{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:32:00Z","timestamp":1762101120578},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Anabolic steroids, such as nandrolone, slow muscle atrophy, but the mechanisms responsible for this effect are largely unknown. Their effects on muscle size and gene expression depend upon time, and the cause of muscle atrophy. Administration of nandrolone for 7 days beginning either concomitantly with sciatic nerve transection (7 days) or 29 days later (35 days) attenuated denervation atrophy at 35 but not 7 days. We reasoned that this model could be used to identify genes that are regulated by nandrolone and slow denervation atrophy, as well as genes that might explain the time-dependence of nandrolone effects on such atrophy. Affymetrix microarrays were used to profile gene expression changes due to nandrolone at 7 and 35 days and to identify major gene expression changes in denervated muscle between 7 and 35 days.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Nandrolone selectively altered expression of 124 genes at 7 days and 122 genes at 35 days, with only 20 genes being regulated at both time points. Marked differences in biological function of genes regulated by nandrolone at 7 and 35 days were observed. At 35, but not 7 days, nandrolone reduced mRNA and protein levels for FOXO1, the mTOR inhibitor REDD2, and the calcineurin inhibitor RCAN2 and increased those for ApoD. At 35 days, correlations between mRNA levels and the size of denervated muscle were negative for RCAN2, and positive for ApoD. Nandrolone also regulated genes for Wnt signaling molecules. Comparison of gene expression at 7 and 35 days after denervation revealed marked alterations in the expression of 9 transcriptional coregulators, including Ankrd1 and 2, and many transcription factors and kinases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Genes regulated in denervated muscle after 7 days administration of nandrolone are almost entirely different at 7 versus 35 days. Alterations in levels of FOXO1, and of genes involved in signaling through calcineurin, mTOR and Wnt may be linked to the favorable action of nandrolone on denervated muscle. Marked changes in the expression of genes regulating transcription and intracellular signaling may contribute to the time-dependent effects of nandrolone on gene expression.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2164-11-596","type":"journal-article","created":{"date-parts":[[2010,11,13]],"date-time":"2010-11-13T19:14:17Z","timestamp":1289675657000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Differential alterations in gene expression profiles contribute to time-dependent effects of nandrolone to prevent denervation atrophy"],"prefix":"10.1186","volume":"11","author":[{"given":"Weiping","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangping","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A","family":"Bauman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P","family":"Cardozo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,22]]},"reference":[{"issue":"3","key":"3293_CR1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/13685530701485998","volume":"10","author":"B Lunenfeld","year":"2007","unstructured":"Lunenfeld B, Nieschlag E: Testosterone therapy in the aging male. Aging Male. 2007, 10 (3): 139-53. 10.1080\/13685530701485998.","journal-title":"Aging Male"},{"issue":"5","key":"3293_CR2","doi-asserted-by":"publisher","first-page":"E1003","DOI":"10.1152\/ajpendo.00100.2006","volume":"291","author":"DT Villareal","year":"2006","unstructured":"Villareal DT, Holloszy JO: DHEA enhances effects of weight training on muscle mass and strength in elderly women and men. Am J Physiol Endocrinol Metab. 2006, 291 (5): E1003-8. 10.1152\/ajpendo.00100.2006.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"3293_CR3","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1468-1293.2006.00380.x","volume":"7","author":"WD Dudgeon","year":"2006","unstructured":"Dudgeon WD, Phillips KD, Carson JA, Brewer RB, Durstine JL, Hand GA: Counteracting muscle wasting in HIV-infected individuals. HIV Med. 2006, 7 (5): 299-310. 