{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:27:31Z","timestamp":1788791251748,"version":"build-2803163510"},"reference-count":125,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Corynebacterium resistens<\/jats:italic>was initially recovered from human infections and recognized as a new coryneform species that is highly resistant to antimicrobial agents. Bacteremia associated with this organism in immunocompromised patients was rapidly fatal as standard minocycline therapies failed.<jats:italic>C. resistens<\/jats:italic>DSM 45100 was isolated from a blood culture of samples taken from a patient with acute myelocytic leukemia. The complete genome sequence of<jats:italic>C. resistens<\/jats:italic>DSM 45100 was determined by pyrosequencing to identify genes contributing to multi-drug resistance, virulence, and the lipophilic lifestyle of this newly described human pathogen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The genome of<jats:italic>C. resistens<\/jats:italic>DSM 45100 consists of a circular chromosome of 2,601,311 bp in size and the 28,312-bp plasmid pJA144188. Metabolic analysis showed that the genome of<jats:italic>C. resistens<\/jats:italic>DSM 45100 lacks genes for typical sugar uptake systems, anaplerotic functions, and a fatty acid synthase, explaining the strict lipophilic lifestyle of this species. The genome encodes a broad spectrum of enzymes ensuring the availability of exogenous fatty acids for growth, including predicted virulence factors that probably contribute to fatty acid metabolism by damaging host tissue.<jats:italic>C. resistens<\/jats:italic>DSM 45100 is able to use external L-histidine as a combined carbon and nitrogen source, presumably as a result of adaptation to the hitherto unknown habitat on the human skin. Plasmid pJA144188 harbors several genes contributing to antibiotic resistance of<jats:italic>C. resistens<\/jats:italic>DSM 45100, including a tetracycline resistance region of the Tet W type known from<jats:italic>Lactobacillus reuteri<\/jats:italic>and<jats:italic>Streptococcus suis<\/jats:italic>. The<jats:italic>tet<\/jats:italic>(W) gene of pJA144188 was cloned in<jats:italic>Corynebacterium glutamicum<\/jats:italic>and was shown to confer high levels of resistance to tetracycline, doxycycline, and minocycline<jats:italic>in vitro<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The detected gene repertoire of<jats:italic>C. resistens<\/jats:italic>DSM 45100 provides insights into the lipophilic lifestyle and virulence functions of this newly recognized pathogen. Plasmid pJA144188 revealed a modular architecture of gene regions that contribute to the multi-drug resistance of<jats:italic>C. resistens<\/jats:italic>DSM 45100. The<jats:italic>tet<\/jats:italic>(W) gene encoding a ribosomal protection protein is reported here for the first time in corynebacteria. Cloning of the<jats:italic>tet<\/jats:italic>(W) gene mediated resistance to second generation tetracyclines in<jats:italic>C. glutamicum<\/jats:italic>, indicating that it might be responsible for the failure of minocycline therapies in patients with<jats:italic>C. resistens<\/jats:italic>bacteremia.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2164-13-141","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T21:03:39Z","timestamp":1335215019000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient"],"prefix":"10.1186","volume":"13","author":[{"given":"Jasmin","family":"Schr\u00f6der","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Maus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"W\u00f6rdemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Blom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Jaenicke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Trost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Tauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,23]]},"reference":[{"key":"3973_CR1","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1128\/MMBR.00005-07","volume":"71","author":"M Ventura","year":"2007","unstructured":"Ventura M, Canchaya C, Tauch A, Chandra G, Fitzgerald GF, Chater KF, van Sinderen D: Genomics of Actinobacteria: tracing the evolutionary history of an ancient phylum. Microbiol Mol Biol Rev. 2007, 71: 495-548. 10.1128\/MMBR.00005-07.","journal-title":"Microbiol Mol Biol Rev"},{"key":"3973_CR2","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1590\/S0074-02762003000800001","volume":"98","author":"AL Mattos-Guaraldi","year":"2003","unstructured":"Mattos-Guaraldi AL, Moreira LO, Damasco PV, Hirata R: Diphtheria remains a threat to health in the developing world-an overview. Mem Inst Oswaldo Cruz. 2003, 98: 987-993. 10.1590\/S0074-02762003000800001.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"3973_CR3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1128\/CMR.10.1.125","volume":"10","author":"G Funke","year":"1997","unstructured":"Funke G, von Graevenitz A, Clarridge JE, Bernard KA: Clinical microbiology of coryneform bacteria. Clin Microbiol Rev. 1997, 10: 125-159.","journal-title":"Clin Microbiol Rev"},{"key":"3973_CR4","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.1128\/JCM.40.11.4375-4381.2002","volume":"40","author":"KA Bernard","year":"2002","unstructured":"Bernard KA, Munro C, Wiebe D, Ongsansoy E: Characteristics of rare or recently described Corynebacterium species recovered from human clinical material in Canada. J Clin Microbiol. 2002, 40: 4375-4381. 10.1128\/JCM.40.11.4375-4381.2002.","journal-title":"J Clin Microbiol"},{"key":"3973_CR5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/0-387-30743-5_31","volume-title":"The Prokaryotes","author":"A von Greavenitz","year":"2006","unstructured":"von Greavenitz A, Bernard KA: The Genus Corynebacterium--Medical. The Prokaryotes. 2006, New York: Springer, 819-842. 3","edition":"3"},{"key":"3973_CR6","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1128\/JCM.42.9.3925-3931.2004","volume":"42","author":"A Khamis","year":"2004","unstructured":"Khamis A, Raoult D, La Scola B: rpo B gene sequencing for identification of Corynebacterium species. J Clin Microbiol. 2004, 42: 3925-3931. 10.1128\/JCM.42.9.3925-3931.2004.","journal-title":"J Clin Microbiol"},{"key":"3973_CR7","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/j.1469-0691.2008.02023.x","volume":"14","author":"F Soriano","year":"2008","unstructured":"Soriano F, Tauch A: Microbiological and clinical features of Corynebacterium urealyticum: urinary tract stones and genomics as the Rosetta Stone. Clin Microbiol Infect. 2008, 14: 632-643. 