{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:57:25Z","timestamp":1791205045515,"version":"4.1.0"},"reference-count":156,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Traumatic brain injury (TBI) induces arachidonic acid (ArA) release from cell membranes. ArA metabolites form a class of over 50 bioactive eicosanoids that can induce both adaptive and\/or maladaptive brain responses. The dynamic metabolism of ArA to eicosanoids, and how they affect the injured brain, is poorly understood due to their diverse activities, trace levels, and short half-lives. The eicosanoids produced in the brain postinjury depend upon the enzymes present locally at any given time. Eicosanoids are synthesized by heme-containing enzymes, including cyclooxygenases, lipoxygenases, and arachidonate monoxygenases. The latter comprise a subset of the cytochrome P450 \u201c<jats:italic>Cyp<\/jats:italic>\u201d gene family that metabolize fatty acids, steroids, as well as endogenous and exogenous toxicants. However, for many of these genes neither baseline neuroanatomical nor injury-related temporal expression have been studied in the brain.<\/jats:p><jats:p>In a rat model of parietal cortex TBI,<jats:italic>Cyp<\/jats:italic>and eicosanoid-related mRNA levels were determined at 6 h, 24 h, 3d, and 7d postinjury in parietal cortex and hippocampus, where dynamic changes in eicosanoids have been observed. Quantitative real-time polymerase chain reaction with low density arrays were used to assay 62 rat<jats:italic>Cyp<\/jats:italic>s, 37 of which metabolize ArA or other unsaturated fatty acids; 16 eicosanoid-related enzymes that metabolize ArA or its metabolites; 8 eicosanoid receptors; 5 other inflammatory- and recovery-related genes, plus 2 mouse<jats:italic>Cyp<\/jats:italic>s as negative controls and 3 highly expressed \u201chousekeeping\u201d genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen arachidonate monoxygenases, 17 eicosanoid-related genes, and 12 other<jats:italic>Cyp<\/jats:italic>s were regulated in the brain postinjury (p\u2009&lt;\u20090.05, Tukey HSD). Discrete tissue levels and distinct postinjury temporal patterns of gene expression were observed in hippocampus and parietal cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest complex regulation of ArA and other lipid metabolism after TBI. Due to the temporal nature of brain injury-induced<jats:italic>Cyp<\/jats:italic>gene induction, manipulation of each gene (or its products)<jats:italic>at a given time after TBI<\/jats:italic>will be required to assess their contributions to secondary injury and\/or recovery. Moreover, a better understanding of brain region localization and cell type-specific expression may be necessary to deduce the role of these eicosanoid-related genes in the healthy and injured brain.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2164-14-303","type":"journal-article","created":{"date-parts":[[2013,5,4]],"date-time":"2013-05-04T20:14:17Z","timestamp":1367698457000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury"],"prefix":"10.1186","volume":"14","author":[{"given":"Matthew","family":"Birnie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramatoulie","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth I","family":"Strauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,4]]},"reference":[{"issue":"1","key":"5009_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00008571-200401000-00001","volume":"14","author":"DR Nelson","year":"2004","unstructured":"Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW: Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. 2004, 14 (1): 1-18. 10.1097\/00008571-200401000-00001.","journal-title":"Pharmacogenetics"},{"issue":"2","key":"5009_CR2","doi-asserted-by":"crossref","first-page":"R455","DOI":"10.1152\/ajpregu.2000.279.2.R455","volume":"279","author":"W Kozak","year":"2000","unstructured":"Kozak W, Kluger MJ, Kozak A, Wachulec M, Dokladny K: Role of cytochrome P-450 in endogenous antipyresis. Am J Physiol Regul Integr Comp Physiol. 2000, 279 (2): R455-R460.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"5009_CR3","first-page":"675","volume":"21B","author":"JC McGiff","year":"1991","unstructured":"McGiff JC, Carroll MA: Cytochrome P450-dependent arachidonate metabolites, renal function and blood pressure regulation. Adv Prostaglandin Thromboxane Leukot Res. 1991, 21B: 675-682.","journal-title":"Adv Prostaglandin Thromboxane Leukot Res"},{"issue":"13","key":"5009_CR4","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1096\/fasebj.10.13.8940291","volume":"10","author":"K Makita","year":"1996","unstructured":"Makita K, Falck JR, Capdevila JH: Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system. FASEB J. 1996, 10 (13): 1456-1463.","journal-title":"FASEB J"},{"issue":"4","key":"5009_CR5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0031-6997(25)00020-1","volume":"40","author":"FA Fitzpatrick","year":"1988","unstructured":"Fitzpatrick FA, Murphy RC: Cytochrome P-450 metabolism of arachidonic acid: formation and biological actions of \"epoxygenase\"-derived eicosanoids. Pharmacol Rev. 1988, 40 (4): 229-241.","journal-title":"Pharmacol Rev"},{"issue":"5 Pt 2","key":"5009_CR6","first-page":"H2098","volume":"266","author":"DR Harder","year":"1994","unstructured":"Harder DR, Gebremedhin D, Narayanan J, Jefcoat C, Falck JR, Campbell WB, Roman R: Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. Am J Physiol. 1994, 266 (5 Pt 2): H2098-H2107.","journal-title":"Am J Physiol"},{"issue":"1","key":"5009_CR7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1161\/01.RES.87.1.60","volume":"87","author":"D Gebremedhin","year":"2000","unstructured":"Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, Hudetz AG, Narayanan J, Falck JR, Okamoto H, Roman RJ: Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res. 2000, 87 (1): 60-65. 10.1161\/01.RES.87.1.60.","journal-title":"Circ Res"},{"issue":"3","key":"5009_CR8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.ejphar.2004.01.009","volume":"486","author":"M Yu","year":"2004","unstructured":"Yu M, Cambj-Sapunar L, Kehl F, Maier KG, Takeuchi K, Miyata N, Ishimoto T, Reddy LM, Falck JR, Gebremedhin D: Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. Eur J Pharmacol. 2004, 486 (3): 297-306. 10.1016\/j.ejphar.2004.01.009.","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"5009_CR9","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/sj.jcbfm.9600309","volume":"26","author":"SM Poloyac","year":"2006","unstructured":"Poloyac SM, Zhang Y, Bies RR, Kochanek PM, Graham SH: Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia. J Cereb Blood Flow Metab. 2006, 26 (12): 1551-1561. 10.1038\/sj.jcbfm.9600309.","journal-title":"J Cereb Blood Flow Metab"},{"key":"5009_CR10","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1017\/S1462399411001773","volume":"13","author":"JD Imig","year":"2011","unstructured":"Imig JD, Simpkins AN, Renic M, Harder DR: Cytochrome P450 eicosanoids and cerebral vascular function. Expert Rev Mol Med. 2011, 13: e7-","journal-title":"Expert Rev Mol Med"},{"key":"5009_CR11","first-page":"201","volume":"21A","author":"EF Ellis","year":"1991","unstructured":"Ellis EF, Amruthesh SC, Police RJ, Yancey LM: Brain synthesis and cerebrovascular action of cytochrome P-450\/monooxygenase metabolites of arachidonic acid. Adv Prostaglandin Thromboxane Leukot Res. 1991, 21A: 201-204.","journal-title":"Adv Prostaglandin Thromboxane Leukot Res"},{"issue":"1 Pt 2","key":"5009_CR12","first-page":"H333","volume":"273","author":"CW Leffler","year":"1997","unstructured":"Leffler CW, Fedinec AL: Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids. Am J Physiol. 1997, 273 (1 Pt 2): H333-H338.","journal-title":"Am J Physiol"},{"issue":"5","key":"5009_CR13","doi-asserted-by":"crossref","first-page":"H2029","DOI":"10.1152\/ajpheart.01130.2000","volume":"283","author":"X Peng","year":"2002","unstructured":"Peng X, Carhuapoma JR, Bhardwaj A, Alkayed NJ, Falck JR, Harder DR, Traystman RJ, Koehler RC: Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. Am J Physiol Heart Circ Physiol. 