{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:18:32Z","timestamp":1779236312949,"version":"3.51.4"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      At present, very little is known about how\n                      <jats:italic>Burkholderia pseudomallei<\/jats:italic>\n                      (\n                      <jats:italic>B. pseudomallei<\/jats:italic>\n                      ) interacts with its host to elicit melioidosis symptoms. We established a murine acute-phase melioidosis model and used DNA microarray technology to investigate the global host\/pathogen interaction. We compared the transcriptome of infected liver and spleen with uninfected tissues over an infection period of 42 hr to identify genes whose expression is altered in response to an acute infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Viable\n                      <jats:italic>B. pseudomallei<\/jats:italic>\n                      cells were consistently detected in the blood, liver and spleen during the 42 hr course of infection. Microarray analysis of the liver and spleen over this time course demonstrated that genes involved in immune response, stress response, cell cycle regulation, proteasomal degradation, cellular metabolism and signal transduction pathways were differentially regulated. Up regulation of toll-like receptor 2 (TLR2) gene expression suggested that a TLR2-mediated signalling pathway is responsible for recognition and initiation of an inflammatory response to the acute\n                      <jats:italic>B. pseudomallei<\/jats:italic>\n                      infection. Most of the highly elevated inflammatory genes are a cohort of \"core host immune response\" genes commonly seen in general inflammation infections. Concomitant to this initial inflammatory response, we observed an increase in transcripts associated with cell-death, caspase activation and peptidoglysis that ultimately promote tissue injury in the host. The complement system responsible for restoring host cellular homeostasis and eliminating intracellular bacteria was activated only after 24 hr post-infection. However, at this time point, diverse host nutrient metabolic and cellular pathways including glycolysis, fatty acid metabolism and tricarboxylic acid (TCA) cycle were repressed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This detailed picture of the host transcriptional response during acute melioidosis highlights a broad range of innate immune mechanisms that are activated in the host within 24 hrs, including the core immune response commonly seen in general inflammatory infections. Nevertheless, this activation is suppressed at 42 hr post-infection and in addition, suboptimal activation and function of the downstream complement system promotes uncontrolled spread of the bacteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2164-11-672","type":"journal-article","created":{"date-parts":[[2010,11,27]],"date-time":"2010-11-27T02:13:58Z","timestamp":1290824038000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Genome wide transcriptome profiling of a murine acute melioidosis model reveals new insights into how Burkholderia pseudomallei overcomes host innate immunity"],"prefix":"10.1186","volume":"11","author":[{"given":"Chui-Yoke","family":"Chin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise M","family":"Monack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,11,27]]},"reference":[{"issue":"2","key":"3369_CR1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1128\/CMR.18.2.383-416.2005","volume":"18","author":"AC Cheng","year":"2005","unstructured":"Cheng AC, Currie BJ: Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev. 2005, 18 (2): 383-416. 10.1128\/CMR.18.2.383-416.2005.","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"3369_CR2","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nrmicro1385","volume":"4","author":"WJ Wiersinga","year":"2006","unstructured":"Wiersinga WJ, van der Poll T, White NJ, Day NP, Peacock SJ: Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. Nat Rev Microbiol. 2006, 4 (4): 272-282. 