{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:39:19Z","timestamp":1791272359727,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Neurofibromatosis type 1 (NF1) is a common dominant tumor predisposition syndrome affecting 1 in 3,500 individuals. The hallmarks of NF1 are the development of peripheral nerve sheath tumors either benign (dermal and plexiform neurofibromas) or malignant (MPNSTs).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>To comprehensively characterize the role of microRNAs in NF1 tumorigenesis, we analyzed 377 miRNAs expression in a large panel of dermal and plexiform neurofibromas, and MPNSTs. The most significantly upregulated miRNA in plexiform neurofibromas was miR-486-3p that targets the major tumor suppressor gene, <jats:italic>PTEN<\/jats:italic>. We confirmed <jats:italic>PTEN<\/jats:italic> downregulation at mRNA level. In plexiform neurofibromas, we also report aberrant expression of four miRNAs involved in the RAS-MAPK pathway (miR-370, miR-143, miR-181a, and miR-145). In MPNSTs, significant deregulated miRNAs were involved in <jats:italic>PTEN<\/jats:italic> repression (miR-301a, miR-19a, and miR-106b), RAS-MAPK pathway regulation (Let-7b, miR-195, and miR-10b), mesenchymal transition (miR-200c, let-7b, miR-135a, miR-135b, and miR-9), <jats:italic>HOX<\/jats:italic> genes expression (miR-210, miR-196b, miR-10a, miR-10b, and miR-9), and cell cycle progression (miR-195, let-7b, miR-20a, miR-210, miR-129-3p, miR-449a, and miR-106b).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We confirmed the implication of <jats:italic>PTEN<\/jats:italic> in genesis of plexiform neurofibromas and MPNSTs in NF1. Markedly deregulated miRNAs might have potential diagnostic or prognostic value and could represent novel strategies for effective pharmacological therapies of NF1 tumors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2164-14-473","type":"journal-article","created":{"date-parts":[[2013,7,13]],"date-time":"2013-07-13T02:43:30Z","timestamp":1373683410000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis"],"prefix":"10.1186","volume":"14","author":[{"given":"Julien","family":"Masliah-Planchon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Pasmant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"Luscan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Laurendeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Ortonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Hivelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Varin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Valeyrie-Allanore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Dumaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Lantieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Leroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Parfait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Wolkenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Vidaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Vidaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Bi\u00e8che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,13]]},"reference":[{"key":"5181_CR1","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1093\/hmg\/ddp212","volume":"18","author":"A Sabbagh","year":"2009","unstructured":"Sabbagh A, Pasmant E, Laurendeau I, Parfait B, Barbarot S, Guillot B, Combemale P, Ferkal S, Vidaud M, Aubourg P, Vidaud D, Wolkenstein P: Unravelling the genetic basis of variable clinical expression in neurofibromatosis 1. Hum Mol Genet. 2009, 18: 2768-2778. 10.1093\/hmg\/ddp212.","journal-title":"Hum Mol Genet"},{"key":"5181_CR2","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1093\/jnci\/djr416","volume":"103","author":"E Pasmant","year":"2011","unstructured":"Pasmant E, Sabbagh A, Masliah-Planchon J, Ortonne N, Laurendeau I, Melin L, Ferkal S, Hernandez L, Leroy K, Valeyrie-Allanore L, Parfait B, Vidaud D, Bi\u00e8che I, Lantieri L, Wolkenstein P, Vidaud M, NF France Network: Role of Noncoding RNA ANRIL in Genesis of Plexiform Neurofibromas in Neurofibromatosis Type 1. J Natl Cancer Inst. 2011, 103: 1713-1722. 