{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:52:37Z","timestamp":1791190357941,"version":"4.1.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Studies conducted with gilthead sea bream (<jats:italic>Sparus aurata<\/jats:italic> L.) have determined the maximum dietary replacement of fish meal and oil without compromising growth or product quality. The present study aimed to analyze the effect of the nutritional background on fish health and fish fed plant protein-based diets with fish oil (FO diet) or a blend of vegetable oils (66VO diet) were exposed for 102 days to the intestinal myxosporean parasite <jats:italic>Enteromyxum leei<\/jats:italic>, and the intestine transcriptome was analyzed with a customized oligo-microarray of 7,500 annotated genes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Infection prevalence was high and similar in the two diet groups, but the outcome of the disease was more pronounced in fish fed the 66VO diet. No differences were found in the transcriptome of both diet control groups, whereas the number of differentially expressed genes in infected groups was considerable. K-means clustering of these differentially expressed genes identified four expression patterns that reflected the progression of the disease with the magnitude of the fold-change being higher in infected 66VO fish. A positive correlation was found between the time of infection and the magnitude of the transcriptional change within the 66VO group, being higher in early infected animals. Within this diet group, a strong up-regulation of many components of the immune specific response was evidenced, whereas other genes related to complement response and xenobiotic metabolism were down-regulated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The high replacement of fish oil by vegetable oils in practical fish feeds did not modify the intestine transcriptome of gilthead sea bream, but important changes were apparent when fish were exposed to the myxosporean <jats:italic>E. leei<\/jats:italic>. The detected changes were mostly a consequence rather than a cause of the different disease progression in the two diet groups. Hence, the developed microarray constitutes an excellent diagnostic tool to address changes associated with the action of intestinal pathogens, but lacks a prognostic value to predict in advance the different susceptibility of growing fish to the current pathogen.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2164-13-470","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T01:56:44Z","timestamp":1347415004000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Dietary vegetable oils do not alter the intestine transcriptome of gilthead sea bream (Sparus aurata), but modulate the transcriptomic response to infection with Enteromyxum leei"],"prefix":"10.1186","volume":"13","author":[{"given":"Josep A","family":"Calduch-Giner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Sitj\u00e0-Bobadilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace C","family":"Davey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Cairns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadasivam","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"P\u00e9rez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"4189_CR1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.aquaculture.2007.01.011","volume":"267","author":"L Benedito-Palos","year":"2007","unstructured":"Benedito-Palos L, Saera-Vila A, Calduch-Giner JA, Kaushik S, P\u00e9rez-S\u00e1nchez J: Combined replacement of fish meal and oil in practical diets for fast growing juveniles of gilthead sea bream (Sparus aurata L.): Networking of systemic and local components of GH\/IGF axis. Aquaculture. 2007, 267: 199-212. 10.1016\/j.aquaculture.2007.01.011.","journal-title":"Aquaculture"},{"key":"4189_CR2","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1017\/S0007114508966071","volume":"100","author":"L Benedito-Palos","year":"2008","unstructured":"Benedito-Palos L, Navarro JC, Sitj\u00e0-Bobadilla A, Bell JG, Kaushik S, P\u00e9rez-S\u00e1nchez J: High levels of vegetable oils in plant protein-rich diets fed to gilthead sea bream (Sparus aurata L.): growth performance, muscle fatty acid profiles and histological alterations of target tissues. Brit J Nutr. 2008, 100: 992-1003. 