10.1038\/nrmicro1385.","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"3369_CR3","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1128\/IAI.68.4.2034-2042.2000","volume":"68","author":"GC Ulett","year":"2000","unstructured":"Ulett GC, Ketheesan N, Hirst RG: Cytokine gene expression in innately susceptible BALB\/c mice and relatively resistant C57BL\/6 mice during infection with virulent Burkholderia pseudomallei. Infect Immun. 2000, 68 (4): 2034-2042. 10.1128\/IAI.68.4.2034-2042.2000.","journal-title":"Infect Immun"},{"issue":"9","key":"3369_CR4","doi-asserted-by":"publisher","first-page":"5290","DOI":"10.1128\/IAI.70.9.5290-5294.2002","volume":"70","author":"T Atkins","year":"2002","unstructured":"Atkins T, Prior RG, Mack K, Russell P, Nelson M, Oyston PC, Dougan G, Titball RW: A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis. Infect Immun. 2002, 70 (9): 5290-5294. 10.1128\/IAI.70.9.5290-5294.2002.","journal-title":"Infect Immun"},{"issue":"5","key":"3369_CR5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/21548331.1997.11443493","volume":"32","author":"U Chodimella","year":"1997","unstructured":"Chodimella U, Hoppes WL, Whalen S, Ognibene AJ, Rutecki GW: Septicemia and suppuration in a Vietnam veteran. Hosp Pract (Minneap). 1997, 32 (5): 219-221.","journal-title":"Hosp Pract (Minneap)"},{"issue":"6","key":"3369_CR6","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1128\/IAI.67.6.2891-2900.1999","volume":"67","author":"I Hoppe","year":"1999","unstructured":"Hoppe I, Brenneke B, Rohde M, Kreft A, Haussler S, Reganzerowski A, Steinmetz I: Characterization of a murine model of melioidosis: comparison of different strains of mice. Infect Immun. 1999, 67 (6): 2891-2900.","journal-title":"Infect Immun"},{"issue":"5","key":"3369_CR7","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1097\/01.qco.0000244046.31135.b3","volume":"19","author":"SJ Peacock","year":"2006","unstructured":"Peacock SJ: Melioidosis. Curr Opin Infect Dis. 2006, 19 (5): 421-428. 10.1097\/01.qco.0000244046.31135.b3.","journal-title":"Curr Opin Infect Dis"},{"issue":"10","key":"3369_CR8","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1086\/497382","volume":"192","author":"YH Gan","year":"2005","unstructured":"Gan YH: Interaction between Burkholderia pseudomallei and the host immune response: sleeping with the enemy?. J Infect Dis. 2005, 192 (10): 1845-1850. 10.1086\/497382.","journal-title":"J Infect Dis"},{"issue":"7","key":"3369_CR9","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1128\/IAI.67.7.3593-3600.1999","volume":"67","author":"P Santanirand","year":"1999","unstructured":"Santanirand P, Harley VS, Dance DA, Drasar BS, Bancroft GJ: Obligatory role of gamma interferon for host survival in a murine model of infection with Burkholderia pseudomallei. Infect Immun. 1999, 67 (7): 3593-3600.","journal-title":"Infect Immun"},{"key":"3369_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1471-2172-7-19","volume":"7","author":"GC Koo","year":"2006","unstructured":"Koo GC, Gan YH: The innate interferon gamma response of BALB\/c and C57BL\/6 mice to in vitro Burkholderia pseudomallei infection. BMC Immunol. 2006, 7: 19-10.1186\/1471-2172-7-19.","journal-title":"BMC Immunol"},{"issue":"2","key":"3369_CR11","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1128\/IAI.70.2.504-511.2002","volume":"70","author":"B Liu","year":"2002","unstructured":"Liu B, Koo GC, Yap EH, Chua KL, Gan YH: Model of differential susceptibility to mucosal Burkholderia pseudomallei infection. Infect Immun. 2002, 70 (2): 504-511. 10.1128\/IAI.70.2.504-511.2002.","journal-title":"Infect Immun"},{"issue":"Suppl 1","key":"3369_CR12","doi-asserted-by":"publisher","first-page":"S82","DOI":"10.1016\/S0035-9203(08)70021-X","volume":"102","author":"M Feterl","year":"2008","unstructured":"Feterl M, Govan BL, Ketheesan N: The effect of different Burkholderia pseudomallei isolates of varying levels of virulence on toll-like-receptor expression. Trans R Soc Trop Med Hyg. 2008, 102 (Suppl 1): S82-88. 10.1016\/S0035-9203(08)70021-X.","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"7","key":"3369_CR13","doi-asserted-by":"publisher","first-page":"e248","DOI":"10.1371\/journal.pmed.0040248","volume":"4","author":"WJ Wiersinga","year":"2007","unstructured":"Wiersinga WJ, Wieland CW, Dessing MC, Chantratita N, Cheng AC, Limmathurotsakul D, Chierakul W, Leendertse M, Florquin S, de Vos AF, et al: Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). PLoS Med. 2007, 4 (7): e248-10.1371\/journal.pmed.0040248.","journal-title":"PLoS Med"},{"key":"3369_CR14","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1471-2172-9-46","volume":"9","author":"TE West","year":"2008","unstructured":"West TE, Ernst RK, Jansson-Hutson MJ, Skerrett SJ: Activation of Toll-like receptors by Burkholderia pseudomallei. BMC Immunol. 