10.1111\/j.1469-0691.2008.02023.x.","journal-title":"Clin Microbiol Infect"},{"key":"3973_CR8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2334-7-4","volume":"7","author":"J Belmares","year":"2007","unstructured":"Belmares J, Detterline S, Pak JB, Parada JP: Corynebacterium endocarditis species-specific risk factors and outcomes. BMC Infect Dis. 2007, 7: 4-10.1186\/1471-2334-7-4.","journal-title":"BMC Infect Dis"},{"key":"3973_CR9","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3109\/00365549509047071","volume":"27","author":"H van der Lelie","year":"1995","unstructured":"van der Lelie H, Leverstein-Van Hall M, Mertens M, van Zaanen HC, van Oers RH, Thomas BL, von dem Borne AE, Kuijper EJ: Corynebacterium CDC group JK (Corynebacterium jeikeium) sepsis in haematological patients: a report of three cases and a systematic literature review. Scand J Infect Dis. 1995, 27: 581-584. 10.3109\/00365549509047071.","journal-title":"Scand J Infect Dis"},{"key":"3973_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0195-6701(91)90075-J","volume":"17","author":"D De Briel","year":"1991","unstructured":"De Briel D, Langs JC, Rougeron G, Chabot P, Le Faou A: Multiresistant corynebacteria in bacteriuria: a comparative study of the role of Corynebacterium group D2 and Corynebacterium jeikeium. J Hosp Infect. 1991, 17: 35-43. 10.1016\/0195-6701(91)90075-J.","journal-title":"J Hosp Infect"},{"key":"3973_CR11","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1128\/AAC.35.10.2140","volume":"35","author":"JA Garcia-Rodriguez","year":"1991","unstructured":"Garcia-Rodriguez JA, Garcia Sanchez JE, Munoz Bellido JL, Nebreda Mayoral T, Garcia Sanchez E, Garcia Garcia I: In vitr activity of 79 antimicrobial agents against Corynebacterium group D2. Antimicrob Agents Chemother. 1991, 35: 2140-2143.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR12","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1099\/0022-1317-49-8-759","volume":"49","author":"E Nieto","year":"2000","unstructured":"Nieto E, Vindel A, Valero-Guillen PL, Saez-Nieto JA, Soriano F: Biochemical, antimicrobial susceptibility and genotyping studies on Corynebacterium urealyticum isolates from diverse sources. J Med Microbiol. 2000, 49: 759-763.","journal-title":"J Med Microbiol"},{"key":"3973_CR13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1128\/AAC.40.2.497","volume":"40","author":"M Garcia-Bravo","year":"1996","unstructured":"Garcia-Bravo M, Aguado JM, Morales JM, Noriega AR: Influence of external factors in resistance of Corynebacterium urealyticum to antimicrobial agents. Antimicrob Agents Chemother. 1996, 40: 497-499.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR14","doi-asserted-by":"publisher","first-page":"3713","DOI":"10.1128\/JCM.43.8.3713-3717.2005","volume":"43","author":"Y Otsuka","year":"2005","unstructured":"Otsuka Y, Kawamura Y, Koyama T, Iihara H, Ohkusu K, Ezaki T: Corynebacterium resistens sp. nov., a new multidrug-resistant coryneform bacterium isolated from human infections. J Clin Microbiol. 2005, 43: 3713-3717. 10.1128\/JCM.43.8.3713-3717.2005.","journal-title":"J Clin Microbiol"},{"key":"3973_CR15","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00018-009-0172-6","volume":"67","author":"M Thaker","year":"2009","unstructured":"Thaker M, Spanogiannopoulos P, Wright GD: The tetracycline resistome. Cell Mol Life Sci. 2009, 67: 419-431.","journal-title":"Cell Mol Life Sci"},{"key":"3973_CR16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1101\/gr.8.3.195","volume":"8","author":"D Gordon","year":"1998","unstructured":"Gordon D, Abajian C, Green P: Consed: a graphical tool for sequence finishing. Genome Res. 1998, 8: 195-202.","journal-title":"Genome Res"},{"key":"3973_CR17","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1093\/nar\/gkg312","volume":"31","author":"F Meyer","year":"2003","unstructured":"Meyer F, Goesmann A, McHardy AC, Bartels D, Bekel T, Clausen J, Kalinowski J, Linke B, Rupp O, Giegerich R, P\u00fchler A: GenDB-an open source genome annotation system for prokaryote genomes. Nucleic Acids Res. 2003, 31: 2187-2195. 10.1093\/nar\/gkg312.","journal-title":"Nucleic Acids Res"},{"key":"3973_CR18","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.1093\/nar\/gkm160","volume":"35","author":"K Lagesen","year":"2007","unstructured":"Lagesen K, Hallin P, Rodland E, Staerfeldt H, Rognes T, Ussery D: RNAmmer: consistent and rapid annotation of ribosomal RNA genes. Nucleic Acids Res. 2007, 35: 3100-3108. 10.1093\/nar\/gkm160.","journal-title":"Nucleic Acids Res"},{"key":"3973_CR19","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/nar\/25.5.955","volume":"25","author":"TM Lowe","year":"1997","unstructured":"Lowe TM, Eddy SR: tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. Nucleic Acids Res. 1997, 25: 955-964.","journal-title":"Nucleic Acids Res"},{"key":"3973_CR20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1471-2105-9-79","volume":"9","author":"F Gao","year":"2008","unstructured":"Gao F, Zhang CT: Ori-Finder: a web-based system for finding ori Cs in unannotated bacterial genomes. BMC Bioinformatics. 2008, 9: 79-10.1186\/1471-2105-9-79.","journal-title":"BMC Bioinformatics"},{"key":"3973_CR21","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s00239-005-0192-2","volume":"62","author":"H Hendrickson","year":"2006","unstructured":"Hendrickson H, Lawrence JG: Selection for chromosome architecture in bacteria. J Mol Evol. 2006, 62: 615-629. 10.1007\/s00239-005-0192-2.","journal-title":"J Mol Evol"},{"key":"3973_CR22","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/1471-2105-10-154","volume":"10","author":"J Blom","year":"2009","unstructured":"Blom J, Albaum SP, Doppmeier D, P\u00fchler A, Vorh\u00f6lter FJ, Zakrzewski M, Goesmann A: EDGAR: a software framework for the comparative analysis of prokaryotic genomes. BMC Bioinformatics. 2009, 10: 154-10.1186\/1471-2105-10-154.","journal-title":"BMC Bioinformatics"},{"key":"3973_CR23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0378-1119(03)00653-X","volume":"317","author":"Y Nakamura","year":"2003","unstructured":"Nakamura Y, Nishio Y, Ikeo K, Gojobori T: The genome stability in Corynebacterium species due to lack of the recombinational repair system. Gene. 2003, 317: 149-155.","journal-title":"Gene"},{"key":"3973_CR24","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jbiotec.2008.02.009","volume":"136","author":"A Tauch","year":"2008","unstructured":"Tauch A, Trost E, Tilker A, Ludewig U, Schneiker S, Goesmann A, Arnold W, Bekel T, Brinkrolf K, Brune I: The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing. J Biotechnol. 2008, 136: 11-21. 10.1016\/j.jbiotec.2008.02.009.","journal-title":"J Biotechnol"},{"key":"3973_CR25","doi-asserted-by":"publisher","first-page":"4671","DOI":"10.1128\/JB.187.13.4671-4682.2005","volume":"187","author":"A Tauch","year":"2005","unstructured":"Tauch A, Kaiser O, Hain T, Goesmann A, Weisshaar B, Albersmeier A, Bekel T, Bischoff N, Brune I, Chakraborty T: Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora. J Bacteriol. 2005, 187: 4671-4682. 