10.1093\/jnci\/djr416.","journal-title":"J Natl Cancer Inst"},{"key":"5181_CR3","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1158\/1078-0432.CCR-07-1305","volume":"14","author":"KK Mantripragada","year":"2008","unstructured":"Mantripragada KK, Spurlock G, Kluwe L, Chuzhanova N, Ferner RE, Frayling IM, Dumanski JP, Guha A, Mautner V, Upadhyaya M: High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization. Clin Cancer Res. 2008, 14: 1015-1024. 10.1158\/1078-0432.CCR-07-1305.","journal-title":"Clin Cancer Res"},{"key":"5181_CR4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/path.2633","volume":"220","author":"S Subramanian","year":"2010","unstructured":"Subramanian S, Thayanithy V, West RB, Lee CH, Beck AH, Zhu S, Downs-Kelly E, Montgomery K, Goldblum JR, Hogendoorn PC, Corless CL, Oliveira AM, Dry SM, Nielsen TO, Rubin BP, Fletcher JA, Fletcher CD, van de Rijn M: Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of mir-34a expression in malignant peripheral nerve sheath tumours. J Pathol. 2010, 220: 58-70. 10.1002\/path.2633.","journal-title":"J Pathol"},{"key":"5181_CR5","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1097\/NEN.0b013e3181c79bff","volume":"69","author":"E Pasmant","year":"2010","unstructured":"Pasmant E, Ortonne N, Ritti\u00e9 L, Laurendeau I, L\u00e9vy P, Lazar V, Parfait B, Leroy K, Dessen P, Valeyrie-Allanore L, Perbal B, Wolkenstein P, Vidaud M, Vidaud D, Bi\u00e8che I: Differential expression of CCN1\/CYR61, CCN3\/NOV, CCN4\/WISP1, and CCN5\/WISP2 in neurofibromatosis type 1 tumorigenesis. J Neuropathol Exp Neurol. 2010, 69: 60-69. 10.1097\/NEN.0b013e3181c79bff.","journal-title":"J Neuropathol Exp Neurol"},{"key":"5181_CR6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1476-4598-3-20","volume":"3","author":"P L\u00e9vy","year":"2004","unstructured":"L\u00e9vy P, Vidaud D, Leroy K, Laurendeau I, Wechsler J, Bolasco G, Parfait B, Wolkenstein P, Vidaud M, Bi\u00e8che I: Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCR. Mol Cancer. 2004, 3: 20-10.1186\/1476-4598-3-20.","journal-title":"Mol Cancer"},{"key":"5181_CR7","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1126\/science.286.5447.2176","volume":"286","author":"KS Vogel","year":"1999","unstructured":"Vogel KS, Klesse LJ, Velasco-Miguel S, Meyers K, Rushing EJ, Parada LF: Mouse tumor model for neurofibromatosis type 1. Science. 1999, 286: 2176-2179. 10.1126\/science.286.5447.2176.","journal-title":"Science"},{"key":"5181_CR8","doi-asserted-by":"publisher","first-page":"19479","DOI":"10.1073\/pnas.0910398106","volume":"106","author":"C Gregorian","year":"2009","unstructured":"Gregorian C, Nakashima J, Dry SM, Nghiemphu PL, Smith KB, Ao Y, Dang J, Lawson G, Mellinghoff IK, Mischel PS, Phelps M, Parada LF, Liu X, Sofroniew MV, Eilber FC, Wu H: PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A. 2009, 106: 19479-19484. 10.1073\/pnas.0910398106.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5181_CR9","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","volume":"75","author":"RC Lee","year":"1993","unstructured":"Lee RC, Feinbaum RL, Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993, 75: 843-854. 10.1016\/0092-8674(93)90529-Y.","journal-title":"Cell"},{"key":"5181_CR10","doi-asserted-by":"publisher","first-page":"4218","DOI":"10.1073\/pnas.1000300107","volume":"107","author":"EM Small","year":"2010","unstructured":"Small EM, O'Rourke JR, Moresi V, Sutherland LB, McAnally J, Gerard RD, Richardson JA, Olson EN: Regulation of PI3-kinase\/Akt signaling by muscle-enriched microRNA-486. Proc Natl Acad Sci U S A. 2010, 107: 4218-4223. 10.1073\/pnas.1000300107.