2008, 9: 46-10.1186\/1471-2172-9-46.","journal-title":"BMC Immunol"},{"issue":"14","key":"3369_CR15","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1056\/NEJM200104053441406","volume":"344","author":"MJ Walport","year":"2001","unstructured":"Walport MJ: Complement. First of two parts. N Engl J Med. 2001, 344 (14): 1058-1066. 10.1056\/NEJM200104053441406.","journal-title":"N Engl J Med"},{"issue":"15","key":"3369_CR16","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1056\/NEJM200104123441506","volume":"344","author":"MJ Walport","year":"2001","unstructured":"Walport MJ: Complement. Second of two parts. N Engl J Med. 2001, 344 (15): 1140-1144. 10.1056\/NEJM200104123441506.","journal-title":"N Engl J Med"},{"key":"3369_CR17","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1034\/j.1600-065X.2003.00048.x","volume":"193","author":"EM Creagh","year":"2003","unstructured":"Creagh EM, Conroy H, Martin SJ: Caspase-activation pathways in apoptosis and immunity. Immunol Rev. 2003, 193: 10-21. 10.1034\/j.1600-065X.2003.00048.x.","journal-title":"Immunol Rev"},{"issue":"1","key":"3369_CR18","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.cbpb.2008.05.010","volume":"151","author":"I Chowdhury","year":"2008","unstructured":"Chowdhury I, Tharakan B, Bhat GK: Caspases - an update. Comp Biochem Physiol B Biochem Mol Biol. 2008, 151 (1): 10-27. 10.1016\/j.cbpb.2008.05.010.","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"issue":"1","key":"3369_CR19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1600-065X.2008.00730.x","volume":"227","author":"M Lamkanfi","year":"2009","unstructured":"Lamkanfi M, Dixit VM: Inflammasomes: guardians of cytosolic sanctity. Immunol Rev. 2009, 227 (1): 95-105. 10.1111\/j.1600-065X.2008.00730.x.","journal-title":"Immunol Rev"},{"key":"3369_CR20","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1196\/annals.1409.005","volume":"1105","author":"DS Weiss","year":"2007","unstructured":"Weiss DS, Henry T, Monack DM: Francisella tularensis: activation of the inflammasome. Ann N Y Acad Sci. 2007, 1105: 219-237. 10.1196\/annals.1409.005.","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"3369_CR21","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.chom.2008.08.007","volume":"4","author":"HB Yu","year":"2008","unstructured":"Yu HB, Finlay BB: The caspase-1 inflammasome: a pilot of innate immune responses. Cell Host Microbe. 2008, 4 (3): 198-208. 10.1016\/j.chom.2008.08.007.","journal-title":"Cell Host Microbe"},{"issue":"5","key":"3369_CR22","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1084\/jem.20062665","volume":"204","author":"T Henry","year":"2007","unstructured":"Henry T, Brotcke A, Weiss DS, Thompson LJ, Monack DM: Type I interferon signaling is required for activation of the inflammasome during Francisella infection. J Exp Med. 2007, 204 (5): 987-994. 10.1084\/jem.20062665.","journal-title":"J Exp Med"},{"issue":"10","key":"3369_CR23","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1111\/j.1462-5822.2005.00569.x","volume":"7","author":"GW Sun","year":"2005","unstructured":"Sun GW, Lu J, Pervaiz S, Cao WP, Gan YH: Caspase-1 dependent macrophage death induced by Burkholderia pseudomallei. Cell Microbiol. 2005, 7 (10): 1447-1458. 10.1111\/j.1462-5822.2005.00569.x.","journal-title":"Cell Microbiol"},{"issue":"3","key":"3369_CR24","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ni.1703","volume":"10","author":"L Franchi","year":"2009","unstructured":"Franchi L, Eigenbrod T, Munoz-Planillo R, Nunez G: The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol. 2009, 10 (3): 241-247. 10.1038\/ni.1703.","journal-title":"Nat Immunol"},{"issue":"6","key":"3369_CR25","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1056\/NEJM199902113400607","volume":"340","author":"C Gabay","year":"1999","unstructured":"Gabay C, Kushner I: Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999, 340 (6): 448-454. 