{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T10:08:51Z","timestamp":1776247731236,"version":"3.50.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Dev Biol"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Normal growth and development of organisms requires maintenance of a dynamic balance between systems that promote cell survival and those that induce apoptosis. The molecular mechanisms that regulate these processes remain poorly understood, and thus further <jats:italic>in vivo<\/jats:italic> study is required. Survivin is a member of the inhibitor of apoptosis protein (IAP) family, that uniquely also promotes mitosis and cell proliferation. Postnatally, survivin is hardly detected in most tissues, but is upregulated in all cancers, and as such, is a potential therapeutic target. Prenatally, survivin is also highly expressed in several tissues. Fully delineating the properties of survivin <jats:italic>in vivo<\/jats:italic> in mice has been confounded by early lethal phenotypes following <jats:italic>survivin<\/jats:italic> gene inactivation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>To gain further insights into the properties of survivin, we used the zebrafish model. There are 2 zebrafish <jats:italic>survivin<\/jats:italic> genes (<jats:italic>Birc5a<\/jats:italic> and <jats:italic>Birc5b<\/jats:italic>) with overlapping expression patterns during early development, prominently in neural and vascular structures. Morpholino-induced depletion of <jats:italic>Birc5a<\/jats:italic> causes profound neuro-developmental, hematopoietic, cardiogenic, vasculogenic and angiogenic defects. Similar abnormalities, all less severe except for hematopoiesis, were evident with suppression of <jats:italic>Birc5b<\/jats:italic>. The phenotypes induced by morpholino knockdown of one <jats:italic>survivin<\/jats:italic> gene, were rescued by overexpression of the other, indicating that the <jats:italic>Birc5<\/jats:italic> paralogs may compensate for each. The potent vascular endothelial growth factor (VEGF) also entirely rescues the phenotypes induced by depletion of either <jats:italic>Birc5a<\/jats:italic> and <jats:italic>Birc5b<\/jats:italic>, highlighting its multi-functional properties, as well as the power of the model in characterizing the activities of growth factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Overall, with the zebrafish model, we identify survivin as a key regulator of neurogenesis, vasculo-angiogenesis, hematopoiesis and cardiogenesis. These properties of survivin, which are consistent with those identified in mice, indicate that its functions are highly conserved across species, and point to the value of the zebrafish model in understanding the role of this IAP in the pathogenesis of human disease, and for exploring its potential as a therapeutic target.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-213x-9-25","type":"journal-article","created":{"date-parts":[[2009,4,17]],"date-time":"2009-04-17T18:14:33Z","timestamp":1239992073000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Role of the 2 zebrafish survivingenes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis"],"prefix":"10.1186","volume":"9","author":[{"given":"Mieke","family":"Delvaeye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"De Vriese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke","family":"Zwerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Betz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Moons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Autiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward M","family":"Conway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,3,26]]},"reference":[{"key":"429_CR1","doi-asserted-by":"publisher","first-page":"7183","DOI":"10.1158\/0008-5472.CAN-04-1918","volume":"64","author":"AD Schimmer","year":"2004","unstructured":"Schimmer AD: Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 2004, 64: 7183-90. 