10.1017\/S0007114508966071.","journal-title":"Brit J Nutr"},{"key":"4189_CR3","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.2527\/jas.2009-2564","volume":"88","author":"L Benedito-Palos","year":"2010","unstructured":"Benedito-Palos L, Navarro JC, Kaushik S, P\u00e9rez-S\u00e1nchez J: Tissue-specific robustness of fatty acid signatures in cultured gilthead sea bream (Sparus aurata L.) fed practical diets with a combined high replacement of fish meal and fish oil. J Anim Sci. 2010, 88: 1759-1770. 10.2527\/jas.2009-2564.","journal-title":"J Anim Sci"},{"key":"4189_CR4","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.foodchem.2010.06.066","volume":"124","author":"L Benedito-Palos","year":"2011","unstructured":"Benedito-Palos L, Bermejo-Nogales A, Karampatos AI, Ballester-Lozano GF, Navarro JC, Diez A, Bautista JM, Bell JG, Tocher DR, Obach A, Kaushik S, P\u00e9rez-S\u00e1nchez J: Modelling the predictable effects of dietary lipid sources on the fillet fatty acid composition of one-year-old gilthead sea bream (Sparus aurata L.). Food Chem. 2011, 124: 538-544. 10.1016\/j.foodchem.2010.06.066.","journal-title":"Food Chem"},{"key":"4189_CR5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.aquaculture.2011.06.015","volume":"319","author":"GF Ballester-Lozano","year":"2011","unstructured":"Ballester-Lozano GF, Benedito-Palos L, Navarro JC, Kaushik S, P\u00e9rez-S\u00e1nchez J: Prediction of fillet fatty acid composition of market-size gilthead sea bream (Sparus aurata) using a regression modelling approach. Aquaculture. 2011, 319: 81-88. 10.1016\/j.aquaculture.2011.06.015.","journal-title":"Aquaculture"},{"key":"4189_CR6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.aquaculture.2008.11.010","volume":"288","author":"L Benedito-Palos","year":"2009","unstructured":"Benedito-Palos L, Navarro JC, Bermejo-Nogales A, Saera-Vila A, Kaushik S, P\u00e9rez-S\u00e1nchez J: The time-course of fish oil wash-out follows a simple dilution model in gilthead sea bream (Sparus aurata L.) fed graded levels of vegetable oils. Aquaculture. 2009, 288: 98-105. 10.1016\/j.aquaculture.2008.11.010.","journal-title":"Aquaculture"},{"key":"4189_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1365-2761.2011.01333.x","volume":"35","author":"A Oliva-Teles","year":"2012","unstructured":"Oliva-Teles A: Nutrition and health of aquaculture fish. J Fish Dis. 2012, 35: 83-108. 10.1111\/j.1365-2761.2011.01333.x.","journal-title":"J Fish Dis"},{"key":"4189_CR8","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1111\/j.1365-2109.2009.02374.x","volume":"41","author":"VV Trichet","year":"2010","unstructured":"Trichet VV: Nutrition and immunity: an update. Aquac Res. 2010, 41: 356-372. 10.1111\/j.1365-2109.2009.02374.x.","journal-title":"Aquac Res"},{"key":"4189_CR9","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1201\/9781439808634-c14","volume-title":"Fish oil replacement and alternative lipid sources in aquaculture feeds","author":"D Montero","year":"2010","unstructured":"Montero D, Izquierdo M: Welfare and health of fish fed vegetable oils as alternative lipid sources to fish oil. Fish oil replacement and alternative lipid sources in aquaculture feeds. Edited by: Turchini GM, Wing-Keong N, Tocher DR. 2010, CRC Press, Boca Raton, 439-485."},{"key":"4189_CR10","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.aquaculture.2009.07.028","volume":"296","author":"A Saera-Vila","year":"2009","unstructured":"Saera-Vila A, Benedito-Palos L, Sitj\u00e0-Bobadilla A, N\u00e1cher-Mestre J, Serrano R, Kaushik S, P\u00e9rez-S\u00e1nchez J: Assessment of the health and antioxidant trade-off in gilthead sea bream (Sparus aurata L.) fed alternative diets with low levels of contaminants. Aquaculture. 2009, 296: 87-95. 10.1016\/j.aquaculture.2009.07.028.","journal-title":"Aquaculture"},{"key":"4189_CR11","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.aquaculture.2010.11.050","volume":"311","author":"R Ganga","year":"2011","unstructured":"Ganga R, Montero D, Bell JG, Atalah E, Ganuza E, Vega-Orellana O, Tort L, Acerete L, Afonso JM, Benitez-Sanatana T, Fern\u00e1ndez Vaquero A, Izquierdo M: Stress response in sea bream (Sparus aurata) held under crowded conditions and fed diets containing linseed and\/or soybean oil. Aquaculture. 2011, 311: 215-223. 10.1016\/j.aquaculture.2010.11.050.","journal-title":"Aquaculture"},{"key":"4189_CR12","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.vetpar.2010.09.015","volume":"175","author":"I Estensoro","year":"2011","unstructured":"Estensoro I, Benedito-Palos L, Palenzuela O, Kaushik S, Sitj\u00e0-Bobadilla A, P\u00e9rez-S\u00e1nchez J: The nutritional background of the host alters the disease course in a fish-myxosporean system. Vet Parasitol. 