{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:46:48Z","timestamp":1791035208191,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T00:00:00Z","timestamp":1222300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"},{"start":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T00:00:00Z","timestamp":1222300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Dev Biol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The frogs <jats:italic>Xenopus laevis<\/jats:italic> and <jats:italic>Xenopus (Silurana) tropicalis<\/jats:italic> are model systems that have produced a wealth of genetic, genomic, and developmental information. Xenbase is a model organism database that provides centralized access to this information, including gene function data from high-throughput screens and the scientific literature. A controlled, structured vocabulary for <jats:italic>Xenopus<\/jats:italic> anatomy and development is essential for organizing these data.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We have constructed a <jats:italic>Xenopus<\/jats:italic> anatomical ontology that represents the lineage of tissues and the timing of their development. We have classified many anatomical features in a common framework that has been adopted by several model organism database communities. The ontology is available for download at the Open Biomedical Ontologies Foundry <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/obofoundry.org\">http:\/\/obofoundry.org<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The <jats:italic>Xenopus<\/jats:italic> Anatomical Ontology will be used to annotate <jats:italic>Xenopus<\/jats:italic> gene expression patterns and mutant and morphant phenotypes. Its robust developmental map will enable powerful database searches and data analyses. We encourage community recommendations for updates and improvements to the ontology.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/1471-213x-8-92","type":"journal-article","created":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T18:14:27Z","timestamp":1222366467000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["An ontology for Xenopus anatomy and development"],"prefix":"10.1186","volume":"8","author":[{"given":"Erik","family":"Segerdell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff B","family":"Bowes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Pollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D","family":"Vize","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,9,25]]},"reference":[{"key":"376_CR1","volume-title":"Normal Table of Xenopus laevis (Daudin)","year":"1994","unstructured":"Nieuwkoop PD, Faber J, (Eds): Normal Table of Xenopus laevis (Daudin). 1994, New York: Garland Publishing"},{"key":"376_CR2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/nar\/28.1.139","volume":"28","author":"N Pollet","year":"2000","unstructured":"Pollet N, Schmidt HA, Gawantka V, Vingron M, Niehrs C: Axeldb: a Xenopus laevis database focusing on gene expression. 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