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5181_CR11","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/sj.onc.1210648","volume":"27","author":"F Meng","year":"2008","unstructured":"Meng F, Wehbe-Janek H, Henson R, Smith H, Patel T: Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes. Oncogene. 2008, 27: 378-386. 10.1038\/sj.onc.1210648.","journal-title":"Oncogene"},{"key":"5181_CR12","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1038\/onc.2008.474","volume":"28","author":"X Chen","year":"2009","unstructured":"Chen X, Guo X, Zhang H, Xiang Y, Chen J, Yin Y, Cai X, Wang K, Wang G, Ba Y, Zhu L, Wang J, Yang R, Zhang Y, Ren Z, Zen K, Zhang J, Zhang CY: Role of mir-143 targeting KRAS in colorectal tumorigenesis. Oncogene. 2009, 28: 1385-1392. 10.1038\/onc.2008.474.","journal-title":"Oncogene"},{"key":"5181_CR13","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.bbrc.2010.12.055","volume":"404","author":"KH Shin","year":"2011","unstructured":"Shin KH, Bae SD, Hong HS, Kim RH, Kang MK, Park NH: MiR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-RAS. Biochem Biophys Res Commun. 2011, 404: 896-902. 10.1016\/j.bbrc.2010.12.055.","journal-title":"Biochem Biophys Res Commun"},{"key":"5181_CR14","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/onc.2010.531","volume":"30","author":"Y Wang","year":"2011","unstructured":"Wang Y, Yu Y, Tsuyada A, Ren X, Wu X, Stubblefield K, Rankin-Gee EK, Wang SE: Transforming growth factor-\u03b2 regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM. Oncogene. 2011, 30: 1470-1480. 10.1038\/onc.2010.531.","journal-title":"Oncogene"},{"key":"5181_CR15","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1101\/gad.1950610","volume":"24","author":"OA Kent","year":"2010","unstructured":"Kent OA, Chivukula RR, Mullendore M, Wentzel EA, Feldmann G, Lee KH, Liu S, Leach SD, Maitra A, Mendell JT: Repression of the miR-143\/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. Genes Dev. 2010, 24: 2754-2759. 10.1101\/gad.1950610.","journal-title":"Genes Dev"},{"key":"5181_CR16","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.bbrc.2010.08.046","volume":"400","author":"L Liu","year":"2010","unstructured":"Liu L, Chen L, Xu Y, Li R, Du X: MicroRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells. Biochem Biophys Res Commun. 2010, 400: 236-240. 10.1016\/j.bbrc.2010.08.046.","journal-title":"Biochem Biophys Res Commun"},{"key":"5181_CR17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/hep.22919","volume":"50","author":"T Xu","year":"2009","unstructured":"Xu T, Zhu Y, Xiong Y, Ge YY, Yun JP, Zhuang SM: MicroRNA-195 suppresses tumorigenicity and regulates G1\/S transition of human hepatocellular carcinoma cells. Hepatology. 2009, 50: 113-121. 10.1002\/hep.22919.","journal-title":"Hepatology"},{"key":"5181_CR18","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1523\/JNEUROSCI.21-04-01110.2001","volume":"21","author":"HA Kim","year":"2001","unstructured":"Kim HA, Ratner N, Roberts TM, Stiles CD: Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. J Neurosci. 2001, 21: 1110-1116.","journal-title":"J Neurosci"},{"key":"5181_CR19","doi-asserted-by":"publisher","first-page":"7972","DOI":"10.1158\/0008-5472.CAN-07-1058","volume":"67","author":"GJ Hurteau","year":"2007","unstructured":"Hurteau GJ, Carlson JA, Spivack SD, Brock GJ: Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin. Cancer Res. 2007, 67: 7972-7976. 10.1158\/0008-5472.CAN-07-1058.","journal-title":"Cancer Res"},{"key":"5181_CR20","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1002\/jcp.22598","volume":"226","author":"Y Sekiya","year":"2011","unstructured":"Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N: Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-\u03b2-induced inhibition of hepatic stellate cell proliferation. J Cell Physiol. 2011, 226: 2535-2542. 