10.1158\/0008-5472.CAN-04-1918.","journal-title":"Cancer Res"},{"key":"429_CR2","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nm0897-917","volume":"3","author":"G Ambrosini","year":"1997","unstructured":"Ambrosini G, Adida C, Altieri D: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nature Medicine. 1997, 3: 917-921. 10.1038\/nm0897-917.","journal-title":"Nature Medicine"},{"key":"429_CR3","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/S0960-9822(00)00769-7","volume":"10","author":"AG Uren","year":"2000","unstructured":"Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL, Choo KH: Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr Biol. 2000, 10: 1319-28. 10.1016\/S0960-9822(00)00769-7.","journal-title":"Curr Biol"},{"key":"429_CR4","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1038\/sj.onc.1203429","volume":"19","author":"A Suzuki","year":"2000","unstructured":"Suzuki A, Ito T, Kawano H, Hayashida M, Hayasaki Y, Tsutomi Y, Akahane K, Nakano T, Miura M, Shiraki K: Survivin initiates procaspase 3\/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death. Oncogene. 2000, 19: 1346-53. 10.1038\/sj.onc.1203429.","journal-title":"Oncogene"},{"key":"429_CR5","first-page":"43","volume":"152","author":"C Adida","year":"1998","unstructured":"Adida C, Crotty P, McGrath J, Berrebi D, Diebold J, Altieri D: Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am J Path. 1998, 152: 43-49.","journal-title":"Am J Path"},{"key":"429_CR6","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1158\/1535-7163.MCT-05-0375","volume":"5","author":"S Fukuda","year":"2006","unstructured":"Fukuda S, Pelus LM: Survivin, a cancer target with an emerging role in normal adult tissues. Mol Cancer Ther. 2006, 5: 1087-98. 10.1158\/1535-7163.MCT-05-0375.","journal-title":"Mol Cancer Ther"},{"key":"429_CR7","doi-asserted-by":"publisher","first-page":"6276","DOI":"10.1038\/onc.2008.303","volume":"27","author":"DC Altieri","year":"2008","unstructured":"Altieri DC: New wirings in the survivin networks. Oncogene. 2008, 27: 6276-84. 10.1038\/onc.2008.303.","journal-title":"Oncogene"},{"key":"429_CR8","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1002\/jcp.20634","volume":"208","author":"F Li","year":"2006","unstructured":"Li F, Ling X: Survivin study: an update of \"what is the next wave\"?. J Cell Physiol. 2006, 208: 476-86. 10.1002\/jcp.20634.","journal-title":"J Cell Physiol"},{"key":"429_CR9","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1084\/jem.20032033","volume":"199","author":"F Altznauer","year":"2004","unstructured":"Altznauer F, Martinelli S, Yousefi S, Thurig C, Schmid I, Conway E, Schoni M, Vogt P, Mueller C, Fey M, et al: Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J Exp Med. 2004, 199: 1343-54. 10.1084\/jem.20032033.","journal-title":"J Exp Med"},{"key":"429_CR10","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1053\/gast.2002.34753","volume":"123","author":"EM Conway","year":"2002","unstructured":"Conway EM, Pollefeyt S, Steiner-Mosonyi M, Luo W, DeVriese A, Lupu F, Bono F, Leducq N, Dol F, Schaeffer P, et al: Deficiency of Survivin in Transgenic Mice Exacerbates Fas-Induced Apoptosis via Mitochondrial Pathways. Gastroenterology. 2002, 123: 619-631. 10.1053\/gast.2002.34753.","journal-title":"Gastroenterology"},{"key":"429_CR11","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1084\/jem.20062395","volume":"204","author":"CG Leung","year":"2007","unstructured":"Leung CG, Xu Y, Mularski B, Liu H, Gurbuxani S, Crispino JD: Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells. J Exp Med. 2007, 204: 1603-11.","journal-title":"J Exp Med"},{"key":"429_CR12","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/S0002-9440(10)63453-0","volume":"163","author":"EM Conway","year":"2003","unstructured":"Conway EM, Zwerts F, Van Eygen V, DeVries A, Nagai N, Luo W, Collen D: Survivin-dependent angiogenesis in ischemic brain: Molecular mechanisms of hypoxia-induced upregulation. Am J Pathol. 