10.1111\/j.1468-1293.2006.00380.x.","journal-title":"HIV Med"},{"issue":"1","key":"3293_CR4","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1177\/011542650502000193","volume":"20","author":"C Cuerda","year":"2005","unstructured":"Cuerda C, Zugasti A, Breton I, Camblor M, Miralles P, Garcia P: Treatment with nandrolone decanoate and megestrol acetate in HIV-infected men. Nutr Clin Pract. 2005, 20 (1): 93-7. 10.1177\/011542650502000193.","journal-title":"Nutr Clin Pract"},{"issue":"1","key":"3293_CR5","doi-asserted-by":"publisher","first-page":"e109","DOI":"10.1542\/peds.2006-1548","volume":"119","author":"R Przkora","year":"2007","unstructured":"Przkora R, Herndon DN, Suman OE: The effects of oxandrolone and exercise on muscle mass and function in children with severe burns. Pediatrics. 2007, 119 (1): e109-16. 10.1542\/peds.2006-1548.","journal-title":"Pediatrics"},{"issue":"3","key":"3293_CR6","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.pharmthera.2006.11.004","volume":"113","author":"GS Lynch","year":"2007","unstructured":"Lynch GS, Schertzer JD, Ryall JG: Therapeutic approaches for muscle wasting disorders. Pharmacol Ther. 2007, 113 (3): 461-87. 10.1016\/j.pharmthera.2006.11.004.","journal-title":"Pharmacol Ther"},{"issue":"1","key":"3293_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/sj.sc.3101370","volume":"41","author":"CM Gregory","year":"2003","unstructured":"Gregory CM, Vandenborne K, Huang HF, Ottenweller JE, Dudley GA: Effects of testosterone replacement therapy on skeletal muscle after spinal cord injury. Spinal Cord. 2003, 41 (1): 23-8. 10.1038\/sj.sc.3101370.","journal-title":"Spinal Cord"},{"issue":"6","key":"3293_CR8","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1152\/jappl.1999.86.6.1841","volume":"86","author":"SM Wimalawansa","year":"1999","unstructured":"Wimalawansa SM, Chapa MT, Wei JN, Westlund KN, Quast MJ, Wimalawansa SJ: Reversal of weightlessness-induced musculoskeletal losses with androgens: quantification by MRI. J Appl Physiol. 1999, 86 (6): 1841-6.","journal-title":"J Appl Physiol"},{"issue":"10","key":"3293_CR9","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1016\/j.biocel.2005.04.018","volume":"37","author":"DJ Glass","year":"2005","unstructured":"Glass DJ: Skeletal muscle hypertrophy and atrophy signaling pathways. Int J Biochem Cell Biol. 2005, 37 (10): 1974-84.","journal-title":"Int J Biochem Cell Biol"},{"issue":"5547","key":"3293_CR10","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1126\/science.1065874","volume":"294","author":"SC Bodine","year":"2001","unstructured":"Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ: Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 2001, 294 (5547): 1704-8. 10.1126\/science.1065874.","journal-title":"Science"},{"issue":"1","key":"3293_CR11","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1096\/fj.03-0610com","volume":"18","author":"SH Lecker","year":"2004","unstructured":"Lecker SH, Jagoe RT, Gilbert A, Gomes M, Baracos V, Bailey J, Price SR, Mitch WE, Goldberg AL: Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J. 2004, 18 (1): 39-51. 10.1096\/fj.03-0610com.","journal-title":"FASEB J"},{"issue":"5","key":"3293_CR12","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.cmet.2007.09.009","volume":"6","author":"BA Clarke","year":"2007","unstructured":"Clarke BA, Drujan D, Willis MS, Murphy LO, Corpina RA, Burova E, Rakhilin SV, Stitt TN, Patterson C, Latres E, Glass DJ: The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle. Cell Metab. 2007, 6 (5): 376-85. 10.1016\/j.cmet.2007.09.009.","journal-title":"Cell Metab"},{"issue":"3","key":"3293_CR13","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","volume":"117","author":"M Sandri","year":"2004","unstructured":"Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL: Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell. 2004, 117 (3): 399-412. 10.1016\/S0092-8674(04)00400-3.","journal-title":"Cell"},{"issue":"4","key":"3293_CR14","doi-asserted-by":"publisher","first-page":"E785","DOI":"10.1152\/ajpendo.00646.2007","volume":"295","author":"DS Waddell","year":"2008","unstructured":"Waddell DS, Baehr LM, van den Brandt J, Johnsen SA, Reichardt HM, Furlow JD, Bodine SC: The Glucocorticoid Receptor and Foxo1 Synergistically Activate the Skeletal Muscle Atrophy Associated Murf1 Gene. Am J Physiol Endocrinol Metab. 2008, 295 (4): E785-97. 10.1152\/ajpendo.00646.2007.