2002, 283 (5): H2029-H2037.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"5009_CR14","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1113\/expphysiol.2006.036889","volume":"92","author":"JJ Iliff","year":"2007","unstructured":"Iliff JJ, Close LN, Selden NR, Alkayed NJ: A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat. Exp Physiol. 2007, 92 (4): 653-658.","journal-title":"Exp Physiol"},{"issue":"7","key":"5009_CR15","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1161\/STROKEAHA.107.508325","volume":"39","author":"W Zhang","year":"2008","unstructured":"Zhang W, Otsuka T, Sugo N, Ardeshiri A, Alhadid YK, Iliff JJ, DeBarber AE, Koop DR, Alkayed NJ: Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia. Stroke. 2008, 39 (7): 2073-2078. 10.1161\/STROKEAHA.107.508325.","journal-title":"Stroke"},{"issue":"3","key":"5009_CR16","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1161\/01.RES.78.3.415","volume":"78","author":"WB Campbell","year":"1996","unstructured":"Campbell WB, Gebremedhin D, Pratt PF, Harder DR: Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res. 1996, 78 (3): 415-423. 10.1161\/01.RES.78.3.415.","journal-title":"Circ Res"},{"issue":"1 Pt 2","key":"5009_CR17","first-page":"R228","volume":"270","author":"AP Zou","year":"1996","unstructured":"Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ: 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. Am J Physiol. 1996, 270 (1 Pt 2): R228-R237.","journal-title":"Am J Physiol"},{"issue":"2","key":"5009_CR18","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0006-2952(00)00317-8","volume":"60","author":"SN Wu","year":"2000","unstructured":"Wu SN, Li HF, Chiang HT: Actions of epoxyeicosatrienoic acid on large-conductance Ca(2+)-activated K(+) channels in pituitary GH(3) cells. Biochem Pharmacol. 2000, 60 (2): 251-262. 10.1016\/S0006-2952(00)00317-8.","journal-title":"Biochem Pharmacol"},{"issue":"27","key":"5009_CR19","doi-asserted-by":"publisher","first-page":"25467","DOI":"10.1074\/jbc.M100545200","volume":"276","author":"W Qu","year":"2001","unstructured":"Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR: Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain. J Biol Chem. 2001, 276 (27): 25467-25479. 10.1074\/jbc.M100545200.","journal-title":"J Biol Chem"},{"issue":"3","key":"5009_CR20","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1097\/00041433-200206000-00007","volume":"13","author":"DL Kroetz","year":"2002","unstructured":"Kroetz DL, Zeldin DC: Cytochrome P450 pathways of arachidonic acid metabolism. Curr Opin Lipidol. 2002, 13 (3): 273-283. 10.1097\/00041433-200206000-00007.","journal-title":"Curr Opin Lipidol"},{"issue":"3","key":"5009_CR21","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/jnr.10580","volume":"72","author":"S Ferroni","year":"2003","unstructured":"Ferroni S, Valente P, Caprini M, Nobile M, Schubert P, Rapisarda C: Arachidonic acid activates an open rectifier potassium channel in cultured rat cortical astrocytes. J Neurosci Res. 2003, 72 (3): 363-372. 10.1002\/jnr.10580.","journal-title":"J Neurosci Res"},{"issue":"1\u20134","key":"5009_CR22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.prostaglandins.2006.05.004","volume":"82","author":"B Inceoglu","year":"2007","unstructured":"Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD: Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins Other Lipid Mediat. 2007, 82 (1\u20134): 42-49.","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"6","key":"5009_CR23","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1111\/j.1471-4159.2010.07059.x","volume":"115","author":"JJ Iliff","year":"2010","unstructured":"Iliff JJ, Fairbanks SL, Balkowiec A, Alkayed NJ: Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons. J Neurochem. 2010, 115 (6): 1530-1542. 10.1111\/j.1471-4159.2010.07059.x.","journal-title":"J Neurochem"},{"issue":"5","key":"5009_CR24","doi-asserted-by":"publisher","first-page":"C1068","DOI":"10.1152\/ajpcell.00225.2010","volume":"299","author":"H Higashimori","year":"2010","unstructured":"Higashimori H, Blanco VM, Tuniki VR, Falck JR, Filosa JA: Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K+ signaling in perivascular astrocytes. Am J Physiol Cell Physiol. 2010, 299 (5): C1068-C1078. 10.1152\/ajpcell.00225.2010.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"5009_CR25","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0165-6147(00)01472-3","volume":"21","author":"WB Campbell","year":"2000","unstructured":"Campbell WB: New role for epoxyeicosatrienoic acids as anti-inflammatory mediators. Trends Pharmacol Sci. 2000, 21 (4): 125-127. 10.1016\/S0165-6147(00)01472-3.","journal-title":"Trends Pharmacol Sci"},{"issue":"18","key":"5009_CR26","doi-asserted-by":"publisher","first-page":"6322","DOI":"10.1128\/MCB.21.18.6322-6331.2001","volume":"21","author":"JK Chen","year":"2001","unstructured":"Chen JK, Capdevila J, Harris RC: Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis. Mol Cell Biol. 2001, 21 (18): 6322-6331. 10.1128\/MCB.21.18.6322-6331.2001.","journal-title":"Mol Cell Biol"},{"key":"5009_CR27","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1126\/science.285.5431.1276","volume":"285","author":"K Node","year":"1999","unstructured":"Node K, Huo YQ, Ruan XL, Yang BC, Spiecker M, Ley K, Zeldin DC, Liao JK: Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science. 1999, 285: 1276-1279. 10.1126\/science.285.5431.1276.","journal-title":"Science"},{"issue":"1","key":"5009_CR28","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1523\/JNEUROSCI.22-01-00257.2002","volume":"22","author":"AJ Hampson","year":"2002","unstructured":"Hampson AJ, Grimaldi M: 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor. J Neurosci. 2002, 22 (1): 257-264.","journal-title":"J Neurosci"},{"issue":"4","key":"5009_CR29","first-page":"632","volume":"117","author":"E Abdu","year":"2011","unstructured":"Abdu E, Bruun DA, Yang D, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ: Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. J Neurochem. 2011, 117 (4): 632-642.","journal-title":"J Neurochem"},{"key":"5009_CR30","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/1744-8069-7-78","volume":"7","author":"C Brenneis","year":"2011","unstructured":"Brenneis C, Sisignano M, Coste O, Altenrath K, Fischer MJ, Angioni C, Fleming I, Brandes RP, Reeh PW, Woolf CJ: Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation. Mol Pain. 2011, 7: 78-10.1186\/1744-8069-7-78.","journal-title":"Mol Pain"},{"issue":"12","key":"5009_CR31","doi-asserted-by":"publisher","first-page":"5093","DOI":"10.1073\/pnas.1101073108","volume":"108","author":"B Inceoglu","year":"2011","unstructured":"Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD: Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A. 2011, 108 (12): 5093-5097. 10.1073\/pnas.1101073108.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"18","key":"5009_CR32","doi-asserted-by":"publisher","first-page":"6364","DOI":"10.1523\/JNEUROSCI.5793-11.2012","volume":"32","author":"M Sisignano","year":"2012","unstructured":"Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R: 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. J Neurosci. 2012, 32 (18): 6364-6372. 10.1523\/JNEUROSCI.5793-11.2012.","journal-title":"J Neurosci"},{"issue":"2","key":"5009_CR33","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1124\/jpet.108.136739","volume":"326","author":"M Terashvili","year":"2008","unstructured":"Terashvili M, Tseng LF, Wu HE, Narayanan J, Hart LM, Falck JR, Pratt PF, Harder DR: Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. J Pharmacol Exp Ther. 2008, 326 (2): 614-622. 10.1124\/jpet.108.136739.","journal-title":"J Pharmacol Exp Ther"},{"issue":"1\u20134","key":"5009_CR34","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.prostaglandins.2011.08.001","volume":"96","author":"K Wagner","year":"2011","unstructured":"Wagner K, Inceoglu B, Hammock BD: Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. Prostaglandins Other Lipid Mediat. 