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ADAMTS proteins have recently gained attention with the discovery of their role in a variety of diseases, including tissue and blood disorders, cancer, osteoarthritis, Alzheimer's and the genetic syndromes Weill-Marchesani syndrome (ADAMTS10), thrombotic thrombocytopenic purpura (ADAMTS13), and Ehlers-Danlos syndrome type VIIC (ADAMTS2) in humans and belted white-spotting mutation in mice (\n                      <jats:italic>ADAMTS20<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Phylogenetic analysis and comparison of the exon\/intron organization of vertebrate (\n                      <jats:italic>Homo<\/jats:italic>\n                      ,\n                      <jats:italic>Mus<\/jats:italic>\n                      ,\n                      <jats:italic>Fugu<\/jats:italic>\n                      ), chordate (\n                      <jats:italic>Ciona<\/jats:italic>\n                      ) and invertebrate (\n                      <jats:italic>Drosophila<\/jats:italic>\n                      and\n                      <jats:italic>Caenorhabditis<\/jats:italic>\n                      ) ADAMTS homologs has elucidated the evolutionary relationships of this important gene family, which comprises 19 members in humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The evolutionary history of\n                      <jats:italic>ADAMTS<\/jats:italic>\n                      genes in vertebrate genomes has been marked by rampant gene duplication, including a retrotransposition that gave rise to a distinct\n                      <jats:italic>ADAMTS<\/jats:italic>\n                      subfamily (\n                      <jats:italic>ADAMTS1<\/jats:italic>\n                      ,\n                      <jats:italic>-4<\/jats:italic>\n                      ,\n                      <jats:italic>-5<\/jats:italic>\n                      ,\n                      <jats:italic>-8<\/jats:italic>\n                      ,\n                      <jats:italic>-15<\/jats:italic>\n                      ) that may have distinct aggrecanase and angiogenesis functions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2148-5-11","type":"journal-article","created":{"date-parts":[[2005,2,5]],"date-time":"2005-02-05T02:25:12Z","timestamp":1107570312000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Functional evolution of ADAMTS genes: Evidence from analyses of phylogeny and gene organization"],"prefix":"10.1186","volume":"5","author":[{"given":"Ainsley C","family":"Nicholson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shehre-Banoo","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John M","family":"Logsdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin G","family":"Van Meir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"issue":"1","key":"123_CR1","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1074\/jbc.272.1.556","volume":"272","author":"K Kuno","year":"1997","unstructured":"Kuno K, Kanada N, Nakashima E, Fujiki F, Ichimura F, Matsushima K: Molecular cloning of a gene encoding a new type of metalloproteinase- disintegrin family protein with thrombospondin motifs as an inflammation associated gene. 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