{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:24:11Z","timestamp":1791285851701,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,1,11]],"date-time":"2009-01-11T00:00:00Z","timestamp":1231632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      With the recent completion of numerous sequenced bacterial genomes, notable advances have been made in understanding the level of conservation between various species. However, relatively little is known about the genomic diversity among strains. We determined the complete genome sequence of the Florida strain of\n                      <jats:italic>Anaplasma marginale<\/jats:italic>\n                      , and near complete (&gt;96%) sequences for an additional three strains, for comparative analysis with the previously fully sequenced St. Maries strain genome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      These comparisons revealed that\n                      <jats:italic>A. marginale<\/jats:italic>\n                      has a closed-core genome with few highly plastic regions, which include the\n                      <jats:italic>msp2<\/jats:italic>\n                      and\n                      <jats:italic>msp3<\/jats:italic>\n                      genes, as well as the\n                      <jats:italic>aaap<\/jats:italic>\n                      locus. Comparison of the Florida and St. Maries genome sequences found that SNPs comprise 0.8% of the longer Florida genome, with 33.5% of the total SNPs between all five strains present in at least two strains and 3.0% of SNPs present in all strains except Florida. Comparison of genomes from three strains of\n                      <jats:italic>Mycobacterium tuberculosis, Bacillus anthracis<\/jats:italic>\n                      , and\n                      <jats:italic>Nessieria meningiditis<\/jats:italic>\n                      , as well as four\n                      <jats:italic>Chlamydophila pneumoniae<\/jats:italic>\n                      strains found that 98.8%\u2013100% of SNPs are unique to each strain, suggesting\n                      <jats:italic>A. marginale<\/jats:italic>\n                      , with 76.0%, has an intermediate level of strain-specific SNPs. Comparison of genomes from other organisms revealed variation in diversity that did not segregate with the environmental niche the bacterium occupies, ranging from 0.00% to 8.00% of the larger pairwise-compared genome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Analysis of multiple\n                      <jats:italic>A. marginale<\/jats:italic>\n                      strains suggests intracellular bacteria have more variable SNP retention rates than previously reported, and may have closed-core genomes in response to the host organism environment and\/or reductive evolution.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2164-10-16","type":"journal-article","created":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T02:12:58Z","timestamp":1231812778000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Conservation in the face of diversity: multistrain analysis of an intracellular bacterium"],"prefix":"10.1186","volume":"10","author":[{"given":"Michael J","family":"Dark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Herndon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lowell S","family":"Kappmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel P","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Nordeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy H","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Donald P","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A","family":"Brayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,1,11]]},"reference":[{"key":"1900_CR1","volume-title":"J Clin Microbiol","author":"P Mobius","year":"2008","unstructured":"Mobius P, Luyven G, Hotzel H, Kohler H: High Genetic diversity among Mycobacterium avium subsp. paratuberculosis strains of German cattle herds shown by combination of IS900 RFLP analysis and MIRU-VNTR typing. J Clin Microbiol. 