{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:05:22Z","timestamp":1780661122056,"version":"3.54.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genet"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1471-2156-15-42","type":"journal-article","created":{"date-parts":[[2014,3,29]],"date-time":"2014-03-29T00:22:16Z","timestamp":1396052536000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA\/2J mice"],"prefix":"10.1186","volume":"15","author":[{"given":"K Saidas","family":"Nair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Barbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Masli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon WM","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,28]]},"reference":[{"issue":"6","key":"1219_CR1","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1001\/archopht.120.6.714","volume":"120","author":"MO Gordon","year":"2002","unstructured":"Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK, Wilson MR, Kass MA: The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002, 120 (6): 714-720. 10.1001\/archopht.120.6.714.","journal-title":"Arch Ophthalmol"},{"key":"1219_CR2","first-page":"1504","volume-title":"Ophthalmology","author":"SF Ball","year":"2004","unstructured":"Ball SF: Pigmentary Glaucoma. Ophthalmology. Edited by: Yanoff M, Duker JS. 2004, St. Louise: Mosby, 1504-1507."},{"key":"1219_CR3","first-page":"381","volume":"94","author":"R Ritch","year":"1996","unstructured":"Ritch R: A unification hypothesis of pigment dispersion syndrome. Trans Am Ophthalmol Soc. 1996, 94: 381-405.","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"3","key":"1219_CR4","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0002-9394(89)90110-4","volume":"108","author":"SM Farrar","year":"1989","unstructured":"Farrar SM, Shields MB, Miller KN, Stoup CM: Risk factors for the development and severity of glaucoma in the pigment dispersion syndrome. Am J Ophthalmol. 1989, 108 (3): 223-229.","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"1219_CR5","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1016\/S0161-6420(86)33526-7","volume":"93","author":"CV Migliazzo","year":"1986","unstructured":"Migliazzo CV, Shaffer RN, Nykin R, Magee S: Long-term analysis of pigmentary dispersion syndrome and pigmentary glaucoma. Ophthalmology. 1986, 93 (12): 1528-1536. 10.1016\/S0161-6420(86)33526-7.","journal-title":"Ophthalmology"},{"issue":"2","key":"1219_CR6","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1001\/archopht.1986.01050140065021","volume":"104","author":"CU Richter","year":"1986","unstructured":"Richter CU, Richardson TM, Grant WM: Pigmentary dispersion syndrome and pigmentary glaucoma. A prospective study of the natural history. Arch Ophthalmol. 1986, 104 (2): 211-215. 10.1001\/archopht.1986.01050140065021.","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"1219_CR7","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1136\/bjo.65.4.264","volume":"65","author":"HG Scheie","year":"1981","unstructured":"Scheie HG, Cameron JD: Pigment dispersion syndrome: a clinical study. Br J Ophthalmol. 1981, 65 (4): 264-269. 10.1136\/bjo.65.4.264.","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"1219_CR8","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/S0002-9394(02)02289-4","volume":"135","author":"Y Siddiqui","year":"2003","unstructured":"Siddiqui Y, Ten Hulzen RD, Cameron JD, Hodge DO, Johnson DH: What is the risk of developing pigmentary glaucoma from pigment dispersion syndrome?. Am J Ophthalmol. 2003, 135 (6): 794-799. 10.1016\/S0002-9394(02)02289-4.","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"1219_CR9","first-page":"1258","volume":"42","author":"AU Bayer","year":"2001","unstructured":"Bayer AU, Neuhardt T, May AC, Martus P, Maag KP, Brodie S, Lutjen-Drecoll E, Podos SM, Mittag T: Retinal morphology and ERG response in the DBA\/2NNia mouse model of angle-closure glaucoma. Invest Ophthalmol Vis Sci. 2001, 42 (6): 1258-1265.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"1219_CR10","first-page":"951","volume":"39","author":"SWM John","year":"1998","unstructured":"John SWM, Smith RS, Savinova OV, Hawes NL, Chang B, Turnbull D, Davisson M, Roderick TH, Heckenlively JR: Essential iris atrophy, pigment dispersion, and glaucoma in DBA\/2J mice. Invest Ophthalmol Vis Sci. 1998, 39 (6): 951-962.