{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:58:56Z","timestamp":1785419936030,"version":"3.56.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genet"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Rainbow trout have an XX\/XY genetic mechanism of sex determination where males are the heterogametic sex. The homology of the sex-determining gene (SDG) in medaka to <jats:italic>Dmrt1<\/jats:italic> suggested that SDGs evolve from downstream genes by gene duplication. Orthologous sequences of the major genes of the mammalian sex determination pathway have been reported in the rainbow trout but the map position for the majority of these genes has not been assigned.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Five loci of four candidate genes (<jats:italic>Amh<\/jats:italic>, <jats:italic>Dax1<\/jats:italic>, <jats:italic>Dmrt1<\/jats:italic> and <jats:italic>Sox6<\/jats:italic>) were tested for linkage to the Y chromosome of rainbow trout. We exclude the role of all these loci as candidates for the primary SDG in this species. <jats:italic>Sox6i<\/jats:italic> and <jats:italic>Sox6ii<\/jats:italic>, duplicated copies of <jats:italic>Sox6<\/jats:italic>, mapped to homeologous linkage groups 10 and 18 respectively. Genotyping fishes of the OSU \u00d7 Arlee mapping family for <jats:italic>Sox6i<\/jats:italic> and <jats:italic>Sox6ii<\/jats:italic> alleles indicated that <jats:italic>Sox6i<\/jats:italic> locus might be deleted in the Arlee lineage.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Additional candidate genes should be tested for their linkage to the Y chromosome. Mapping data of duplicated <jats:italic>Sox6<\/jats:italic> loci supports previously suggested homeology between linkage groups 10 and 18. Enrichment of the rainbow trout genomic map with known gene markers allows map comparisons with other salmonids. Mapping of candidate sex-determining loci is important for analyses of potential autosomal modifiers of sex-determination in rainbow trout.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2156-10-2","type":"journal-article","created":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T19:14:06Z","timestamp":1232046846000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Mapping of five candidate sex-determining loci in rainbow trout (Oncorhynchus mykiss)"],"prefix":"10.1186","volume":"10","author":[{"given":"Mahmoud A","family":"Alfaqih","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P","family":"Brunelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E","family":"Drew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary H","family":"Thorgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,1,15]]},"reference":[{"issue":"3\u20134","key":"660_CR1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0044-8486(02)00057-1","volume":"208","author":"RH Devlin","year":"2002","unstructured":"Devlin RH, Nagahama Y: Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences. 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