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"3293_CR15","doi-asserted-by":"publisher","first-page":"e4973","DOI":"10.1371\/journal.pone.0004973","volume":"4","author":"J Lagirand-Cantaloube","year":"2009","unstructured":"Lagirand-Cantaloube J, Cornille K, Csibi A, Batonnet-Pichon S, Leibovitch MP, Leibovitch SA: Inhibition of atrogin-1\/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo. PLOS One. 2009, 4 (3): e4973-10.1371\/journal.pone.0004973.","journal-title":"PLOS One"},{"issue":"8","key":"3293_CR16","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1038\/emboj.2008.52","volume":"27","author":"J Lagirand-Cantaloube","year":"2008","unstructured":"Lagirand-Cantaloube J, Offner N, Csibi A, Leibovitch MP, Batonnet-Pichon S, Tintignac LA, Segura CT, Leibovitch SA: The initiation factor eIF3-f is a major target for Atrogin1\/MAFbx function in skeletal muscle atrophy. EMBO J. 2008, 27 (8): 1266-76. 10.1038\/emboj.2008.52.","journal-title":"EMBO J"},{"issue":"8","key":"3293_CR17","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1172\/JCI200422220","volume":"114","author":"HH Li","year":"2004","unstructured":"Li HH, Kedar V, Zhang C, McDonough H, Arya R, Wang DZ, Patterson C: Atrogin-1\/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J Clin Invest. 2004, 114 (8): 1058-71.","journal-title":"J Clin Invest"},{"issue":"11","key":"3293_CR18","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/ncb1101-1014","volume":"3","author":"SC Bodine","year":"2001","unstructured":"Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, Yancopoulos GD: Akt\/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol. 2001, 3 (11): 1014-9. 10.1038\/ncb1101-1014.","journal-title":"Nat Cell Biol"},{"issue":"11","key":"3293_CR19","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/ncb1101-1009","volume":"3","author":"C Rommel","year":"2001","unstructured":"Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulos GD, Glass DJ: Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K\/Akt\/mTOR and PI(3)K\/Akt\/GSK3 pathways. Nat Cell Biol. 2001, 3 (11): 1009-13. 10.1038\/ncb1101-1009.","journal-title":"Nat Cell Biol"},{"issue":"51","key":"3293_CR20","doi-asserted-by":"publisher","first-page":"39128","DOI":"10.1074\/jbc.M610023200","volume":"281","author":"H Wang","year":"2006","unstructured":"Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR: Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J Biol Chem. 2006, 281 (51): 39128-34. 10.1074\/jbc.M610023200.","journal-title":"J Biol Chem"},{"issue":"5","key":"3293_CR21","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/j.1530-0277.2008.00637.x","volume":"32","author":"CH Lang","year":"2008","unstructured":"Lang CH, Frost RA, Vary TC: Acute alcohol intoxication increases REDD1 in skeletal muscle. Alcohol Clin Exp Res. 2008, 32 (5): 796-805. 10.1111\/j.1530-0277.2008.00637.x.","journal-title":"Alcohol Clin Exp Res"},{"issue":"11","key":"3293_CR22","doi-asserted-by":"publisher","first-page":"9769","DOI":"10.1074\/jbc.C400557200","volume":"280","author":"MN Corradetti","year":"2005","unstructured":"Corradetti MN, Inoki K, Guan KL: The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005, 280 (11): 9769-72. 10.1074\/jbc.C400557200.","journal-title":"J Biol Chem"},{"issue":"3","key":"3293_CR23","doi-asserted-by":"publisher","first-page":"C583","DOI":"10.1152\/ajpcell.00464.2008","volume":"296","author":"M Miyazaki","year":"2009","unstructured":"Miyazaki M, Esser KA: REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch. Am J Physiol Cell Physiol. 2009, 296 (3): C583-92. 10.1152\/ajpcell.00464.2008.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"3293_CR24","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1083\/jcb.200710100","volume":"180","author":"KF Harvey","year":"2008","unstructured":"Harvey KF, Mattila J, Sofer A, Bennett FC, Ramsey MR, Ellisen LW, Puig O, Hariharan IK: FOXO-regulated transcription restricts overgrowth of Tsc mutant organs. J Cell Biol. 2008, 180 (4): 691-6. 10.1083\/jcb.200710100.","journal-title":"J Cell Biol"},{"issue":"3","key":"3293_CR25","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1210\/en.2007-1470","volume":"149","author":"AL Wu","year":"2008","unstructured":"Wu AL, Kim JH, Zhang C, Unterman TG, Chen J: Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components. Endocrinology. 2008, 149 (3): 1407-14. 