10.1056\/NEJM199902113400607.","journal-title":"N Engl J Med"},{"issue":"2","key":"3369_CR26","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1046\/j.1432-1327.1999.00657.x","volume":"265","author":"CM Uhlar","year":"1999","unstructured":"Uhlar CM, Whitehead AS: Serum amyloid A, the major vertebrate acute-phase reactant. Eur J Biochem. 1999, 265 (2): 501-523. 10.1046\/j.1432-1327.1999.00657.x.","journal-title":"Eur J Biochem"},{"key":"3369_CR27","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1146\/annurev.physiol.66.032102.150251","volume":"66","author":"AR Crofts","year":"2004","unstructured":"Crofts AR: The cytochrome bc1 complex: function in the context of structure. Annu Rev Physiol. 2004, 66: 689-733. 10.1146\/annurev.physiol.66.032102.150251.","journal-title":"Annu Rev Physiol"},{"issue":"2-3","key":"3369_CR28","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0001-706X(99)00075-3","volume":"74","author":"GC Ulett","year":"2000","unstructured":"Ulett GC, Ketheesan N, Hirst RG: Proinflammatory cytokine mRNA responses in experimental Burkholderia pseudomallei infection in mice. Acta Trop. 2000, 74 (2-3): 229-234. 10.1016\/S0001-706X(99)00075-3.","journal-title":"Acta Trop"},{"issue":"6","key":"3369_CR29","doi-asserted-by":"publisher","first-page":"3074","DOI":"10.1128\/IAI.01733-06","volume":"75","author":"WJ Wiersinga","year":"2007","unstructured":"Wiersinga WJ, Dessing MC, Kager PA, Cheng AC, Limmathurotsakul D, Day NP, Dondorp AM, van der Poll T, Peacock SJ: High-throughput mRNA profiling characterizes the expression of inflammatory molecules in sepsis caused by Burkholderia pseudomallei. Infect Immun. 2007, 75 (6): 3074-3079. 10.1128\/IAI.01733-06.","journal-title":"Infect Immun"},{"issue":"5","key":"3369_CR30","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1046\/j.1440-1711.2001.01038.x","volume":"79","author":"JL Barnes","year":"2001","unstructured":"Barnes JL, Ulett GC, Ketheesan N, Clair T, Summers PM, Hirst RG: Induction of multiple chemokine and colony-stimulating factor genes in experimental Burkholderia pseudomallei infection. Immunol Cell Biol. 2001, 79 (5): 490-501. 10.1046\/j.1440-1711.2001.01038.x.","journal-title":"Immunol Cell Biol"},{"issue":"8","key":"3369_CR31","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/j.micinf.2008.04.019","volume":"10","author":"WJ Wiersinga","year":"2008","unstructured":"Wiersinga WJ, Dessing MC, van der Poll T: Gene-expression profiles in murine melioidosis. Microbes Infect. 2008, 10 (8): 868-877. 10.1016\/j.micinf.2008.04.019.","journal-title":"Microbes Infect"},{"issue":"9","key":"3369_CR32","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1086\/592220","volume":"198","author":"WJ Wiersinga","year":"2008","unstructured":"Wiersinga WJ, de Vos AF, Wieland CW, Leendertse M, Roelofs JJ, van der Poll T: CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice. J Infect Dis. 2008, 198 (9): 1388-1397. 10.1086\/592220.","journal-title":"J Infect Dis"},{"issue":"10","key":"3369_CR33","doi-asserted-by":"publisher","first-page":"5803","DOI":"10.1128\/IAI.71.10.5803-5813.2003","volume":"71","author":"RJ Feezor","year":"2003","unstructured":"Feezor RJ, Oberholzer C, Baker HV, Novick D, Rubinstein M, Moldawer LL, Pribble J, Souza S, Dinarello CA, Ertel W, et al: Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Infect Immun. 2003, 71 (10): 5803-5813. 10.1128\/IAI.71.10.5803-5813.2003.","journal-title":"Infect Immun"},{"issue":"7","key":"3369_CR34","doi-asserted-by":"publisher","first-page":"e2596","DOI":"10.1371\/journal.pone.0002596","volume":"3","author":"JL Pennings","year":"2008","unstructured":"Pennings JL, Kimman TG, Janssen R: Identification of a common gene expression response in different lung inflammatory diseases in rodents and macaques. PLoS One. 2008, 3 (7): e2596-10.1371\/journal.pone.0002596.","journal-title":"PLoS One"},{"issue":"5543","key":"3369_CR35","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1126\/science.294.5543.870","volume":"294","author":"Q Huang","year":"2001","unstructured":"Huang Q, Liu D, Majewski P, Schulte LC, Korn JM, Young RA, Lander ES, Hacohen N: The plasticity of dendritic cell responses to pathogens and their components. Science. 2001, 294 (5543): 870-875. 