{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:31:20Z","timestamp":1753921880147},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"S1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1186\/1471-2164-15-s1-s13","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T16:36:10Z","timestamp":1390581370000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Application of microRNA and mRNA expression profiling on prognostic biomarker discovery for hepatocellular carcinoma"],"prefix":"10.1186","volume":"15","author":[{"given":"Lin","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baofeng","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuannv","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianren","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghuo","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,1,24]]},"reference":[{"key":"5686_CR1","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/S0140-6736(11)61347-0","volume":"379","author":"A Forner","year":"2012","unstructured":"Forner A, Llovet JM, Bruix J: Hepatocellular carcinoma. Lancet. 2012, 379: 1245-1255. 10.1016\/S0140-6736(11)61347-0.","journal-title":"Lancet"},{"key":"5686_CR2","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","volume":"132","author":"HB El-Serag","year":"2007","unstructured":"El-Serag HB, Rudolph KL: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007, 132: 2557-2576. 10.1053\/j.gastro.2007.04.061.","journal-title":"Gastroenterology"},{"key":"5686_CR3","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.3748\/wjg.v13.i16.2271","volume":"13","author":"A Teufel","year":"2007","unstructured":"Teufel A, Staib F, Kanzler S, Weinmann A, Schulze-Bergkamen H, Galle PR: Genetics of hepatocellular carcinoma. World J Gastroenterol WJG. 2007, 13: 2271-2282.","journal-title":"World J Gastroenterol WJG"},{"key":"5686_CR4","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/ng0802-339","volume":"31","author":"SS Thorgeirsson","year":"2002","unstructured":"Thorgeirsson SS, Grisham JW: Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet. 2002, 31: 339-346. 10.1038\/ng0802-339.","journal-title":"Nat Genet"},{"issue":"5 Suppl 1","key":"5686_CR5","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1053\/j.gastro.2004.09.014","volume":"127","author":"G Fattovich","year":"2004","unstructured":"Fattovich G, Stroffolini T, Zagni I, Donato F: Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology. 2004, 127 (5 Suppl 1): S35-50.","journal-title":"Gastroenterology"},{"key":"5686_CR6","doi-asserted-by":"publisher","first-page":"b5039","DOI":"10.1136\/bmj.b5039","volume":"339","author":"T Kumagi","year":"2009","unstructured":"Kumagi T, Hiasa Y, Hirschfield GM: Hepatocellular carcinoma for the non-specialist. BMJ. 2009, 339: b5039-10.1136\/bmj.b5039.","journal-title":"BMJ"},{"key":"5686_CR7","doi-asserted-by":"publisher","first-page":"401","DOI":"10.2188\/jea.JE20100190","volume":"21","author":"M Tanaka","year":"2011","unstructured":"Tanaka M, Katayama F, Kato H, Tanaka H, Wang J, Qiao YL, Inoue M: Hepatitis B and C virus infection and hepatocellular carcinoma in China: a review of epidemiology and control measures. J Epidemiol Jpn Epidemiol Assoc. 2011, 21: 401-416. 10.2188\/jea.JE20100190.","journal-title":"J Epidemiol Jpn Epidemiol Assoc"},{"key":"5686_CR8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.febslet.2004.03.081","volume":"565","author":"JK Choi","year":"2004","unstructured":"Choi JK, Choi JY, Kim DG, Choi DW, Kim BY, Lee KH, Yeom YI, Yoo HS, Yoo OJ, Kim S: Integrative analysis of multiple gene expression profiles applied to liver cancer study. FEBS Lett. 2004, 565: 93-100. 10.1016\/j.febslet.2004.03.081.","journal-title":"FEBS Lett"},{"key":"5686_CR9","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/hep.20105","volume":"39","author":"SY Neo","year":"2004","unstructured":"Neo SY, Leow CK, Vega VB, Long PM, Islam AFM, Lai PBS, Liu ET, Ren EC: Identification of discriminators of hepatoma by gene expression profiling using a minimal dataset approach. Hepatol Baltim Md. 2004, 39: 944-953. 