2011, 96 (1\u20134): 76-83.","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"5","key":"5009_CR35","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3171\/jns.1982.56.5.0695","volume":"56","author":"EP Wei","year":"1982","unstructured":"Wei EP, Lamb RG, Kontos HA: Increased phospholipase C activity after experimental brain injury. J Neurosurg. 1982, 56 (5): 695-698. 10.3171\/jns.1982.56.5.0695.","journal-title":"J Neurosurg"},{"issue":"1","key":"5009_CR36","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1471-4159.1997.69010199.x","volume":"69","author":"P Homayoun","year":"1997","unstructured":"Homayoun P, Rodriguez deTurco EB, Parkins NE, Lane DC, Soblosky J, Carey ME, Bazan NG: Delayed phospholipid degradation in rat brain after traumatic brain injury. J Neurochem. 1997, 69 (1): 199-205.","journal-title":"J Neurochem"},{"issue":"1","key":"5009_CR37","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.brainresrev.2003.10.002","volume":"44","author":"JW Phillis","year":"2004","unstructured":"Phillis JW, O'Regan MH: A potentially critical role of phospholipases in central nervous system ischemic, traumatic, and neurodegenerative disorders. Brain Res Brain Res Rev. 2004, 44 (1): 13-47. 10.1016\/j.brainresrev.2003.10.002.","journal-title":"Brain Res Brain Res Rev"},{"issue":"2","key":"5009_CR38","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/S0304-3940(03)00803-6","volume":"349","author":"JG Pilitsis","year":"2003","unstructured":"Pilitsis JG, Coplin WM, O'Regan MH, Wellwood JM, Diaz FG, Fairfax MR, Michael DB, Phillis JW: Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury. Neuroscience Letters. 2003, 349 (2): 136-138. 10.1016\/S0304-3940(03)00803-6.","journal-title":"Neuroscience Letters"},{"issue":"8","key":"5009_CR39","first-page":"2326","volume":"40","author":"HA Kontos","year":"1981","unstructured":"Kontos HA, Wei EP, Ellis EF, Dietrich WD, Povlishock JT: Prostaglandins in physiological and in certain pathological responses of the cerebral circulation. Fed Proc. 1981, 40 (8): 2326-2330.","journal-title":"Fed Proc"},{"issue":"3","key":"5009_CR40","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/j.1471-4159.1985.tb04059.x","volume":"45","author":"SA Adesuyi","year":"1985","unstructured":"Adesuyi SA, Cockrell CS, Gamache DA, Ellis EF: Lipoxygenase metabolism of arachidonic acid in brain. J Neurochem. 1985, 45 (3): 770-776. 10.1111\/j.1471-4159.1985.tb04059.x.","journal-title":"J Neurochem"},{"issue":"1","key":"5009_CR41","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/jcbfm.1987.8","volume":"7","author":"E Shohami","year":"1987","unstructured":"Shohami E, Shapira Y, Sidi A, Cotev S: Head injury induces increased prostaglandin synthesis in rat brain. J Cereb Blood Flow Metab. 1987, 7 (1): 58-63. 10.1038\/jcbfm.1987.8.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"5009_CR42","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0090-6980(87)90068-2","volume":"34","author":"JY Westcott","year":"1987","unstructured":"Westcott JY, Murphy RC, Stenmark K: Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. Prostaglandins. 1987, 34 (6): 877-887.","journal-title":"Prostaglandins"},{"issue":"1","key":"5009_CR43","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1089\/neu.1989.6.31","volume":"6","author":"EF Ellis","year":"1989","unstructured":"Ellis EF, Police RJ, Rice LY, Grabeel M, Holt S: Increased plasma PGE2, 6-keto-PGF1 alpha, and 12-HETE levels following experimental concussive brain injury. J Neurotrauma. 1989, 6 (1): 31-37. 10.1089\/neu.1989.6.31.","journal-title":"J Neurotrauma"},{"issue":"3 Pt 2","key":"5009_CR44","first-page":"H1249","volume":"268","author":"T Ohtsuki","year":"1995","unstructured":"Ohtsuki T, Matsumoto M, Hayashi Y, Yamamoto K, Kitagawa K, Ogawa S, Yamamoto S, Kamada T: Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. Am J Physiol. 1995, 268 (3 Pt 2): H1249-H1257.","journal-title":"Am J Physiol"},{"issue":"12","key":"5009_CR45","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1089\/neu.1996.13.781","volume":"13","author":"HS Dhillon","year":"1996","unstructured":"Dhillon HS, Dose JM, Prasad MR: Regional generation of leukotriene C4 after experimental brain injury in anesthetized rats. J Neurotrauma. 1996, 13 (12): 781-789. 10.1089\/neu.1996.13.781.","journal-title":"J Neurotrauma"},{"issue":"1","key":"5009_CR46","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1471-4159.1996.66010147.x","volume":"66","author":"CH Lammers","year":"1996","unstructured":"Lammers CH, Schweitzer P, Facchinetti P, Arrang JM, Madamba SG, Siggins GR, Piomelli D: Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling. J Neurochem. 1996, 66 (1): 147-152.","journal-title":"J Neurochem"},{"issue":"8","key":"5009_CR47","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1089\/089771500415436","volume":"17","author":"KI Strauss","year":"2000","unstructured":"Strauss KI, Barbe MF, Marshall RM, Raghupathi R, Mehta S, Narayan RK: Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat. J Neurotrauma. 2000, 17 (8): 695-711. 10.1089\/089771500415436. [erratum appears in J Neurotrauma 2000 Nov;17(11):1115]","journal-title":"J Neurotrauma"},{"issue":"9","key":"5009_CR48","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1089\/089771502760341965","volume":"19","author":"T Kunz","year":"2002","unstructured":"Kunz T, Marklund N, Hillered L, Oliw EH: Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the rat. J Neurotrauma. 2002, 19 (9): 1051-1064. 10.1089\/089771502760341965.","journal-title":"J Neurotrauma"},{"issue":"2\u20134","key":"5009_CR49","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuint.2007.05.009","volume":"51","author":"T Takemiya","year":"2007","unstructured":"Takemiya T, Matsumura K, Yamagata K: Roles of prostaglandin synthesis in excitotoxic brain diseases. Neurochem Int. 2007, 51 (2\u20134): 112-120.","journal-title":"Neurochem Int"},{"issue":"10","key":"5009_CR50","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1089\/neu.2008.0542","volume":"25","author":"Y Wang","year":"2008","unstructured":"Wang Y, Zhao J, Kalsotra A, Turman CM, Grill RJ, Dash PK, Strobel HW: CYP4Fs expression in rat brain correlates with changes in LTB4 levels after traumatic brain injury. J Neurotrauma. 2008, 25 (10): 1187-1194. 10.1089\/neu.2008.0542.","journal-title":"J Neurotrauma"},{"issue":"3","key":"5009_CR51","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1227\/01.NEU.0000154060.14900.8F","volume":"56","author":"JJ Gopez","year":"2005","unstructured":"Gopez JJ, Yue H, Vasudevan R, Malik AS, Fogelsanger LN, Lewis S, Panikashvili D, Shohami E, Jansen SA, Narayan RK: Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury. Neurosurgery. 2005, 56 (3): 590-604. 10.1227\/01.NEU.0000154060.14900.8F.","journal-title":"Neurosurgery"},{"issue":"6","key":"5009_CR52","doi-asserted-by":"publisher","first-page":"478","DOI":"10.2133\/dmpk.20.478","volume":"20","author":"S Imaoka","year":"2005","unstructured":"Imaoka S, Hashizume T, Funae Y: Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs. Drug Metab Pharmacokinet. 2005, 20 (6): 478-484. 10.2133\/dmpk.20.478.","journal-title":"Drug Metab Pharmacokinet"},{"issue":"8","key":"5009_CR53","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/sj.jcbfm.9600085","volume":"25","author":"M Liu","year":"2005","unstructured":"Liu M, Alkayed NJ: Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes. J Cereb Blood Flow Metab. 2005, 25 (8): 939-948. 10.1038\/sj.jcbfm.9600085.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"5009_CR54","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jneumeth.2004.11.015","volume":"144","author":"SM Poloyac","year":"2005","unstructured":"Poloyac SM, Reynolds RB, Yonas H, Kerr ME: Identification and quantification of the hydroxyeicosatetraenoic acids, 20-HETE and 12-HETE, in the cerebrospinal fluid after subarachnoid hemorrhage. J Neurosci Methods. 2005, 144 (2): 257-263. 