{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:06:04Z","timestamp":1791327964689,"version":"4.3.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Dev Biol"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The exocrine pancreas is composed of a branched network of ducts connected to acini. They are lined by a monolayered epithelium that derives from the endoderm and is surrounded by mesoderm-derived mesenchyme. The morphogenic mechanisms by which the ductal network is established as well as the signaling pathways involved in this process are poorly understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>By morphological analyzis of wild-type and mutant mouse embryos and using cultured embryonic explants we investigated how epithelial morphogenesis takes place and is regulated by chemokine signaling. Pancreas ontogenesis displayed a sequence of two opposite epithelial transitions. During the first transition, the monolayered and polarized endodermal cells give rise to tissue buds composed of a mass of non polarized epithelial cells. During the second transition the buds reorganize into branched and polarized epithelial monolayers that further differentiate into tubulo-acinar glands. We found that the second epithelial transition is controlled by the chemokine Stromal cell-Derived Factor (SDF)-1. The latter is expressed by the mesenchyme, whereas its receptor CXCR4 is expressed by the epithelium. Reorganization of cultured pancreatic buds into monolayered epithelia was blocked in the presence of AMD3100, a SDF-1 antagonist. Analyzis of <jats:italic>sdf1<\/jats:italic> and <jats:italic>cxcr4<\/jats:italic> knockout embryos at the stage of the second epithelial transition revealed transient defective morphogenesis of the ventral and dorsal pancreas. Reorganization of a globular mass of epithelial cells in polarized monolayers is also observed during submandibular glands development. We found that SDF-1 and CXCR4 are expressed in this organ and that AMD3100 treatment of submandibular gland explants blocks its branching morphogenesis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>In conclusion, our data show that the primitive pancreatic ductal network, which is lined by a monolayered and polarized epithelium, forms by remodeling of a globular mass of non polarized epithelial cells. Our data also suggest that SDF-1 controls the branching morphogenesis of several exocrine tissues.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-213x-9-66","type":"journal-article","created":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T07:16:07Z","timestamp":1260861367000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1"],"prefix":"10.1186","volume":"9","author":[{"given":"Anne-Christine","family":"Hick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"van Eyll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Cordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Forez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Passante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nagasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Vanderhaeghen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre J","family":"Courtoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy G","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric P","family":"Lemaigre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe E","family":"Pierreux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,14]]},"reference":[{"key":"470_CR1","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/j.1432-0436.2006.00107.x","volume":"74","author":"BL Hogan","year":"2006","unstructured":"Hogan BL: Building organs from buds, branches and tubes. Differentiation. 2006, 74: 323-325. 10.1111\/j.1432-0436.2006.00107.x.","journal-title":"Differentiation"},{"key":"470_CR2","volume-title":"Dev Biol","author":"DJ Andrew","year":"2009","unstructured":"Andrew DJ, Ewald AJ: Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration. Dev Biol. 2009"},{"key":"470_CR3","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1126\/science.1162783","volume":"322","author":"P Lu","year":"2008","unstructured":"Lu P, Werb Z: Patterning mechanisms of branched organs. Science. 2008, 322: 1506-1509. 10.1126\/science.1162783.","journal-title":"Science"},{"key":"470_CR4","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/nrm2523","volume":"9","author":"DM Bryant","year":"2008","unstructured":"Bryant DM, Mostov KE: From cells to organs: building polarized tissue. Nat Rev Mol Cell Biol. 2008, 9: 887-901. 10.1038\/nrm2523.