10.1002\/hep.20105.","journal-title":"Hepatol Baltim Md"},{"key":"5686_CR10","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/bjs.6011","volume":"95","author":"S Tanaka","year":"2008","unstructured":"Tanaka S, Arii S, Yasen M, Mogushi K, Su NT, Zhao C, Imoto I, Eishi Y, Inazawa J, Miki Y, Tanaka H: Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy. Br J Surg. 2008, 95: 611-619. 10.1002\/bjs.6011.","journal-title":"Br J Surg"},{"key":"5686_CR11","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/hep.23650","volume":"52","author":"K Wang","year":"2010","unstructured":"Wang K, Liu J, Yan ZL, Li J, Shi LH, Cong WM, Xia Y, Zou QF, Xi T, Shen F, Wang HY, Wu MC: Overexpression of aspartyl-(asparaginyl)-beta-hydroxylase in hepatocellular carcinoma is associated with worse surgical outcome. Hepatol Baltim Md. 2010, 52: 164-173. 10.1002\/hep.23650.","journal-title":"Hepatol Baltim Md"},{"key":"5686_CR12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/gcc.20838","volume":"50","author":"JD Yang","year":"2011","unstructured":"Yang JD, Sun Z, Hu C, Lai J, Dove R, Nakamura I, Lee JS, Thorgeirsson SS, Kang KJ, Chu IS, Roberts LR: Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival. Genes Chromosomes Cancer. 2011, 50: 122-135. 10.1002\/gcc.20838.","journal-title":"Genes Chromosomes Cancer"},{"key":"5686_CR13","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/nm843","volume":"9","author":"QH Ye","year":"2003","unstructured":"Ye QH, Qin LX, Forgues M, He P, Kim JW, Peng AC, Simon R, Li Y, Robles AI, Chen Y, Ma ZC, Wu ZQ, Ye SL, Liu YK, Tang ZY, Wang XW: Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med. 2003, 9: 416-423. 10.1038\/nm843.","journal-title":"Nat Med"},{"key":"5686_CR14","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ccr.2006.06.016","volume":"10","author":"A Budhu","year":"2006","unstructured":"Budhu A, Forgues M, Ye QH, Jia HL, He P, Zanetti KA, Kammula US, Chen Y, Qin LX, Tang ZY, Wang XW: Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell. 2006, 10: 99-111. 10.1016\/j.ccr.2006.06.016.","journal-title":"Cancer Cell"},{"key":"5686_CR15","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S0002-9440(10)63700-5","volume":"163","author":"V Paradis","year":"2003","unstructured":"Paradis V, Bi\u00e8che I, Darg\u00e8re D, Laurendeau I, Laurent C, Bioulac Sage P, Degott C, Belghiti J, Vidaud M, Bedossa P: Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic index. Am J Pathol. 2003, 163: 733-741. 10.1016\/S0002-9440(10)63700-5.","journal-title":"Am J Pathol"},{"key":"5686_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1504\/IJCBDD.2011.038654","volume":"4","author":"T Huang","year":"2011","unstructured":"Huang T, Liu L, Liu Q, Ding G, Tan Y, Tu Z, Li Y, Dai H, Xie L: The role of Hepatitis C Virus in the dynamic protein interaction networks of hepatocellular cirrhosis and carcinoma. Int J Comput Biol Drug Des. 2011, 4: 5-18. 10.1504\/IJCBDD.2011.038654.","journal-title":"Int J Comput Biol Drug Des"},{"key":"5686_CR17","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1002\/ijc.23693","volume":"123","author":"W Li","year":"2008","unstructured":"Li W, Xie L, He X, Li J, Tu K, Wei L, Wu J, Guo Y, Ma X, Zhang P, Pan Z, Hu X, Zhao Y, Xie H, Jiang G, Chen T, Wang J, Zheng S, Cheng J, Wan D, Yang S, Li Y, Gu J: Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma. Int J Cancer. 2008, 123: 1616-1622. 10.1002\/ijc.23693.","journal-title":"Int J Cancer"},{"key":"5686_CR18","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar R, Domrachev M, Lash AE: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 2002, 30: 207-210. 10.1093\/nar\/30.1.207.","journal-title":"Nucleic Acids Res"},{"key":"5686_CR19","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/0-387-29362-0_23","volume-title":"Bioinforma Comput Biol Solut Using R Bioconductor","author":"GK Smyth","year":"2005","unstructured":"Smyth GK: Limma: linear models for microarray data. Bioinforma Comput Biol Solut Using R Bioconductor. 