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These findings have prompted the development of a multilocus approach to investigate in more detail the genetic exchanges between the two species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed ten nuclear loci using the \"isolation with migration\" model implemented in the IM program, finding evidence for introgression from<jats:italic>L. intermedia<\/jats:italic>towards<jats:italic>L. whitmani<\/jats:italic>in three loci. These results confirm that introgression is occurring between the two species and suggest variation in the effects of gene flow among the different regions of the genome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The demonstration that these two vectors are not fully reproductively isolated might have important epidemiological consequences as these species could be exchanging genes controlling aspects of their vectorial capacity.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2148-8-141","type":"journal-article","created":{"date-parts":[[2008,5,13]],"date-time":"2008-05-13T06:14:30Z","timestamp":1210659270000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Multilocus analysis of introgression between two sand fly vectors of leishmaniasis"],"prefix":"10.1186","volume":"8","author":[{"given":"Camila J","family":"Mazzoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra S","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel EM","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata VDM","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Barbujani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre A","family":"Peixoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,5,12]]},"reference":[{"key":"710_CR1","volume-title":"Speciation","author":"JA Coyne","year":"2004","unstructured":"Coyne JA, Orr HA: Speciation. 2004, Sunderland: Sinauer Associates"},{"key":"710_CR2","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1534\/genetics.103.024182","volume":"167","author":"J Hey","year":"2004","unstructured":"Hey J, Nielsen R: Multilocus methods for estimating population sizes, migration rates and divergence time, with applications to the divergence of Drosophila pseudoobscura and D. persimilis. 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