10.1016\/j.jneumeth.2004.11.015.","journal-title":"J Neurosci Methods"},{"key":"5009_CR55","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2011.07.058","volume":"194","author":"P Sarkar","year":"2011","unstructured":"Sarkar P, Narayanan J, Harder DR: Differential effect of amyloid beta on the cytochrome P450 epoxygenase activity in rat brain. Neuroscience. 2011, 194: 241-249.","journal-title":"Neuroscience"},{"issue":"10","key":"5009_CR56","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1016\/j.pain.2012.04.027","volume":"153","author":"S Ruparel","year":"2012","unstructured":"Ruparel S, Henry MA, Akopian A, Patil M, Zeldin DC, Roman L, Hargreaves KM: Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. Pain. 2012, 153 (10): 2031-2039. 10.1016\/j.pain.2012.04.027.","journal-title":"Pain"},{"key":"5009_CR57","volume-title":"Prostaglandins Other Lipid Mediat","author":"KI Strauss","year":"2012","unstructured":"Strauss KI, Gruzdev A, Zeldin DC: Improved functional recovery in soluble epoxide hydrolase knockout mice after traumatic brain injury. Prostaglandins Other Lipid Mediat. 2012, in press"},{"issue":"6982","key":"5009_CR58","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature02426","volume":"428","author":"RA Gibbs","year":"2004","unstructured":"Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE: Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 2004, 428 (6982): 493-521.","journal-title":"Nature"},{"key":"5009_CR59","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/1744-8069-8-73","volume":"8","author":"S Ruparel","year":"2012","unstructured":"Ruparel S, Green D, Chen P, Hargreaves KM: The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. Mol Pain. 2012, 8: 73-10.1186\/1744-8069-8-73.","journal-title":"Mol Pain"},{"issue":"4","key":"5009_CR60","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1111\/j.1471-4159.1981.tb04476.x","volume":"37","author":"EF Ellis","year":"1981","unstructured":"Ellis EF, Wright KF, Wei EP, Kontos HA: Cyclooxygenase products of arachidonic acid metabolism in cat cerebral cortex after experimental concussive brain injury. J Neurochem. 1981, 37 (4): 892-896. 10.1111\/j.1471-4159.1981.tb04476.x.","journal-title":"J Neurochem"},{"issue":"11","key":"5009_CR61","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1097\/00004647-199911000-00005","volume":"19","author":"M Nagayama","year":"1999","unstructured":"Nagayama M, Niwa K, Nagayama T, Ross ME, Iadecola C: The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene. J Cereb Blood Flow Metab. 1999, 19 (11): 1213-1219.","journal-title":"J Cereb Blood Flow Metab"},{"key":"5009_CR62","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1089\/neu.2000.17.69","volume":"17","author":"P Dash","year":"2000","unstructured":"Dash P, Mach S, Moore A: Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury. J Neurotrauma. 2000, 17: 69-81. 10.1089\/neu.2000.17.69.","journal-title":"J Neurotrauma"},{"issue":"3","key":"5009_CR63","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1073\/pnas.98.3.1294","volume":"98","author":"C Iadecola","year":"2001","unstructured":"Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S, Ross ME: Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc Natl Acad Sci U S A. 2001, 98 (3): 1294-1299. 10.1073\/pnas.98.3.1294.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"5009_CR64","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/S0006-8993(01)03358-3","volume":"927","author":"E Candelario-Jalil","year":"2002","unstructured":"Candelario-Jalil E, Alvarez D, Castaneda JM, Al-Dalain SM, Martinez-Sanchez G, Merino N, Leon OS: The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. Brain Res. 2002, 927 (2): 212-215. 10.1016\/S0006-8993(01)03358-3.","journal-title":"Brain Res"},{"issue":"2","key":"5009_CR65","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00221-002-1245-z","volume":"147","author":"I Cernak","year":"2002","unstructured":"Cernak I, O'Connor C, Vink R: Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats. Exp Brain Res. 2002, 147 (2): 193-199. 10.1007\/s00221-002-1245-z.","journal-title":"Exp Brain Res"},{"issue":"1","key":"5009_CR66","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1742-2094-2-3","volume":"2","author":"E Candelario-Jalil","year":"2005","unstructured":"Candelario-Jalil E, Mhadu NH, Gonzalez-Falcon A, Garcia-Cabrera M, Munoz E, Leon OS, Fiebich BL: Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. J Neuroinflammation. 2005, 2 (1): 3-10.1186\/1742-2094-2-3.","journal-title":"J Neuroinflammation"},{"key":"5009_CR67","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/1471-2202-10-108","volume":"10","author":"ML Kelso","year":"2009","unstructured":"Kelso ML, Scheff SW, Pauly JR, Loftin CD: Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice. BMC Neurosci. 2009, 10: 108-10.1186\/1471-2202-10-108.","journal-title":"BMC Neurosci"},{"key":"5009_CR68","volume-title":"Crit Care Med","author":"N Fathali","year":"2009","unstructured":"Fathali N, Ostrowski RP, Lekic T, Jadhav V, Tong W, Tang J, Zhang JH: Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury. Crit Care Med. 2009, in press"},{"issue":"2","key":"5009_CR69","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1097\/CCM.0b013e3181cb1158","volume":"38","author":"N Fathali","year":"2010","unstructured":"Fathali N, Ostrowski RP, Lekic T, Jadhav V, Tong W, Tang J, Zhang JH: Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury. Crit Care Med. 2010, 38 (2): 572-578. 10.1097\/CCM.0b013e3181cb1158.","journal-title":"Crit Care Med"},{"issue":"5","key":"5009_CR70","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1089\/089771503765355531","volume":"20","author":"AS Malik","year":"2003","unstructured":"Malik AS, Narayan RK, Wendling WW, Cole RW, Pashko LL, Schwartz AG, Strauss KI: A novel dehydroepiandrosterone analog improves functional recovery in a rat traumatic brain injury model. J Neurotrauma. 2003, 20 (5): 463-476. 10.1089\/089771503765355531.","journal-title":"J Neurotrauma"},{"key":"5009_CR71","first-page":"263","volume":"16","author":"KI Strauss","year":"2000","unstructured":"Strauss KI, Meagher RJ, Narayan RK: Hippocampal prostaglandin changes following TBI- treatment with COX2 inhibitors. Restor Neurol Neurosci. 2000, 16: 263-P298","journal-title":"Restor Neurol Neurosci"},{"key":"5009_CR72","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1089\/neu.1988.5.303","volume":"5","author":"D Dewitt","year":"1988","unstructured":"Dewitt D, Kong D, Lyeth B, Jenkins L, Hayes R, Wooten E, Prough D: Experimental traumatic brain injury elevates brain prostaglandin E2 and thromboxane B2 levels in rats. J Neurotrauma. 1988, 5: 303-313. 10.1089\/neu.1988.5.303.","journal-title":"J Neurotrauma"},{"issue":"1","key":"5009_CR73","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/jcbfm.1990.20","volume":"10","author":"JA Yergey","year":"1990","unstructured":"Yergey JA, Heyes MP: Brain eicosanoid formation following acute penetration injury as studied by in vivo microdialysis. J Cerebr Blood Flow Metabol. 1990, 10 (1): 143-146. 10.1038\/jcbfm.1990.20.","journal-title":"J Cerebr Blood Flow Metabol"},{"issue":"4","key":"5009_CR74","doi-asserted-by":"crossref","first-page":"L744","DOI":"10.1152\/ajplung.2000.278.4.L744","volume":"278","author":"L Ermert","year":"2000","unstructured":"Ermert L, Ermert M, Duncker HR, Grimminger F, Seeger W: In situ localization and regulation of thromboxane A(2) synthase in normal and LPS-primed lungs. Am J Physiol Lung Cell Mol Physiol. 2000, 278 (4): L744-L753.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"5","key":"5009_CR75","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1097\/00005072-199805000-00008","volume":"57","author":"W McDonough","year":"1998","unstructured":"McDonough W, Tran N, Giese A, Norman SA, Berens ME: Altered gene expression in human astrocytoma cells selected for migration: I. Thromboxane synthase. J Neuropathol Exp Neurol. 1998, 57 (5): 449-455. 10.1097\/00005072-199805000-00008.