of this PKC isoform during development is still lacking. Through Lac Z and antibody staining procedures, we show here the in vivo expression of PKC\u03b4 during mouse embryogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ganglia were the domains with most prominent expression of PKC\u03b4 in most of the stages analysed, although PKC\u03b4 could also be detected in heart and somites at earlier stages, and cartilage primordium and skin among other sites in older embryos.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The strong expression of PKC\u03b4 in ganglia during murine development shown in this study suggests a significant role of this isoform as well as redundancy with other PKCs within the nervous system, since PKC\u03b4 deficient mice develop normally.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-213x-13-2","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T14:23:18Z","timestamp":1357827798000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Expression pattern of protein kinase C \u03b4 during mouse embryogenesis"],"prefix":"10.1186","volume":"13","author":[{"given":"Sergio","family":"Carracedo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Leitges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,10]]},"reference":[{"issue":"2","key":"712_CR1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nrm2847","volume":"11","author":"C Rosse","year":"2010","unstructured":"Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ: PKC and the control of localized signal dynamics. 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