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A stark clinical contrast exists between physiological LVH and pathological cardiac remodeling in response to diseases such as hypertension, but little is known about the precise molecular mechanisms driving physiological adaptation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In this study, the first large-scale analysis of publicly available genome-wide expression data of several <jats:italic>in vivo<\/jats:italic> murine models of physiological LVH was carried out using network analysis. On evaluating 3 million gene co-expression patterns across 141 relevant microarray experiments, it was found that physiological adaptation is an evolutionarily conserved processes involving preservation of the function of cytochrome c oxidase, induction of autophagy compatible with cell survival, and coordinated regulation of angiogenesis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This analysis not only identifies known biological pathways involved in physiological LVH, but also offers novel insights into the molecular basis of this phenotype by identifying key networks of co-expressed genes, as well as their topological and functional properties, using relevant high-quality microarray experiments and network inference.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/1471-2164-11-557","type":"journal-article","created":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T06:15:46Z","timestamp":1286864146000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Genome-wide expression patterns in physiological cardiac hypertrophy"],"prefix":"10.1186","volume":"11","author":[{"given":"Ignat","family":"Drozdov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Tsoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos A","family":"Ouzounis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay M","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,11]]},"reference":[{"key":"9937_CR1","doi-asserted-by":"publisher","first-page":"312","DOI":"10.2741\/2681","volume":"13","author":"D Catalucci","year":"2008","unstructured":"Catalucci D, Latronico MV, Ellingsen O, Condorelli G: Physiological myocardial hypertrophy: how and why?. 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