10.1210\/en.2007-1470.","journal-title":"Endocrinology"},{"issue":"2","key":"3293_CR26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1042\/BJ20070024","volume":"403","author":"CG Proud","year":"2007","unstructured":"Proud CG: Signalling to translation: how signal transduction pathways control the protein synthetic machinery. Biochem J. 2007, 403 (2): 217-234. 10.1042\/BJ20070024.","journal-title":"Biochem J"},{"issue":"1","key":"3293_CR27","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/mus.20888","volume":"37","author":"J Zhao","year":"2008","unstructured":"Zhao J, Zhang Y, Zhao W, Wu Y, Pan J, Bauman WA, Cardozo C: Effects of nandrolone on denervation atrophy depend upon time after nerve transection. Muscle Nerve. 2008, 37 (1): 42-9. 10.1002\/mus.20888.","journal-title":"Muscle Nerve"},{"issue":"6","key":"3293_CR28","doi-asserted-by":"publisher","first-page":"R1589","DOI":"10.1152\/ajpregu.00668.2005","volume":"290","author":"MU Fareed","year":"2006","unstructured":"Fareed MU, Evenson AR, Wei W, Menconi M, Poylin V, Petkova V, Pignol B, Hasselgren PO: Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1\/MAFbx and MuRF1 expression. Am J Physiol Regul Integr Comp Physiol. 2006, 290 (6): R1589-97.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"3293_CR29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ydbio.2003.08.011","volume":"264","author":"J Laurikkala","year":"2003","unstructured":"Laurikkala J, Kassai Y, Pakkasjarvi L, Thesleff I, Itoh N: Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol. 2003, 264 (1): 91-105. 10.1016\/j.ydbio.2003.08.011.","journal-title":"Dev Biol"},{"issue":"3","key":"3293_CR30","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1128\/MCB.00996-06","volume":"27","author":"S Goruppi","year":"2007","unstructured":"Goruppi S, Patten RD, Force T, Kyriakis JM: Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. Mol Cell Biol. 2007, 27 (3): 993-1006. 10.1128\/MCB.00996-06.","journal-title":"Mol Cell Biol"},{"issue":"5","key":"3293_CR31","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.jmb.2003.09.012","volume":"333","author":"MK Miller","year":"2003","unstructured":"Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K, Granzier H, McElhinny AS, Gregorio CC, Labeit S: The muscle ankyrin repeat proteins: CARP, ankrd2\/Arpp and DARP as a family of titin filament-based stress response molecules. J Mol Biol. 2003, 333 (5): 951-64. 10.1016\/j.jmb.2003.09.012.","journal-title":"J Mol Biol"},{"issue":"39","key":"3293_CR32","doi-asserted-by":"publisher","first-page":"41114","DOI":"10.1074\/jbc.M400674200","volume":"279","author":"Y Kamei","year":"2004","unstructured":"Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T, Mochida K, Hata T, Matsuda J, Aburatani H, Nishino I, Ezaki O: Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch\/red muscle) fiber genes, and impaired glycemic control. J Biol Chem. 2004, 279 (39): 41114-23. 10.1074\/jbc.M400674200.","journal-title":"J Biol Chem"},{"issue":"3","key":"3293_CR33","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S1097-2765(04)00211-4","volume":"14","author":"TN Stitt","year":"2004","unstructured":"Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ: The IGF-1\/PI3K\/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell. 2004, 14 (3): 395-403. 10.1016\/S1097-2765(04)00211-4.","journal-title":"Mol Cell"},{"issue":"29","key":"3293_CR34","doi-asserted-by":"publisher","first-page":"21176","DOI":"10.1074\/jbc.M702039200","volume":"282","author":"RJ Southgate","year":"2007","unstructured":"Southgate RJ, Neill B, Prelovsek O, El-Osta A, Kamei Y, Miura S, Ezaki O, McLoughlin TJ, Zhang W, Unterman TG, Febbraio MA: FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle. J Biol Chem. 2007, 282 (29): 21176-86. 10.1074\/jbc.M702039200.","journal-title":"J Biol Chem"},{"issue":"6","key":"3293_CR35","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/(SICI)1521-1878(200006)22:6<510::AID-BIES4>3.0.CO;2-1","volume":"22","author":"EN Olson","year":"2000","unstructured":"Olson EN, Williams RS: Remodeling muscles with calcineurin. Bioessays. 2000, 22 (6): 510-9. 