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"1219_CR11","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1017\/S0952523805225130","volume":"22","author":"RT Libby","year":"2005","unstructured":"Libby RT, Anderson MG, Pang I-H, Savinova OV, Cosma IM, Snow A, Wilson LA, Clark AF, Smith RS, John SWM: Inherited glaucoma in DBA\/2J mice: pertinent disease features for studying the neurodegeneration. Vis Neurosci. 2005, 22 (5): 637-648.","journal-title":"Vis Neurosci"},{"key":"1219_CR12","first-page":"508","volume":"45","author":"WG Sheldon","year":"1995","unstructured":"Sheldon WG, Warbritton AR, Bucci TJ, Turturro A: Glaucoma in food-restricted and ad libitum-fed DBA\/2NNia mice. Lab Anim Sci. 1995, 45: 508-518.","journal-title":"Lab Anim Sci"},{"key":"1219_CR13","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/7741","volume":"21","author":"B Chang","year":"1999","unstructured":"Chang B, Smith RS, Hawes NL, Anderson MG, Zabaleta A, Savinova O, Roderick TH, Heckenlively JR, Davisson MT, John SWM: Interacting loci cause severe iris atrophy and glaucoma in DBA\/2J mice. Nat Genet. 1999, 21: 405-409. 10.1038\/7741.","journal-title":"Nat Genet"},{"key":"1219_CR14","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/ng794","volume":"30","author":"MG Anderson","year":"2002","unstructured":"Anderson MG, Smith RS, Hawes NL, Zabaleta A, Chang B, Wiggs JL, John SWM: Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA\/2J mice. Nat Genet. 2002, 30: 81-85. 10.1038\/ng794.","journal-title":"Nat Genet"},{"issue":"Pt 15","key":"1219_CR15","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1242\/jcs.114.15.2831","volume":"114","author":"R Le Borgne","year":"2001","unstructured":"Le Borgne R, Planque N, Martin P, Dewitte F, Saule S, Hoflack B: The AP-3-dependent targeting of the melanosomal glycoprotein QNR-71 requires a di-leucine-based sorting signal. J Cell Sci. 2001, 114 (Pt 15): 2831-2841.","journal-title":"J Cell Sci"},{"issue":"11","key":"1219_CR16","doi-asserted-by":"publisher","first-page":"8125","DOI":"10.1074\/jbc.M008539200","volume":"276","author":"S Shikano","year":"2001","unstructured":"Shikano S, Bonkobara M, Zukas PK, Ariizumi K: Molecular cloning of a dendritic cell-associated transmembrane protein, DC-HIL, that promotes RGD-dependent adhesion of endothelial cells through recognition of heparan sulfate proteoglycans. J Biol Chem. 2001, 276 (11): 8125-8134. 10.1074\/jbc.M008539200.","journal-title":"J Biol Chem"},{"issue":"10","key":"1219_CR17","doi-asserted-by":"publisher","first-page":"6557","DOI":"10.4049\/jimmunol.178.10.6557","volume":"178","author":"VM Ripoll","year":"2007","unstructured":"Ripoll VM, Irvine KM, Ravasi T, Sweet MJ, Hume DA: Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J Immunol. 2007, 178 (10): 6557-6566.","journal-title":"J Immunol"},{"issue":"24","key":"1219_CR18","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1002\/j.1460-2075.1994.tb06925.x","volume":"13","author":"T Kobayashi","year":"1994","unstructured":"Kobayashi T, Urabe K, Winder A, Jimenez-Cervantes C, Imokawa G, Brewington T, Solano F, Garcia-Borron JC, Hearing VJ: Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis. EMBO J. 1994, 13 (24): 5818-5825.","journal-title":"EMBO J"},{"issue":"48","key":"1219_CR19","doi-asserted-by":"publisher","first-page":"31801","DOI":"10.1074\/jbc.273.48.31801","volume":"273","author":"T Kobayashi","year":"1998","unstructured":"Kobayashi T, Imokawa G, Bennett DC, Hearing VJ: Tyrosinase stabilization by Tyrp1 (the brown locus protein). J Biol Chem. 1998, 273 (48): 31801-31805. 10.1074\/jbc.273.48.31801.","journal-title":"J Biol Chem"},{"issue":"4","key":"1219_CR20","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1600-0749.1994.tb00054.x","volume":"7","author":"T Kobayashi","year":"1994","unstructured":"Kobayashi T, Urabe K, Winder A, Tsukamoto K, Brewington T, Imokawa G, Potterf B, Hearing VJ: DHICA oxidase activity of TRP1 and interactions with other melanogenic enzymes. Pigment Cell Res. 1994, 7 (4): 227-234. 