10.1002\/jcp.22598.","journal-title":"J Cell Physiol"},{"key":"5181_CR21","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cell.2005.01.014","volume":"120","author":"SM Johnson","year":"2005","unstructured":"Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ: Ras is regulated by the let-7 microRNA family. Cell. 2005, 120: 635-647. 10.1016\/j.cell.2005.01.014.","journal-title":"Cell"},{"key":"5181_CR22","doi-asserted-by":"publisher","first-page":"843","DOI":"10.4161\/cc.8.6.7907","volume":"8","author":"ME Peter","year":"2009","unstructured":"Peter ME: Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle. 2009, 8: 843-852. 10.4161\/cc.8.6.7907.","journal-title":"Cell Cycle"},{"key":"5181_CR23","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1158\/0008-5472.CAN-11-4092","volume":"72","author":"VW Keng","year":"2012","unstructured":"Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Rizvi TA, Collins MH, Ratner N, Largaespada DA: PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. Cancer Res. 2012, 72: 3405-3413. 10.1158\/0008-5472.CAN-11-4092.","journal-title":"Cancer Res"},{"key":"5181_CR24","doi-asserted-by":"publisher","first-page":"3240","DOI":"10.1073\/pnas.0914882107","volume":"107","author":"X Qin","year":"2010","unstructured":"Qin X, Wang X, Wang Y, Tang Z, Cui Q, Xi J, Li YS, Chien S, Wang N: MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A. 2010, 107: 3240-3244. 10.1073\/pnas.0914882107.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5181_CR25","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.molcel.2009.09.006","volume":"35","author":"X Huang","year":"2009","unstructured":"Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ: Hypoxia-inducible miR-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell. 2009, 35: 856-867. 10.1016\/j.molcel.2009.09.006.","journal-title":"Mol Cell"},{"key":"5181_CR26","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1158\/0008-5472.CAN-10-3369","volume":"71","author":"W Shi","year":"2011","unstructured":"Shi W, Gerster K, Alajez NM, Tsang J, Waldron L, Pintilie M, Hui AB, Sykes J, P'ng C, Miller N, McCready D, Fyles A, Liu FF: MicroRNA-301 mediates proliferation and invasion in human breast cancer. Cancer Res. 2011, 71: 2926-2937. 10.1158\/0008-5472.CAN-10-3369.","journal-title":"Cancer Res"},{"key":"5181_CR27","doi-asserted-by":"publisher","first-page":"36734","DOI":"10.1074\/jbc.274.51.36734","volume":"274","author":"S Roura","year":"1999","unstructured":"Roura S, Miravet S, Piedra J, Garc\u00eda de Herreros A, Du\u00f1ach M: Regulation of E-cadherin\/catenin association by tyrosine phosphorylation. J Biol Chem. 1999, 274: 36734-36740. 10.1074\/jbc.274.51.36734.","journal-title":"J Biol Chem"},{"key":"5181_CR28","first-page":"1284","volume":"6","author":"L Han","year":"2007","unstructured":"Han L, Witmer PD, Casey E, Valle D, Sukumar S: DNA methylation regulates microRNA expression. Cancer Biol Ther. 2007, 6: 1284-1288.","journal-title":"Cancer Biol Ther"},{"key":"5181_CR29","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","volume":"115","author":"BP Lewis","year":"2003","unstructured":"Lewis BP, Shih I-h, Jones-Rhoades MW, Bartel DP, Burge CB: Prediction of mammalian microRNA targets. Cell. 2003, 115: 787-798. 10.1016\/S0092-8674(03)01018-3.","journal-title":"Cell"},{"key":"5181_CR30","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/cr.2008.45","volume":"18","author":"J Schultz","year":"2008","unstructured":"Schultz J, Lorenz P, Gross G, Ibrahim S, Kunz M: MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Res. 2008, 18: 549-557. 