10.1002\/(SICI)1521-1878(200006)22:6<510::AID-BIES4>3.0.CO;2-1.","journal-title":"Bioessays"},{"issue":"11","key":"3293_CR36","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1161\/CIRCULATIONAHA.106.637124","volume":"114","author":"YG Ni","year":"2006","unstructured":"Ni YG, Berenji K, Wang N, Oh M, Sachan N, Dey A, Cheng J, Lu G, Morris DJ, Castrillon DH, Gerard RD, Rothermel BA, Hill JA: Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation. 2006, 114 (11): 1159-68. 10.1161\/CIRCULATIONAHA.106.637124.","journal-title":"Circulation"},{"issue":"5","key":"3293_CR37","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1249\/01.mss.0000218119.67120.b9","volume":"38","author":"MG Zbreski","year":"2006","unstructured":"Zbreski MG, Helwig BG, Mitchell KE, Musch TI, Weiss ML, McAllister RM: Effects of cyclosporine-A on rat soleus muscle fiber size and phenotype. Med Sci Sports Exerc. 2006, 38 (5): 833-9. 10.1249\/01.mss.0000218119.67120.b9.","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"3293_CR38","doi-asserted-by":"publisher","first-page":"C984","DOI":"10.1152\/ajpcell.00483.2001","volume":"282","author":"PO Mitchell","year":"2002","unstructured":"Mitchell PO, Mills ST, Pavlath GK: Calcineurin differentially regulates maintenance and growth of phenotypically distinct muscles. Am J Physiol Cell Physiol. 2002, 282 (5): C984-92.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6","key":"3293_CR39","doi-asserted-by":"publisher","first-page":"C1387","DOI":"10.1152\/ajpcell.00424.2001","volume":"282","author":"EE Dupont-Versteegden","year":"2002","unstructured":"Dupont-Versteegden EE, Knox M, Gurley CM, Houle JD, Peterson CA: Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway. Am J Physiol Cell Physiol. 2002, 282 (6): C1387-95.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"12","key":"3293_CR40","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/S0165-6147(02)02111-9","volume":"23","author":"S Serrano","year":"2002","unstructured":"Serrano S, Schiaffino A: Calcineurin signaling and neural control of skeletal muscle fiber type and size. Trends Pharmacol Sci. 2002, 23 (12): 569-75. 10.1016\/S0165-6147(02)02111-9.","journal-title":"Trends Pharmacol Sci"},{"issue":"6","key":"3293_CR41","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.ceb.2005.09.009","volume":"17","author":"DD Sarbassov","year":"2005","unstructured":"Sarbassov DD, Ali SM, Sabatini DM: Growing roles for the mTOR pathway. Curr Opin Cell Biol. 2005, 17 (6): 596-603. 10.1016\/j.ceb.2005.09.009.","journal-title":"Curr Opin Cell Biol"},{"key":"3293_CR42","volume-title":"Endocrinology","author":"Y Wu","year":"2009","unstructured":"Wu Y, Zhao W, Zhao J, Zhang Y, Qin W, Pan J, Bauman WA, Blitzer RD, Cardozo C: REDD1 Is a Major Target of Testosterone Action in Preventing Dexamethasone-Induced Muscle Loss. Endocrinology. 2009"},{"issue":"3","key":"3293_CR43","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1096\/fj.05-5125fje","volume":"20","author":"CA Steelman","year":"2006","unstructured":"Steelman CA, Recknor JC, Nettleton D, Reecy JM: Transcriptional profiling of myostatin-knockout mice implicates Wnt signaling in postnatal skeletal muscle growth and hypertrophy. Faseb J. 2006, 20 (3): 580-2.","journal-title":"Faseb J"},{"issue":"4","key":"3293_CR44","doi-asserted-by":"publisher","first-page":"C853","DOI":"10.1152\/ajpcell.00093.2005","volume":"289","author":"DD Armstrong","year":"2005","unstructured":"Armstrong DD, Esser KA: Wnt\/beta-catenin signaling activates growth-control genes during overload-induced skeletal muscle hypertrophy. Am J Physiol Cell Physiol. 2005, 289 (4): C853-9. 10.1152\/ajpcell.00093.2005.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"3293_CR45","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1210\/en.2004-1649","volume":"147","author":"R Singh","year":"2006","unstructured":"Singh R, Artaza JN, Taylor WE, Braga M, Yuan X, Gonzalez NF, Cadavid Bhasin S: Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology. 2006, 147 (1): 141-54. 10.1210\/en.2004-1649.","journal-title":"Endocrinology"},{"issue":"1-2","key":"3293_CR46","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0167-4838(00)00162-X","volume":"1482","author":"E Rassart","year":"2000","unstructured":"Rassart E, Bedirian A, Do Carmo S, Guinard O, Sirois J, Terrisse L, Milne R: Apolipoprotein D. Biochim Biophys Acta. 2000, 1482 (1-2): 185-98.","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"3293_CR47","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1152\/physiolgenomics.00115.2006","volume":"31","author":"YW Chen","year":"2007","unstructured":"Chen YW, Gregory CM, Scarborough MT, Shi R, Walter GA, Vandenborne K: Transcriptional pathways associated with skeletal muscle disuse atrophy in humans. Physiol Genomics. 