10.1111\/j.1600-0749.1994.tb00054.x.","journal-title":"Pigment Cell Res"},{"issue":"10","key":"1219_CR21","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1084\/jem.20022041","volume":"197","author":"JS Mo","year":"2003","unstructured":"Mo JS, Anderson MG, Gregory M, Smith RS, Savinova OV, Serreze DV, Ksander BR, Streilein JW, John SWM: By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA\/2J pigmentary glaucoma. J Exp Med. 2003, 197 (10): 1335-1344. 10.1084\/jem.20022041.","journal-title":"J Exp Med"},{"key":"1219_CR22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1471-2156-9-30","volume":"9","author":"MG Anderson","year":"2008","unstructured":"Anderson MG, Nair KS, Amonoo LA, Mehalow A, Trantow CM, Masli S, John SW: GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA\/2J glaucoma. BMC Genet. 2008, 9: 30-","journal-title":"BMC Genet"},{"key":"1219_CR23","first-page":"2171","volume":"38","author":"NS Bora","year":"1997","unstructured":"Bora NS, Woon MD, Tandhasetti MT, Cirrito TP, Kaplan HJ: Induction of experimental autoimmune anterior uveitis by a self-antigen: melanin complex without adjuvant. Invest Ophthalmol Vis Sci. 1997, 38: 2171-2175.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"1219_CR24","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/j.1365-2567.2010.03360.x","volume":"131","author":"N Schleinitz","year":"2010","unstructured":"Schleinitz N, V\u00e9ly F, Harl\u00e9 JR, Vivier E: Natural killer cells in human autoimmune diseases. Immunology. 2010, 131 (4): 451-458. 10.1111\/j.1365-2567.2010.03360.x.","journal-title":"Immunology"},{"issue":"2","key":"1219_CR25","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1073\/pnas.022500599","volume":"99","author":"RE Vance","year":"2002","unstructured":"Vance RE, Jamieson AM, Cado D, Raulet DH: Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. Proc Natl Acad Sci USA. 2002, 99 (2): 868-873. 10.1073\/pnas.022500599.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"1219_CR26","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/intimm\/dxn008","volume":"20","author":"S Chattopadhyay","year":"2008","unstructured":"Chattopadhyay S, O\u2019Rourke J, Cone RE: Implication for the CD94\/NKG2A-Qa-1 system in the generation and function of ocular-induced splenic CD8+ regulatory T cells. Int Immunol. 2008, 20 (4): 509-516. 10.1093\/intimm\/dxn008.","journal-title":"Int Immunol"},{"issue":"1","key":"1219_CR27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1385\/IR:30:1:029","volume":"30","author":"A Gunturi","year":"2004","unstructured":"Gunturi A, Berg RE, Forman J: The role of CD94\/NKG2 in innate and adaptive immunity. Immunol Res. 2004, 30 (1): 29-34. 10.1385\/IR:30:1:029.","journal-title":"Immunol Res"},{"issue":"3","key":"1219_CR28","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1385\/IR:35:3:263","volume":"35","author":"F Borrego","year":"2006","unstructured":"Borrego F, Masilamani M, Marusina AI, Tang X, Coligan JE: The CD94\/NKG2 family of receptors: from molecules and cells to clinical relevance. Immunol Res. 2006, 35 (3): 263-278. 10.1385\/IR:35:3:263.","journal-title":"Immunol Res"},{"issue":"1\u20133","key":"1219_CR29","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1385\/IR:29:1-3:081","volume":"29","author":"PE Jensen","year":"2004","unstructured":"Jensen PE, Sullivan BA, Reed-Loisel LM, Weber DA: Qa-1, a nonclassical class I histocompatibility molecule with roles in innate and adaptive immunity. Immunol Res. 2004, 29 (1\u20133): 81-92.","journal-title":"Immunol Res"},{"issue":"4","key":"1219_CR30","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1080\/09273940590951052","volume":"13","author":"CY Kim","year":"2005","unstructured":"Kim CY, Masli S, Streilein JW: Qa-1, a nonclassical MHC molecule with immunomodulatory functions, is ubiquitously expressed in the immune-privileged anterior chamber of the eye. Ocul Immunol Inflamm. 2005, 13 (4): 271-277. 