10.1128\/JB.187.13.4671-4682.2005.","journal-title":"J Bacteriol"},{"key":"3973_CR26","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jbiotec.2008.03.004","volume":"136","author":"A Tauch","year":"2008","unstructured":"Tauch A, Schneider J, Szczepanowski R, Tilker A, Viehoever P, Gartemann KH, Arnold W, Blom J, Brinkrolf K, Brune I: Ultrafast pyrosequencing of Corynebacterium kroppenstedtii DSM44385 revealed insights into the physiology of a lipophilic corynebacterium that lacks mycolic acids. J Biotechnol. 2008, 136: 22-30. 10.1016\/j.jbiotec.2008.03.004.","journal-title":"J Biotechnol"},{"key":"3973_CR27","doi-asserted-by":"crossref","first-page":"INTERACTIONS100","DOI":"10.1186\/gb-2001-2-12-interactions1004","volume":"2","author":"P Mackiewicz","year":"2001","unstructured":"Mackiewicz P, Mackiewicz D, Kowalczuk M, Cebrat S: Flip-flop around the origin and terminus of replication in prokaryotic genomes. Genome Biol. 2001, 2: INTERACTIONS1004-","journal-title":"Genome Biol"},{"key":"3973_CR28","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/ng1209","volume":"34","author":"EP Rocha","year":"2003","unstructured":"Rocha EP, Danchin A: Essentiality, not expressiveness, drives gene-strand bias in bacteria. Nat Genet. 2003, 34: 377-378. 10.1038\/ng1209.","journal-title":"Nat Genet"},{"key":"3973_CR29","doi-asserted-by":"publisher","first-page":"3750","DOI":"10.1128\/AEM.72.5.3750-3755.2006","volume":"72","author":"N Suzuki","year":"2006","unstructured":"Suzuki N, Okai N, Nonaka H, Tsuge Y, Inui M, Yukawa H: High-throughput transposon mutagenesis of Corynebacterium glutamicum and construction of a single-gene disruptant mutant library. Appl Environ Microbiol. 2006, 72: 3750-3755. 10.1128\/AEM.72.5.3750-3755.2006.","journal-title":"Appl Environ Microbiol"},{"key":"3973_CR30","doi-asserted-by":"publisher","first-page":"W52","DOI":"10.1093\/nar\/gkm360","volume":"35","author":"I Grissa","year":"2007","unstructured":"Grissa I, Vergnaud G, Pourcel C: CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats. Nucleic Acids Res. 2007, 35: W52-57. 10.1093\/nar\/gkm360.","journal-title":"Nucleic Acids Res"},{"key":"3973_CR31","doi-asserted-by":"publisher","first-page":"14925","DOI":"10.1073\/pnas.0406410101","volume":"101","author":"J Ishikawa","year":"2004","unstructured":"Ishikawa J, Yamashita A, Mikami Y, Hoshino Y, Kurita H, Hotta K, Shiba T, Hattori M: The complete genomic sequence of Nocardia farcinica IFM 10152. Proc Natl Acad Sci USA. 2004, 101: 14925-14930. 10.1073\/pnas.0406410101.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3973_CR32","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1126\/science.1138140","volume":"315","author":"R Barrangou","year":"2007","unstructured":"Barrangou R, Fremaux C, Deveau H, Richards M, Boyaval P, Moineau S, Romero DA, Horvath P: CRISPR provides acquired resistance against viruses in prokaryotes. Science. 2007, 315: 1709-1712. 10.1126\/science.1138140.","journal-title":"Science"},{"key":"3973_CR33","first-page":"423","volume":"3","author":"S Parche","year":"2001","unstructured":"Parche S, Burkovski A, Sprenger GA, Weil B, Kr\u00e4mer R, Titgemeyer F: Corynebacterium glutamicum: a dissection of the PTS. J Mol Microbiol Biotechnol. 2001, 3: 423-428.","journal-title":"J Mol Microbiol Biotechnol"},{"key":"3973_CR34","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1099\/mic.0.2007\/014001-0","volume":"154","author":"K Brinkrolf","year":"2008","unstructured":"Brinkrolf K, Pl\u00f6ger S, Solle S, Brune I, Nentwich SS, H\u00fcser AT, Kalinowski J, P\u00fchler A, Tauch A: The LacI\/GalR family transcriptional regulator UriR negatively controls uridine utilization of Corynebacterium glutamicum by binding to catabolite-responsive element (cre)-like sequences. Microbiology. 2008, 154: 1068-1081. 10.1099\/mic.0.2007\/014001-0.","journal-title":"Microbiology"},{"key":"3973_CR35","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1128\/MMBR.68.3.501-517.2004","volume":"68","author":"E Schweizer","year":"2004","unstructured":"Schweizer E, Hofmann J: Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems. Microbiol Mol Biol Rev. 2004, 68: 501-517. 10.1128\/MMBR.68.3.501-517.2004.","journal-title":"Microbiol Mol Biol Rev"},{"key":"3973_CR36","doi-asserted-by":"publisher","first-page":"19255","DOI":"10.1074\/jbc.M109.006940","volume":"284","author":"S Gavalda","year":"2009","unstructured":"Gavalda S, Leger M, van der Rest B, Stella A, Bardou F, Montrozier H, Chalut C, Burlet-Schiltz O, Marrakchi H, Daffe M, Quemard A: The Pks13\/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis. J Biol Chem. 2009, 284: 19255-19264. 10.1074\/jbc.M109.006940.","journal-title":"J Biol Chem"},{"key":"3973_CR37","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1128\/MMBR.67.3.454-472.2003","volume":"67","author":"PN Black","year":"2003","unstructured":"Black PN, DiRusso CC: Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification. Microbiol Mol Biol Rev. 2003, 67: 454-472. 10.1128\/MMBR.67.3.454-472.2003.","journal-title":"Microbiol Mol Biol Rev"},{"key":"3973_CR38","doi-asserted-by":"publisher","first-page":"6295","DOI":"10.1128\/JB.05450-11","volume":"193","author":"A Pech-Canul","year":"2011","unstructured":"Pech-Canul A, Nogales J, Miranda-Molina A, Alvarez L, Geiger O, Soto MJ, Lopez-Lara IM: FadD is required for utilization of endogenous fatty acids released from membrane lipids. J Bacteriol. 2011, 193: 6295-6304. 10.1128\/JB.05450-11.","journal-title":"J Bacteriol"},{"key":"3973_CR39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1388-1981(00)00013-5","volume":"1484","author":"JK Hiltunen","year":"2000","unstructured":"Hiltunen JK, Qin Y: Beta-oxidation - strategies for the metabolism of a wide variety of acyl-CoA esters. Biochim Biophys Acta. 2000, 1484: 117-128.","journal-title":"Biochim Biophys Acta"},{"key":"3973_CR40","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1111\/j.1365-2958.2006.05155.x","volume":"60","author":"EJ Munoz-Elias","year":"2006","unstructured":"Munoz-Elias EJ, Upton AM, Cherian J, McKinney JD: Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. Mol Microbiol. 2006, 60: 1109-1122. 10.1111\/j.1365-2958.2006.05155.x.","journal-title":"Mol Microbiol"},{"key":"3973_CR41","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1128\/JB.01155-08","volume":"191","author":"E Jolkver","year":"2009","unstructured":"Jolkver E, Emer D, Ballan S, Kr\u00e4mer R, Eikmanns BJ, Marin K: Identification and characterization of a bacterial transport system for the uptake of pyruvate, propionate, and acetate in Corynebacterium glutamicum. J Bacteriol. 2009, 191: 940-948. 10.1128\/JB.01155-08.","journal-title":"J Bacteriol"},{"key":"3973_CR42","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1073\/pnas.0305439101","volume":"101","author":"D Portevin","year":"2004","unstructured":"Portevin D, De Sousa-D'Auria C, Houssin C, Grimaldi C, Chami M, Daffe M, Guilhot C: A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms. Proc Natl Acad Sci USA. 2004, 101: 314-319. 