10.1126\/science.294.5543.870.","journal-title":"Science"},{"issue":"2","key":"3369_CR36","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1073\/pnas.231625398","volume":"99","author":"JC Boldrick","year":"2002","unstructured":"Boldrick JC, Alizadeh AA, Diehn M, Dudoit S, Liu CL, Belcher CE, Botstein D, Staudt LM, Brown PO, Relman DA: Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Proc Natl Acad Sci USA. 2002, 99 (2): 972-977. 10.1073\/pnas.231625398.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"3369_CR37","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1164\/rccm.200211-1278OC","volume":"169","author":"SL Yu","year":"2004","unstructured":"Yu SL, Chen HW, Yang PC, Peck K, Tsai MH, Chen JJ, Lin FY: Differential gene expression in gram-negative and gram-positive sepsis. Am J Respir Crit Care Med. 2004, 169 (10): 1135-1143. 10.1164\/rccm.200211-1278OC.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"3369_CR38","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1073\/pnas.022649799","volume":"99","author":"GJ Nau","year":"2002","unstructured":"Nau GJ, Richmond JF, Schlesinger A, Jennings EG, Lander ES, Young RA: Human macrophage activation programs induced by bacterial pathogens. Proc Natl Acad Sci USA. 2002, 99 (3): 1503-1508. 10.1073\/pnas.022649799.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"3369_CR39","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/nrmicro1126","volume":"3","author":"RG Jenner","year":"2005","unstructured":"Jenner RG, Young RA: Insights into host responses against pathogens from transcriptional profiling. Nat Rev Microbiol. 2005, 3 (4): 281-294. 10.1038\/nrmicro1126.","journal-title":"Nat Rev Microbiol"},{"issue":"2","key":"3369_CR40","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1172\/JCI34431","volume":"118","author":"GM Barton","year":"2008","unstructured":"Barton GM: A calculated response: control of inflammation by the innate immune system. J Clin Invest. 2008, 118 (2): 413-420. 10.1172\/JCI34431.","journal-title":"J Clin Invest"},{"issue":"1-3","key":"3369_CR41","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.molimm.2006.06.021","volume":"44","author":"SS Bohlson","year":"2007","unstructured":"Bohlson SS, Fraser DA, Tenner AJ: Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions. Mol Immunol. 2007, 44 (1-3): 33-43. 10.1016\/j.molimm.2006.06.021.","journal-title":"Mol Immunol"},{"issue":"6","key":"3369_CR42","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/j.1574-6976.2009.00189.x","volume":"33","author":"NR Adler","year":"2009","unstructured":"Adler NR, Govan B, Cullinane M, Harper M, Adler B, Boyce JD: The molecular and cellular basis of pathogenesis in melioidosis: how does Burkholderia pseudomallei cause disease?. FEMS Microbiol Rev. 2009, 33 (6): 1079-1099. 10.1111\/j.1574-6976.2009.00189.x.","journal-title":"FEMS Microbiol Rev"},{"issue":"3","key":"3369_CR43","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1046\/j.1365-2249.2000.01386.x","volume":"122","author":"P Utaisincharoen","year":"2000","unstructured":"Utaisincharoen P, Tangthawornchaikul N, Kespichayawattana W, Anuntagool N, Chaisuriya P, Sirisinha S: Kinetic studies of the production of nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) in macrophages stimulated with Burkholderia pseudomallei endotoxin. Clin Exp Immunol. 2000, 122 (3): 324-329. 10.1046\/j.1365-2249.2000.01386.x.","journal-title":"Clin Exp Immunol"},{"issue":"1 Pt 2","key":"3369_CR44","first-page":"H342","volume":"274","author":"CI Chang","year":"1998","unstructured":"Chang CI, Liao JC, Kuo L: Arginase modulates nitric oxide production in activated macrophages. Am J Physiol. 1998, 274 (1 Pt 2): H342-348.","journal-title":"Am J Physiol"},{"issue":"12","key":"3369_CR45","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1038\/ni.1671","volume":"9","author":"KC El Kasmi","year":"2008","unstructured":"El Kasmi KC, Qualls JE, Pesce JT, Smith AM, Thompson RW, Henao-Tamayo M, Basaraba RJ, Konig T, Schleicher U, Koo MS, et al: Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol. 2008, 9 (12): 1399-1406. 10.1038\/ni.1671.","journal-title":"Nat Immunol"},{"issue":"10-11","key":"3369_CR46","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1016\/j.micinf.2008.06.008","volume":"10","author":"A Lahiri","year":"2008","unstructured":"Lahiri A, Das P, Chakravortty D: Arginase modulates Salmonella induced nitric oxide production in RAW264.7 macrophages and is required for Salmonella pathogenesis in mice model of infection. Microbes Infect. 