2003, 163: 935-946.","journal-title":"Am J Pathol"},{"key":"429_CR13","doi-asserted-by":"publisher","first-page":"6962","DOI":"10.1523\/JNEUROSCI.1446-05.2005","volume":"25","author":"Y Jiang","year":"2005","unstructured":"Jiang Y, de Bruin A, Caldas H, Fangusaro J, Hayes J, Conway EM, Robinson M, Altura RA: Essential role for survivin in early brain development. J Neurosci. 2005, 25: 6962-70. 10.1523\/JNEUROSCI.1446-05.2005.","journal-title":"J Neurosci"},{"key":"429_CR14","doi-asserted-by":"publisher","first-page":"4742","DOI":"10.1182\/blood-2006-06-028068","volume":"109","author":"F Zwerts","year":"2007","unstructured":"Zwerts F, Lupu F, De Vriese A, Pollefeyt S, Moons L, Altura RA, Jiang Y, Maxwell PH, Hill P, Oh H, et al: Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure. Blood. 2007, 109: 4742-52. 10.1182\/blood-2006-06-028068.","journal-title":"Blood"},{"key":"429_CR15","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1432-0436.2006.00073.x","volume":"74","author":"D Du Pasquier","year":"2006","unstructured":"Du Pasquier D, Phung AC, Ymlahi-Ouazzani Q, Sinzelle L, Ballagny C, Bronchain O, Du Pasquier L, Mazabraud A: Survivin increased vascular development during Xenopus ontogenesis. Differentiation. 2006, 74: 244-53. 10.1111\/j.1432-0436.2006.00073.x.","journal-title":"Differentiation"},{"key":"429_CR16","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/1471-213X-7-50","volume":"7","author":"A Ma","year":"2007","unstructured":"Ma A, Lin R, Chan PK, Leung JC, Chan LY, Meng A, Verfaillie CM, Liang R, Leung AY: The role of survivin in angiogenesis during zebrafish embryonic development. BMC Dev Biol. 2007, 7: 50-10.1186\/1471-213X-7-50.","journal-title":"BMC Dev Biol"},{"key":"429_CR17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/0168-9525(90)90008-T","volume":"10","author":"G Hauptmann","year":"1994","unstructured":"Hauptmann G, Gerster T: Two-color whole-mount in situ hybridization to vertebrate and Drosophila embryos. Trends Genet. 1994, 10: 266-10.1016\/0168-9525(90)90008-T.","journal-title":"Trends Genet"},{"key":"429_CR18","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm1285","volume":"11","author":"A Ny","year":"2005","unstructured":"Ny A, Koch M, Schneider M, Neven E, Tong RT, Maity S, Fischer C, Plaisance S, Lambrechts D, Heligon C, et al: A genetic Xenopus laevis tadpole model to study lymphangiogenesis. Nat Med. 2005, 11: 998-1004.","journal-title":"Nat Med"},{"key":"429_CR19","doi-asserted-by":"publisher","first-page":"e78","DOI":"10.1371\/journal.pgen.0030078","volume":"3","author":"ME Robu","year":"2007","unstructured":"Robu ME, Larson JD, Nasevicius A, Beiraghi S, Brenner C, Farber SA, Ekker SC: p53 activation by knockdown technologies. PLoS Genet. 2007, 3: e78-10.1371\/journal.pgen.0030078.","journal-title":"PLoS Genet"},{"key":"429_CR20","doi-asserted-by":"publisher","first-page":"7293","DOI":"10.1523\/JNEUROSCI.0095-06.2006","volume":"26","author":"RW Koster","year":"2006","unstructured":"Koster RW, Fraser SE: FGF signaling mediates regeneration of the differentiating cerebellum through repatterning of the anterior hindbrain and reinitiation of neuronal migration. J Neurosci. 2006, 26: 7293-304. 10.1523\/JNEUROSCI.0095-06.2006.","journal-title":"J Neurosci"},{"key":"429_CR21","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1242\/dev.121.12.4117","volume":"121","author":"B Appel","year":"1995","unstructured":"Appel B, Korzh V, Glasgow E, Thor S, Edlund T, Dawid IB, Eisen JS: Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish. Development. 1995, 121: 4117-25.","journal-title":"Development"},{"key":"429_CR22","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1006\/dbio.2002.0711","volume":"248","author":"ND Lawson","year":"2002","unstructured":"Lawson ND, Weinstein BM: In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol. 2002, 248: 307-18. 