2008"},{"issue":"Pt 10","key":"1900_CR2","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1099\/jmm.0.47262-0","volume":"56","author":"SY Tartof","year":"2007","unstructured":"Tartof SY, Solberg OD, Riley LW: Genotypic analyses of uropathogenic Escherichia coli based on fimH single nucleotide polymorphisms (SNPs). J Med Microbiol. 2007, 56 (Pt 10): 1363-1369. 10.1099\/jmm.0.47262-0.","journal-title":"J Med Microbiol"},{"issue":"2","key":"1900_CR3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s00248-007-9276-4","volume":"55","author":"T Wu","year":"2008","unstructured":"Wu T, Chellemi DO, Graham JH, Martin KJ, Rosskopf EN: Comparison of soil bacterial communities under diverse agricultural land management and crop production practices. Microb Ecol. 2008, 55 (2): 293-310. 10.1007\/s00248-007-9276-4.","journal-title":"Microb Ecol"},{"key":"1900_CR4","volume-title":"Environ Microbiol","author":"EM Bottos","year":"2008","unstructured":"Bottos EM, Vincent WF, Greer CW, Whyte LG: Prokaryotic diversity of arctic ice shelf microbial mats. Environ Microbiol. 2008"},{"issue":"19","key":"1900_CR5","doi-asserted-by":"publisher","first-page":"5479","DOI":"10.1128\/JB.184.19.5479-5490.2002","volume":"184","author":"RD Fleischmann","year":"2002","unstructured":"Fleischmann RD, Alland D, Eisen JA, Carpenter L, White O, Peterson J, DeBoy R, Dodson R, Gwinn M, Haft D, et al: Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. J Bacteriol. 2002, 184 (19): 5479-5490. 10.1128\/JB.184.19.5479-5490.2002.","journal-title":"J Bacteriol"},{"issue":"5577","key":"1900_CR6","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1126\/science.1071278","volume":"296","author":"I Tamas","year":"2002","unstructured":"Tamas I, Klasson L, Canback B, Naslund AK, Eriksson AS, Wernegreen JJ, Sandstrom JP, Moran NA, Andersson SG: 50 million years of genomic stasis in endosymbiotic bacteria. Science. 2002, 296 (5577): 2376-2379. 10.1126\/science.1071278.","journal-title":"Science"},{"issue":"10","key":"1900_CR7","doi-asserted-by":"publisher","first-page":"6407","DOI":"10.1128\/IAI.73.10.6407-6418.2005","volume":"73","author":"JH Carlson","year":"2005","unstructured":"Carlson JH, Porcella SF, McClarty G, Caldwell HD: Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains. Infect Immun. 2005, 73 (10): 6407-6418. 10.1128\/IAI.73.10.6407-6418.2005.","journal-title":"Infect Immun"},{"issue":"37","key":"1900_CR8","doi-asserted-by":"publisher","first-page":"13536","DOI":"10.1073\/pnas.0403844101","volume":"101","author":"T Pearson","year":"2004","unstructured":"Pearson T, Busch JD, Ravel J, Read TD, Rhoton SD, U'Ren JM, Simonson TS, Kachur SM, Leadem RR, Cardon ML, Van Ert MN, Huynh LY, Fraser CM, Keim P: Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencing. Proc Natl Acad Sci USA. 2004, 101 (37): 13536-13541. 10.1073\/pnas.0403844101.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"1900_CR9","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1128\/JCM.44.3.777-782.2006","volume":"44","author":"CW Stratilo","year":"2006","unstructured":"Stratilo CW, Lewis CT, Bryden L, Mulvey MR, Bader D: Single-nucleotide repeat analysis for subtyping Bacillus anthracis isolates. J Clin Microbiol. 2006, 44 (3): 777-782. 