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"470_CR5","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1242\/dev.121.6.1569","volume":"121","author":"JM Slack","year":"1995","unstructured":"Slack JM: Developmental biology of the pancreas. Development. 1995, 121: 1569-1580.","journal-title":"Development"},{"key":"470_CR6","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nrg841","volume":"3","author":"H Edlund","year":"2002","unstructured":"Edlund H: Pancreatic organogenesis--developmental mechanisms and implications for therapy. Nat Rev Genet. 2002, 3: 524-532. 10.1038\/nrg841.","journal-title":"Nat Rev Genet"},{"key":"470_CR7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/S0959-437X(02)00338-6","volume":"12","author":"SK Kim","year":"2002","unstructured":"Kim SK, MacDonald RJ: Signaling and transcriptional control of pancreatic organogenesis. Curr Opin Genet Dev. 2002, 12: 540-547. 10.1016\/S0959-437X(02)00338-6.","journal-title":"Curr Opin Genet Dev"},{"key":"470_CR8","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev.cellbio.19.111301.144752","volume":"19","author":"LC Murtaugh","year":"2003","unstructured":"Murtaugh LC, Melton DA: Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol. 2003, 19: 71-89. 10.1146\/annurev.cellbio.19.111301.144752.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"470_CR9","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.biocel.2004.07.010","volume":"37","author":"A Grapin-Botton","year":"2005","unstructured":"Grapin-Botton A: Ductal cells of the pancreas. Int J Biochem Cell Biol. 2005, 37: 504-510. 10.1016\/j.biocel.2004.07.010.","journal-title":"Int J Biochem Cell Biol"},{"key":"470_CR10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ydbio.2008.10.024","volume":"326","author":"GK Gittes","year":"2009","unstructured":"Gittes GK: Developmental biology of the pancreas: a comprehensive review. Dev Biol. 2009, 326: 4-35. 10.1016\/j.ydbio.2008.10.024.","journal-title":"Dev Biol"},{"key":"470_CR11","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1432-0436.2006.00088.x","volume":"74","author":"VN Patel","year":"2006","unstructured":"Patel VN, Rebustini IT, Hoffman MP: Salivary gland branching morphogenesis. Differentiation. 2006, 74: 349-364. 10.1111\/j.1432-0436.2006.00088.x.","journal-title":"Differentiation"},{"key":"470_CR12","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.semcdb.2007.01.006","volume":"18","author":"AS Tucker","year":"2007","unstructured":"Tucker AS: Salivary gland development. Semin Cell Dev Biol. 2007, 18: 237-244. 10.1016\/j.semcdb.2007.01.006.","journal-title":"Semin Cell Dev Biol"},{"key":"470_CR13","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/0012-1606(62)90042-8","volume":"4","author":"N Golosow","year":"1962","unstructured":"Golosow N, Grobstein C: Epitheliomesenchymal interaction in pancreatic morphogenesis. Dev Biol. 1962, 4: 242-255. 10.1016\/0012-1606(62)90042-8.","journal-title":"Dev Biol"},{"key":"470_CR14","first-page":"287","volume":"84","author":"E Borghese","year":"1950","unstructured":"Borghese E: The development in vitro of the submandibular and sublingual glands of Mus musculus. J Anat. 1950, 84: 287-302.","journal-title":"J Anat"},{"key":"470_CR15","doi-asserted-by":"publisher","first-page":"5767","DOI":"10.1242\/dev.00172","volume":"129","author":"MP Hoffman","year":"2002","unstructured":"Hoffman MP, Kidder BL, Steinberg ZL, Lakhani S, Ho S, Kleinman HK, Larsen M: Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. Development. 2002, 129: 5767-5778. 10.1242\/dev.00172.","journal-title":"Development"},{"key":"470_CR16","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1242\/dev.01690","volume":"132","author":"Z Steinberg","year":"2005","unstructured":"Steinberg Z, Myers C, Heim VM, Lathrop CA, Rebustini IT, Stewart JS, Larsen M, Hoffman MP: FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development. 2005, 132: 1223-1234. 10.1242\/dev.01690.","journal-title":"Development"},{"key":"470_CR17","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/(SICI)1097-0185(19991101)256:3<252::AID-AR5>3.0.CO;2-6","volume":"256","author":"T Jaskoll","year":"1999","unstructured":"Jaskoll T, Melnick M: Submandibular gland morphogenesis: stage-specific expression of TGF-alpha\/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec. 1999, 256: 252-268. 10.1002\/(SICI)1097-0185(19991101)256:3<252::AID-AR5>3.0.CO;2-6.","journal-title":"Anat Rec"},{"key":"470_CR18","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1002\/dvdy.10472","volume":"229","author":"T Jaskoll","year":"2004","unstructured":"Jaskoll T, Leo T, Witcher D, Ormestad M, Astorga J, Bringas P, Carlsson P, Melnick M: Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis. Dev Dyn. 2004, 229: 722-732. 