10.1006\/dbio.2002.0711.","journal-title":"Dev Biol"},{"key":"429_CR23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1006\/dbio.1996.8495","volume":"183","author":"B Fouquet","year":"1997","unstructured":"Fouquet B, Weinstein BM, Serluca FC, Fishman MC: Vessel patterning in the embryo of the zebrafish: guidance by notochord. Dev Biol. 1997, 183: 37-48. 10.1006\/dbio.1996.8495.","journal-title":"Dev Biol"},{"key":"429_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0070-2153(05)71002-4","volume":"71","author":"TP Zhong","year":"2005","unstructured":"Zhong TP: Zebrafish genetics and formation of embryonic vasculature. Curr Top Dev Biol. 2005, 71: 53-81. 10.1016\/S0070-2153(05)71002-4.","journal-title":"Curr Top Dev Biol"},{"key":"429_CR25","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.pharmthera.2008.02.010","volume":"118","author":"D Baldessari","year":"2008","unstructured":"Baldessari D, Mione M: How to create the vascular tree? (Latest) help from the zebrafish. Pharmacol Ther. 2008, 118: 206-30. 10.1016\/j.pharmthera.2008.02.010.","journal-title":"Pharmacol Ther"},{"key":"429_CR26","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/(SICI)1526-968X(200001)26:1<86::AID-GENE11>3.0.CO;2-Q","volume":"26","author":"AL Rubinstein","year":"2000","unstructured":"Rubinstein AL, Lee D, Luo R, Henion PD, Halpern ME: Genes dependent on zebrafish cyclops function identified by AFLP differential gene expression screen. Genesis. 2000, 26: 86-97. 10.1002\/(SICI)1526-968X(200001)26:1<86::AID-GENE11>3.0.CO;2-Q.","journal-title":"Genesis"},{"key":"429_CR27","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1100\/tsw.2007.189","volume":"7","author":"P Snider","year":"2007","unstructured":"Snider P, Olaopa M, Firulli AB, Conway SJ: Cardiovascular development and the colonizing cardiac neural crest lineage. ScientificWorldJournal. 2007, 7: 1090-113. 10.1100\/tsw.2007.189.","journal-title":"ScientificWorldJournal"},{"key":"429_CR28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature05045","volume":"443","author":"KM Vogeli","year":"2006","unstructured":"Vogeli KM, Jin SW, Martin GR, Stainier DY: A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula. Nature. 2006, 443: 337-9. 10.1038\/nature05045.","journal-title":"Nature"},{"key":"429_CR29","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.exphem.2006.11.010","volume":"35","author":"AC Ma","year":"2007","unstructured":"Ma AC, Liang R, Leung AY: The role of phospholipase C gamma 1 in primitive hematopoiesis during zebrafish development. Exp Hematol. 2007, 35: 368-73. 10.1016\/j.exphem.2006.11.010.","journal-title":"Exp Hematol"},{"key":"429_CR30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1006\/dbio.1999.9406","volume":"214","author":"D Yelon","year":"1999","unstructured":"Yelon D, Horne SA, Stainier DY: Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish. Dev Biol. 1999, 214: 23-37. 10.1006\/dbio.1999.9406.","journal-title":"Dev Biol"},{"key":"429_CR31","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1242\/dev.124.21.4373","volume":"124","author":"JN Chen","year":"1997","unstructured":"Chen JN, van Eeden FJ, Warren KS, Chin A, Nusslein-Volhard C, Haffter P, Fishman MC: Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development. 1997, 124: 4373-82.","journal-title":"Development"},{"key":"429_CR32","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S1084952102001040","volume":"13","author":"NS Glickman","year":"2002","unstructured":"Glickman NS, Yelon D: Cardiac development in zebrafish: coordination of form and function. Semin Cell Dev Biol. 2002, 13: 507-13. 10.1016\/S1084952102001040.","journal-title":"Semin Cell Dev Biol"},{"key":"429_CR33","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nature01282","volume":"421","author":"JR Hove","year":"2003","unstructured":"Hove JR, Koster RW, Forouhar AS, Acevedo-Bolton G, Fraser SE, Gharib M: Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature. 2003, 421: 172-7. 