10.1073\/pnas.0305439101.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3973_CR43","doi-asserted-by":"publisher","first-page":"11000","DOI":"10.1074\/jbc.M608686200","volume":"282","author":"DJ Lea-Smith","year":"2007","unstructured":"Lea-Smith DJ, Pyke JS, Tull D, McConville MJ, Coppel RL, Crellin PK: The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan. J Biol Chem. 2007, 282: 11000-11008. 10.1074\/jbc.M608686200.","journal-title":"J Biol Chem"},{"key":"3973_CR44","doi-asserted-by":"publisher","first-page":"7323","DOI":"10.1128\/JB.01042-09","volume":"191","author":"X Meniche","year":"2009","unstructured":"Meniche X, Labarre C, de Sousa-d'Auria C, Huc E, Laval F, Tropis M, Bayan N, Portevin D, Guilhot C, Daffe M, Houssin C: Identification of a stress-induced factor of Corynebacterineae that is involved in the regulation of the outer membrane lipid composition. J Bacteriol. 2009, 191: 7323-7332. 10.1128\/JB.01042-09.","journal-title":"J Bacteriol"},{"key":"3973_CR45","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0168-1656(03)00163-9","volume":"104","author":"N Bayan","year":"2003","unstructured":"Bayan N, Houssin C, Chami M, Leblon G: Mycomembrane and S-layer: two important structures of Corynebacterium glutamicum cell envelope with promising biotechnology applications. J Biotechnol. 2003, 104: 55-67. 10.1016\/S0168-1656(03)00163-9.","journal-title":"J Biotechnol"},{"key":"3973_CR46","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1468-2494.2011.00669.x","volume":"34","author":"H Barzantny","year":"2011","unstructured":"Barzantny H, Brune I, Tauch A: Molecular basis of human body odour formation: insights deduced from corynebacterial genome sequences. Int J Cosmet Sci. 2011, 34: 2-11.","journal-title":"Int J Cosmet Sci"},{"key":"3973_CR47","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1534\/genetics.107.075713","volume":"176","author":"XX Zhang","year":"2007","unstructured":"Zhang XX, Rainey PB: Genetic analysis of the histidine utilization (hut) genes in Pseudomonas fluorescens SBW25. Genetics. 2007, 176: 2165-2176. 10.1534\/genetics.107.075713.","journal-title":"Genetics"},{"key":"3973_CR48","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1128\/JCM.38.12.4657-4659.2000","volume":"38","author":"LA Devriese","year":"2000","unstructured":"Devriese LA, Riegel P, Hommez J, Vaneechoutte M, de Baere T, Haesebrouck F: Identification of Corynebacterium glucuronolyticum strains from the urogenital tract of humans and pigs. J Clin Microbiol. 2000, 38: 4657-4659.","journal-title":"J Clin Microbiol"},{"key":"3973_CR49","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1099\/ijs.0.02907-0","volume":"54","author":"C Feurer","year":"2004","unstructured":"Feurer C, Clermont D, Bimet F, Candrea A, Jackson M, Glaser P, Bizet C, Dauga C: Taxonomic characterization of nine strains isolated from clinical and environmental specimens, and proposal of Corynebacterium tuberculostearicum sp. nov. Int J Syst Evol Microbiol. 2004, 54: 1055-1061. 10.1099\/ijs.0.02907-0.","journal-title":"Int J Syst Evol Microbiol"},{"key":"3973_CR50","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3201\/eid1202.050950","volume":"12","author":"G Vedel","year":"2006","unstructured":"Vedel G, Toussaint G, Riegel P, Fouilladieu JL, Billoet A, Poyart C: Corynebacterium pseudogenitalium urinary tract infection. Emerg Infect Dis. 2006, 12: 355-356. 10.3201\/eid1202.050950.","journal-title":"Emerg Infect Dis"},{"key":"3973_CR51","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0378-1097(97)00118-3","volume":"150","author":"G Funke","year":"1997","unstructured":"Funke G, Hutson RA, Hilleringmann M, Heizmann WR, Collins MD: Corynebacterium lipophiloflavum sp. nov. isolated from a patient with bacterial vaginosis. FEMS Microbiol Lett. 1997, 150: 219-224. 10.1016\/S0378-1097(97)00118-3.","journal-title":"FEMS Microbiol Lett"},{"key":"3973_CR52","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1471-2164-11-91","volume":"11","author":"E Trost","year":"2010","unstructured":"Trost E, G\u00f6tker S, Schneider J, Schneiker-Bekel S, Szczepanowski R, Tilker A, Viehoever P, Arnold W, Bekel T, Blom J: Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion. BMC Genomics. 2010, 11: 91-10.1186\/1471-2164-11-91.","journal-title":"BMC Genomics"},{"key":"3973_CR53","first-page":"125","volume":"29","author":"N Dusitsin","year":"1967","unstructured":"Dusitsin N, Gregoire AT, Johnson WD, Rakoff AE: Histidine in human vaginal fluid. Obstet Gynecol. 1967, 29: 125-129.","journal-title":"Obstet Gynecol"},{"key":"3973_CR54","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1128\/CMR.3.3.227","volume":"3","author":"MB Coyle","year":"1990","unstructured":"Coyle MB, Lipsky BA: Coryneform bacteria in infectious diseases: clinical and laboratory aspects. Clin Microbiol Rev. 1990, 3: 227-246.","journal-title":"Clin Microbiol Rev"},{"key":"3973_CR55","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1101\/gr.096651.109","volume":"19","author":"J Peterson","year":"2009","unstructured":"NIH HMP Working Group, Peterson J, Garges S, Giovanni M, McInnes P, Wang L, Schloss J, Bonazzi V, McEwen J, Wetterstrand K: The NIH human microbiome project. Genome Res. 2009, 19: 2317-2323.","journal-title":"Genome Res"},{"key":"3973_CR56","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1142\/S0129065797000537","volume":"8","author":"H Nielsen","year":"1997","unstructured":"Nielsen H, Engelbrecht J, Brunak S, von Heijne G: A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Int J Neural Syst. 1997, 8: 581-599. 10.1142\/S0129065797000537.","journal-title":"Int J Neural Syst"},{"key":"3973_CR57","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/pmic.200500144","volume":"6","author":"N Hansmeier","year":"2006","unstructured":"Hansmeier N, Chao T-C, P\u00fchler A, Tauch A, Kalinowski J: The cytosolic, cell surface and extracellular proteomes of the biotechnologically important soil bacterium Corynebacterium efficiens YS-314 in comparison to those of Corynebacterium glutamicum ATCC 13032. Proteomics. 2006, 6: 233-250. 10.1002\/pmic.200500144.","journal-title":"Proteomics"},{"key":"3973_CR58","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","volume":"305","author":"A Krogh","year":"2001","unstructured":"Krogh A, Larsson B, von Heijne G, Sonnhammer EL: Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol. 2001, 305: 567-580. 10.1006\/jmbi.2000.4315.","journal-title":"J Mol Biol"},{"key":"3973_CR59","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/bip.21472","volume":"94","author":"KW Clancy","year":"2010","unstructured":"Clancy KW, Melvin JA, McCafferty DG: Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition. Biopolymers. 2010, 94: 385-396. 