10.1038\/cr.2008.45.","journal-title":"Cell Res"},{"key":"5181_CR31","doi-asserted-by":"publisher","first-page":"e16138","DOI":"10.1371\/journal.pone.0016138","volume":"6","author":"HI Trompeter","year":"2011","unstructured":"Trompeter HI, Abbad H, Iwaniuk KM, Hafner M, Renwick N, Tuschl T, Schira J, M\u00fcller HW, Wernet P: MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC. PLoS One. 2011, 6: e16138-10.1371\/journal.pone.0016138.","journal-title":"PLoS One"},{"key":"5181_CR32","doi-asserted-by":"publisher","first-page":"ra29","DOI":"10.1126\/scisignal.2000594","volume":"3","author":"L Poliseno","year":"2010","unstructured":"Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, Sportoletti P, Varmeh S, Egia A, Fedele G, Rameh L, Loda M, Pandolfi PP: Identification of the miR-106b 25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Sci Signal. 2010, 3: ra29-10.1126\/scisignal.2000594.","journal-title":"Sci Signal"},{"key":"5181_CR33","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nature06174","volume":"449","author":"L Ma","year":"2007","unstructured":"Ma L, Teruya-Feldstein J, Weinberg RA: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 2007, 449: 682-688. 10.1038\/nature06174.","journal-title":"Nature"},{"key":"5181_CR34","doi-asserted-by":"publisher","first-page":"39524","DOI":"10.1074\/jbc.M503707200","volume":"280","author":"T Ozawa","year":"2005","unstructured":"Ozawa T, Araki N, Yunoue S, Tokuo H, Feng L, Patrakitkomjorn S, Hara T, Ichikawa Y, Matsumoto K, Fujii K, Saya H: The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway. J Biol Chem. 2005, 280: 39524-39533. 10.1074\/jbc.M503707200.","journal-title":"J Biol Chem"},{"key":"5181_CR35","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1126\/science.1097434","volume":"304","author":"S Yekta","year":"2004","unstructured":"Yekta S, Shih I-H, Bartel DP: MicroRNA-directed cleavage of HOXB8 mRNA. Science. 2004, 304: 594-596. 10.1126\/science.1097434.","journal-title":"Science"},{"key":"5181_CR36","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/ng2003","volume":"39","author":"MS Kumar","year":"2007","unstructured":"Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T: Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet. 2007, 39: 673-677. 10.1038\/ng2003.","journal-title":"Nat Genet"},{"key":"5181_CR37","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2011.09.029","volume":"147","author":"Y Tay","year":"2011","unstructured":"Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP: Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs. Cell. 2011, 147: 344-357. 10.1016\/j.cell.2011.09.029.","journal-title":"Cell"},{"key":"5181_CR38","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/nrm2858","volume":"11","author":"S Negrini","year":"2010","unstructured":"Negrini S, Gorgoulis VG, Halazonetis TD: Genomic instability-an evolving hallmark of cancer. Nat Rev Mol Cell Biol. 2010, 11: 220-228. 10.1038\/nrm2858.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5181_CR39","doi-asserted-by":"publisher","first-page":"5795","DOI":"10.1158\/0008-5472.CAN-08-0951","volume":"68","author":"R Nagel","year":"2008","unstructured":"Nagel R, le Sage C, Diosdado B, van der Waal M, Oude Vrielink JA, Bolijn A, Meijer GA, Agami R: Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res. 2008, 68: 5795-5802. 10.1158\/0008-5472.CAN-08-0951.","journal-title":"Cancer Res"},{"key":"5181_CR40","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ncb2024","volume":"12","author":"L Ma","year":"2010","unstructured":"Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, Westermann F, Speleman F, Vandesompele J, Weinberg RA: MiR-9, a MYC\/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol. 2010, 12: 247-256.","journal-title":"Nat Cell Biol"},{"key":"5181_CR41","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1101\/gad.1540407","volume":"21","author":"YS Lee","year":"2007","unstructured":"Lee YS, Dutta A: The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev. 2007, 21: 1025-1030. 10.1101\/gad.1540407.","journal-title":"Genes Dev"},{"key":"5181_CR42","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1083\/jcb.200512110","volume":"174","author":"S Thuault","year":"2006","unstructured":"Thuault S, Valcourt U, Petersen M, Manfioletti G, Heldin CH, Moustakas A: Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol. 2006, 174: 175-183. 