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"11","key":"5009_CR76","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/S0300-9084(00)88886-0","volume":"80","author":"G Levi","year":"1998","unstructured":"Levi G, Minghetti L, Aloisi F: Regulation of prostanoid synthesis in microglial cells and effects of prostaglandin E2 on microglial functions. Biochimie. 1998, 80 (11): 899-904. 10.1016\/S0300-9084(00)88886-0.","journal-title":"Biochimie"},{"issue":"7","key":"5009_CR77","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1002\/jnr.21061","volume":"84","author":"S Ramamurthy","year":"2006","unstructured":"Ramamurthy S, Mir F, Gould RM, Le Breton GC: Characterization of thromboxane A2 receptor signaling in developing rat oligodendrocytes: nuclear receptor localization and stimulation of myelin basic protein expression. J Neurosci Res. 2006, 84 (7): 1402-1414. 10.1002\/jnr.21061.","journal-title":"J Neurosci Res"},{"issue":"1","key":"5009_CR78","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1523\/JNEUROSCI.4485-03.2004","volume":"24","author":"L McCullough","year":"2004","unstructured":"McCullough L, Wu L, Haughey N, Liang X, Hand T, Wang Q, Breyer RM, Andreasson K: Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. J Neurosci. 2004, 24 (1): 257-268. 10.1523\/JNEUROSCI.4485-03.2004.","journal-title":"J Neurosci"},{"issue":"12","key":"5009_CR79","doi-asserted-by":"publisher","first-page":"7207","DOI":"10.4049\/jimmunol.0903487","volume":"184","author":"J Shi","year":"2010","unstructured":"Shi J, Johansson J, Woodling NS, Wang Q, Montine TJ, Andreasson K: The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity. J Immunol. 2010, 184 (12): 7207-7218. 10.4049\/jimmunol.0903487.","journal-title":"J Immunol"},{"issue":"8","key":"5009_CR80","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1046\/j.1460-9568.1999.00682.x","volume":"11","author":"J Zhang","year":"1999","unstructured":"Zhang J, Rivest S: Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation. Eur J Neurosci. 1999, 11 (8): 2651-2668. 10.1046\/j.1460-9568.1999.00682.x.","journal-title":"Eur J Neurosci"},{"issue":"5","key":"5009_CR81","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1089\/neu.1995.12.791","volume":"12","author":"NG Bazan","year":"1995","unstructured":"Bazan NG, Rodriguez de Turco EB, Allan G: Mediators of injury in neurotrauma: intracellular signal transduction and gene expression. J Neurotrauma. 1995, 12 (5): 791-814. 10.1089\/neu.1995.12.791.","journal-title":"J Neurotrauma"},{"issue":"5","key":"5009_CR82","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3171\/jns.1985.63.5.0659","volume":"63","author":"JB Leslie","year":"1985","unstructured":"Leslie JB, Watkins WD: Eicosanoids in the central nervous system. J Neurosurg. 1985, 63 (5): 659-668. 10.3171\/jns.1985.63.5.0659.","journal-title":"J Neurosurg"},{"issue":"2","key":"5009_CR83","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.brainresrev.2006.02.002","volume":"52","author":"JW Phillis","year":"2006","unstructured":"Phillis JW, Horrocks LA, Farooqui AA: Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders. Brain Res Rev. 2006, 52 (2): 201-243. 10.1016\/j.brainresrev.2006.02.002.","journal-title":"Brain Res Rev"},{"issue":"1","key":"5009_CR84","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1089\/108076804772745473","volume":"20","author":"S Ashkar","year":"2004","unstructured":"Ashkar S, Mesentsev A, Zhang WX, Mastyugin V, Dunn MW, Laniado-Schwartzman M: Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids. J Ocul Pharmacol Ther. 2004, 20 (1): 65-74. 10.1089\/108076804772745473.","journal-title":"J Ocul Pharmacol Ther"},{"issue":"3","key":"5009_CR85","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/S0022-3565(24)38312-0","volume":"289","author":"V Mastyugin","year":"1999","unstructured":"Mastyugin V, Aversa E, Bonazzi A, Vafaes C, Mieyal P, Schwartzman ML: Hypoxia-induced production of 12-hydroxyeicosanoids in the corneal epithelium: involvement of a cytochrome P-4504B1 isoform. J Pharmacol Exp Ther. 1999, 289 (3): 1611-1619.","journal-title":"J Pharmacol Exp Ther"},{"issue":"24","key":"5009_CR86","doi-asserted-by":"publisher","first-page":"21542","DOI":"10.1074\/jbc.M213174200","volume":"278","author":"S Canals","year":"2003","unstructured":"Canals S, Casarejos MJ, de Bernardo S, Rodriguez-Martin E, Mena MA: Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase. J Biol Chem. 2003, 278 (24): 21542-21549. 10.1074\/jbc.M213174200.","journal-title":"J Biol Chem"},{"issue":"2","key":"5009_CR87","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.neuroscience.2006.04.012","volume":"141","author":"Y Chiba","year":"2006","unstructured":"Chiba Y, Shimada A, Satoh M, Saitoh Y, Kawamura N, Hanai A, Keino H, Ide Y, Shimizu T, Hosokawa M: Sensory system-predominant distribution of leukotriene A4 hydrolase and its colocalization with calretinin in the mouse nervous system. Neuroscience. 2006, 141 (2): 917-927. 10.1016\/j.neuroscience.2006.04.012.","journal-title":"Neuroscience"},{"issue":"2","key":"5009_CR88","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S0022-3565(25)39399-7","volume":"267","author":"S Imaoka","year":"1993","unstructured":"Imaoka S, Wedlund PJ, Ogawa H, Kimura S, Gonzalez FJ, Kim HY: Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase. J Pharmacol Exp Ther. 1993, 267 (2): 1012-1016.","journal-title":"J Pharmacol Exp Ther"},{"issue":"6","key":"5009_CR89","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1172\/JCI7013","volume":"104","author":"VR Holla","year":"1999","unstructured":"Holla VR, Makita K, Zaphiropoulos PG, Capdevila JH: The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. J Clin Invest. 1999, 104 (6): 751-760. 10.1172\/JCI7013.","journal-title":"J Clin Invest"},{"issue":"7","key":"5009_CR90","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1194\/jlr.M002840","volume":"51","author":"L Qian","year":"2010","unstructured":"Qian L, Zolfaghari R, Ross AC: Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver. J Lipid Res. 2010, 51 (7): 1781-1792. 10.1194\/jlr.M002840.","journal-title":"J Lipid Res"},{"issue":"5","key":"5009_CR91","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0026-895X(24)26512-3","volume":"57","author":"Z Yu","year":"2000","unstructured":"Yu Z, Huse LM, Adler P, Graham L, Ma J, Zeldin DC, Kroetz DL: Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. Mol Pharmacol. 2000, 57 (5): 1011-1020.","journal-title":"Mol Pharmacol"},{"issue":"5","key":"5009_CR92","doi-asserted-by":"publisher","first-page":"H1352","DOI":"10.1152\/ajpheart.00950.2008","volume":"296","author":"JJ Iliff","year":"2009","unstructured":"Iliff JJ, Wang R, Zeldin DC, Alkayed NJ: Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels. Am J Physiol Heart Circ Physiol. 2009, 296 (5): H1352-H1363. 10.1152\/ajpheart.00950.2008.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"5009_CR93","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.addr.2011.03.006","volume":"63","author":"X Xu","year":"2011","unstructured":"Xu X, Zhang XA, Wang DW: The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases. Adv Drug Deliv Rev. 2011, 63 (8): 597-609. 10.1016\/j.addr.2011.03.006.","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"5009_CR94","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/HJH.0b013e32833f5de5","volume":"29","author":"J Bolbrinker","year":"2011","unstructured":"Bolbrinker J, Beige J, Huber M, Sharma A, Thomas A, Deter H, Kreutz R: Role of CYP2C9 genetic variants for salt sensitivity and the regulation of the renin-angiotensin-aldosterone system in normotensive men. J Hypertens. 2011, 29 (1): 56-61. 10.1097\/HJH.0b013e32833f5de5.","journal-title":"J Hypertens"},{"issue":"1","key":"5009_CR95","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/MNH.0b013e32831a9df7","volume":"18","author":"NO Camara","year":"2009","unstructured":"Camara NO, Martins JO, Landgraf RG, Jancar S: Emerging roles for eicosanoids in renal diseases. Curr Opin Nephrol Hypertens. 2009, 18 (1): 21-27. 