10.1002\/dvdy.10472.","journal-title":"Dev Dyn"},{"key":"470_CR19","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1242\/dev.005066","volume":"134","author":"L Chung","year":"2007","unstructured":"Chung L, Yang TL, Huang HR, Hsu SM, Cheng HJ, Huang PH: Semaphorin signaling facilitates cleft formation in the developing salivary gland. Development. 2007, 134: 2935-2945. 10.1242\/dev.005066.","journal-title":"Development"},{"key":"470_CR20","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1242\/dev.127.12.2617","volume":"127","author":"PJ Miettinen","year":"2000","unstructured":"Miettinen PJ, Huotari M, Koivisto T, Ustinov J, Palgi J, Rasilainen S, Lehtonen E, Keski-Oja J, Otonkoski T: Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors. Development. 2000, 127: 2617-2627.","journal-title":"Development"},{"key":"470_CR21","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1242\/dev.128.24.5109","volume":"128","author":"A Bhushan","year":"2001","unstructured":"Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R: Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development. 2001, 128: 5109-5117.","journal-title":"Development"},{"key":"470_CR22","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.2337\/diabetes.50.7.1571","volume":"50","author":"C Cras-Meneur","year":"2001","unstructured":"Cras-Meneur C, Elghazi L, Czernichow P, Scharfmann R: Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: a balance between proliferation and differentiation. Diabetes. 2001, 50: 1571-1579. 10.2337\/diabetes.50.7.1571.","journal-title":"Diabetes"},{"key":"470_CR23","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1242\/dev.01280","volume":"131","author":"F Esni","year":"2004","unstructured":"Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, Yu X, MacDonald RJ, Civin CI, Real FX, Pack MA, et al: Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development. 2004, 131: 4213-4224. 10.1242\/dev.01280.","journal-title":"Development"},{"key":"470_CR24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/jlb.65.1.6","volume":"65","author":"CH Kim","year":"1999","unstructured":"Kim CH, Broxmeyer HE: Chemokines: signal lamps for trafficking of T and B cells for development and effector function. J Leukoc Biol. 1999, 65: 6-15.","journal-title":"J Leukoc Biol"},{"key":"470_CR25","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/glia.10139","volume":"42","author":"F Lazarini","year":"2003","unstructured":"Lazarini F, Tham TN, Casanova P, Arenzana-Seisdedos F, Dubois-Dalcq M: Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system. Glia. 2003, 42: 139-148. 10.1002\/glia.10139.","journal-title":"Glia"},{"key":"470_CR26","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1387\/ijdb.041814hk","volume":"48","author":"H Kulbe","year":"2004","unstructured":"Kulbe H, Levinson NR, Balkwill F, Wilson JL: The chemokine network in cancer--much more than directing cell movement. Int J Dev Biol. 2004, 48: 489-496. 10.1387\/ijdb.041814hk.","journal-title":"Int J Dev Biol"},{"key":"470_CR27","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1084\/jem.20052144","volume":"203","author":"JM Burns","year":"2006","unstructured":"Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, Miao Z, Penfold ME, Sunshine MJ, Littman DR, Kuo CJ, et al: A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med. 2006, 203: 2201-2213. 10.1084\/jem.20052144.","journal-title":"J Exp Med"},{"key":"470_CR28","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/382635a0","volume":"382","author":"T Nagasawa","year":"1996","unstructured":"Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T: Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF\/SDF-1. Nature. 1996, 382: 635-638. 10.1038\/382635a0.","journal-title":"Nature"},{"key":"470_CR29","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/31261","volume":"393","author":"K Tachibana","year":"1998","unstructured":"Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S, et al: The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature. 1998, 393: 591-594. 10.1038\/31261.","journal-title":"Nature"},{"key":"470_CR30","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/31269","volume":"393","author":"YR Zou","year":"1998","unstructured":"Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR: Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 1998, 393: 595-599. 10.1038\/31269.","journal-title":"Nature"},{"key":"470_CR31","doi-asserted-by":"publisher","first-page":"9448","DOI":"10.1073\/pnas.95.16.9448","volume":"95","author":"Q Ma","year":"1998","unstructured":"Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA. 1998, 95: 9448-9453. 