10.1128\/JCM.44.3.777-782.2006.","journal-title":"J Clin Microbiol"},{"issue":"39","key":"1900_CR10","doi-asserted-by":"publisher","first-page":"13950","DOI":"10.1073\/pnas.0506758102","volume":"102","author":"H Tettelin","year":"2005","unstructured":"Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, Deboy RT, Davidsen TM, Mora M, Scarselli M, Margarit y Ros I, Peterson JD, Hauser CR, Sundaram JP, Nelson WC, Madupu R, Brinkac LM, Dodson RJ, Rosovitz MJ, Sullivan SA, Daugherty SC, Haft DH, Selengut J, Gwinn ML, Zhou L, Zafar N: Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial \"pan-genome\". Proc Natl Acad Sci USA. 2005, 102 (39): 13950-13955. 10.1073\/pnas.0506758102.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"1900_CR11","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1073\/pnas.0406656102","volume":"102","author":"KA Brayton","year":"2005","unstructured":"Brayton KA, Kappmeyer LS, Herndon DR, Dark MJ, Tibbals DL, Palmer GH, McGuire TC, Knowles DP: Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins. Proc Natl Acad Sci USA. 2005, 102 (3): 844-849. 10.1073\/pnas.0406656102.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 6","key":"1900_CR12","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1099\/00207713-51-6-2145","volume":"51","author":"JS Dumler","year":"2001","unstructured":"Dumler JS, Barbet AF, Bekker CP, Dasch GA, Palmer GH, Ray SC, Rikihisa Y, Rurangirwa FR: Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila. Int J Syst Evol Microbiol. 2001, 51 (Pt 6): 2145-2165.","journal-title":"Int J Syst Evol Microbiol"},{"issue":"8","key":"1900_CR13","doi-asserted-by":"publisher","first-page":"3220","DOI":"10.1073\/pnas.87.8.3220","volume":"87","author":"DR Allred","year":"1990","unstructured":"Allred DR, McGuire TC, Palmer GH, Leib SR, Harkins TM, McElwain TF, Barbet AF: Molecular basis for surface antigen size polymorphisms and conservation of a neutralization-sensitive epitope in Anaplasma marginale. Proc Natl Acad Sci USA. 1990, 87 (8): 3220-3224. 10.1073\/pnas.87.8.3220.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2\u20134","key":"1900_CR14","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.vetmic.2006.09.015","volume":"119","author":"J de la Fuente","year":"2007","unstructured":"de la Fuente J, Ruybal P, Mtshali MS, Naranjo V, Shuqing L, Mangold AJ, Rodriguez SD, Jimenez R, Vicente J, Moretta R, Torina A, Almazan C, Mbati PM, de Echaide ST, Farber M, Rosario-Cruz R, Gortazar C, Kocan KM: Analysis of world strains of Anaplasma marginale using major surface protein 1a repeat sequences. Vet Microbiol. 2007, 119 (2\u20134): 382-390. 10.1016\/j.vetmic.2006.09.015.","journal-title":"Vet Microbiol"},{"issue":"3","key":"1900_CR15","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0378-1135(02)00122-0","volume":"88","author":"J de la Fuente","year":"2002","unstructured":"de la Fuente J, Bussche Van Den RA, Garcia-Garcia JC, Rodriguez SD, Garcia MA, Guglielmone AA, Mangold AJ, Friche Passos LM, Barbosa Ribeiro MF, Blouin EF, Kocan KM: Phylogeography of New World isolates of Anaplasma marginale based on major surface protein sequences. Vet Microbiol. 2002, 88 (3): 275-285. 10.1016\/S0378-1135(02)00122-0.","journal-title":"Vet Microbiol"},{"issue":"3","key":"1900_CR16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1128\/iai.45.3.697-700.1984","volume":"45","author":"TC McGuire","year":"1984","unstructured":"McGuire TC, Palmer GH, Goff WL, Johnson MI, Davis WC: Common and isolate-restricted antigens of Anaplasma marginale detected with monoclonal antibodies. Infect Immun. 1984, 45 (3): 697-700.","journal-title":"Infect Immun"},{"issue":"6","key":"1900_CR17","doi-asserted-by":"publisher","first-page":"3471","DOI":"10.1128\/IAI.01843-05","volume":"74","author":"SM Noh","year":"2006","unstructured":"Noh SM, Brayton KA, Knowles DP, Agnes JT, Dark MJ, Brown WC, Baszler TV, Palmer GH: Differential expression and sequence conservation of the Anaplasma marginale msp2 gene superfamily outer membrane proteins. Infect Immun. 2006, 74 (6): 3471-3479. 