10.1083\/jcb.200512110.","journal-title":"J Cell Biol"},{"key":"5181_CR43","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.cell.2008.09.017","volume":"135","author":"J Nishino","year":"2008","unstructured":"Nishino J, Kim I, Chada K, Morrison SJ: Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell. 2008, 135: 227-239. 10.1016\/j.cell.2008.09.017.","journal-title":"Cell"},{"key":"5181_CR44","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1111\/j.1349-7006.2010.01616.x","volume":"101","author":"G Chai","year":"2010","unstructured":"Chai G, Liu N, Ma J, Li H, Oblinger JL, Prahalad AK, Gong M, Chang LS, Wallace M, Muir D, Guha A, Phipps RJ, Hock JM, Yu X: MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1. Cancer Sci. 2010, 101: 1997-2004. 10.1111\/j.1349-7006.2010.01616.x.","journal-title":"Cancer Sci"},{"key":"5181_CR45","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1002\/ijc.25923","volume":"129","author":"P Rotkrua","year":"2011","unstructured":"Rotkrua P, Akiyama Y, Hashimoto Y, Otsubo T, Yuasa Y: MiR-9 downregulates CDX2 expression in gastric cancer cells. Int J Cancer. 2011, 129: 2611-2620. 10.1002\/ijc.25923.","journal-title":"Int J Cancer"},{"key":"5181_CR46","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nrc2826","volume":"10","author":"N Shah","year":"2010","unstructured":"Shah N, Sukumar S: The HOX genes and their roles in oncogenesis. Nat Rev Cancer. 2010, 10: 361-371. 10.1038\/nrc2826.","journal-title":"Nat Rev Cancer"},{"key":"5181_CR47","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.4161\/cc.9.9.11535","volume":"9","author":"J Wu","year":"2010","unstructured":"Wu J, Qian J, Li C, Kwok L, Cheng F, Liu P, Perdomo C, Kotton D, Vaziri C, Anderlind C, Spira A, Cardoso WV, L\u00fc J: MiR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle. 2010, 9: 1809-1818. 10.4161\/cc.9.9.11535.","journal-title":"Cell Cycle"},{"key":"5181_CR48","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1158\/1078-0432.CCR-10-1800","volume":"17","author":"D Li","year":"2011","unstructured":"Li D, Zhao Y, Liu C, Chen X, Qi Y, Jiang Y, Zou C, Zhang X, Liu S, Wang X, Zhao D, Sun Q, Zeng Z, Dress A, Lin MC, Kung HF, Rui H, Liu LZ, Mao F, Jiang BH, Lai L: Analysis of miR-195 and miR-497 expression, regulation and role in breast cancer. Clin Cancer Res. 2011, 17: 1722-1730. 10.1158\/1078-0432.CCR-10-1800.","journal-title":"Clin Cancer Res"},{"key":"5181_CR49","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1261\/rna.939908","volume":"14","author":"HJ Peltier","year":"2008","unstructured":"Peltier HJ, Latham GJ: Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA. 2008, 14: 844-852. 10.1261\/rna.939908.","journal-title":"RNA"},{"key":"5181_CR50","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2119\/molmed.2010.00079","volume":"17","author":"E Pasmant","year":"2011","unstructured":"Pasmant E, Masliah-Planchon J, L\u00e9vy P, Laurendeau I, Ortonne N, Parfait B, Valeyrie-Allanore L, Leroy K, Wolkenstein P, Vidaud M, Vidaud D, Bi\u00e8che I: Identification of genes potentially involved in the increased risk of malignancy in NF1-microdeleted patients. Mol Med. 2011, 17: 79-87.","journal-title":"Mol Med"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2164-14-473.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:37:44Z","timestamp":1630543064000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/1471-2164-14-473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,13]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["5181"],"URL":"https:\/\/doi.org\/10.1186\/1471-2164-14-473","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,13]]},"assertion":[{"value":"30 April 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"473"}}