10.1073\/pnas.95.16.9448.","journal-title":"Proc Natl Acad Sci USA"},{"key":"470_CR32","doi-asserted-by":"publisher","first-page":"7090","DOI":"10.1073\/pnas.092013799","volume":"99","author":"M Lu","year":"2002","unstructured":"Lu M, Grove EA, Miller RJ: Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. Proc Natl Acad Sci USA. 2002, 99: 7090-7095. 10.1073\/pnas.092013799.","journal-title":"Proc Natl Acad Sci USA"},{"key":"470_CR33","doi-asserted-by":"publisher","first-page":"14759","DOI":"10.1073\/pnas.0702229104","volume":"104","author":"F Sierro","year":"2007","unstructured":"Sierro F, Biben C, Martinez-Munoz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, et al: Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12\/SDF-1 receptor, CXCR7. Proc Natl Acad Sci USA. 2007, 104: 14759-14764. 10.1073\/pnas.0702229104.","journal-title":"Proc Natl Acad Sci USA"},{"key":"470_CR34","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1083\/jcb.200304153","volume":"163","author":"AG Kayali","year":"2003","unstructured":"Kayali AG, Van Gunst K, Campbell IL, Stotland A, Kritzik M, Liu G, Flodstrom-Tullberg M, Zhang YQ, Sarvetnick N: The stromal cell-derived factor-1alpha\/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. J Cell Biol. 2003, 163: 859-869. 10.1083\/jcb.200304153.","journal-title":"J Cell Biol"},{"key":"470_CR35","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.2337\/db07-0291","volume":"56","author":"T Yano","year":"2007","unstructured":"Yano T, Liu Z, Donovan J, Thomas MK, Habener JF: Stromal cell derived factor-1 (SDF-1)\/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt. Diabetes. 2007, 56: 2946-2957. 10.2337\/db07-0291.","journal-title":"Diabetes"},{"key":"470_CR36","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1146\/annurev.cellbio.22.010305.104219","volume":"22","author":"K Shin","year":"2006","unstructured":"Shin K, Fogg VC, Margolis B: Tight junctions and cell polarity. Annu Rev Cell Dev Biol. 2006, 22: 207-235. 10.1146\/annurev.cellbio.22.010305.104219.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"470_CR37","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1242\/dev.122.2.439","volume":"122","author":"GK Gittes","year":"1996","unstructured":"Gittes GK, Galante PE, Hanahan D, Rutter WJ, Debase HT: Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors. Development. 1996, 122: 439-447.","journal-title":"Development"},{"key":"470_CR38","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1006\/dbio.1999.9405","volume":"213","author":"KE McGrath","year":"1999","unstructured":"McGrath KE, Koniski AD, Maltby KM, McGann JK, Palis J: Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev Biol. 1999, 213: 442-456. 10.1006\/dbio.1999.9405.","journal-title":"Dev Biol"},{"key":"470_CR39","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1126\/science.1160038","volume":"322","author":"S Nair","year":"2008","unstructured":"Nair S, Schilling TF: Chemokine signaling controls endodermal migration during zebrafish gastrulation. Science. 2008, 322: 89-92. 10.1126\/science.1160038.","journal-title":"Science"},{"key":"470_CR40","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1242\/jcs.01067","volume":"117","author":"JM van Eyll","year":"2004","unstructured":"van Eyll JM, Pierreux CE, Lemaigre FP, Rousseau GG: Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin A. J Cell Sci. 2004, 117: 2077-2086. 10.1242\/jcs.01067.","journal-title":"J Cell Sci"},{"key":"470_CR41","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0014-5793(02)03143-5","volume":"527","author":"S Hatse","year":"2002","unstructured":"Hatse S, Princen K, Bridger G, De Clercq E, Schols D: Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett. 2002, 527: 255-262. 10.1016\/S0014-5793(02)03143-5.","journal-title":"FEBS Lett"},{"key":"470_CR42","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/(SICI)1097-0177(199612)207:4<395::AID-AJA4>3.0.CO;2-C","volume":"207","author":"Y Hieda","year":"1996","unstructured":"Hieda Y, Iwai K, Morita T, Nakanishi Y: Mouse embryonic submandibular gland epithelium loses its tissue integrity during early branching morphogenesis. Dev Dyn. 1996, 207: 395-403. 10.1002\/(SICI)1097-0177(199612)207:4<395::AID-AJA4>3.0.CO;2-C.","journal-title":"Dev Dyn"},{"key":"470_CR43","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1053\/j.gastro.2006.12.054","volume":"132","author":"DA Cano","year":"2007","unstructured":"Cano DA, Hebrok M, Zenker M: Pancreatic development and disease. Gastroenterology. 2007, 132: 745-762. 