2008, 10 (10-11): 1166-1174. 10.1016\/j.micinf.2008.06.008.","journal-title":"Microbes Infect"},{"issue":"11","key":"3369_CR47","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.tim.2004.09.004","volume":"12","author":"MG Netea","year":"2004","unstructured":"Netea MG, Van der Meer JW, Kullberg BJ: Toll-like receptors as an escape mechanism from the host defense. Trends Microbiol. 2004, 12 (11): 484-488. 10.1016\/j.tim.2004.09.004.","journal-title":"Trends Microbiol"},{"issue":"5963","key":"3369_CR48","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1126\/science.1183021","volume":"327","author":"A Iwasaki","year":"2010","unstructured":"Iwasaki A, Medzhitov R: Regulation of adaptive immunity by the innate immune system. Science. 2010, 327 (5963): 291-295. 10.1126\/science.1183021.","journal-title":"Science"},{"issue":"1","key":"3369_CR49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S1471-4906(02)00014-5","volume":"24","author":"GB Johnson","year":"2003","unstructured":"Johnson GB, Brunn GJ, Tang AH, Platt JL: Evolutionary clues to the functions of the Toll-like family as surveillance receptors. Trends Immunol. 2003, 24 (1): 19-24. 10.1016\/S1471-4906(02)00014-5.","journal-title":"Trends Immunol"},{"issue":"3","key":"3369_CR50","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.diagmicrobio.2007.01.002","volume":"58","author":"SH Lee","year":"2007","unstructured":"Lee SH, Chong CE, Lim BS, Chai SJ, Sam KK, Mohamed R, Nathan S: Burkholderia pseudomallei animal and human isolates from Malaysia exhibit different phenotypic characteristics. Diagn Microbiol Infect Dis. 2007, 58 (3): 263-270. 10.1016\/j.diagmicrobio.2007.01.002.","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"8","key":"3369_CR51","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/S1286-4579(01)01417-4","volume":"3","author":"GC Ulett","year":"2001","unstructured":"Ulett GC, Currie BJ, Clair TW, Mayo M, Ketheesan N, Labrooy J, Gal D, Norton R, Smith CA, Barnes J, et al: Burkholderia pseudomallei virulence: definition, stability and association with clonality. Microbes Infect. 2001, 3 (8): 621-631. 10.1016\/S1286-4579(01)01417-4.","journal-title":"Microbes Infect"},{"issue":"5","key":"3369_CR52","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1006\/mpat.1997.0179","volume":"24","author":"AK Leakey","year":"1998","unstructured":"Leakey AK, Ulett GC, Hirst RG: BALB\/c and C57Bl\/6 mice infected with virulent Burkholderia pseudomallei provide contrasting animal models for the acute and chronic forms of human melioidosis. Microb Pathog. 1998, 24 (5): 269-275. 10.1006\/mpat.1997.0179.","journal-title":"Microb Pathog"},{"key":"3369_CR53","doi-asserted-by":"publisher","first-page":"e97","DOI":"10.1371\/journal.pone.0000097","volume":"1","author":"R Laaksonen","year":"2006","unstructured":"Laaksonen R, Katajamaa M, Paiva H, Sysi-Aho M, Saarinen L, Junni P, Lutjohann D, Smet J, Van Coster R, Seppanen-Laakso T, et al: A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. PLoS One. 2006, 1: e97-10.1371\/journal.pone.0000097.","journal-title":"PLoS One"},{"issue":"11","key":"3369_CR54","doi-asserted-by":"publisher","first-page":"R127","DOI":"10.1186\/gb-2009-10-11-r127","volume":"10","author":"R Pankla","year":"2009","unstructured":"Pankla R, Buddhisa S, Berry M, Blankenship DM, Bancroft GJ, Banchereau J, Lertmemongkolchai G, Chaussabel D: Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis. Genome Biol. 2009, 10 (11): R127-10.1186\/gb-2009-10-11-r127.","journal-title":"Genome Biol"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2164-11-672.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T02:52:30Z","timestamp":1630464750000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/1471-2164-11-672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,27]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["3369"],"URL":"https:\/\/doi.org\/10.1186\/1471-2164-11-672","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.7330956.7590054","asserted-by":"object"}]},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,27]]},"assertion":[{"value":"8 July 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"672"}}