2007, 31 (3): 510-20. 10.1152\/physiolgenomics.00115.2006.","journal-title":"Physiol Genomics"},{"issue":"2","key":"3293_CR48","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1210\/edrv.23.2.0460","volume":"23","author":"CA Heinlein","year":"2002","unstructured":"Heinlein CA, Chang C: Androgen receptor (AR) coregulators: an overview. Endocr Rev. 2002, 23 (2): 175-200. 10.1210\/er.23.2.175.","journal-title":"Endocr Rev"},{"issue":"11","key":"3293_CR49","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1210\/me.2004-0245","volume":"18","author":"Z Kang","year":"2004","unstructured":"Kang Z, Janne OA, Palvimo JJ: Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor. Mol Endocrinol. 2004, 18 (11): 2633-48. 10.1210\/me.2004-0245.","journal-title":"Mol Endocrinol"},{"issue":"11","key":"3293_CR50","doi-asserted-by":"publisher","first-page":"5449","DOI":"10.1210\/en.2008-0664","volume":"149","author":"W Zhao","year":"2008","unstructured":"Zhao W, Pan J, Wang X, Wu Y, Bauman WA, Cardozo CP: Expression of the muscle arophy factor MAFbx is suppressed by testosterone. Endocrinology. 2008, 149 (11): 5449-5460. 10.1210\/en.2008-0664.","journal-title":"Endocrinology"},{"issue":"9","key":"3293_CR51","doi-asserted-by":"publisher","first-page":"6420","DOI":"10.1074\/jbc.M008689200","volume":"276","author":"MI Gonzalez","year":"2001","unstructured":"Gonzalez MI, Robins DM: Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that facilitates recruitment of SRC-1. J Biol Chem. 2001, 276 (9): 6420-8. 10.1074\/jbc.M008689200.","journal-title":"J Biol Chem"},{"issue":"41","key":"3293_CR52","doi-asserted-by":"publisher","first-page":"30014","DOI":"10.1074\/jbc.M704817200","volume":"282","author":"C Handschin","year":"2007","unstructured":"Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, Lebrasseur NK, Yan Z, Spiegelman BM: Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem. 2007, 282 (41): 30014-21. 10.1074\/jbc.M704817200.","journal-title":"J Biol Chem"},{"issue":"5","key":"3293_CR53","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1073\/pnas.95.5.2122","volume":"95","author":"P Aarnisalo","year":"1998","unstructured":"Aarnisalo P, Palvimo JJ, Janne OA: CREB-binding protein in androgen receptor-mediated signaling. Proc Natl Acad Sci USA. 1998, 95 (5): 2122-7. 10.1073\/pnas.95.5.2122.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"3293_CR54","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1210\/me.15.11.1918","volume":"15","author":"M Sharma","year":"2001","unstructured":"Sharma M, Sun Z: 5'TG3' interacting factor interacts with Sin3A and represses AR-mediated transcription. Mol Endocrinol. 2001, 15 (11): 1918-28. 10.1210\/me.15.11.1918.","journal-title":"Mol Endocrinol"},{"issue":"12","key":"3293_CR55","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.1038\/sj.emboj.7601161","volume":"25","author":"J Thompson","year":"2006","unstructured":"Thompson J, Lepikhova T, Teixido-Travesa N, Whitehead MA, Palvimo JJ, Janne OA: Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription. EMBO J. 2006, 25 (12): 2757-67. 10.1038\/sj.emboj.7601161.","journal-title":"EMBO J"},{"issue":"7","key":"3293_CR56","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1210\/me.2005-0286","volume":"20","author":"S Carascossa","year":"2006","unstructured":"Carascossa S, Gobinet S, Georget V, Lucas A, Badia E, Castet A, White R, Nicolas JC, Cavailles V, Jalaguier S: Receptor-interacting protein 140 is a repressor of the androgen receptor activity. Mol Endocrinol. 2006, 20 (7): 1506-18. 10.1210\/me.2005-0286.","journal-title":"Mol Endocrinol"},{"issue":"10","key":"3293_CR57","doi-asserted-by":"publisher","first-page":"7329","DOI":"10.1074\/jbc.M610447200","volume":"282","author":"W Fan","year":"2007","unstructured":"Fan W, Yanase T, Morinaga H, Okabe T, Nomura M, Daitoku H, Fukamizu A, Kato S, Takayanagi R, Nawata H: Insulin-like growth factor 1\/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor. J Biol Chem. 2007, 282 (10): 7329-38. 