10.1128\/IAI.01843-05.","journal-title":"Infect Immun"},{"issue":"4","key":"1900_CR18","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1177\/104063879400600406","volume":"6","author":"IS Eriks","year":"1994","unstructured":"Eriks IS, Stiller D, Goff WL, Panton M, Parish SM, McElwain TF, Palmer GH: Molecular and biological characterization of a newly isolated Anaplasma marginale strain. J Vet Diagn Invest. 1994, 6 (4): 435-441.","journal-title":"J Vet Diagn Invest"},{"issue":"1","key":"1900_CR19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2460\/ajvr.1987.48.01.96","volume":"48","author":"KB Wickwire","year":"1987","unstructured":"Wickwire KB, Kocan KM, Barron SJ, Ewing SA, Smith RD, Hair JA: Infectivity of three Anaplasma marginale isolates for Dermacentor andersoni. Am J Vet Res. 1987, 48 (1): 96-99.","journal-title":"Am J Vet Res"},{"issue":"7","key":"1900_CR20","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1128\/JB.188.7.2533-2542.2006","volume":"188","author":"R Frutos","year":"2006","unstructured":"Frutos R, Viari A, Ferraz C, Morgat A, Eychenie S, Kandassamy Y, Chantal I, Bensaid A, Coissac E, Vachiery N, Demaille J, Martinez D: Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity. J Bacteriol. 2006, 188 (7): 2533-2542. 10.1128\/JB.188.7.2533-2542.2006.","journal-title":"J Bacteriol"},{"issue":"5537","key":"1900_CR21","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1126\/science.1061471","volume":"293","author":"H Ogata","year":"2001","unstructured":"Ogata H, Audic S, Renesto-Audiffren P, Fournier PE, Barbe V, Samson D, Roux V, Cossart P, Weissenbach J, Claverie JM, Raoult D: Mechanisms of evolution in Rickettsia conorii and R. prowazekii. Science. 2001, 293 (5537): 2093-2098. 10.1126\/science.1061471.","journal-title":"Science"},{"key":"1900_CR22","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.gene.2005.06.038","volume":"361","author":"JL Rodriguez","year":"2005","unstructured":"Rodriguez JL, Palmer GH, Knowles DP, Brayton KA: Distinctly different msp2 pseudogene repertoires in Anaplasma marginale strains that are capable of superinfection. Gene. 2005, 361: 127-132. 10.1016\/j.gene.2005.06.038.","journal-title":"Gene"},{"issue":"12","key":"1900_CR23","doi-asserted-by":"publisher","first-page":"7257","DOI":"10.1128\/IAI.72.12.7257-7264.2004","volume":"72","author":"RW Stich","year":"2004","unstructured":"Stich RW, Olah GA, Brayton KA, Brown WC, Fechheimer M, Green-Church K, Jittapalapong S, Kocan KM, McGuire TC, Rurangirwa FR, Palmer GH: Identification of a novel Anaplasma marginale appendage-associated protein that localizes with actin filaments during intraerythrocytic infection. Infect Immun. 2004, 72 (12): 7257-7264. 10.1128\/IAI.72.12.7257-7264.2004.","journal-title":"Infect Immun"},{"issue":"7057","key":"1900_CR24","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature03959","volume":"437","author":"M Margulies","year":"2005","unstructured":"Margulies M, Egholm M, Altman WE, Attiya S, Bader JS, Bemben LA, Berka J, Braverman MS, Chen YJ, Chen Z, Dewell SB, Du L, Fierro JM, Gomes XV, Godwin BC, He W, Helgesen S, Ho CH, Irzyk GP, Jando SC, Alenquer ML, Jarvie TP, Jirage KB, Kim JB, Knight JR, Lanza JR, Leamon JH, Lefkowitz SM, Lei M, Li J, et al: Genome sequencing in microfabricated high-density picolitre reactors. Nature. 2005, 437 (7057): 376-380.","journal-title":"Nature"},{"issue":"6","key":"1900_CR25","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1128\/IAI.00284-07","volume":"75","author":"MW Ueti","year":"2007","unstructured":"Ueti MW, Reagan JO, Knowles DP, Scoles GA, Shkap V, Palmer GH: Identification of midgut and salivary glands as specific and distinct barriers to efficient tick-borne transmission of Anaplasma marginale. Infect Immun. 2007, 75 (6): 2959-2964. 