10.1002\/bip.21472.","journal-title":"Biopolymers"},{"key":"3973_CR60","doi-asserted-by":"publisher","first-page":"10060","DOI":"10.1073\/pnas.89.21.10060","volume":"89","author":"JL Michel","year":"1992","unstructured":"Michel JL, Madoff LC, Olson K, Kling DE, Kasper DL, Ausubel FM: Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci. Proc Natl Acad Sci USA. 1992, 89: 10060-10064. 10.1073\/pnas.89.21.10060.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3973_CR61","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1128\/IAI.66.9.4347-4354.1998","volume":"66","author":"C Gravekamp","year":"1998","unstructured":"Gravekamp C, Rosner B, Madoff LC: Deletion of repeats in the alpha C protein enhances the pathogenicity of group B streptococci in immune mice. Infect Immun. 1998, 66: 4347-4354.","journal-title":"Infect Immun"},{"key":"3973_CR62","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1046\/j.1365-2958.1999.01470.x","volume":"33","author":"M Stalhammar-Carlemalm","year":"1999","unstructured":"Stalhammar-Carlemalm M, Areschoug T, Larsson C, Lindahl G: The R28 protein of Streptococcus pyogenes is related to several group B streptococcal surface proteins, confers protective immunity and promotes binding to human epithelial cells. Mol Microbiol. 1999, 33: 208-219. 10.1046\/j.1365-2958.1999.01470.x.","journal-title":"Mol Microbiol"},{"key":"3973_CR63","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/978-94-007-0940-9_6","volume":"715","author":"EA Rogers","year":"2011","unstructured":"Rogers EA, Das A, Ton-That H: Adhesion by pathogenic corynebacteria. Adv Exp Med Biol. 2011, 715: 91-103. 10.1007\/978-94-007-0940-9_6.","journal-title":"Adv Exp Med Biol"},{"key":"3973_CR64","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1365-2958.2007.05630.x","volume":"64","author":"A Mandlik","year":"2007","unstructured":"Mandlik A, Swierczynski A, Das A, Ton-That H: Corynebacterium diphtheriae employs specific minor pilins to target human pharyngeal epithelial cells. Mol Microbiol. 2007, 64: 111-124. 10.1111\/j.1365-2958.2007.05630.x.","journal-title":"Mol Microbiol"},{"key":"3973_CR65","doi-asserted-by":"publisher","first-page":"e1000001","DOI":"10.1371\/journal.ppat.1000001","volume":"4","author":"EC Hett","year":"2008","unstructured":"Hett EC, Chao MC, Deng LL, Rubin EJ: A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor. PLoS Pathog. 2008, 4: e1000001-10.1371\/journal.ppat.1000001.","journal-title":"PLoS Pathog"},{"key":"3973_CR66","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2180-10-2","volume":"10","author":"L Ott","year":"2010","unstructured":"Ott L, Holler M, Gerlach RG, Hensel M, Rheinlaender J, Sch\u00e4ffer TE, Burkovski A: Corynebacterium diphtheriae invasion-associated protein (DIP1281) is involved in cell surface organization, adhesion and internalization in epithelial cells. BMC Microbiol. 2010, 10: 2-10.1186\/1471-2180-10-2.","journal-title":"BMC Microbiol"},{"key":"3973_CR67","doi-asserted-by":"publisher","first-page":"D225","DOI":"10.1093\/nar\/gkq1189","volume":"39","author":"A Marchler-Bauer","year":"2011","unstructured":"Marchler-Bauer A, Lu S, Anderson JB, Chitsaz F, Derbyshire MK, DeWeese-Scott C, Fong JH, Geer LY, Geer RC, Gonzales NR: CDD: a Conserved Domain Database for the functional annotation of proteins. Nucleic Acids Res. 2011, 39: D225-229. 10.1093\/nar\/gkq1189.","journal-title":"Nucleic Acids Res"},{"key":"3973_CR68","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.meegid.2010.11.004","volume":"11","author":"V Kolodkina","year":"2011","unstructured":"Kolodkina V, Denisevich T, Titov L: Identification of Corynebacterium diphtheriae gene involved in adherence to epithelial cells. Infect Genet Evol. 2011, 11: 518-521. 10.1016\/j.meegid.2010.11.004.","journal-title":"Infect Genet Evol"},{"key":"3973_CR69","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0378-1135(97)00095-3","volume":"56","author":"R Linder","year":"1997","unstructured":"Linder R, Bernheimer AW: Oxidation of macrophage membrane cholesterol by intracellular Rhodococcus equi. Vet Microbiol. 1997, 56: 269-276. 10.1016\/S0378-1135(97)00095-3.","journal-title":"Vet Microbiol"},{"key":"3973_CR70","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/j.1574-6968.2007.00865.x","volume":"275","author":"A Brzostek","year":"2007","unstructured":"Brzostek A, Dziadek B, Rumijowska-Galewicz A, Pawelczyk J, Dziadek J: Cholesterol oxidase is required for virulence of Mycobacterium tuberculosi. FEMS Microbiol Lett. 2007, 275: 106-112. 10.1111\/j.1574-6968.2007.00865.x.","journal-title":"FEMS Microbiol Lett"},{"key":"3973_CR71","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0960-0760(00)00044-3","volume":"72","author":"J MacLachlan","year":"2000","unstructured":"MacLachlan J, Wotherspoon AT, Ansell RO, Brooks CJ: Cholesterol oxidase: sources, physical properties and analytical applications. J Steroid Biochem Mol Biol. 2000, 72: 169-195. 10.1016\/S0960-0760(00)00044-3.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"3973_CR72","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.bbalip.2008.06.002","volume":"1781","author":"C Mao","year":"2008","unstructured":"Mao C, Obeid LM: Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta. 2008, 1781: 424-434.","journal-title":"Biochim Biophys Acta"},{"key":"3973_CR73","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S1046-5928(03)00099-8","volume":"30","author":"WF Nieuwenhuizen","year":"2003","unstructured":"Nieuwenhuizen WF, van Leeuwen S, Jack RW, Egmond MR, Gotz F: Molecular cloning and characterization of the alkaline ceramidase from Pseudomonas aeruginosa PA01. Protein Expr Purif. 2003, 30: 94-104. 10.1016\/S1046-5928(03)00099-8.","journal-title":"Protein Expr Purif"},{"key":"3973_CR74","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s002030000218","volume":"174","author":"B Hube","year":"2000","unstructured":"Hube B, Stehr F, Bossenz M, Mazur A, Kretschmar M, Sch\u00e4fer W: Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members. Arch Microbiol. 2000, 174: 362-374. 10.1007\/s002030000218.","journal-title":"Arch Microbiol"},{"key":"3973_CR75","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.plipres.2004.09.002","volume":"43","author":"CC Akoh","year":"2004","unstructured":"Akoh CC, Lee GC, Liaw YC, Huang TH, Shaw JF: GDSL family of serine esterases\/lipases. Prog Lipid Res. 2004, 43: 534-552. 10.1016\/j.plipres.2004.09.002.","journal-title":"Prog Lipid Res"},{"key":"3973_CR76","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2174\/157340911793743538","volume":"7","author":"KS Goo","year":"2011","unstructured":"Goo KS, Sim TS: Designing new beta-lactams: implications from their targets, resistance factors and synthesizing enzymes. Curr Comput Aided Drug Des. 2011, 7: 53-80. 