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We sequenced the genomes of 12 isolates linked to these outbreaks, in order to investigate the microevolution of a pathogenic <jats:italic>S<\/jats:italic>. Typhimurium clone in a natural, spatiotemporally restricted population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The isolates, which shared a phage type similar to DT135 known locally as 135@ or 135a, formed a clade within the <jats:italic>S<\/jats:italic>. Typhimurium population with close similarity to the reference genome SL1334 (160 single nucleotide polymorphisms, or SNPs). Ten of the isolates belonged to a single clone (&lt;23 SNPs between isolate pairs) which likely represents the population of <jats:italic>S<\/jats:italic>. Typhimurium circulating at the chicken farm; the other two were from sporadic cases and were genetically distinct from this clone. Divergence dating indicated that all 12 isolates diverged from a common ancestor in the mid 1990s, and the clone began to diversify in 2003\u20132004. This clone spilled out into the human population several times between 2005\u20132008, during which time it continued to accumulate SNPs at a constant rate of 3\u20135 SNPs per year or 1x10<jats:sup>-6<\/jats:sup> substitutions site<jats:sup>-1<\/jats:sup>\u00a0year<jats:sup>-1<\/jats:sup>, faster than the longer-term (~50\u00a0year) rates estimated previously for <jats:italic>S.<\/jats:italic> Typhimurium. Our data suggest that roughly half of non-synonymous substitutions are rapidly removed from the <jats:italic>S<\/jats:italic>. Typhimurium population, after which purifying selection is no longer important and the remaining substitutions become fixed in the population. The <jats:italic>S<\/jats:italic>. Typhimurium 135@ isolates were nearly identical to SL1344 in terms of gene content and virulence plasmids. Their phage contents were close to SL1344, except that they carried a different variant of Gifsy-1, lacked the P2 remnant found in SL1344 and carried a novel P2 phage, P2-Hawk, in place SL1344\u2019s P2 phage SopE\u03d5. DT135 lacks P2 prophage. Two additional plasmids were identified in the <jats:italic>S<\/jats:italic>. Typhimurium 135@ isolates, pSTM2 and pSTM7. Both plasmids were IncI1, but phylogenetic analysis of the plasmids and their bacterial hosts shows these plasmids are genetically distinct and result from independent plasmid acquisition events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This study provides a high-resolution insight into short-term microevolution of the important human pathogen <jats:italic>S.<\/jats:italic> Typhimurium<jats:italic>.<\/jats:italic> It indicates that purifying selection occurs rapidly in this population (\u22646\u00a0years) and then declines, and provides an estimate for the short-term substitution rate. The latter is likely to be more relevant for foodborne outbreak investigation than previous estimates based on longer time scales.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2164-14-800","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T04:05:50Z","timestamp":1384833950000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Evidence of microevolution of Salmonella Typhimurium during a series of egg-associated outbreaks linked to a single chicken farm"],"prefix":"10.1186","volume":"14","author":[{"given":"Jane","family":"Hawkey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Dimovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester","family":"Hiley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Billman-Jacobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Hogg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn E","family":"Holt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,11,19]]},"reference":[{"issue":"6","key":"5508_CR1","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1086\/650733","volume":"50","author":"SE Majowicz","year":"2010","unstructured":"Majowicz SE, Musto J, Scallan E, Angulo FJ, Kirk M, O'Brien SJ, Jones TF, Fazil A, Hoekstra RM: The global burden of nontyphoidal Salmonella gastroenteritis. 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