10.1128\/IAI.00284-07.","journal-title":"Infect Immun"},{"issue":"7","key":"1900_CR26","doi-asserted-by":"publisher","first-page":"4130","DOI":"10.1073\/pnas.071056298","volume":"98","author":"KA Brayton","year":"2001","unstructured":"Brayton KA, Knowles DP, McGuire TC, Palmer GH: Efficient use of a small genome to generate antigenic diversity in tick-borne ehrlichial pathogens. Proc Natl Acad Sci USA. 2001, 98 (7): 4130-4135. 10.1073\/pnas.071056298.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"1900_CR27","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1046\/j.1365-2958.2002.02792.x","volume":"43","author":"KA Brayton","year":"2002","unstructured":"Brayton KA, Palmer GH, Lundgren A, Yi J, Barbet AF: Antigenic variation of Anaplasma marginale msp2 occurs by combinatorial gene conversion. Mol Microbiol. 2002, 43 (5): 1151-1159. 10.1046\/j.1365-2958.2002.02792.x.","journal-title":"Mol Microbiol"},{"issue":"6","key":"1900_CR28","doi-asserted-by":"publisher","first-page":"RESEARCH0011","DOI":"10.1186\/gb-2000-1-6-research0011","volume":"1","author":"JA Eisen","year":"2000","unstructured":"Eisen JA, Heidelberg JF, White O, Salzberg SL: Evidence for symmetric chromosomal inversions around the replication origin in bacteria. Genome Biol. 2000, 1 (6): RESEARCH0011-10.1186\/gb-2000-1-6-research0011.","journal-title":"Genome Biol"},{"issue":"3","key":"1900_CR29","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1073\/pnas.0406633102","volume":"102","author":"NE Collins","year":"2005","unstructured":"Collins NE, Liebenberg J, de Villiers EP, Brayton KA, Louw E, Pretorius A, Faber FE, van Heerden H, Josemans A, van Kleef M, Steyn HC, van Strijp MF, Zweygarth E, Jongejan F, Maillard JC, Berthier D, Botha M, Joubert F, Corton CH, Thomson NR, Allsopp MT, Allsopp BA: The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number. Proc Natl Acad Sci USA. 2005, 102 (3): 838-843. 10.1073\/pnas.0406633102.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"1900_CR30","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1371\/journal.pgen.0020021","volume":"2","author":"JC Hotopp","year":"2006","unstructured":"Hotopp JC, Lin M, Madupu R, Crabtree J, Angiuoli SV, Eisen J, Seshadri R, Ren Q, Wu M, Utterback TR, Smith S, Lewis M, Khouri H, Zhang C, Niu H, Lin Q, Ohashi N, Zhi N, Nelson W, Brinkac LM, Dodson RJ, Rosovitz MJ, Sundaram J, Daugherty SC, Davidsen T, Durkin AS, Gwinn M, Haft DH, Selengut JD, Sullivan SA, et al: Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet. 2006, 2 (2): e21-10.1371\/journal.pgen.0020021.","journal-title":"PLoS Genet"},{"key":"1900_CR31","first-page":"56","volume":"72","author":"M Ristic","year":"1968","unstructured":"Ristic M, Sibinovic S, Welter CJ: An attenuated Anaplasma marginale vaccine. Proc Annu Meet U S Anim Health Assoc. 1968, 72: 56-69.","journal-title":"Proc Annu Meet U S Anim Health Assoc"},{"key":"1900_CR32","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/978-1-4615-8855-9_10","volume-title":"Immunity to Blood Parasites of Animals and Man","author":"M Ristic","year":"1977","unstructured":"Ristic M, Carson CA: Methods of Immunoprophylaxis Against Bovine Anaplasmosis with Emphasis on use of the Attenuated Anaplasma marginale Vaccine. Immunity to Blood Parasites of Animals and Man. Edited by: Miller LH, Pino JA, McKelvey JJJ. 1977, New York: Plenum Press, 151-188."},{"issue":"12","key":"1900_CR33","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.2460\/ajvr.1989.50.12.2033","volume":"50","author":"RJ Hidalgo","year":"1989","unstructured":"Hidalgo RJ, Palmer GH, Jones EW, Brown JE, Ainsworth AJ: Infectivity and antigenicity of Anaplasma marginale from tick cell culture. Am J Vet Res. 1989, 50 (12): 2033-2036.","journal-title":"Am J Vet Res"},{"issue":"2","key":"1900_CR34","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0378-1135(84)90033-6","volume":"9","author":"KL Kuttler","year":"1984","unstructured":"Kuttler KL, Winward LD: Serologic comparisons of 4 Anaplasma isolates as measured by the complement-fixation test. Vet Microbiol. 