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Although a report initially describing this mouse variant suggested that<jats:italic>jal<\/jats:italic>maps to mouse Chromosome 13, our preliminary mapping analysis did not support that claim.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>To map<jats:italic>jal<\/jats:italic>to a particular mouse chromosome, we produced a 103-member intraspecific backcross panel that segregated for<jats:italic>jal,<\/jats:italic>and typed it for 93 PCR-scorable, microsatellite markers that are located throughout the mouse genome. Only markers from the centromeric tip of Chromosome 2 failed to segregate independently from<jats:italic>jal<\/jats:italic>, suggesting that<jats:italic>jal<\/jats:italic>resides in that region. To more precisely define<jats:italic>jal<\/jats:italic>\u2019s location, we characterized a second, 374-member backcross panel for the inheritance of five microsatellite markers from proximal Chromosome 2. This analysis restricted<jats:italic>jal<\/jats:italic>\u2019s position between<jats:italic>D2Mit359<\/jats:italic>and<jats:italic>D2Mit80<\/jats:italic>, an interval that includes<jats:italic>Il2ra<\/jats:italic>(for interleukin 2 receptor, alpha chain), a gene that is known to be associated with alopecia areata in humans. Complementation testing with an engineered null allele of<jats:italic>Il2ra<\/jats:italic>, however, showed that<jats:italic>jal<\/jats:italic>is a mutation in a distinct gene. To further refine the location of<jats:italic>jal<\/jats:italic>, the 374-member panel was typed for a set of four single-nucleotide markers located between<jats:italic>D2Mit359<\/jats:italic>and<jats:italic>D2Mit80<\/jats:italic>, identifying a 0.55\u2009Mb interval where<jats:italic>jal<\/jats:italic>must lie. This span includes ten genes\u2014only one of which,<jats:italic>Gata3<\/jats:italic>(for GATA binding protein 3)\u2014is known to be expressed in skin. Complementation testing between<jats:italic>jal<\/jats:italic>and a<jats:italic>Gata3<\/jats:italic>null allele produced doubly heterozygous, phenotypically mutant offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results presented indicate that the<jats:italic>jal<\/jats:italic>mutation is a mutant allele of the<jats:italic>Gata3<\/jats:italic>gene on mouse Chromosome 2. We therefore recommend that the<jats:italic>jal<\/jats:italic>designation be changed to<jats:italic>Gata3<\/jats:italic><jats:sup><jats:italic>jal<\/jats:italic><\/jats:sup><jats:italic>,<\/jats:italic>and suggest that this mouse variant may provide an animal model for at least some forms of focal alopecia that have their primary defect in the hair follicle and lack an inflammatory component.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2156-14-40","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T12:21:51Z","timestamp":1368102111000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The juvenile alopecia mutation (jal) maps to mouse Chromosome 2, and is an allele of GATA binding protein 3 (Gata3)"],"prefix":"10.1186","volume":"14","author":[{"given":"Francisco","family":"Ramirez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron M","family":"Feliciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth B","family":"Adkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M","family":"Child","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Legairre A","family":"Radden II","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Salas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Vila-Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M","family":"Hor\u00e1k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha R","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damek V","family":"Spacek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,5,9]]},"reference":[{"key":"1106_CR1","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/0092-8674(93)90369-2","volume":"73","author":"LD Schultz","year":"1993","unstructured":"Schultz LD, Schweitzer PA, Rajan TV, Yi T, Ihle JN, Matthews RJ, Thomas ML, Beier DR: Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. 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