10.1080\/09273940590951052.","journal-title":"Ocul Immunol Inflamm"},{"key":"1219_CR31","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1741-7007-4-20","volume":"4","author":"MG Anderson","year":"2006","unstructured":"Anderson MG, Libby RT, Mao M, Cosma IM, Wilson LA, Smith RS, John SW: Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol. 2006, 4: 20-10.1186\/1741-7007-4-20.","journal-title":"BMC Biol"},{"issue":"6475","key":"1219_CR32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/369031a0","volume":"369","author":"D Kagi","year":"1994","unstructured":"Kagi D, Ledermann B, Burki K, Seiler P, Odermatt B, Olsen KJ, Podack ER, Zinkernagel RM, Hengartner H: Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 1994, 369 (6475): 31-37. 10.1038\/369031a0.","journal-title":"Nature"},{"issue":"3","key":"1219_CR33","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/1074-7613(95)90047-0","volume":"2","author":"X Cao","year":"1995","unstructured":"Cao X, Shores EW, Hu-Li J, Anver MR, Kelsall BL, Russell SM, Drago J, Noguchi M, Grinberg A, Bloom ET, Paul WE, Katz SI, Love PE, Leonard WJ: Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity. 1995, 2 (3): 223-238. 10.1016\/1074-7613(95)90047-0.","journal-title":"Immunity"},{"key":"1219_CR34","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1159\/000099251","volume":"92","author":"JY Niederkorn","year":"2007","unstructured":"Niederkorn JY: The induction of anterior chamber-associated immune deviation. Chem Immunol Allergy. 2007, 92: 27-35.","journal-title":"Chem Immunol Allergy"},{"issue":"3","key":"1219_CR35","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1167\/iovs.12-9781","volume":"54","author":"J Rieck","year":"2013","unstructured":"Rieck J: The pathogenesis of glaucoma in the interplay with the immune system. Invest Ophthalmol Vis Sci. 2013, 54 (3): 2393-2409. 10.1167\/iovs.12-9781.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1219_CR36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1471-2172-9-53","volume":"9","author":"H He","year":"2008","unstructured":"He H, Yang P, Jiang L, Zhang J, Zhao C, Chen L, Lin X, Zhou H, Kijlstra A: Upregulation of CD94 on CD8\u2009+\u2009T cells in anterior chamber-associated immune deviation. BMC Immunol. 2008, 9: 53-10.1186\/1471-2172-9-53.","journal-title":"BMC Immunol"},{"issue":"4","key":"1219_CR37","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.4049\/jimmunol.160.4.1589","volume":"160","author":"M Takeuchi","year":"1998","unstructured":"Takeuchi M, Alard P, Streilein JW: TGF-beta promotes immune deviation by altering accessory signals of antigen-presenting cells. J Immunol. 1998, 160 (4): 1589-1597.","journal-title":"J Immunol"},{"issue":"9","key":"1219_CR38","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1172\/JCI23874","volume":"115","author":"K Maruyama","year":"2005","unstructured":"Maruyama K, Ii M, Cursiefen C, Jackson DG, Keino H, Tomita M, Van Rooijen N, Takenaka H, D'Amore PA, Stein-Streilein J, Losordo DW, Streilein JW: Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest. 2005, 115 (9): 2363-2372. 10.1172\/JCI23874.","journal-title":"J Clin Invest"},{"key":"1219_CR39","first-page":"249","volume":"38","author":"SWM John","year":"1997","unstructured":"John SWM, Hagaman JR, MacTaggart TE, Peng L, Smithes O: Intraocular pressure in inbred mouse strains. Invest Ophthalmol Vis Sci. 1997, 38: 249-253.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1219_CR40","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1083\/jcb.200706181","volume":"179","author":"GR Howell","year":"2007","unstructured":"Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, Barter JW, Barbay JM, Marchant JK, Mahesh N, Porciatti V, Whitmore AV, Masland RH, John SW: Axons of retinal ganglion cells are insulted in the optic nerve early in DBA\/2J glaucoma. J Cell Biol. 2007, 179: 1523-1537. 10.1083\/jcb.200706181.","journal-title":"J Cell Biol"}],"container-title":["BMC Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2156-15-42.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T16:38:02Z","timestamp":1689093482000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenet.biomedcentral.com\/articles\/10.1186\/1471-2156-15-42"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,28]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1219"],"URL":"https:\/\/doi.org\/10.1186\/1471-2156-15-42","relation":{},"ISSN":["1471-2156"],"issn-type":[{"value":"1471-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,28]]},"assertion":[{"value":"18 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"42"}}