10.2174\/157340911793743538.","journal-title":"Curr Comput Aided Drug Des"},{"key":"3973_CR77","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/j.1365-2958.2009.06887.x","volume":"74","author":"M Lavollay","year":"2009","unstructured":"Lavollay M, Arthur M, Fourgeaud M, Dubost L, Marie A, Riegel P, Gutmann L, Mainardi JL: The beta-lactam-sensitive D, D-carboxypeptidase activity of Pbp4 controls the L, D and D, D transpeptidation pathways in Corynebacterium jeikeium. Mol Microbiol. 2009, 74: 650-661. 10.1111\/j.1365-2958.2009.06887.x.","journal-title":"Mol Microbiol"},{"key":"3973_CR78","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1054\/drup.1998.0068","volume":"2","author":"DC Hooper","year":"1999","unstructured":"Hooper DC: Mechanisms of fluoroquinolone resistance. Drug Resist Updat. 1999, 2: 38-55. 10.1054\/drup.1998.0068.","journal-title":"Drug Resist Updat"},{"key":"3973_CR79","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1128\/JCM.01741-07","volume":"46","author":"H Eguchi","year":"2008","unstructured":"Eguchi H, Kuwahara T, Miyamoto T, Nakayama-Imaohji H, Ichimura M, Hayashi T, Shiota H: High-level fluoroquinolone resistance in ophthalmic clinical isolates belonging to the species Corynebacterium macginleyi. J Clin Microbiol. 2008, 46: 527-532. 10.1128\/JCM.01741-07.","journal-title":"J Clin Microbiol"},{"key":"3973_CR80","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1128\/AAC.49.5.1714-1719.2005","volume":"49","author":"JM Sierra","year":"2005","unstructured":"Sierra JM, Martinez-Martinez L, Vazquez F, Giralt E, Vila J: Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum. Antimicrob Agents Chemother. 2005, 49: 1714-1719. 10.1128\/AAC.49.5.1714-1719.2005.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR81","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1093\/jac\/dkl361","volume":"58","author":"V Cattoir","year":"2006","unstructured":"Cattoir V, Lesprit P, Lascols C, Denamur E, Legrand P, Soussy CJ, Cambau E: In viv selection during ofloxacin therapy of Escherichia coli with combined topoisomerase mutations that confer high resistance to ofloxacin but susceptibility to nalidixic acid. J Antimicrob Chemother. 2006, 58: 1054-1057. 10.1093\/jac\/dkl361.","journal-title":"J Antimicrob Chemother"},{"key":"3973_CR82","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0168-1656(03)00157-3","volume":"104","author":"A Tauch","year":"2003","unstructured":"Tauch A, P\u00fchler A, Kalinowski J, Thierbach G: Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics. J Biotechnol. 2003, 104: 27-40. 10.1016\/S0168-1656(03)00157-3.","journal-title":"J Biotechnol"},{"key":"3973_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/PL00008668","volume":"263","author":"A Tauch","year":"2000","unstructured":"Tauch A, Krieft S, Kalinowski J, P\u00fchler A: The 51,409-bp R-plasmid pTP10 from the multiresistant clinical isolate Corynebacterium striatum M82B is composed of DNA segments initially identified in soil bacteria and in plant, animal, and human pathogens. Mol Gen Genet. 2000, 263: 1-11. 10.1007\/PL00008668.","journal-title":"Mol Gen Genet"},{"key":"3973_CR84","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0378-1119(91)90298-P","volume":"107","author":"H Sonnen","year":"1991","unstructured":"Sonnen H, Thierbach G, Kautz S, Kalinowski J, Schneider J, P\u00fchler A, Kutzner HJ: Characterization of pGA1, a new plasmid from Corynebacterium glutamicum LP-6. Gene. 1991, 107: 69-74. 10.1016\/0378-1119(91)90298-P.","journal-title":"Gene"},{"key":"3973_CR85","doi-asserted-by":"publisher","first-page":"4899","DOI":"10.1128\/AEM.00354-06","volume":"72","author":"LE Williams","year":"2006","unstructured":"Williams LE, Detter C, Barry K, Lapidus A, Summers AO: Facile recovery of individual high-molecular-weight, low-copy-number natural plasmids for genomic sequencing. Appl Environ Microbiol. 2006, 72: 4899-4906. 10.1128\/AEM.00354-06.","journal-title":"Appl Environ Microbiol"},{"key":"3973_CR86","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1365-2958.2000.01986.x","volume":"37","author":"DK Chattoraj","year":"2000","unstructured":"Chattoraj DK: Control of plasmid DNA replication by iterons: no longer paradoxical. Mol Microbiol. 2000, 37: 467-476.","journal-title":"Mol Microbiol"},{"key":"3973_CR87","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1574-6968.2008.01145.x","volume":"282","author":"MC Roberts","year":"2008","unstructured":"Roberts MC: Update on macrolide-lincosamide-streptogramin, ketolide, and oxazolidinone resistance genes. FEMS Microbiol Lett. 2008, 282: 147-159. 10.1111\/j.1574-6968.2008.01145.x.","journal-title":"FEMS Microbiol Lett"},{"key":"3973_CR88","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1128\/AAC.39.4.797","volume":"39","author":"B Weisblum","year":"1995","unstructured":"Weisblum B: Insights into erythromycin action from studies of its activity as inducer of resistance. Antimicrob Agents Chemother. 1995, 39: 797-805.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR89","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0147-619X(02)00115-4","volume":"49","author":"A Tauch","year":"2003","unstructured":"Tauch A, Bischoff N, Brune I, Kalinowski J: Insights into the genetic organization of the Corynebacterium diphtheriae erythromycin resistance plasmid pNG2 deduced from its complete nucleotide sequence. Plasmid. 2003, 49: 63-74. 10.1016\/S0147-619X(02)00115-4.","journal-title":"Plasmid"},{"key":"3973_CR90","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1128\/AAC.18.5.814","volume":"18","author":"J Schiller","year":"1980","unstructured":"Schiller J, Groman N, Coyle M: Plasmids in Corynebacterium diphtheriae and diphtheroids mediating erythromycin resistance. Antimicrob Agents Chemother. 1980, 18: 814-821.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR91","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/jac\/49.1.165","volume":"49","author":"JI Ross","year":"2002","unstructured":"Ross JI, Eady EA, Carnegie E, Cove JH: Detection of transposon Tn5432-mediated macrolide-lincosamide-streptogramin B (MLSB) resistance in cutaneous propionibacteria from six European cities. J Antimicrob Chemother. 2002, 49: 165-168. 10.1093\/jac\/49.1.165.","journal-title":"J Antimicrob Chemother"},{"key":"3973_CR92","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1128\/AAC.45.7.1982-1989.2001","volume":"45","author":"AE Rosato","year":"2001","unstructured":"Rosato AE, Lee BS, Nash KA: Inducible macrolide resistance in Corynebacterium jeikeium. Antimicrob Agents Chemother. 2001, 45: 1982-1989. 10.1128\/AAC.45.7.1982-1989.2001.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR93","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.mib.2008.08.003","volume":"11","author":"AS Mankin","year":"2008","unstructured":"Mankin AS: Macrolide myths. Curr Opin Microbiol. 2008, 11: 414-421. 