10.1097\/MNH.0b013e32831a9df7.","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"5","key":"5009_CR96","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/MNH.0b013e32827ab48c","volume":"16","author":"JH Capdevila","year":"2007","unstructured":"Capdevila JH: Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Curr Opin Nephrol Hypertens. 2007, 16 (5): 465-470. 10.1097\/MNH.0b013e32827ab48c.","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"3","key":"5009_CR97","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0306-3623(96)00246-7","volume":"28","author":"AE Simpson","year":"1997","unstructured":"Simpson AE: The cytochrome P450 4 (CYP4) family. Gen Pharmacol. 1997, 28 (3): 351-359. 10.1016\/S0306-3623(96)00246-7.","journal-title":"Gen Pharmacol"},{"issue":"9","key":"5009_CR98","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1291\/hypres.31.1821","volume":"31","author":"CJ Ying","year":"2008","unstructured":"Ying CJ, Noguchi T, Aso H, Ikeda K, Yamori Y, Nara Y: The role of cytochrome p-450 in salt-sensitive stroke in stroke-prone spontaneously hypertensive rats. Hypertens Res. 2008, 31 (9): 1821-1827. 10.1291\/hypres.31.1821.","journal-title":"Hypertens Res"},{"issue":"6","key":"5009_CR99","first-page":"497","volume":"23","author":"F Zhang","year":"2002","unstructured":"Zhang F, Qian JQ, Wang DW: Arachidonate CYP hydroxylases of kidney contribute to formation of hypertension and maintenance of blood pressure. Acta Pharmacol Sin. 2002, 23 (6): 497-502.","journal-title":"Acta Pharmacol Sin"},{"issue":"6","key":"5009_CR100","doi-asserted-by":"publisher","first-page":"H2455","DOI":"10.1152\/ajpheart.00512.2008","volume":"295","author":"KM Dunn","year":"2008","unstructured":"Dunn KM, Renic M, Flasch AK, Harder DR, Falck J, Roman RJ: Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2008, 295 (6): H2455-H2465. 10.1152\/ajpheart.00512.2008.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2 Pt 2","key":"5009_CR101","first-page":"F246","volume":"276","author":"MH Wang","year":"1999","unstructured":"Wang MH, Guan H, Nguyen X, Zand BA, Nasjletti A, Laniado-Schwartzman M: Contribution of cytochrome P-450 4A1 and 4A2 to vascular 20-hydroxyeicosatetraenoic acid synthesis in rat kidneys. Am J Physiol. 1999, 276 (2 Pt 2): F246-F253.","journal-title":"Am J Physiol"},{"issue":"1","key":"5009_CR102","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1006\/abbi.1999.1504","volume":"373","author":"U Hoch","year":"2000","unstructured":"Hoch U, Zhang Z, Kroetz DL, Ortiz de Montellano PR: Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases. Arch Biochem Biophys. 2000, 373 (1): 63-71. 10.1006\/abbi.1999.1504.","journal-title":"Arch Biochem Biophys"},{"issue":"9","key":"5009_CR103","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/sj.cr.7290341","volume":"15","author":"F Zhang","year":"2005","unstructured":"Zhang F, Chen CL, Qian JQ, Yan JT, Cianflone K, Xiao X, Wang DW: Long-term modifications of blood pressure in normotensive and spontaneously hypertensive rats by gene delivery of rAAV-mediated cytochrome P450 arachidonic acid hydroxylase. Cell Res. 2005, 15 (9): 717-724. 10.1038\/sj.cr.7290341.","journal-title":"Cell Res"},{"issue":"2","key":"5009_CR104","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1006\/abbi.1997.9922","volume":"340","author":"QY Zhang","year":"1997","unstructured":"Zhang QY, Ding X, Kaminsky LS: CDNA cloning, heterologous expression, and characterization of rat intestinal CYP2J4. Arch Biochem Biophys. 1997, 340 (2): 270-278. 10.1006\/abbi.1997.9922.","journal-title":"Arch Biochem Biophys"},{"issue":"8","key":"5009_CR105","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.1074\/jbc.M311830200","volume":"279","author":"SS Chuang","year":"2004","unstructured":"Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B: CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. J Biol Chem. 2004, 279 (8): 6305-6314.","journal-title":"J Biol Chem"},{"issue":"1","key":"5009_CR106","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1006\/abbi.1997.0342","volume":"347","author":"H Kawashima","year":"1997","unstructured":"Kawashima H, Kusunose E, Thompson CM, Strobel HW: Protein expression, characterization, and regulation of CYP4F4 and CYP4F5 cloned from rat brain. Arch Biochem Biophys. 1997, 347 (1): 148-154. 10.1006\/abbi.1997.0342.","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"5009_CR107","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1124\/jpet.103.059626","volume":"308","author":"F Xu","year":"2004","unstructured":"Xu F, Falck JR, Ortiz de Montellano PR, Kroetz DL: Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. J Pharmacol Exp Ther. 2004, 308 (3): 887-895.","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"5009_CR108","doi-asserted-by":"publisher","first-page":"7189","DOI":"10.1074\/jbc.M513101200","volume":"281","author":"P Christmas","year":"2006","unstructured":"Christmas P, Tolentino K, Primo V, Berry KZ, Murphy RC, Chen M, Lee DM, Soberman RJ: Cytochrome P-450 4F18 is the leukotriene B4 omega-1\/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4. J Biol Chem. 2006, 281 (11): 7189-7196. 10.1074\/jbc.M513101200.","journal-title":"J Biol Chem"},{"issue":"1","key":"5009_CR109","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1124\/jpet.105.088211","volume":"315","author":"A Mezentsev","year":"2005","unstructured":"Mezentsev A, Mastyugin V, Seta F, Ashkar S, Kemp R, Reddy DS, Falck JR, Dunn MW, Laniado-Schwartzman M: Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels. J Pharmacol Exp Ther. 2005, 315 (1): 42-50. 10.1124\/jpet.105.088211.","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"5009_CR110","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1089\/neu.1997.14.179","volume":"14","author":"RS Clark","year":"1997","unstructured":"Clark RS, Kochanek PM, Dixon CE, Chen M, Marion DW, Heineman S, DeKosky ST, Graham SH: Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact injury in rats. J Neurotrauma. 1997, 14 (4): 179-189. 10.1089\/neu.1997.14.179.","journal-title":"J Neurotrauma"},{"issue":"15","key":"5009_CR111","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.1523\/JNEUROSCI.18-15-05663.1998","volume":"18","author":"AC Conti","year":"1998","unstructured":"Conti AC, Raghupathi R, Trojanowski JQ, McIntosh TK: Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period. J Neurosci. 1998, 18 (15): 5663-5672.","journal-title":"J Neurosci"},{"issue":"10","key":"5009_CR112","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1089\/neu.2000.17.927","volume":"17","author":"R Raghupathi","year":"2000","unstructured":"Raghupathi R, Graham DI, McIntosh TK: Apoptosis after traumatic brain injury. J Neurotrauma. 2000, 17 (10): 927-938. 10.1089\/neu.2000.17.927.","journal-title":"J Neurotrauma"},{"issue":"3","key":"5009_CR113","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/S0006-291X(02)00918-X","volume":"296","author":"J Bylund","year":"2002","unstructured":"Bylund J, Zhang C, Harder DR: Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. Biochem Biophys Res Commun. 2002, 296 (3): 677-684. 10.1016\/S0006-291X(02)00918-X.","journal-title":"Biochem Biophys Res Commun"},{"issue":"14","key":"5009_CR114","doi-asserted-by":"publisher","first-page":"3706","DOI":"10.1111\/j.1742-4658.2008.06518.x","volume":"275","author":"K Stark","year":"2008","unstructured":"Stark K, Dostalek M, Guengerich FP: Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. FEBS J. 2008, 275 (14): 3706-3717. 10.1111\/j.1742-4658.2008.06518.x.","journal-title":"FEBS J"},{"issue":"1","key":"5009_CR115","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1124\/pr.109.001081","volume":"62","author":"NT Snider","year":"2010","unstructured":"Snider NT, Walker VJ, Hollenberg PF: Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications. Pharmacol Rev. 2010, 62 (1): 136-154. 10.1124\/pr.109.001081.","journal-title":"Pharmacol Rev"},{"issue":"1","key":"5009_CR116","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.expneurol.2010.03.022","volume":"224","author":"HS Hansen","year":"2010","unstructured":"Hansen HS: Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain. Exp Neurol. 