2005, New York: Springer, 397-420."},{"key":"5686_CR20","doi-asserted-by":"crossref","first-page":"Article3","DOI":"10.2202\/1544-6115.1027","volume":"3","author":"GK Smyth","year":"2004","unstructured":"Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004, 3: Article3-","journal-title":"Stat Appl Genet Mol Biol"},{"key":"5686_CR21","unstructured":"Bioconductor. [http:\/\/www.bioconductor.org]"},{"key":"5686_CR22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y: Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J R Stat Soc Ser B Methodol. 1995, 57: 289-300.","journal-title":"J R Stat Soc Ser B Methodol"},{"key":"5686_CR23","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1093\/bioinformatics\/btr028","volume":"27","author":"X Wang","year":"2011","unstructured":"Wang X, Terfve C, Rose JC, Markowetz F: HTSanalyzeR: an R\/Bioconductor package for integrated network analysis of high-throughput screens. Bioinforma Oxf Engl. 2011, 27: 879-880. 10.1093\/bioinformatics\/btr028.","journal-title":"Bioinforma Oxf Engl"},{"key":"5686_CR24","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005, 102: 15545-15550. 10.1073\/pnas.0506580102.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5686_CR25","unstructured":"BioCarta. [http:\/\/www.biocarta.com]"},{"key":"5686_CR26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S: KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 2000, 28: 27-30. 10.1093\/nar\/28.1.27.","journal-title":"Nucleic Acids Res"},{"key":"5686_CR27","unstructured":"PID. [http:\/\/pid.nci.nih.gov]"},{"key":"5686_CR28","unstructured":"Reactome. [http:\/\/www.reactome.org]"},{"key":"5686_CR29","unstructured":"SigmaAldrich. [http:\/\/www.sigmaaldrich.com\/life-science.html]"},{"key":"5686_CR30","unstructured":"Signaling Gateway. [http:\/\/www.signaling-gateway.org]"},{"key":"5686_CR31","unstructured":"Signal Transduction KE. [http:\/\/stke.sciencemag.org]"},{"key":"5686_CR32","unstructured":"SuperArray. [http:\/\/www.superarray.com]"},{"key":"5686_CR33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000, 25: 25-29. 10.1038\/75556.","journal-title":"Nat Genet"},{"key":"5686_CR34","unstructured":"Francesco F: RmiR: Package to work with miRNAs and miRNA targets with R. R package version 1.16.0."},{"issue":"Database","key":"5686_CR35","doi-asserted-by":"publisher","first-page":"D154","DOI":"10.1093\/nar\/gkm952","volume":"36","author":"S Griffiths-Jones","year":"2008","unstructured":"Griffiths-Jones S, Saini HK, van Dongen S, Enright AJ: miRBase: tools for microRNA genomics. Nucleic Acids Res. 2008, 36 (Database): D154-158.","journal-title":"Nucleic Acids Res"},{"key":"5686_CR36","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1038\/nsmb.2115","volume":"18","author":"DM Garcia","year":"2011","unstructured":"Garcia DM, Baek D, Shin C, Bell GW, Grimson A, Bartel DP: Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol. 2011, 18: 1139-1146. 10.1038\/nsmb.2115.","journal-title":"Nat Struct Mol Biol"},{"issue":"suppl 1","key":"5686_CR37","first-page":"D149","volume":"36","author":"D Betel","year":"2008","unstructured":"Betel D, Wilson M, Gabow A, Marks DS, Sander C: The microRNA.org resource: targets and expression. Nucleic Acids Res. 2008, 36 (suppl 1): D149-D153.","journal-title":"Nucleic Acids Res"},{"issue":"Database","key":"5686_CR38","doi-asserted-by":"publisher","first-page":"D155","DOI":"10.1093\/nar\/gkn809","volume":"37","author":"GL Papadopoulos","year":"2009","unstructured":"Papadopoulos GL, Reczko M, Simossis VA, Sethupathy P, Hatzigeorgiou AG: The database of experimentally supported targets: a functional update of TarBase. Nucleic Acids Res. 2009, 37 (Database): D155-158. 10.1093\/nar\/gkn809.","journal-title":"Nucleic Acids Res"},{"key":"5686_CR39","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1261\/rna.965408","volume":"14","author":"X Wang","year":"2008","unstructured":"Wang X: miRDB: a microRNA target prediction and functional annotation database with a wiki interface. RNA N Y N. 2008, 14: 1012-1017. 