2011, 175: 141-150. 10.1016\/j.vetpar.2010.09.015.","journal-title":"Vet Parasitol"},{"key":"4189_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1017\/S0031182005008759","volume":"132","author":"A Cuesta","year":"2006","unstructured":"Cuesta A, Mu\u00f1oz P, Rodr\u00edguez A, Salinas I, Sitj\u00e0-Bobadilla A, \u00c1lvarez-Pellitero P, Esteban MA, Meseguer J: Gilthead seabream (Sparus aurata L.) innate defence against the parasite Enteromyxum leei (Myxozoa). Parasitology. 2006, 132: 95-104.","journal-title":"Parasitology"},{"key":"4189_CR14","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.fsi.2008.01.014","volume":"24","author":"A Sitj\u00e0-Bobadilla","year":"2008","unstructured":"Sitj\u00e0-Bobadilla A, Calduch-Giner J, Saera-Vila A, Palenzuela O, \u00c1lvarez-Pellitero P, P\u00e9rez-S\u00e1nchez J: Chronic exposure to the parasite Enteromyxum leei (Myxozoa: Myxosporea) modulates the immune response and the expression of growth, redox and immune relevant genes in gilthead sea bream, Sparus aurata L. Fish Shellfish Immunol. 2008, 24: 610-619. 10.1016\/j.fsi.2008.01.014.","journal-title":"Fish Shellfish Immunol"},{"key":"4189_CR15","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1016\/j.molimm.2011.07.003","volume":"48","author":"GC Davey","year":"2011","unstructured":"Davey GC, Calduch-Giner JA, Houeix B, Talbot A, Sitj\u00e0-Bobadilla A, Prunet P, P\u00e9rez-S\u00e1nchez J, Cairns MT: Molecular profiling of the gilthead sea bream (Sparus aurata L.) response to chronic exposure to the myxosporean parasite Enteromyxum leei. Mol Immunol. 2011, 48: 2102-2212. 10.1016\/j.molimm.2011.07.003.","journal-title":"Mol Immunol"},{"key":"4189_CR16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/1471-2164-11-193","volume":"11","author":"JA Calduch-Giner","year":"2010","unstructured":"Calduch-Giner JA, Davey G, Saera-Vila A, Houeix B, Talbot A, Prunet P, Cairns MT, P\u00e9rez-S\u00e1nchez J: Use of microarray technology to assess the time course of liver stress response after confinement exposure in gilthead sea bream (Sparus aurata L.). BMC Genomics. 2010, 11: 193-10.1186\/1471-2164-11-193.","journal-title":"BMC Genomics"},{"key":"4189_CR17","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1089\/omi.2006.10.474","volume":"10","author":"SE Douglas","year":"2006","unstructured":"Douglas SE: Microarray studies of gene expression in fish. OMICS. 2006, 10: 474-489. 10.1089\/omi.2006.10.474.","journal-title":"OMICS"},{"key":"4189_CR18","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/j.1467-2979.2008.00301.x","volume":"9","author":"FW Goetz","year":"2008","unstructured":"Goetz FW, MacKenzie S: Functional genomics with microarrays in fish biology and fisheries. Fish Fish. 2008, 9: 378-395.","journal-title":"Fish Fish"},{"key":"4189_CR19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s10695-011-9522-z","volume":"38","author":"P Prunet","year":"2012","unstructured":"Prunet P, Overli O, Douxfils J, Bernardini G, Kestemont P, Baron D: Fish welfare and genomics. Fish Physiol Biochem. 2012, 38: 43-60. 10.1007\/s10695-011-9522-z.","journal-title":"Fish Physiol Biochem"},{"key":"4189_CR20","first-page":"51","volume":"3","author":"MT Cairns","year":"2008","unstructured":"Cairns MT, Johnson MC, Talbot AT, Pemmasani JK, McNeill RE, Houeix B, Sangrador-Vegas A, Pottinger TG: A cDNA microarray assessment of gene expression in the liver of rainbow trout (Oncorhynchus mykiss) in response to a handling and confinement stressor. Comp Biochem Physiol D. 2008, 3: 51-66.","journal-title":"Comp Biochem Physiol D"},{"key":"4189_CR21","first-page":"406","volume":"6","author":"JK Pemmasani","year":"2011","unstructured":"Pemmasani JK, Pottinger TG, Cairns MT: Analysis of stress-induced hepatic gene expression in rainbow trout (Oncorhynchus mykiss) selected for high- and low-responsiveness to stress. Comp Biochem Physiol D. 2011, 6: 406-419.","journal-title":"Comp Biochem Physiol D"},{"key":"4189_CR22","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.aquatox.2006.08.009","volume":"80","author":"H Reynders","year":"2006","unstructured":"Reynders H, Van der Ven K, Moens LN, Van Remortel P, De Coen WM, Blust R: Patterns of gene expression in carp liver after exposure to a mixture of waterborne and dietary cadmium using a custom-made microarray. Aquat Toxicol. 2006, 80: 180-193. 