2010, 224 (1): 48-55. 10.1016\/j.expneurol.2010.03.022.","journal-title":"Exp Neurol"},{"issue":"7","key":"5009_CR117","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1111\/j.1476-5381.2011.01343.x","volume":"163","author":"E Shohami","year":"2011","unstructured":"Shohami E, Cohen-Yeshurun A, Magid L, Algali M, Mechoulam R: Endocannabinoids and traumatic brain injury. Br J Pharmacol. 2011, 163 (7): 1402-1410. 10.1111\/j.1476-5381.2011.01343.x.","journal-title":"Br J Pharmacol"},{"issue":"29","key":"5009_CR118","doi-asserted-by":"publisher","first-page":"25574","DOI":"10.1074\/jbc.M111.236877","volume":"286","author":"L Mateos","year":"2011","unstructured":"Mateos L, Ismail MA, Gil-Bea FJ, Schule R, Schols L, Heverin M, Folkesson R, Bjorkhem I, Cedazo-Minguez A: Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. J Biol Chem. 2011, 286 (29): 25574-25585. 10.1074\/jbc.M111.236877.","journal-title":"J Biol Chem"},{"issue":"4","key":"5009_CR119","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0026-895X(25)13257-4","volume":"44","author":"PM Shaw","year":"1993","unstructured":"Shaw PM, Adesnik M, Weiss MC, Corcos L: The phenobarbital-induced transcriptional activation of cytochrome P-450 genes is blocked by the glucocorticoid-progesterone antagonist RU486. Mol Pharmacol. 1993, 44 (4): 775-783.","journal-title":"Mol Pharmacol"},{"issue":"2","key":"5009_CR120","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/0003-9861(95)90023-3","volume":"320","author":"AB Rifkind","year":"1995","unstructured":"Rifkind AB, Lee C, Chang TK, Waxman DJ: Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes. Arch Biochem Biophys. 1995, 320 (2): 380-389. 10.1016\/0003-9861(95)90023-3.","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"5009_CR121","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0022-3565(24)37230-1","volume":"284","author":"J Bylund","year":"1998","unstructured":"Bylund J, Kunz T, Valmsen K, Oliw EH: Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. J Pharmacol Exp Ther. 1998, 284 (1): 51-60.","journal-title":"J Pharmacol Exp Ther"},{"issue":"Pt 23","key":"5009_CR122","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1242\/jcs.02674","volume":"118","author":"UR Michaelis","year":"2005","unstructured":"Michaelis UR, Fisslthaler B, Barbosa-Sicard E, Falck JR, Fleming I, Busse R: Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis. J Cell Sci. 2005, 118 (Pt 23): 5489-5498.","journal-title":"J Cell Sci"},{"issue":"17","key":"5009_CR123","doi-asserted-by":"crossref","first-page":"12912","DOI":"10.1016\/S0021-9258(18)31472-8","volume":"268","author":"RM Laethem","year":"1993","unstructured":"Laethem RM, Balazy M, Falck JR, Laethem CL, Koop DR: Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1. J Biol Chem. 1993, 268 (17): 12912-12918.","journal-title":"J Biol Chem"},{"issue":"5","key":"5009_CR124","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1046\/j.1471-4159.1996.67052066.x","volume":"67","author":"N Tindberg","year":"1996","unstructured":"Tindberg N, Ingelman-Sundberg M: Expression, catalytic activity, and inducibility of cytochrome P450 2E1 (CYP2E1) in the rat central nervous system. J Neurochem. 1996, 67 (5): 2066-2073.","journal-title":"J Neurochem"},{"issue":"4","key":"5009_CR125","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/syn.1052","volume":"40","author":"H Nissbrandt","year":"2001","unstructured":"Nissbrandt H, Bergquist F, Jonason J, Engberg G: Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway?. Synapse. 2001, 40 (4): 294-301. 10.1002\/syn.1052.","journal-title":"Synapse"},{"issue":"2\u20133","key":"5009_CR126","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejphar.2009.09.062","volume":"626","author":"E Bromek","year":"2010","unstructured":"Bromek E, Haduch A, Daniel WA: The ability of cytochrome P450 2D isoforms to synthesize dopamine in the brain: An in vitro study. Eur J Pharmacol. 2010, 626 (2\u20133): 171-178.","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"5009_CR127","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/j.1471-4159.2011.07339.x","volume":"118","author":"E Bromek","year":"2011","unstructured":"Bromek E, Haduch A, Golembiowska K, Daniel WA: Cytochrome P450 mediates dopamine formation in the brain in vivo. J Neurochem. 2011, 118 (5): 806-815. 10.1111\/j.1471-4159.2011.07339.x.","journal-title":"J Neurochem"},{"issue":"4","key":"5009_CR128","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1046\/j.1471-4159.1994.63041426.x","volume":"63","author":"TK McIntosh","year":"1994","unstructured":"McIntosh TK, Yu T, Gennarelli TA: Alterations in regional brain catecholamine concentrations after experimental brain injury in the rat. J Neurochem. 1994, 63 (4): 1426-1433.","journal-title":"J Neurochem"},{"issue":"1","key":"5009_CR129","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1242\/dev.02706","volume":"134","author":"RE Hernandez","year":"2007","unstructured":"Hernandez RE, Putzke AP, Myers JP, Margaretha L, Moens CB: Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development. Development. 2007, 134 (1): 177-187. 10.1242\/dev.02706.","journal-title":"Development"},{"issue":"1","key":"5009_CR130","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.devcel.2009.11.010","volume":"18","author":"R Gonzalez-Quevedo","year":"2010","unstructured":"Gonzalez-Quevedo R, Lee Y, Poss KD, Wilkinson DG: Neuronal regulation of the spatial patterning of neurogenesis. Dev Cell. 2010, 18 (1): 136-147. 10.1016\/j.devcel.2009.11.010.","journal-title":"Dev Cell"},{"issue":"5773","key":"5009_CR131","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1126\/science.1125691","volume":"312","author":"J Bowles","year":"2006","unstructured":"Bowles J, Knight D, Smith C, Wilhelm D, Richman J, Mamiya S, Yashiro K, Chawengsaksophak K, Wilson MJ, Rossant J: Retinoid signaling determines germ cell fate in mice. Science. 2006, 312 (5773): 596-600. 10.1126\/science.1125691.","journal-title":"Science"},{"issue":"8","key":"5009_CR132","doi-asserted-by":"publisher","first-page":"6542","DOI":"10.1074\/jbc.M110.198382","volume":"286","author":"C Wang","year":"2011","unstructured":"Wang C, Kane MA, Napoli JL: Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. J Biol Chem. 2011, 286 (8): 6542-6553. 10.1074\/jbc.M110.198382.","journal-title":"J Biol Chem"},{"issue":"12","key":"5009_CR133","doi-asserted-by":"publisher","first-page":"3281","DOI":"10.1523\/JNEUROSCI.4955-05.2006","volume":"26","author":"M Hagglund","year":"2006","unstructured":"Hagglund M, Berghard A, Strotmann J, Bohm S: Retinoic acid receptor-dependent survival of olfactory sensory neurons in postnatal and adult mice. J Neurosci. 2006, 26 (12): 3281-3291. 10.1523\/JNEUROSCI.4955-05.2006.","journal-title":"J Neurosci"},{"issue":"1","key":"5009_CR134","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.bbapap.2010.06.021","volume":"1814","author":"AA Gilep","year":"2011","unstructured":"Gilep AA, Sushko TA, Usanov SA: At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17. Biochim Biophys Acta. 2011, 1814 (1): 200-209. 10.1016\/j.bbapap.2010.06.021.","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"5009_CR135","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1073\/pnas.2630225100","volume":"101","author":"Y Hojo","year":"2004","unstructured":"Hojo Y, Hattori TA, Enami T, Furukawa A, Suzuki K, Ishii HT, Mukai H, Morrison JH, Janssen WG, Kominami S: Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. Proc Natl Acad Sci U S A. 2004, 101 (3): 865-870. 10.1073\/pnas.2630225100.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"5009_CR136","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1111\/j.1471-4159.2005.03113.x","volume":"93","author":"C Kibaly","year":"2005","unstructured":"Kibaly C, Patte-Mensah C, Mensah-Nyagan AG: Molecular and neurochemical evidence for the biosynthesis of dehydroepiandrosterone in the adult rat spinal cord. J Neurochem. 