10.1074\/jbc.M610447200.","journal-title":"J Biol Chem"},{"issue":"10","key":"3293_CR58","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1210\/me.11.10.1497","volume":"11","author":"LL Heckert","year":"1997","unstructured":"Heckert LL, Wilson EM, Nilson JH: Transcriptional repression of the alpha-subunit gene by androgen receptor occurs independently of DNA binding but requires the DNA-binding and ligand-binding domains of the receptor. Mol Endocrinol. 1997, 11 (10): 1497-506. 10.1210\/me.11.10.1497.","journal-title":"Mol Endocrinol"},{"issue":"34","key":"3293_CR59","doi-asserted-by":"publisher","first-page":"21856","DOI":"10.1074\/jbc.273.34.21856","volume":"273","author":"CS Song","year":"1998","unstructured":"Song CS, Jung MH, Kim SC, Hassan T, Roy AK, Chatterjee B: Tissue-specific and androgen-repressible regulation of the rat dehydroepiandrosterone sulfotransferase gene promoter. J Biol Chem. 1998, 273 (34): 21856-66. 10.1074\/jbc.273.34.21856.","journal-title":"J Biol Chem"},{"issue":"39","key":"3293_CR60","doi-asserted-by":"publisher","first-page":"23907","DOI":"10.1074\/jbc.271.39.23907","volume":"271","author":"J Schneikert","year":"1996","unstructured":"Schneikert J, Peterziel H, Defossez PA, Klocker H, Launoit Y, Cato AC: Androgen receptor-Ets protein interaction is a novel mechanism for steroid hormone-mediated down-modulation of matrix metalloproteinase expression. J Biol Chem. 1996, 271 (39): 23907-13. 10.1074\/jbc.271.39.23907.","journal-title":"J Biol Chem"},{"issue":"39","key":"3293_CR61","doi-asserted-by":"publisher","first-page":"24151","DOI":"10.1074\/jbc.271.39.24151","volume":"271","author":"JJ Palvimo","year":"1996","unstructured":"Palvimo JJ, Reinikainen P, Ikonen T, Kallio PJ, Moilanen A, Janne OA: Mutual transcriptional interference between RelA and androgen receptor. J Biol Chem. 1996, 271 (39): 24151-6. 10.1074\/jbc.271.39.24151.","journal-title":"J Biol Chem"},{"issue":"8","key":"3293_CR62","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1210\/me.9.8.1017","volume":"9","author":"PJ Kallio","year":"1995","unstructured":"Kallio PJ, Poukka H, Moilanen A, Janne OA, Palvimo JJ: Androgen receptor-mediated transcriptional regulation in the absence of direct interaction with a specific DNA element. Mol Endocrinol. 1995, 9 (8): 1017-28. 10.1210\/me.9.8.1017.","journal-title":"Mol Endocrinol"},{"issue":"5","key":"3293_CR63","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.steroids.2004.01.006","volume":"69","author":"J Zhao","year":"2004","unstructured":"Zhao J, Bauman WA, Huang R, Caplan AJ, Cardozo C: Oxandrolone blocks glucocorticoid signaling in an androgen receptor-dependent manner. Steroids. 2004, 69 (5): 357-66. 10.1016\/j.steroids.2004.01.006.","journal-title":"Steroids"},{"issue":"10","key":"3293_CR64","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1210\/me.2002-0070","volume":"16","author":"CA Heinlein","year":"2002","unstructured":"Heinlein CA, Chang C: The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol Endocrinol. 2002, 16 (10): 2181-7. 10.1210\/me.2002-0070.","journal-title":"Mol Endocrinol"},{"issue":"29","key":"3293_CR65","doi-asserted-by":"publisher","first-page":"12017","DOI":"10.1073\/pnas.0705070104","volume":"104","author":"S Jager","year":"2007","unstructured":"Jager S, Handschin C, St-Pierre J, Spiegelman BM: AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci USA. 2007, 104 (29): 12017-22. 10.1073\/pnas.0705070104.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"20","key":"3293_CR66","doi-asserted-by":"publisher","first-page":"19587","DOI":"10.1074\/jbc.M408862200","volume":"280","author":"T Akimoto","year":"2005","unstructured":"Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, Williams RS, Yan Z: Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem. 2005, 280 (20): 19587-93. 10.1074\/jbc.M408862200.","journal-title":"J Biol Chem"},{"issue":"4","key":"3293_CR67","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1152\/jappl.1997.82.4.1112","volume":"82","author":"A Bisschop","year":"1997","unstructured":"Bisschop A, Gayan-Ramirez G, Rollier H, Dekhuijzen PN, Dom R, de Bock V, Decramer M: Effects of nandrolone decanoate on respiratory and peripheral muscles in male and female rats. J Appl Physiol. 