10.1016\/j.aquatox.2006.08.009.","journal-title":"Aquat Toxicol"},{"key":"4189_CR23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/1471-2164-8-149","volume":"8","author":"L Gunnarsson","year":"2007","unstructured":"Gunnarsson L, Kristiansson E, F\u00f6rlin L, Nerman O, Larsson DGJ: Sensitive and robust gene expression changes in fish exposed to estrogen \u2013 a microarray approach. BMC Genomics. 2007, 8: 149-10.1186\/1471-2164-8-149.","journal-title":"BMC Genomics"},{"key":"4189_CR24","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/j.scitotenv.2011.01.013","volume":"409","author":"S Meland","year":"2011","unstructured":"Meland S, Farmen E, Heier LS, Rosseland BO, Salbu B, Song Y, Tollefsen KE: Hepatic gene expression profile in brown trout (Salmo trutta) exposed to traffic related contaminants. Sci Total Environ. 2011, 409: 1430-1443. 10.1016\/j.scitotenv.2011.01.013.","journal-title":"Sci Total Environ"},{"key":"4189_CR25","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1093\/jn\/135.10.2355","volume":"135","author":"AEO Jordal","year":"2005","unstructured":"Jordal AEO, Torstensen BE, Tsoi S, Tocher DR, Lall SP, Douglas SE: Dietary rapeseed oil affects the expression of genes involved in hepatic lipid metabolism in Atlantic salmon (Salmo salar L.). J Nutr. 2005, 135: 2355-2361.","journal-title":"J Nutr"},{"key":"4189_CR26","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1186\/1471-2164-12-522","volume":"12","author":"F Geay","year":"2011","unstructured":"Geay F, Ferraresso S, Zambonino-Infante JL, Bargelloni L, Quentel C, Vandeputte M, Kaushik S, Cahu CL, Mazurais D: Effects of the total replacement of fish-based diet with plant-based diet on the hepatic transcriptome of two European sea bass (Dicentrarchus labrax) half-sibfamilies showing different growth rates with the plant-based diet. BMC Genomics. 2011, 12: 522-10.1186\/1471-2164-12-522.","journal-title":"BMC Genomics"},{"key":"4189_CR27","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/1471-2164-12-255","volume":"12","author":"S Morais","year":"2011","unstructured":"Morais S, Pratoomyot J, Taggart JB, Bron JE, Guy DR, Bell JG, Tocher DR: Genotype-specific responses in Atlantic salmon (Salmo salar) subject to dietary fish oil replacement by vegetable oil: a liver transcriptomic analysis. BMC Genomics. 2011, 12: 255-10.1186\/1471-2164-12-255.","journal-title":"BMC Genomics"},{"key":"4189_CR28","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.fsi.2011.02.023","volume":"31","author":"L Tacchi","year":"2011","unstructured":"Tacchi L, Bickerdike R, Douglas A, Secombes CJ, Martin SAM: Transcriptomic responses to functional feeds in Atlantic salmon (Salmo salar). Fish Shellfish Immunol. 2011, 31: 704-715. 10.1016\/j.fsi.2011.02.023.","journal-title":"Fish Shellfish Immunol"},{"key":"4189_CR29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1152\/physiolgenomics.00036.2004","volume":"20","author":"ML Rise","year":"2004","unstructured":"Rise ML, Jones SRM, Brown GD, Von Schalburg KR, Davidson WS, Koop BF: Microarray analyses identify molecular biomarkers of Atlantic salmon macrophage and hematopoietic kidney response to Piscirickettsia salmonis infection. Physiol Genomics. 2004, 20: 21-35. 10.1152\/physiolgenomics.00036.2004.","journal-title":"Physiol Genomics"},{"key":"4189_CR30","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.fsi.2009.09.009","volume":"27","author":"MD Fast","year":"2009","unstructured":"Fast MD, Tse B, Boyd JM, Johnson SC: Mutations in the Aeromonas salmonicida subsp. salmonicida type III secretion system affect Atlantic salmon leucocyte activation and downstream immune responses. Fish Shellfish Immunol. 2009, 27: 721-728. 10.1016\/j.fsi.2009.09.009.","journal-title":"Fish Shellfish Immunol"},{"key":"4189_CR31","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1186\/1471-2164-12-556","volume":"12","author":"Y Huang","year":"2011","unstructured":"Huang Y, Huang X, Yan Y, Cai J, Ouyang Z, Cui H, Wang P, Qin Q: Transcriptome analysis of orange-spotted grouper (Epinephelus coioides) spleen in response to Singapore grouper iridovirus. BMC Genomics. 2011, 12: 556-10.1186\/1471-2164-12-556.","journal-title":"BMC Genomics"},{"key":"4189_CR32","first-page":"111","volume-title":"Fish Physiology. Volume 30","author":"K Cain","year":"2010","unstructured":"Cain K, Swan C: Barrier function and immunology. Fish Physiology. Volume 30. Edited by: Grosell M, Farrell AP, Brauner CJ. 2010, Academic Press, New York, 111-134."