10.1053\/j.gastro.2006.12.054.","journal-title":"Gastroenterology"},{"key":"470_CR44","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ydbio.2005.04.035","volume":"284","author":"NS Yee","year":"2005","unstructured":"Yee NS, Lorent K, Pack M: Exocrine pancreas development in zebrafish. Dev Biol. 2005, 284: 84-101. 10.1016\/j.ydbio.2005.04.035.","journal-title":"Dev Biol"},{"key":"470_CR45","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/ncb1621","volume":"9","author":"M Bagnat","year":"2007","unstructured":"Bagnat M, Cheung ID, Mostov KE, Stainier DY: Genetic control of single lumen formation in the zebrafish gut. Nat Cell Biol. 2007, 9: 954-960. 10.1038\/ncb1621.","journal-title":"Nat Cell Biol"},{"key":"470_CR46","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ydbio.2007.03.003","volume":"306","author":"S Puri","year":"2007","unstructured":"Puri S, Hebrok M: Dynamics of embryonic pancreas development using real-time imaging. Dev Biol. 2007, 306: 82-93. 10.1016\/j.ydbio.2007.03.003.","journal-title":"Dev Biol"},{"key":"470_CR47","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1002\/dvdy.21943","volume":"238","author":"J Ueland","year":"2009","unstructured":"Ueland J, Yuan A, Marlier A, Gallagher AR, Karihaloo A: A novel role for the chemokine receptor Cxcr4 in kidney morphogenesis: an in vitro study. Dev Dyn. 2009, 238: 1083-1091. 10.1002\/dvdy.21943.","journal-title":"Dev Dyn"},{"key":"470_CR48","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1006\/dbio.2001.0405","volume":"238","author":"F Esni","year":"2001","unstructured":"Esni F, Johansson BR, Radice GL, Semb H: Dorsal pancreas agenesis in N-cadherin- deficient mice. Dev Biol. 2001, 238: 202-212. 10.1006\/dbio.2001.0405.","journal-title":"Dev Biol"},{"key":"470_CR49","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1242\/dev.01643","volume":"132","author":"J Edsbagge","year":"2005","unstructured":"Edsbagge J, Johansson JK, Esni F, Luo Y, Radice GL, Semb H: Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development. 2005, 132: 1085-1092. 10.1242\/dev.01643.","journal-title":"Development"},{"key":"470_CR50","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1101\/gad.346205","volume":"19","author":"E Vasyutina","year":"2005","unstructured":"Vasyutina E, Stebler J, Brand-Saberi B, Schulz S, Raz E, Birchmeier C: CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev. 2005, 19: 2187-2198. 10.1101\/gad.346205.","journal-title":"Genes Dev"},{"key":"470_CR51","doi-asserted-by":"publisher","first-page":"421","DOI":"10.4049\/jimmunol.170.1.421","volume":"170","author":"HE Broxmeyer","year":"2003","unstructured":"Broxmeyer HE, Cooper S, Kohli L, Hangoc G, Lee Y, Mantel C, Clapp DW, Kim CH: Transgenic expression of stromal cell-derived factor-1\/CXC chemokine ligand 12 enhances myeloid progenitor cell survival\/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo. J Immunol. 2003, 170: 421-429.","journal-title":"J Immunol"},{"key":"470_CR52","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/S1567-133X(03)00110-8","volume":"3","author":"P Jacquemin","year":"2003","unstructured":"Jacquemin P, Pierreux CE, Fierens S, van Eyll JM, Lemaigre FP, Rousseau GG: Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2. Gene Expr Patterns. 2003, 3: 639-644. 10.1016\/S1567-133X(03)00110-8.","journal-title":"Gene Expr Patterns"},{"key":"470_CR53","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0012-1606(03)00115-5","volume":"258","author":"P Jacquemin","year":"2003","unstructured":"Jacquemin P, Lemaigre FP, Rousseau GG: The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade. Dev Biol. 2003, 258: 105-116. 10.1016\/S0012-1606(03)00115-5.","journal-title":"Dev Biol"},{"key":"470_CR54","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1053\/j.gastro.2005.12.005","volume":"130","author":"CE Pierreux","year":"2006","unstructured":"Pierreux CE, Poll AV, Kemp CR, Clotman F, Maestro MA, Cordi S, Ferrer J, Leyns L, Rousseau GG, Lemaigre FP: The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology. 2006, 130: 532-541. 10.1053\/j.gastro.2005.12.005.","journal-title":"Gastroenterology"}],"container-title":["BMC Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-213X-9-66.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T21:31:14Z","timestamp":1630445474000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcdevbiol.biomedcentral.com\/articles\/10.1186\/1471-213X-9-66"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["470"],"URL":"https:\/\/doi.org\/10.1186\/1471-213x-9-66","relation":{},"ISSN":["1471-213X"],"issn-type":[{"value":"1471-213X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"29 April 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"66"}}