10.1016\/j.mib.2008.08.003.","journal-title":"Curr Opin Microbiol"},{"key":"3973_CR94","first-page":"171","volume":"9","author":"T Shen","year":"1993","unstructured":"Shen T, Jia P, Na S, Men D: Determination of nucleotide sequence of Corynebacterium plasmid pXZ10145. Chin J Biotechnol. 1993, 9: 171-178.","journal-title":"Chin J Biotechnol"},{"key":"3973_CR95","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0378-1119(94)00721-4","volume":"152","author":"CS Chiou","year":"1995","unstructured":"Chiou CS, Jones AL: Expression and identification of the strA-strB gene pair from streptomycin-resistant Erwinia amylovora. Gene. 1995, 152: 47-51. 10.1016\/0378-1119(94)00721-4.","journal-title":"Gene"},{"key":"3973_CR96","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1146\/annurev.phyto.40.120301.093927","volume":"40","author":"PS McManus","year":"2002","unstructured":"McManus PS, Stockwell VO, Sundin GW, Jones AL: Antibiotic use in plant agriculture. Annu Rev Phytopathol. 2002, 40: 443-465. 10.1146\/annurev.phyto.40.120301.093927.","journal-title":"Annu Rev Phytopathol"},{"key":"3973_CR97","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1128\/mr.57.1.138-163.1993","volume":"57","author":"KJ Shaw","year":"1993","unstructured":"Shaw KJ, Rather PN, Hare RS, Miller GH: Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol Rev. 1993, 57: 138-163.","journal-title":"Microbiol Rev"},{"key":"3973_CR98","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1128\/CMR.16.3.430-450.2003","volume":"16","author":"SB Vakulenko","year":"2003","unstructured":"Vakulenko SB, Mobashery S: Versatility of aminoglycosides and prospects for their future. Clin Microbiol Rev. 2003, 16: 430-450. 10.1128\/CMR.16.3.430-450.2003.","journal-title":"Clin Microbiol Rev"},{"key":"3973_CR99","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1515\/CCLM.2000.070","volume":"38","author":"MC Ploy","year":"2000","unstructured":"Ploy MC, Lambert T, Couty JP, Denis F: Integrons: an antibiotic resistance gene capture and expression system. Clin Chem Lab Med. 2000, 38: 483-487.","journal-title":"Clin Chem Lab Med"},{"key":"3973_CR100","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1111\/j.1574-6976.2009.00175.x","volume":"33","author":"SR Partridge","year":"2009","unstructured":"Partridge SR, Tsafnat G, Coiera E, Iredell JR: Gene cassettes and cassette arrays in mobile resistance integrons. FEMS Microbiol Rev. 2009, 33: 757-784. 10.1111\/j.1574-6976.2009.00175.x.","journal-title":"FEMS Microbiol Rev"},{"key":"3973_CR101","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1128\/AAC.48.6.1960-1967.2004","volume":"48","author":"J Wachino","year":"2004","unstructured":"Wachino J, Doi Y, Yamane K, Shibata N, Yagi T, Kubota T, Ito H, Arakawa Y: Nosocomial spread of ceftazidime-resistant Klebsiella pneumoniae strains producing a novel class a beta-lactamase, GES-3, in a neonatal intensive care unit in Japan. Antimicrob Agents Chemother. 2004, 48: 1960-1967. 10.1128\/AAC.48.6.1960-1967.2004.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR102","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1128\/AAC.46.8.2427-2434.2002","volume":"46","author":"Y Doi","year":"2002","unstructured":"Doi Y, Shibata N, Shibayama K, Kamachi K, Kurokawa H, Yokoyama K, Yagi T, Arakawa Y: Characterization of a novel plasmid-mediated cephalosporinase (CMY-9) and its genetic environment in an Escherichia coli clinical isolate. Antimicrob Agents Chemother. 2002, 46: 2427-2434. 10.1128\/AAC.46.8.2427-2434.2002.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR103","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1128\/jb.174.9.2891-2897.1992","volume":"174","author":"R Parent","year":"1992","unstructured":"Parent R, Roy PH: The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat. J Bacteriol. 1992, 174: 2891-2897.","journal-title":"J Bacteriol"},{"key":"3973_CR104","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/j.1574-6968.1998.tb13345.x","volume":"169","author":"J Nesvera","year":"1998","unstructured":"Nesvera J, Hochmannova J, Patek M: An integron of class 1 is present on the plasmid pCG4 from gram-positive bacterium Corynebacterium glutamicum. FEMS Microbiol Lett. 1998, 169: 391-395. 10.1111\/j.1574-6968.1998.tb13345.x.","journal-title":"FEMS Microbiol Lett"},{"key":"3973_CR105","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0147-619X(02)00120-8","volume":"48","author":"A Tauch","year":"2002","unstructured":"Tauch A, G\u00f6tker S, P\u00fchler A, Kalinowski J, Thierbach G: The 27.8-kb R-plasmid pTET3 from Corynebacterium glutamicum encodes the aminoglycoside adenyltransferase gene cassette aadA9 and the regulated tetracycline efflux system Tet 33 flanked by active copies of the widespread insertion sequence IS6100. Plasmid. 2002, 48: 117-129. 10.1016\/S0147-619X(02)00120-8.","journal-title":"Plasmid"},{"key":"3973_CR106","doi-asserted-by":"publisher","first-page":"6032","DOI":"10.1128\/AEM.00991-08","volume":"74","author":"A Rosander","year":"2008","unstructured":"Rosander A, Connolly E, Roos S: Removal of antibiotic resistance gene-carrying plasmids from Lactobacillus reuteri ATCC 55730 and characterization of the resulting daughter strain, L. reuteri DSM 17938. Appl Environ Microbiol. 2008, 74: 6032-6040. 10.1128\/AEM.00991-08.","journal-title":"Appl Environ Microbiol"},{"key":"3973_CR107","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1128\/AAC.47.12.3675-3681.2003","volume":"47","author":"SR Connell","year":"2003","unstructured":"Connell SR, Tracz DM, Nierhaus KH, Taylor DE: Ribosomal protection proteins and their mechanism of tetracycline resistance. Antimicrob Agents Chemother. 2003, 47: 3675-3681. 10.1128\/AAC.47.12.3675-3681.2003.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR108","doi-asserted-by":"crossref","first-page":"19310","DOI":"10.2807\/ese.14.33.19310-en","volume":"14","author":"MS Princivalli","year":"2009","unstructured":"Princivalli MS, Palmieri C, Magi G, Vignaroli C, Manzin A, Camporese A, Barocci S, Magistrali C, Facinelli B: Genetic diversity of Streptococcus suis clinical isolates from pigs and humans in Italy (2003-2007). Euro Surveill. 2009, 14: 19310-","journal-title":"Euro Surveill"},{"key":"3973_CR109","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1128\/AAC.46.5.1281-1287.2002","volume":"46","author":"SJ Billington","year":"2002","unstructured":"Billington SJ, Songer JG, Jost BH: Widespread distribution of a tet(W) determinant among tetracycline-resistant isolates of the animal pathogen Arcanobacterium pyogenes. Antimicrob Agents Chemother. 2002, 46: 1281-1287. 10.1128\/AAC.46.5.1281-1287.2002.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR110","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1128\/AAC.01587-05","volume":"50","author":"KA Kazimierczak","year":"2006","unstructured":"Kazimierczak KA, Flint HJ, Scott KP: Comparative analysis of sequences flanking tet(W) resistance genes in multiple species of gut bacteria. Antimicrob Agents Chemother. 