},{"key":"4189_CR33","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.fsi.2010.09.001","volume":"31","author":"JHWM Rombout","year":"2011","unstructured":"Rombout JHWM, Abelli L, Picchietti S, Scapigliati G, Kiron V: Teleost intestinal immunology. Fish Shellfish Immunol. 2011, 31: 616-626. 10.1016\/j.fsi.2010.09.001.","journal-title":"Fish Shellfish Immunol"},{"key":"4189_CR34","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.ygcen.2006.12.025","volume":"152","author":"S Kalujnaia","year":"2007","unstructured":"Kalujnaia S, McWilliam IS, Zaguinaiko VA, Feilen AL, Nicholson J, Hazon N, Cutler CP, Balment RJ, Cossins AR, Hughes M, Cramb G: Salinity adaptation and gene profiling analysis in the European eel (Anguilla anguilla) using microarray technology. Gen Comp Endocrinol. 2007, 152: 274-280. 10.1016\/j.ygcen.2006.12.025.","journal-title":"Gen Comp Endocrinol"},{"key":"4189_CR35","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1365-2052.2007.01615.x","volume":"38","author":"S Kirchner","year":"2007","unstructured":"Kirchner S, McDaniel NK, Sugiura SH, Soteropoulos P, Tian B, Fletcher JW, Ferraris RP: Salmonid microarrays identify intestinal genes that reliably monitor P deficiency in rainbow trout aquaculture. Anim Genet. 2007, 38: 319-331. 10.1111\/j.1365-2052.2007.01615.x.","journal-title":"Anim Genet"},{"key":"4189_CR36","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s10126-009-9203-4","volume":"12","author":"C Do\u00f1ate","year":"2010","unstructured":"Do\u00f1ate C, Balasch JC, Callol A, Bobe J, Tort L, MacKenzie S: The effects of immunostimulation through dietary manipulation in the rainbow trout; evaluation of mucosal immunity. Mar Biotechnol. 2010, 12: 88-99. 10.1007\/s10126-009-9203-4.","journal-title":"Mar Biotechnol"},{"key":"4189_CR37","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.aquaculture.2009.11.001","volume":"298","author":"HM Murray","year":"2010","unstructured":"Murray HM, Lall SP, Rajaselvam R, Boutilier LA, Blanchard B, Flight RM, Colombo S, Mohindra V, Douglas SE: A nutrigenomic analysis of intestinal response to partial soybean meal replacement in diets for juvenile Atlantic halibut, Hippoglossus hippoglossus, L. Aquaculture. 2010, 298: 282-293. 10.1016\/j.aquaculture.2009.11.001.","journal-title":"Aquaculture"},{"key":"4189_CR38","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/j.1365-2095.2010.00832.x","volume":"17","author":"S Skugor","year":"2011","unstructured":"Skugor S, Grisdale-Helland B, Refstie S, Afanasyev S, Vielma J, Krasnov A: Gene expression responses to restricted feeding and extracted soybean meal in Atlantic salmon (Salmo salar L.). Aquacult Nutr. 2011, 17: 505-517. 10.1111\/j.1365-2095.2010.00832.x.","journal-title":"Aquacult Nutr"},{"key":"4189_CR39","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.cbpb.2011.12.004","volume":"161","author":"S Morais","year":"2012","unstructured":"Morais S, Edvardsen RB, Tocher DR, Bell JG: Transcriptomic analyses of intestinal gene expression of juvenile Atlantic cod (Gadus morhua) fed diets with Camelina oil as replacement for fish oil. Comp Biochem Physiol B. 2012, 161: 282-293.","journal-title":"Comp Biochem Physiol B"},{"key":"4189_CR40","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.molimm.2005.07.022","volume":"43","author":"M Joerink","year":"2006","unstructured":"Joerink M, Savelkoul HFJ, Wiegertjes GF: Evolutionary conservation of alternative activation of macrophages: structural and functional characterization of arginase 1 and 2 in carp (Cyprinus carpio L.). Mol Immunol. 2006, 43: 1116-1128. 10.1016\/j.molimm.2005.07.022.","journal-title":"Mol Immunol"},{"key":"4189_CR41","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.dci.2011.03.008","volume":"35","author":"M Forlenza","year":"2011","unstructured":"Forlenza M, Fink IR, Raes G, Wiegertjes GF: Heterogeneity of macrophage activation in fish. Dev Comp Immunol. 2011, 35: 1246-1255. 10.1016\/j.dci.2011.03.008.","journal-title":"Dev Comp Immunol"},{"key":"4189_CR42","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1023\/A:1007786128254","volume":"16","author":"A P\u00e9res","year":"1997","unstructured":"P\u00e9res A, Cahu CL, Zambonino-Infante JL: Dietary spermine supplementation induces intestinal maturation in sea bass (Dicentrarchus labrax) larvae. Fish Physiol Biochem. 1997, 16: 479-485. 10.1023\/A:1007786128254.","journal-title":"Fish Physiol Biochem"},{"key":"4189_CR43","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.fsi.2010.10.011","volume":"30","author":"M Reyes-Becerril","year":"2011","unstructured":"Reyes-Becerril M, Ascencio-Valle F, Tovar-Ram\u00edrez D, Meseguer J, Esteban MA: Effects of polyamines on cellular innate immune response and the expression of immune-relevant genes in gilthead seabream leucocytes. Fish Shellfish Immunol. 