10.1261\/rna.965408.","journal-title":"RNA N Y N"},{"key":"5686_CR40","unstructured":"PicTar. [http:\/\/pictar.mdc-berlin.de]"},{"key":"5686_CR41","volume-title":"phenoTest: Tools to test association between gene expression and phenotype in a way that is efficient, structured, fast and scalable. We also provide tools to do GSEA (Gene set enrichment analysis) and copy number variation.. R package version 1.6.0","author":"E Planet","year":"2010","unstructured":"Planet E: phenoTest: Tools to test association between gene expression and phenotype in a way that is efficient, structured, fast and scalable. We also provide tools to do GSEA (Gene set enrichment analysis) and copy number variation.. R package version 1.6.0. 2010"},{"key":"5686_CR42","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"D Cox","year":"1972","unstructured":"Cox D: Regression models and life-tables. J R Stat Soc Ser B. 1972, 34: 187-220.","journal-title":"J R Stat Soc Ser B"},{"key":"5686_CR43","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"EL Kaplan","year":"1958","unstructured":"Kaplan EL, Meier P: Nonparametric Estimation from Incomplete Observations. J Am Stat Assoc. 1958, 53: 457-10.1080\/01621459.1958.10501452.","journal-title":"J Am Stat Assoc"},{"key":"5686_CR44","doi-asserted-by":"publisher","first-page":"10202","DOI":"10.1158\/0008-5472.CAN-10-2607","volume":"70","author":"S Roessler","year":"2010","unstructured":"Roessler S, Jia HL, Budhu A, Forgues M, Ye QH, Lee JS, Thorgeirsson SS, Sun Z, Tang ZY, Qin LX, Wang XW: A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. Cancer Res. 2010, 70: 10202-10212. 10.1158\/0008-5472.CAN-10-2607.","journal-title":"Cancer Res"},{"key":"5686_CR45","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1053\/j.gastro.2011.12.039","volume":"142","author":"S Roessler","year":"2012","unstructured":"Roessler S, Long EL, Budhu A, Chen Y, Zhao X, Ji J, Walker R, Jia HL, Ye QH, Qin LX, Tang ZY, He P, Hunter KW, Thorgeirsson SS, Meltzer PS, Wang XW: Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. Gastroenterology. 2012, 142: 957-966.e12. 10.1053\/j.gastro.2011.12.039.","journal-title":"Gastroenterology"},{"key":"5686_CR46","unstructured":"The Cancer Genome Atlas (TCGA). [http:\/\/cancergenome.nih.gov]"},{"key":"5686_CR47","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.dld.2012.10.020","volume":"45","author":"YM Tao","year":"2013","unstructured":"Tao YM, Liu Z, Liu HL: Dickkopf-1 (DKK1) promotes invasion and metastasis of hepatocellular carcinoma. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver. 2013, 45: 251-257. 10.1016\/j.dld.2012.10.020.","journal-title":"Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver"},{"key":"5686_CR48","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S1470-2045(12)70233-4","volume":"13","author":"Q Shen","year":"2012","unstructured":"Shen Q, Fan J, Yang XR, Tan Y, Zhao W, Xu Y, Wang N, Niu Y, Wu Z, Zhou J, Qiu SJ, Shi YH, Yu B, Tang N, Chu W, Wang M, Wu J, Zhang Z, Yang S, Gu J, Wang H, Qin W: Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study. Lancet Oncol. 2012, 13: 817-826. 10.1016\/S1470-2045(12)70233-4.","journal-title":"Lancet Oncol"},{"key":"5686_CR49","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/1471-2350-9-109","volume":"9","author":"F Fernandez","year":"2008","unstructured":"Fernandez F, Esposito T, Lea RA, Colson NJ, Ciccodicola A, Gianfrancesco F, Griffiths LR: Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility. BMC Med Genet. 2008, 9: 109-10.1186\/1471-2350-9-109.","journal-title":"BMC Med Genet"},{"key":"5686_CR50","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1086\/498851","volume":"78","author":"A Grupe","year":"2006","unstructured":"Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JSK, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vri\u00e8ze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, et al: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Am J Hum Genet. 