2006, 50: 2632-2639. 10.1128\/AAC.01587-05.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR111","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1128\/AAC.36.5.913","volume":"36","author":"B Oliva","year":"1992","unstructured":"Oliva B, Gordon G, McNicholas P, Ellestad G, Chopra I: Evidence that tetracycline analogs whose primary target is not the bacterial ribosome cause lysis of Escherichia coli. Antimicrob Agents Chemother. 1992, 36: 913-919.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR112","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1128\/AAC.35.11.2306","volume":"35","author":"B Rasmussen","year":"1991","unstructured":"Rasmussen B, Noller HF, Daubresse G, Oliva B, Misulovin Z, Rothstein DM, Ellestad GA, Gluzman Y, Tally FP, Chopra I: Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome. Antimicrob Agents Chemother. 1991, 35: 2306-2311.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR113","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1128\/AAC.34.11.2273","volume":"34","author":"M Nesin","year":"1990","unstructured":"Nesin M, Svec P, Lupski JR, Godson GN, Kreiswirth B, Kornblum J, Projan SJ: Cloning and nucleotide sequence of a chromosomally encoded tetracycline resistance determinant, tet(M), from a pathogenic, methicillin-resistant strain of Staphylococcus aureus. Antimicrob Agents Chemother. 1990, 34: 2273-2276.","journal-title":"Antimicrob Agents Chemother"},{"key":"3973_CR114","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/jac\/30.4.463","volume":"30","author":"MC Roberts","year":"1992","unstructured":"Roberts MC, Leonard RB, Briselden A, Schoenknecht FD, Coyle MB: Characterization of antibiotic-resistant Corynebacterium striatum strains. J Antimicrob Chemother. 1992, 30: 463-474. 10.1093\/jac\/30.4.463.","journal-title":"J Antimicrob Chemother"},{"key":"3973_CR115","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3201\/eid1501.080804","volume":"15","author":"F Campanile","year":"2009","unstructured":"Campanile F, Carretto E, Barbarini D, Grigis A, Falcone M, Goglio A, Venditti M, Stefani S: Clonal multidrug-resistant Corynebacterium striatum strains, Italy. Emerg Infect Dis. 2009, 15: 75-78. 10.3201\/eid1501.080804.","journal-title":"Emerg Infect Dis"},{"key":"3973_CR116","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.plasmid.2004.05.003","volume":"52","author":"A Tauch","year":"2004","unstructured":"Tauch A, Bischoff N, P\u00fchler A, Kalinowski J: Comparative genomics identified two conserved DNA modules in a corynebacterial plasmid family present in clinical isolates of the opportunistic human pathogen Corynebacterium jeikeium. Plasmid. 2004, 52: 102-118. 10.1016\/j.plasmid.2004.05.003.","journal-title":"Plasmid"},{"key":"3973_CR117","volume-title":"Molecular cloning A laboratory manual","author":"J Sambrook","year":"1989","unstructured":"Sambrook J, Fritsch EF, Maniatis T: Molecular cloning A laboratory manual. 1989, Cold Spring Harbour: Cold Spring Harbour Laboratory Press, 2","edition":"2"},{"key":"3973_CR118","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.1128\/jb.175.17.5595-5603.1993","volume":"175","author":"C Keilhauer","year":"1993","unstructured":"Keilhauer C, Eggeling L, Sahm H: Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon. J Bacteriol. 1993, 175: 5595-5603.","journal-title":"J Bacteriol"},{"key":"3973_CR119","volume-title":"Genetic Manipulation of Streptomyces: A Laboratory Manual","author":"D Hopwood","year":"1985","unstructured":"Hopwood D: Genetic Manipulation of Streptomyces: A Laboratory Manual. 1985, New York: Cold Spring Harbor Laboratory Press"},{"key":"3973_CR120","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/bioinformatics\/btn578","volume":"25","author":"T Carver","year":"2009","unstructured":"Carver T, Thomson N, Bleasby A, Berriman M, Parkhill J: DNAPlotter: circular and linear interactive genome visualization. Bioinformatics. 2009, 25: 119-120. 10.1093\/bioinformatics\/btn578.","journal-title":"Bioinformatics"},{"key":"3973_CR121","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.4238\/vol9-3gmr901","volume":"9","author":"J Schneider","year":"2010","unstructured":"Schneider J, Vorh\u00f6lter FJ, Trost E, Blom J, Musa YR, Neuweger H, Niehaus K, Schatschneider S, Tauch A, Goesmann A: CARMEN - Comparative analysis and in silico reconstruction of organism-specific metabolic networks. Genet Mol Res. 2010, 9: 1660-1672. 10.4238\/vol9-3gmr901.","journal-title":"Genet Mol Res"},{"key":"3973_CR122","volume-title":"Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria. Wayne","author":"Clinical and Laboratory Standards Institute","year":"2006","unstructured":"Clinical and Laboratory Standards Institute: Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria: Approved Guideline. Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria. Wayne. 2006"},{"key":"3973_CR123","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/j.1574-6968.1994.tb07246.x","volume":"123","author":"A Tauch","year":"1994","unstructured":"Tauch A, Kirchner O, Wehmeier L, Kalinowski J, P\u00fchler A: Corynebacterium glutamicum DNA is subjected to methylation-restriction in Escherichia coli. FEMS Microbiol Lett. 1994, 123: 343-347. 10.1111\/j.1574-6968.1994.tb07246.x.","journal-title":"FEMS Microbiol Lett"},{"key":"3973_CR124","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s00284-002-3728-3","volume":"45","author":"A Tauch","year":"2002","unstructured":"Tauch A, Kirchner O, L\u00f6ffler B, G\u00f6tker S, P\u00fchler A, Kalinowski J: Efficient electrotransformation of Corynebacterium diphtheriae with a mini-replicon derived from the Corynebacterium glutamicum plasmid pGA1. Curr Microbiol. 2002, 45: 362-367. 10.1007\/s00284-002-3728-3.","journal-title":"Curr Microbiol"},{"key":"3973_CR125","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1128\/JB.01876-06","volume":"189","author":"I Brune","year":"2007","unstructured":"Brune I, Jochmann N, Brinkrolf K, H\u00fcser AT, Gerstmeir R, Eikmanns BJ, Kalinowski J, P\u00fchler A, Tauch A: The IclR-type transcriptional repressor LtbR regulates the expression of leucine and tryptophan biosynthesis genes in the amino acid producer Corynebacterium glutamicum. J Bacteriol. 2007, 189: 2720-2733. 10.1128\/JB.01876-06.","journal-title":"J Bacteriol"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2164-13-141.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T20:11:03Z","timestamp":1713903063000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/1471-2164-13-141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,23]]},"references-count":125,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["3973"],"URL":"https:\/\/doi.org\/10.1186\/1471-2164-13-141","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,23]]},"assertion":[{"value":"30 September 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"141"}}