2011, 30: 248-254. 10.1016\/j.fsi.2010.10.011.","journal-title":"Fish Shellfish Immunol"},{"key":"4189_CR44","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3354\/dao043109","volume":"43","author":"JJ Campos-Perez","year":"2000","unstructured":"Campos-Perez JJ, Ellis AE, Secombes CJ: Toxicity of nitric oxide and peroxynitrite to bacterial pathogens of fish. Dis Aquat Org. 2000, 43: 109-115.","journal-title":"Dis Aquat Org"},{"key":"4189_CR45","first-page":"445","volume":"21","author":"T Thippeswamy","year":"2006","unstructured":"Thippeswamy T, Mckay JS, Quinn JP, Morris R: Nitric oxide, a biological double-faced Janus - Is this good or bad?. Histol Histopathol. 2006, 21: 445-458.","journal-title":"Histol Histopathol"},{"key":"4189_CR46","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.pneurobio.2010.05.002","volume":"92","author":"RA Stetler","year":"2010","unstructured":"Stetler RA, Gan Y, Zhang W, Liou AK, Gao Y, Cao G, Chen J: Heat shock proteins: Cellular and molecular mechanisms in the central nervous system. Prog Neurobiol. 2010, 92: 184-211. 10.1016\/j.pneurobio.2010.05.002.","journal-title":"Prog Neurobiol"},{"key":"4189_CR47","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s11160-010-9164-8","volume":"21","author":"EE Deane","year":"2011","unstructured":"Deane EE, Woo NYS: Advances and perspectives on the regulation and expression of piscine heat shock proteins. Rev Fish Biol Fisheries. 2011, 21: 153-185. 10.1007\/s11160-010-9164-8.","journal-title":"Rev Fish Biol Fisheries"},{"key":"4189_CR48","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.cbpb.2007.11.003","volume":"149","author":"A Bermejo-Nogales","year":"2008","unstructured":"Bermejo-Nogales A, Benedito-Palos L, Saera-Vila A, Calduch-Giner JA, Sitj\u00e0-Bobadilla A, P\u00e9rez-S\u00e1nchez J: Confinement exposure induces glucose regulated protein 75 (GRP75\/mortalin\/mtHsp70\/PBP74\/HSPA9B) in the hepatic tissue of gilthead sea bream (Sparus aurata L.). Comp Biochem Physiol B. 2008, 149: 428-438. 10.1016\/j.cbpb.2007.11.003.","journal-title":"Comp Biochem Physiol B"},{"key":"4189_CR49","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/j.dci.2008.05.013","volume":"32","author":"JW Wynne","year":"2008","unstructured":"Wynne JW, O\u2019Sullivan MG, Stone G, Cook MT, Nowak BF, Lovell DR, Taylor RS, Elliott NG: Resistance to amoebic gill disease (AGD) is characterised by the transcriptional dysregulation of immune and cell cycle pathways. Dev Comp Immunol. 2008, 32: 1539-1560. 10.1016\/j.dci.2008.05.013.","journal-title":"Dev Comp Immunol"},{"key":"4189_CR50","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.1365-2761.2004.00558.x","volume":"27","author":"J Sigh","year":"2004","unstructured":"Sigh J, Lindenstrom T, Buchmann K: The parasitic ciliate Ichthyophthirius multifiliis induces expression of immune relevant genes in rainbow trout, Oncorhynchus mykiss (Walbaum). J Fish Dis. 2004, 27: 409-417. 10.1111\/j.1365-2761.2004.00558.x.","journal-title":"J Fish Dis"},{"key":"4189_CR51","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.vetimm.2003.08.016","volume":"97","author":"T Lindenstrom","year":"2004","unstructured":"Lindenstrom T, Secombes CJ, Buchmann K: Expression of immune response genes in rainbow trout skin induced by Gyrodactylus derjavini infections. Vet Immunol Immunopathol. 2004, 97: 137-148. 10.1016\/j.vetimm.2003.08.016.","journal-title":"Vet Immunol Immunopathol"},{"key":"4189_CR52","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1007\/s00436-007-0582-z","volume":"101","author":"VIC Severin","year":"2007","unstructured":"Severin VIC, El Matbouli M: Relative quantification of immune-regulatory genes in two rainbow trout strains, Oncorhynchus mykiss, after exposure to Myxobolus cerebralis, the causative agent of whirling disease. Parasitol Res. 2007, 101: 1019-1027. 10.1007\/s00436-007-0582-z.","journal-title":"Parasitol Res"},{"key":"4189_CR53","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.fsi.2007.12.013","volume":"25","author":"M Forlenza","year":"2008","unstructured":"Forlenza M, Walker PD, de Vries BJ, Wendelaar Bonga SE, Wiegertjes GF: Transcriptional analysis of the common carp (Cyprinus carpio L.) immune response to the fish louse Argulus japonicus Thiele (Crustacea: Branchiura). Fish Shellfish Immunol. 