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In order to analyze the function of CRP2 <jats:italic>in vivo<\/jats:italic>, we disrupted the <jats:italic>Csrp2<\/jats:italic> gene in mice and analysed the resulting phenotype.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A ~17.3 kbp fragment of the murine <jats:italic>Csrp2<\/jats:italic> gene containing exon 3 through 6 was isolated. Using this construct we confirmed the recently determined chromosomal localization (Chromosome 10, best fit location between markers D10Mit203 proximal and D10Mit150 central). A gene disruption cassette was cloned into exon 4 and a mouse strain lacking functional <jats:italic>Csrp2<\/jats:italic> was generated. Mice lacking CRP2 are viable and fertile and have no obvious deficits in reproduction and survival. However, detailed histological and electron microscopic studies reveal that CRP2-deficient mice have subtle alterations in their cardiac ultrastructure. In these mice, the cardiomyocytes display a slight increase in their thickness, indicating moderate hypertrophy at the cellular level. Although the expression of several intercalated disc-associated proteins such as \u03b2-catenin, N-RAP and connexin-43 were not affected in these mice, the distribution of respective proteins was changed within heart tissue.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We conclude that the lack of CRP2 is associated with alterations in cardiomyocyte thickness and hypertrophy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-213x-8-80","type":"journal-article","created":{"date-parts":[[2008,8,19]],"date-time":"2008-08-19T18:11:42Z","timestamp":1219169502000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Targeted disruption of the mouse Csrp2gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure"],"prefix":"10.1186","volume":"8","author":[{"given":"Julia F","family":"Sagave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Ehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Weiskirchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Stoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle","family":"G\u00fcnther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"B\u00fcttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Weiskirchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,8,19]]},"reference":[{"key":"364_CR1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/bies.10226","volume":"25","author":"R Weiskirchen","year":"2003","unstructured":"Weiskirchen R, G\u00fcnther K: The CRP\/MLP\/TLP family of LIM domain proteins: acting by connecting. 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