1997, 82 (4): 1112-8.","journal-title":"J Appl Physiol"},{"issue":"12","key":"3293_CR68","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1111\/j.2042-7158.1976.tb04085.x","volume":"28","author":"MA Chaudry","year":"1976","unstructured":"Chaudry MA, James KC, Ng CT, Nicholls PJ: Anabolic and androgenic activities, in rat, of some nandrolone and androstanolone esters. J Pharm Pharmacol. 1976, 28 (12): 882-5.","journal-title":"J Pharm Pharmacol"},{"issue":"5","key":"3293_CR69","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.jsbmb.2004.07.008","volume":"92","author":"T Xu","year":"2004","unstructured":"Xu T, Shen Y, Pink H, Triantafillou J, Stimpson SA, Turnbull P, Han B: Phosphorylation of p70s6 kinase is implicated in androgen-induced levator ani muscle anabolism in castrated rats. J Steroid Biochem Mol Biol. 2004, 92 (5): 447-54. 10.1016\/j.jsbmb.2004.07.008.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"7","key":"3293_CR70","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1210\/jc.2006-2722","volume":"92","author":"M Montano","year":"2007","unstructured":"Montano M, Flanagan JN, Jiang L, Sebastiani P, Rarick M, LeBrasseur NK, Morris CA, Jasuja R, Bhasin S: Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007, 92 (7): 2793-802. 10.1210\/jc.2006-2722.","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"3293_CR71","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.1096\/fj.08-105726","volume":"22","author":"HE Maclean","year":"2008","unstructured":"Maclean HE, Chiu WS, Notini AJ, Axell AM, Davey RA, McManus JF, Ma C, Plant DR, Lynch GS, Zajac JD: Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice. FASEB J. 2008, 22 (8): 2676-89. 10.1096\/fj.08-105726.","journal-title":"FASEB J"},{"issue":"1","key":"3293_CR72","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987, 162 (1): 156-9. 10.1016\/0003-2697(87)90021-2.","journal-title":"Anal Biochem"},{"key":"3293_CR73","volume-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery","author":"G Dennis Jr","year":"2003","unstructured":"Dennis G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA: DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 2003, 4 (5): 10.1186\/gb-2003-4-5-p3. P3 4(5):P3"},{"issue":"1","key":"3293_CR74","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang da","year":"2009","unstructured":"Huang da W, Sherman BT, Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009, 4 (1): 44-57. 10.1038\/nprot.2008.211.","journal-title":"Nat Protoc"},{"issue":"1","key":"3293_CR75","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1093\/nar\/gkg050","volume":"31","author":"M Safran","year":"2003","unstructured":"Safran M, Chalifa-Caspi V, Shmueli O, Olender T, Lapidot M, Rosen N, Shmoish M, Peter Y, Glusman G, Feldmesser E, Adato A, Peter I, Khen M, Atarot T, Groner Y, Lancet D: Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDE. Nucleic Acids Res. 2003, 31 (1): 142-6. 10.1093\/nar\/gkg050.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"3293_CR76","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1152\/japplphysiol.01113.2002","volume":"95","author":"F Haddad","year":"2003","unstructured":"Haddad F, Roy RR, Zhong H, Edgerton VR, Baldwin KM: Atrophy responses to muscle inactivity. II. Molecular markers of protein deficits. J Appl Physiol. 2003, 95 (2): 791-802.","journal-title":"J Appl Physiol"},{"issue":"5","key":"3293_CR77","doi-asserted-by":"publisher","first-page":"C1161","DOI":"10.1152\/ajpcell.00128.2003","volume":"285","author":"JP Hyatt","year":"2003","unstructured":"Hyatt JP, Roy RR, Baldwin KM, Edgerton VR: Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei. Am J Physiol Cell Physiol. 2003, 285 (5): C1161-73.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"3293_CR78","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001, 25 (4): 402-8. 10.1006\/meth.2001.1262.","journal-title":"Methods"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2164-11-596.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T12:50:34Z","timestamp":1630500634000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/1471-2164-11-596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,22]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["3293"],"URL":"https:\/\/doi.org\/10.1186\/1471-2164-11-596","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,22]]},"assertion":[{"value":"13 October 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"596"}}