1984, 9 (2): 181-186. 10.1016\/0378-1135(84)90033-6.","journal-title":"Vet Microbiol"},{"issue":"3","key":"1900_CR35","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1093\/jmedent\/44.3.484","volume":"44","author":"GA Scoles","year":"2007","unstructured":"Scoles GA, Ueti MW, Noh SM, Knowles DP, Palmer GH: Conservation of transmission phenotype of Anaplasma marginale (Rickettsiales: Anaplasmataceae) strains among Dermacentor and Rhipicephalus ticks (Acari: Ixodidae). J Med Entomol. 2007, 44 (3): 484-491. 10.1603\/0022-2585(2007)44[484:COTPOA]2.0.CO;2.","journal-title":"J Med Entomol"},{"issue":"8","key":"1900_CR36","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.1128\/JCM.41.8.3829-3834.2003","volume":"41","author":"JE Futse","year":"2003","unstructured":"Futse JE, Ueti MW, Knowles DP, Palmer GH: Transmission of Anaplasma marginale by Boophilus microplus: retention of vector competence in the absence of vector-pathogen interaction. J Clin Microbiol. 2003, 41 (8): 3829-3834. 10.1128\/JCM.41.8.3829-3834.2003.","journal-title":"J Clin Microbiol"},{"issue":"3","key":"1900_CR37","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1128\/JCM.36.3.777-782.1998","volume":"36","author":"S Torioni de Echaide","year":"1998","unstructured":"Torioni de Echaide S, Knowles DP, McGuire TC, Palmer GH, Suarez CE, McElwain TF: Detection of cattle naturally infected with Anaplasma marginale in a region of endemicity by nested PCR and a competitive enzyme-linked immunosorbent assay using recombinant major surface protein 5. J Clin Microbiol. 1998, 36 (3): 777-782.","journal-title":"J Clin Microbiol"},{"key":"1900_CR38","volume-title":"Genome analysis: a laboratory manual","author":"B Birren","year":"1997","unstructured":"Birren B, Green ED, Klapholz S, Myers RM, Roskams J: Genome analysis: a laboratory manual. 1997, Plainview, N.Y.: Cold Spring Harbor Laboratory Press"},{"issue":"2","key":"1900_CR39","doi-asserted-by":"publisher","first-page":"R12","DOI":"10.1186\/gb-2004-5-2-r12","volume":"5","author":"S Kurtz","year":"2004","unstructured":"Kurtz S, Phillippy A, Delcher AL, Smoot M, Shumway M, Antonescu C, Salzberg SL: Versatile and open software for comparing large genomes. Genome Biol. 2004, 5 (2): R12-10.1186\/gb-2004-5-2-r12.","journal-title":"Genome Biol"},{"key":"1900_CR40","volume-title":"Atlas of protein sequence and structure","author":"RV Eck","year":"1966","unstructured":"Eck RV, Dayhoff MO: Atlas of protein sequence and structure. 1966, Silver Spring, Md.: National Biomedical Research Foundation"},{"issue":"8","key":"1900_CR41","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1093\/molbev\/msm092","volume":"24","author":"K Tamura","year":"2007","unstructured":"Tamura K, Dudley J, Nei M, Kumar S: MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol. 2007, 24 (8): 1596-1599. 10.1093\/molbev\/msm092.","journal-title":"Mol Biol Evol"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2164-10-16.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2164-10-16\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2164-10-16.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T17:50:15Z","timestamp":1738864215000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/1471-2164-10-16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,11]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["1900"],"URL":"https:\/\/doi.org\/10.1186\/1471-2164-10-16","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,11]]},"assertion":[{"value":"3 July 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"16"}}