2008, 25: 76-83. 10.1016\/j.fsi.2007.12.013.","journal-title":"Fish Shellfish Immunol"},{"key":"4189_CR54","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1111\/j.1365-3024.2011.01337.x","volume":"33","author":"YW Li","year":"2011","unstructured":"Li YW, Dan XM, Zhang TW, Luo XC, Li AX: Immune-related genes expression profile in orange-spotted grouper during exposure to Cryptocaryon irritans. Parasite Immunol. 2011, 33: 679-687. 10.1111\/j.1365-3024.2011.01337.x.","journal-title":"Parasite Immunol"},{"key":"4189_CR55","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/1471-2164-12-141","volume":"12","author":"T Tadiso","year":"2011","unstructured":"Tadiso T, Krasnov A, Skugor S, Afanasyev S, Hordvik I, Nilsen F: Gene expression analyses of immune responses in Atlantic salmon during early stages of infection by salmon louse (Lepeophtheirus salmonis) revealed bi-phasic responses coinciding with the copepod-chalimus transition. BMC Genomics. 2011, 12: 141-10.1186\/1471-2164-12-141.","journal-title":"BMC Genomics"},{"key":"4189_CR56","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.tips.2009.02.003","volume":"30","author":"AE Van Herwaarden","year":"2009","unstructured":"Van Herwaarden AE, Van Waterschoot RAB, Schinkel AH: How important is intestinal cytochrome P450 3A metabolism?. Trends Pharmacol Sci. 2009, 30: 223-227. 10.1016\/j.tips.2009.02.003.","journal-title":"Trends Pharmacol Sci"},{"key":"4189_CR57","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00360-009-0441-6","volume":"180","author":"A Bermejo-Nogales","year":"2010","unstructured":"Bermejo-Nogales A, Calduch-Giner JA, P\u00e9rez-S\u00e1nchez J: Gene expression survey of mitocondrial uncoupling proteins (UCP1\/UCP3) in gilthead sea bream (Sparus aurata L.). J Comp Physiol B. 2010, 180: 685-694. 10.1007\/s00360-009-0441-6.","journal-title":"J Comp Physiol B"},{"key":"4189_CR58","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.fsi.2011.05.015","volume":"31","author":"J P\u00e9rez-S\u00e1nchez","year":"2011","unstructured":"P\u00e9rez-S\u00e1nchez J, Bermejo-Nogales A, Calduch-Giner JA, Kaushik S, Sitj\u00e0-Bobadilla A: Molecular characterization and expression analysis of six peroxiredoxin paralogous genes in gilthead sea bream (Sparus aurata): insights from fish exposed to dietary, pathogen and confinement stressors. Fish Shellfish Immunol. 2011, 31: 294-302. 10.1016\/j.fsi.2011.05.015.","journal-title":"Fish Shellfish Immunol"},{"key":"4189_CR59","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1097\/00054725-200411000-00021","volume":"10","author":"AL Theiss","year":"2004","unstructured":"Theiss AL, Fruchtman S, Lund PK: Growth factors in inflammatory bowel disease. The actions and interactions of growth hormone and insulin-like growth factor-I. Inflamm Bowel Dis. 2004, 10: 871-880.","journal-title":"Inflamm Bowel Dis"},{"key":"4189_CR60","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.fsi.2004.09.006","volume":"20","author":"B Magnad\u00f3ttir","year":"2006","unstructured":"Magnad\u00f3ttir B: Innate immunity of fish (overview). Fish Shellfish Immunol. 2006, 20: 137-151. 10.1016\/j.fsi.2004.09.006.","journal-title":"Fish Shellfish Immunol"},{"key":"4189_CR61","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.fsi.2012.05.029","volume":"33","author":"I Estensoro","year":"2012","unstructured":"Estensoro I, Calduch-Giner JA, Kaushik S, P\u00e9rez-S\u00e1nchez J, Sitj\u00e0-Bobadilla A: Modulation of the IgM gene expression and IgM immunoreactive cell distribution by the nutritional background in gilthead sea bream (Sparus aurata) challenged with Enteromyxum leei (Myxozoa). Fish Shellfish Immunol. 2012, 33: 401-410. 10.1016\/j.fsi.2012.05.029.","journal-title":"Fish Shellfish Immunol"},{"key":"4189_CR62","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/ni.1913","volume":"11","author":"YA Zhang","year":"2010","unstructured":"Zhang YA, Salinas I, Li J, Parra D, Bjork S, Xu Z, La Patra SE, Bartholomew J, Sunyer JO: IgT, a primitive immunoglobulin class specialized in mucosal immunity. Nat Immunol. 2010, 11: 827-835. 10.1038\/ni.1913.","journal-title":"Nat Immunol"},{"key":"4189_CR63","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.fsi.2006.02.004","volume":"21","author":"A Sitj\u00e0-Bobadilla","year":"2006","unstructured":"Sitj\u00e0-Bobadilla A, Redondo M, Berm\u00fadez R, Palenzuela O, Ferreiro I, Riaza A, Quiroga I, Nieto J, \u00c1lvarez-Pellitero P: Innate and adaptive responses of turbot, Scopththalmus maximus (L.) following experimental infection with Enteromyxum scophthalmi (Myxosporea: Myxozoa). Fish Shellfish Immunol. 