10.1038\/nature01282.","journal-title":"Nature"},{"key":"429_CR34","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/dvdy.10264","volume":"226","author":"YX Li","year":"2003","unstructured":"Li YX, Zdanowicz M, Young L, Kumiski D, Leatherbury L, Kirby ML: Cardiac neural crest in zebrafish embryos contributes to myocardial cell lineage and early heart function. Dev Dyn. 2003, 226: 540-50. 10.1002\/dvdy.10264.","journal-title":"Dev Dyn"},{"key":"429_CR35","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ydbio.2005.11.014","volume":"290","author":"JA Lister","year":"2006","unstructured":"Lister JA, Cooper C, Nguyen K, Modrell M, Grant K, Raible DW: Zebrafish Foxd3 is required for development of a subset of neural crest derivatives. Dev Biol. 2006, 290: 92-104. 10.1016\/j.ydbio.2005.11.014.","journal-title":"Dev Biol"},{"key":"429_CR36","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0012-1606(03)00037-X","volume":"257","author":"M Sato","year":"2003","unstructured":"Sato M, Yost HJ: Cardiac neural crest contributes to cardiomyogenesis in zebrafish. Dev Biol. 2003, 257: 127-39. 10.1016\/S0012-1606(03)00037-X.","journal-title":"Dev Biol"},{"key":"429_CR37","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1006\/bbrc.1999.1589","volume":"264","author":"J Tran","year":"1999","unstructured":"Tran J, Rak J, Sheehan C, Saibil SD, LaCasse E, Korneluk RG, Kerbel RS: Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells. Biochem Biophys Res Commun. 1999, 264: 781-8. 10.1006\/bbrc.1999.1589.","journal-title":"Biochem Biophys Res Commun"},{"key":"429_CR38","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.devcel.2008.09.012","volume":"15","author":"MX O'Riordan","year":"2008","unstructured":"O'Riordan MX, Bauler LD, Scott FL, Duckett CS: Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. Dev Cell. 2008, 15: 497-508. 10.1016\/j.devcel.2008.09.012.","journal-title":"Dev Cell"},{"key":"429_CR39","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/S0167-4781(97)00233-9","volume":"1397","author":"D Liang","year":"1998","unstructured":"Liang D, Xu X, Chin AJ, Balasubramaniyan NV, Teo MA, Lam TJ, Weinberg ES, Ge R: Cloning and characterization of vascular endothelial growth factor (VEGF) from zebrafish, Danio rerio. Biochim Biophys Acta. 1998, 1397: 14-20.","journal-title":"Biochim Biophys Acta"},{"key":"429_CR40","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1038\/ng.2007.8","volume":"39","author":"MM Santoro","year":"2007","unstructured":"Santoro MM, Samuel T, Mitchell T, Reed JC, Stainier DY: Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nat Genet. 2007, 39: 1397-402. 10.1038\/ng.2007.8.","journal-title":"Nat Genet"},{"key":"429_CR41","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.ahj.2005.10.012","volume":"151","author":"A Vannay","year":"2006","unstructured":"Vannay A, Vasarhelyi B, Kornyei M, Treszl A, Kozma G, Gyorffy B, Tulassay T, Sulyok E: Single-nucleotide polymorphisms of VEGF gene are associated with risk of congenital valvuloseptal heart defects. Am Heart J. 2006, 151: 878-81. 10.1016\/j.ahj.2005.10.012.","journal-title":"Am Heart J"},{"key":"429_CR42","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00401-007-0228-3","volume":"113","author":"S Raab","year":"2007","unstructured":"Raab S, Plate KH: Different networks, common growth factors: shared growth factors and receptors of the vascular and the nervous system. Acta Neuropathol (Berl). 2007, 113: 607-26. 10.1007\/s00401-007-0228-3.","journal-title":"Acta Neuropathol (Berl)"},{"key":"429_CR43","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1006\/scdb.2001.0289","volume":"13","author":"RH Adams","year":"2002","unstructured":"Adams RH: Vascular patterning by Eph receptor tyrosine kinases and ephrins. Semin Cell Dev Biol. 2002, 13: 55-60. 10.1006\/scdb.2001.0289.","journal-title":"Semin Cell Dev Biol"},{"key":"429_CR44","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/S0006-291X(02)00330-3","volume":"293","author":"S Suenobu","year":"2002","unstructured":"Suenobu S, Takakura N, Inada T, Yamada Y, Yuasa H, Zhang XQ, Sakano S, Oike Y, Suda T: A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis. Biochem Biophys Res Commun. 