2005, 93 (5): 1220-1230. 10.1111\/j.1471-4159.2005.03113.x.","journal-title":"J Neurochem"},{"issue":"12","key":"5009_CR137","doi-asserted-by":"publisher","first-page":"5795","DOI":"10.1210\/en.2010-0581","volume":"151","author":"T Kimoto","year":"2010","unstructured":"Kimoto T, Ishii H, Higo S, Hojo Y, Kawato S: Semicomprehensive analysis of the postnatal age-related changes in the mRNA expression of sex steroidogenic enzymes and sex steroid receptors in the male rat hippocampus. Endocrinology. 2010, 151 (12): 5795-5806. 10.1210\/en.2010-0581.","journal-title":"Endocrinology"},{"issue":"2","key":"5009_CR138","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0736-5748(98)00065-3","volume":"17","author":"J Garc\u00eda-Estrada","year":"1999","unstructured":"Garc\u00eda-Estrada J, Luquin S, Fernandez AM, Garcia-Segura LM: Dehydroepiandrosterone, pregnenolone and sex steroids down-regulate reactive astroglia in the male rat brain after a penetrating brain injury. Int J Dev Neurosci. 1999, 17 (2): 145-151. 10.1016\/S0736-5748(98)00065-3.","journal-title":"Int J Dev Neurosci"},{"issue":"5","key":"5009_CR139","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1089\/neu.2000.17.367","volume":"17","author":"RL Roof","year":"2000","unstructured":"Roof RL, Hall ED: Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone. J Neurotrauma. 2000, 17 (5): 367-388. 10.1089\/neu.2000.17.367.","journal-title":"J Neurotrauma"},{"issue":"1","key":"5009_CR140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/1363849031000095279","volume":"6","author":"DG Stein","year":"2003","unstructured":"Stein DG, Hoffman SW: Estrogen and progesterone as neuroprotective agents in the treatment of acute brain injuries. Pediatr Rehabil. 2003, 6 (1): 13-22.","journal-title":"Pediatr Rehabil"},{"issue":"2","key":"5009_CR141","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.expneurol.2004.06.008","volume":"189","author":"J He","year":"2004","unstructured":"He J, Evans CO, Hoffman SW, Oyesiku NM, Stein DG: Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury. Exp Neurol. 2004, 189 (2): 404-412. 10.1016\/j.expneurol.2004.06.008.","journal-title":"Exp Neurol"},{"issue":"7","key":"5009_CR142","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1517\/13543784.2010.489549","volume":"19","author":"DG Stein","year":"2010","unstructured":"Stein DG, Wright DW: Progesterone in the clinical treatment of acute traumatic brain injury. Expert Opin Investig Drugs. 2010, 19 (7): 847-857. 10.1517\/13543784.2010.489549.","journal-title":"Expert Opin Investig Drugs"},{"issue":"9","key":"5009_CR143","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1089\/089771503322385791","volume":"20","author":"SW Hoffman","year":"2003","unstructured":"Hoffman SW, Virmani S, Simkins RM, Stein DG: The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003, 20 (9): 859-870. 10.1089\/089771503322385791.","journal-title":"J Neurotrauma"},{"issue":"2","key":"5009_CR144","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/jcbfm.2008.118","volume":"29","author":"Z Li","year":"2009","unstructured":"Li Z, Cui S, Zhang Z, Zhou R, Ge Y, Sokabe M, Chen L: DHEA-neuroprotection and -neurotoxicity after transient cerebral ischemia in rats. J Cereb Blood Flow Metab. 2009, 29 (2): 287-296. 10.1038\/jcbfm.2008.118.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"5009_CR145","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1080\/00222891003697921","volume":"42","author":"M Tehranipour","year":"2010","unstructured":"Tehranipour M, Moghimi A: Neuroprotective effects of testosterone on regenerating spinal cord motoneurons in rats. J Mot Behav. 2010, 42 (3): 151-155. 10.1080\/00222891003697921.","journal-title":"J Mot Behav"},{"issue":"9","key":"5009_CR146","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1111\/j.1365-2826.2010.02044.x","volume":"22","author":"TV Nguyen","year":"2010","unstructured":"Nguyen TV, Jayaraman A, Quaglino A, Pike CJ: Androgens selectively protect against apoptosis in hippocampal neurones. J Neuroendocrinol. 2010, 22 (9): 1013-1022. 10.1111\/j.1365-2826.2010.02044.x.","journal-title":"J Neuroendocrinol"},{"issue":"8","key":"5009_CR147","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1161\/01.STR.29.8.1666","volume":"29","author":"TJ Toung","year":"1998","unstructured":"Toung TJ, Traystman RJ, Hurn PD: Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke. 1998, 29 (8): 1666-1670. 10.1161\/01.STR.29.8.1666.","journal-title":"Stroke"},{"issue":"4","key":"5009_CR148","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1002\/(SICI)1097-4695(19990915)40:4<574::AID-NEU12>3.0.CO;2-8","volume":"40","author":"LM Garcia-Segura","year":"1999","unstructured":"Garcia-Segura LM, Naftolin F, Hutchison JB, Azcoitia I, Chowen JA: Role of astroglia in estrogen regulation of synaptic plasticity and brain repair [99 refs]. J Neurobiol. 1999, 40 (4): 574-584. 10.1002\/(SICI)1097-4695(19990915)40:4<574::AID-NEU12>3.0.CO;2-8.","journal-title":"J Neurobiol"},{"issue":"25","key":"5009_CR149","doi-asserted-by":"crossref","first-page":"8701","DOI":"10.1523\/JNEUROSCI.23-25-08701.2003","volume":"23","author":"LD McCullough","year":"2003","unstructured":"McCullough LD, Blizzard K, Simpson ER, Oz OK, Hurn PD: Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection. J Neurosci. 2003, 23 (25): 8701-8705.","journal-title":"J Neurosci"},{"issue":"2","key":"5009_CR150","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/jcbfm.2010.181","volume":"31","author":"J Li","year":"2011","unstructured":"Li J, Siegel M, Yuan M, Zeng Z, Finnucan L, Persky R, Hurn PD, McCullough LD: Estrogen enhances neurogenesis and behavioral recovery after stroke. J Cereb Blood Flow Metab. 2011, 31 (2): 413-425. 10.1038\/jcbfm.2010.181.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"5009_CR151","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","volume":"55","author":"SA Bustin","year":"2009","unstructured":"Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL: The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 2009, 55 (4): 611-622. 10.1373\/clinchem.2008.112797.","journal-title":"Clin Chem"},{"key":"5009_CR152","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1471-2105-7-85","volume":"7","author":"JS Yuan","year":"2006","unstructured":"Yuan JS, Reed A, Chen F, Stewart CN: Statistical analysis of real-time PCR data. BMC Bioinformatics. 2006, 7: 85-10.1186\/1471-2105-7-85.","journal-title":"BMC Bioinformatics"},{"issue":"4","key":"5009_CR153","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method. Methods. 2001, 25 (4): 402-408. 10.1006\/meth.2001.1262.","journal-title":"Methods"},{"issue":"6","key":"5009_CR154","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008, 3 (6): 1101-1108. 10.1038\/nprot.2008.73.","journal-title":"Nat Protoc"},{"key":"5009_CR155","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"1986","unstructured":"Paxinos G, Watson C: The rat brain in stereotaxic coordinates. 1986, San Diego: Academic"},{"issue":"3","key":"5009_CR156","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0169-328X(93)90045-Q","volume":"20","author":"K Strauss","year":"1993","unstructured":"Strauss K, Jacobowitz D: Quantitative measurement of calretinin and b-actin mRNA in rat brain micropunches without prior isolation of RNA. Mol Brain Res. 1993, 20 (3): 229-239. 10.1016\/0169-328X(93)90045-Q.","journal-title":"Mol Brain Res"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2164-14-303.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T08:39:31Z","timestamp":1746002371000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/1471-2164-14-303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,4]]},"references-count":156,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["5009"],"URL":"https:\/\/doi.org\/10.1186\/1471-2164-14-303","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,4]]},"assertion":[{"value":"1 October 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"303"}}