2006, 21: 485-500. 10.1016\/j.fsi.2006.02.004.","journal-title":"Fish Shellfish Immunol"},{"key":"4189_CR64","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.parint.2007.09.004","volume":"57","author":"P \u00c1lvarez-Pellitero","year":"2008","unstructured":"\u00c1lvarez-Pellitero P, Palenzuela O, Sitj\u00e0-Bobadilla A: Histopathology and celular response in Enteromyxum leei (Myxozoa) infections of Diplodus puntazo (Teleostei). Parasitol Int. 2008, 57: 110-120. 10.1016\/j.parint.2007.09.004.","journal-title":"Parasitol Int"},{"key":"4189_CR65","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.dci.2004.08.004","volume":"29","author":"KV Ewart","year":"2005","unstructured":"Ewart KV, Belanger JC, Williams J, Karakach T, Penny S, Tsoi SCM, Richards RC, Douglas SE: Identification of genes differentially expressed in Atlantic salmon (Salmo salar) in response to infection by Aeromonas salmonicida using cDNA microarray technology. Dev Comp Immunol. 2005, 29: 333-347. 10.1016\/j.dci.2004.08.004.","journal-title":"Dev Comp Immunol"},{"key":"4189_CR66","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.molimm.2007.05.012","volume":"45","author":"E Peatman","year":"2008","unstructured":"Peatman E, Terhune J, Baoprasertkul P, Xu P, Nandi S, Wang S, Somridhivej B, Kucuktas H, Li P, Dunham R, Liu Z: Microarray analysis of gene expression in the blue catfish liver reveals early activation of the MHC class I pathway after infection with Edwardsiella ictaluri. Mol Immunol. 2008, 45: 553-566. 10.1016\/j.molimm.2007.05.012.","journal-title":"Mol Immunol"},{"key":"4189_CR67","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.fsi.2011.06.015","volume":"31","author":"T Matsuyama","year":"2011","unstructured":"Matsuyama T, Fujiwara A, Takano T, Nakayasu C: Suppression subtractive hybridization coupled with microarray analysis to examine differential expression of genes in Japanese flounder Paralichthys olivaceus leucocytes during Edwardsiella tarda and viral hemorrhagic septicemia virus infection. Fish Shellfish Immunol. 2011, 31: 524-532. 10.1016\/j.fsi.2011.06.015.","journal-title":"Fish Shellfish Immunol"},{"key":"4189_CR68","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.plipres.2007.10.002","volume":"47","author":"NM Carballeira","year":"2008","unstructured":"Carballeira NM: New advances in fatty acids as antimalarial, antimycobacterial and antifungal agents. Prog Lipid Res. 2008, 47: 50-61. 10.1016\/j.plipres.2007.10.002.","journal-title":"Prog Lipid Res"},{"key":"4189_CR69","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1079\/NRR2006117","volume":"19","author":"R Turner","year":"2006","unstructured":"Turner R, McLean CH, Silvers KM: Are the health benefits of fish oils limited by products of oxidation?. Nutr Res Rev. 2006, 19: 53-62. 10.1079\/NRR2006117.","journal-title":"Nutr Res Rev"},{"key":"4189_CR70","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/978-94-017-2315-2_11","volume-title":"Molecular diagnosis of salmonid diseases","author":"O Palenzuela","year":"2002","unstructured":"Palenzuela O, Bartholomew JL: Molecular tools for the diagnosis of Ceratomyxa shasta (Myxozoa). Molecular diagnosis of salmonid diseases. 2002, Kluwer Academic Publishers, Cunningham CO. Dordrecht, 285-298."},{"key":"4189_CR71","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","volume":"21","author":"A Conesa","year":"2005","unstructured":"Conesa A, G\u00f6tz S, Garc\u00eda-G\u00f3mez JM, Perol J, Tal\u00f3n M, Robles M: Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics. 2005, 21: 3674-3676. 10.1093\/bioinformatics\/bti610.","journal-title":"Bioinformatics"},{"key":"4189_CR72","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2T-\u0394\u0394C method. Methods. 2001, 25: 402-408. 10.1006\/meth.2001.1262.","journal-title":"Methods"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2164-13-470.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T19:49:36Z","timestamp":1630525776000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/1471-2164-13-470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,11]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["4189"],"URL":"https:\/\/doi.org\/10.1186\/1471-2164-13-470","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,11]]},"assertion":[{"value":"1 June 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"470"}}