2006, 78: 78-88. 10.1086\/498851.","journal-title":"Am J Hum Genet"},{"key":"5686_CR51","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cell.2009.06.030","volume":"138","author":"JM Svendsen","year":"2009","unstructured":"Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW: Mammalian BTBD12\/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell. 2009, 138: 63-77. 10.1016\/j.cell.2009.06.030.","journal-title":"Cell"},{"key":"5686_CR52","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1053\/j.gastro.2004.06.047","volume":"127","author":"AP Feranchak","year":"2004","unstructured":"Feranchak AP, Doctor RB, Troetsch M, Brookman K, Johnson SM, Fitz JG: Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels. Gastroenterology. 2004, 127: 903-913. 10.1053\/j.gastro.2004.06.047.","journal-title":"Gastroenterology"},{"key":"5686_CR53","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0092-8674(88)90485-0","volume":"53","author":"VP Sukhatme","year":"1988","unstructured":"Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T: A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell. 1988, 53: 37-43. 10.1016\/0092-8674(88)90485-0.","journal-title":"Cell"},{"key":"5686_CR54","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA: Hallmarks of cancer: the next generation. Cell. 2011, 144: 646-674. 10.1016\/j.cell.2011.02.013.","journal-title":"Cell"},{"key":"5686_CR55","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1073\/pnas.93.7.2850","volume":"93","author":"KA Cimprich","year":"1996","unstructured":"Cimprich KA, Shin TB, Keith CT, Schreiber SL: cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci USA. 1996, 93: 2850-2855. 10.1073\/pnas.93.7.2850.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5686_CR56","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1073\/pnas.91.5.1736","volume":"91","author":"U Holtrich","year":"1994","unstructured":"Holtrich U, Wolf G, Br\u00e4uninger A, Karn T, B\u00f6hme B, R\u00fcbsamen-Waigmann H, Strebhardt K: Induction and down-regulation of PLK, a human serine\/threonine kinase expressed in proliferating cells and tumors. Proc Natl Acad Sci USA. 1994, 91: 1736-1740. 10.1073\/pnas.91.5.1736.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5686_CR57","doi-asserted-by":"publisher","first-page":"17564","DOI":"10.1074\/jbc.M111037200","volume":"277","author":"H Wang","year":"2002","unstructured":"Wang H, Gauthier BR, Hagenfeldt-Johansson KA, Iezzi M, Wollheim CB: Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. J Biol Chem. 2002, 277: 17564-17570. 10.1074\/jbc.M111037200.","journal-title":"J Biol Chem"},{"key":"5686_CR58","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1006\/geno.1996.4477","volume":"39","author":"A Mincheva","year":"1997","unstructured":"Mincheva A, Lichter P, Sch\u00fctz G, Kaestner KH: Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4. Genomics. 1997, 39: 417-419. 10.1006\/geno.1996.4477.","journal-title":"Genomics"},{"key":"5686_CR59","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1172\/JCI18698","volume":"112","author":"C Wolfrum","year":"2003","unstructured":"Wolfrum C, Shih DQ, Kuwajima S, Norris AW, Kahn CR, Stoffel M: Role of Foxa-2 in adipocyte metabolism and differentiation. J Clin Invest. 2003, 112: 345-356.","journal-title":"J Clin Invest"},{"key":"5686_CR60","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1002\/ijc.23901","volume":"123","author":"TM Kim","year":"2008","unstructured":"Kim TM, Yim SH, Shin SH, Xu HD, Jung YC, Park CK, Choi JY, Park WS, Kwon MS, Fiegler H, Carter NP, Rhyu MG, Chung YJ: Clinical implication of recurrent copy number alterations in hepatocellular carcinoma and putative oncogenes in recurrent gains on 1q. Int J Cancer J Int Cancer. 2008, 123: 2808-2815. 