2002, 293: 1124-31. 10.1016\/S0006-291X(02)00330-3.","journal-title":"Biochem Biophys Res Commun"},{"key":"429_CR45","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.expneurol.2004.01.022","volume":"187","author":"JM Rosenstein","year":"2004","unstructured":"Rosenstein JM, Krum JM: New roles for VEGF in nervous tissue \u2013 beyond blood vessels. Exp Neurol. 2004, 187: 246-53. 10.1016\/j.expneurol.2004.01.022.","journal-title":"Exp Neurol"},{"issue":"5675","key":"429_CR46","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1126\/science.1095505","volume":"304","author":"Q Shen","year":"2004","unstructured":"Shen Q, Goderie S, Jin L, Karanth N, Sun Y, Abramova N, Vincent P, Pumiglia K, Temple S: Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells. Science. 2004, 304 (5675): 1338-1340. 10.1126\/science.1095505.","journal-title":"Science"},{"key":"429_CR47","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/j.1750-3639.2004.tb00060.x","volume":"14","author":"A Schanzer","year":"2004","unstructured":"Schanzer A, Wachs FP, Wilhelm D, Acker T, Cooper-Kuhn C, Beck H, Winkler J, Aigner L, Plate KH, Kuhn HG: Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor. Brain Pathol. 2004, 14: 237-48.","journal-title":"Brain Pathol"},{"key":"429_CR48","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0925-4773(01)00468-3","volume":"108","author":"D Liang","year":"2001","unstructured":"Liang D, Chang JR, Chin AJ, Smith A, Kelly C, Weinberg ES, Ge R: The role of vascular endothelial growth factor (VEGF) in vasculogenesis, angiogenesis, and hematopoiesis in zebrafish development. Mech Dev. 2001, 108: 29-43. 10.1016\/S0925-4773(01)00468-3.","journal-title":"Mech Dev"},{"key":"429_CR49","first-page":"229","volume":"67","author":"I Stalmans","year":"2005","unstructured":"Stalmans I: Role of the vascular endothelial growth factor isoforms in retinal angiogenesis and DiGeorge syndrome. Verh K Acad Geneeskd Belg. 2005, 67: 229-76.","journal-title":"Verh K Acad Geneeskd Belg"},{"key":"429_CR50","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.mcn.2003.12.011","volume":"25","author":"S Pennartz","year":"2004","unstructured":"Pennartz S, Belvindrah R, Tomiuk S, Zimmer C, Hofmann K, Conradt M, Bosio A, Cremer H: Purification of neuronal precursors from the adult mouse brain: comprehensive gene expression analysis provides new insights into the control of cell migration, differentiation, and homeostasis. Mol Cell Neurosci. 2004, 25: 692-706. 10.1016\/j.mcn.2003.12.011.","journal-title":"Mol Cell Neurosci"},{"key":"429_CR51","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/ng1211","volume":"34","author":"D Lambrechts","year":"2003","unstructured":"Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, Wyns S, Thijs V, Andersson J, van Marion I, et al: VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet. 2003, 34: 383-94. 10.1038\/ng1211.","journal-title":"Nat Genet"},{"key":"429_CR52","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/aja.1002030302","volume":"203","author":"CB Kimmel","year":"1995","unstructured":"Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF: Stages of embryonic development of the zebrafish. Dev Dyn. 1995, 203: 253-310.","journal-title":"Dev Dyn"}],"container-title":["BMC Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-213X-9-25.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T21:31:05Z","timestamp":1630445465000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcdevbiol.biomedcentral.com\/articles\/10.1186\/1471-213X-9-25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,26]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["429"],"URL":"https:\/\/doi.org\/10.1186\/1471-213x-9-25","relation":{},"ISSN":["1471-213X"],"issn-type":[{"value":"1471-213X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,26]]},"assertion":[{"value":"15 November 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"25"}}