10.1002\/ijc.23901.","journal-title":"Int J Cancer J Int Cancer"},{"key":"5686_CR61","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/sj.onc.1210700","volume":"27","author":"A Kauffmann","year":"2008","unstructured":"Kauffmann A, Rosselli F, Lazar V, Winnepenninckx V, Mansuet-Lupo A, Dessen P, van den Oord JJ, Spatz A, Sarasin A: High expression of DNA repair pathways is associated with metastasis in melanoma patients. Oncogene. 2008, 27: 565-573. 10.1038\/sj.onc.1210700.","journal-title":"Oncogene"},{"key":"5686_CR62","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1034\/j.1600-0528.2002.017420.x","volume":"174","author":"GW McCaughan","year":"2000","unstructured":"McCaughan GW, Gorrell MD, Bishop GA, Abbott CA, Shackel NA, McGuinness PH, Levy MT, Sharland AF, Bowen DG, Yu D, Slaitini L, Church WB, Napoli J: Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunol Rev. 2000, 174: 172-191. 10.1034\/j.1600-0528.2002.017420.x.","journal-title":"Immunol Rev"},{"key":"5686_CR63","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1038\/sj.onc.1209292","volume":"25","author":"CD Enk","year":"2006","unstructured":"Enk CD, Jacob-Hirsch J, Gal H, Verbovetski I, Amariglio N, Mevorach D, Ingber A, Givol D, Rechavi G, Hochberg M: The UVB-induced gene expression profile of human epidermis in vivo is different from that of cultured keratinocytes. Oncogene. 2006, 25: 2601-2614. 10.1038\/sj.onc.1209292.","journal-title":"Oncogene"},{"key":"5686_CR64","volume-title":"Clin Cancer Res Off J Am Assoc Cancer Res","author":"RR Wei","year":"2013","unstructured":"Wei RR, Huang GL, Zhang MY, Li BK, Zhang HZ, Shi M, Chen XQ, Huang L, Zhou QM, Jia WHJ, Zheng XFS, Yuan YF, Wang HY: Clinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma. Clin Cancer Res Off J Am Assoc Cancer Res. 2013"},{"key":"5686_CR65","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1158\/0008-5472.CAN-07-5644","volume":"68","author":"M Smid","year":"2008","unstructured":"Smid M, Wang Y, Zhang Y, Sieuwerts AM, Yu J, Klijn JGM, Foekens JA, Martens JWM: Subtypes of breast cancer show preferential site of relapse. Cancer Res. 2008, 68: 3108-3114. 10.1158\/0008-5472.CAN-07-5644.","journal-title":"Cancer Res"},{"key":"5686_CR66","doi-asserted-by":"publisher","first-page":"e3420","DOI":"10.1371\/journal.pone.0003420","volume":"3","author":"M Lu","year":"2008","unstructured":"Lu M, Zhang Q, Deng M, Miao J, Guo Y, Gao W, Cui Q: An Analysis of Human MicroRNA and Disease Associations. PLoS ONE. 2008, 3: e3420-10.1371\/journal.pone.0003420.","journal-title":"PLoS ONE"},{"key":"5686_CR67","doi-asserted-by":"crossref","unstructured":"Zeng L, Yu J, Huang T, Jia H, Dong Q, He F, Yuan W, Qin L, Li Y, Xie L: Differential combinatorial regulatory network analysis related to venous metastasis of hepatocellular carcinoma. BMC Genomics. 2012, S14-13 Suppl 8","DOI":"10.1186\/1471-2164-13-S8-S14"},{"key":"5686_CR68","doi-asserted-by":"publisher","first-page":"5969","DOI":"10.1093\/nar\/gkp638","volume":"37","author":"K Tu","year":"2009","unstructured":"Tu K, Yu H, Hua YJ, Li YY, Liu L, Xie L, Li YX: Combinatorial network of primary and secondary microRNA-driven regulatory mechanisms. Nucleic Acids Res. 2009, 37: 5969-5980. 10.1093\/nar\/gkp638.","journal-title":"Nucleic Acids Res"},{"key":"5686_CR69","doi-asserted-by":"publisher","first-page":"e54082","DOI":"10.1371\/journal.pone.0054082","volume":"8","author":"M Chen","year":"2013","unstructured":"Chen M, Xiao J, Zhang Z, Liu J, Wu J, Yu J: Identification of human HK genes and gene expression regulation study in cancer from transcriptomics data analysis. PloS One. 2013, 8: e54082-10.1371\/journal.pone.0054082.","journal-title":"PloS One"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2164-15-S1-S13.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T16:02:05Z","timestamp":1716480125000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/1471-2164-15-S1-S13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":69,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["5686"],"URL":"https:\/\/doi.org\/10.1186\/1471-2164-15-s1-s13","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"24 January 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"S13"}}