{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:05:39Z","timestamp":1790161539805,"version":"4.1.0"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Craniosynostosis, the premature fusion of calvarial sutures, is a common craniofacial abnormality. Causative mutations in more than 10 genes have been identified, involving fibroblast growth factor, transforming growth factor beta, and Eph\/ephrin signalling pathways. Mutations affect each human calvarial suture (coronal, sagittal, metopic, and lambdoid) differently, suggesting different gene expression patterns exist in each human suture. To better understand the molecular control of human suture morphogenesis we used microarray analysis to identify genes differentially expressed during suture fusion in children with craniosynostosis. Expression differences were also analysed between each unfused suture type, between sutures from syndromic and non-syndromic craniosynostosis patients, and between unfused sutures from individuals with and without craniosynostosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified genes with increased expression in unfused sutures compared to fusing\/fused sutures that may be pivotal to the maintenance of suture patency or in controlling early osteoblast differentiation (i.e.\n                      <jats:italic>RBP4<\/jats:italic>\n                      ,\n                      <jats:italic>GPC3<\/jats:italic>\n                      ,\n                      <jats:italic>C1QTNF3<\/jats:italic>\n                      ,\n                      <jats:italic>IL11RA<\/jats:italic>\n                      ,\n                      <jats:italic>PTN<\/jats:italic>\n                      ,\n                      <jats:italic>POSTN<\/jats:italic>\n                      ). In addition, we have identified genes with increased expression in fusing\/fused suture tissue that we suggest could have a role in premature suture fusion (i.e.\n                      <jats:italic>WIF1<\/jats:italic>\n                      ,\n                      <jats:italic>ANXA3<\/jats:italic>\n                      ,\n                      <jats:italic>CYFIP2<\/jats:italic>\n                      ). Proteins of two of these genes, glypican 3 and retinol binding protein 4, were investigated by immunohistochemistry and localised to the suture mesenchyme and osteogenic fronts of developing human calvaria, respectively, suggesting novel roles for these proteins in the maintenance of suture patency or in controlling early osteoblast differentiation. We show that there is limited difference in whole genome expression between sutures isolated from patients with syndromic and non-syndromic craniosynostosis and confirmed this by quantitative RT-PCR. Furthermore, distinct expression profiles for each unfused suture type were noted, with the metopic suture being most disparate. Finally, although calvarial bones are generally thought to grow without a cartilage precursor, we show histologically and by identification of cartilage-specific gene expression that cartilage may be involved in the morphogenesis of lambdoid and posterior sagittal sutures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study has provided further insight into the complex signalling network which controls human calvarial suture morphogenesis and craniosynostosis. Identified genes are candidates for targeted therapeutic development and to screen for craniosynostosis-causing mutations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2164-8-458","type":"journal-article","created":{"date-parts":[[2007,12,13]],"date-time":"2007-12-13T02:13:08Z","timestamp":1197511988000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis"],"prefix":"10.1186","volume":"8","author":[{"given":"Anna K","family":"Coussens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian P","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Phillip","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"van Daal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry C","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,12,12]]},"reference":[{"key":"1171_CR1","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1073>3.0.CO;2-F","volume":"219","author":"LA Opperman","year":"2000","unstructured":"Opperman LA: Cranial sutures as intramembranous bone growth sites. Dev Dyn. 2000, 219: 472-485. 10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1073>3.0.CO;2-F.","journal-title":"Dev Dyn"},{"key":"1171_CR2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1159\/000146099","volume":"124","author":"JA Furtwangler","year":"1985","unstructured":"Furtwangler JA, Hall SH, Koskinen-Moffett LK: Sutural morphogenesis in the mouse calvaria: the role of apoptosis. Acta Anat (Basel). 1985, 124: 74-80.","journal-title":"Acta Anat (Basel)"},{"key":"1171_CR3","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/(SICI)1096-8628(20000103)90:1<82::AID-AJMG15>3.0.CO;2-5","volume":"90","author":"AO Wilkie","year":"2000","unstructured":"Wilkie AO: Epidemiology and genetics of craniosynostosis. Am J Med Genet. 2000, 90: 82-84. 10.1002\/(SICI)1096-8628(20000103)90:1<82::AID-AJMG15>3.0.CO;2-5.","journal-title":"Am J Med Genet"},{"key":"1171_CR4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/tera.1420210105","volume":"21","author":"JE Yip","year":"1980","unstructured":"Yip JE, Kokich VG, Shepard TH: The effect of high doses of retinoic acid on prenatal craniofacial development in Macaca nemestrina. Teratology. 1980, 21: 29-38. 10.1002\/tera.1420210105.","journal-title":"Teratology"},{"key":"1171_CR5","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/ajmg.1320470507","volume":"47","author":"MM Cohen Jr.","year":"1993","unstructured":"Cohen MM: Sutural biology and the correlates of craniosynostosis. Am J Med Genet. 1993, 47: 581-616. 10.1002\/ajmg.1320470507.","journal-title":"Am J Med Genet"},{"key":"1171_CR6","first-page":"6117","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"M Muenke","year":"2000","unstructured":"Muenke M, Wilkie AO: Craniosynostosis Syndromes. The Metabolic and Molecular Bases of Inherited Disease. Edited by: Sciver CR, Beaudet AL, Sly WS, Valle D, Childs B and Vogelstein B. 2000, New York, McGraw-Hill, 3: 6117-6146. 8th","edition":"8th"},{"key":"1171_CR7","doi-asserted-by":"publisher","first-page":"699","DOI":"10.2174\/156652405774641043","volume":"5","author":"DP Rice","year":"2005","unstructured":"Rice DP: Craniofacial anomalies: from development to molecular pathogenesis. Curr Mol Med. 2005, 5: 699-722. 10.2174\/156652405774641043.","journal-title":"Curr Mol Med"},{"key":"1171_CR8","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1359\/jbmr.1997.12.3.311","volume":"12","author":"DA Roth","year":"1997","unstructured":"Roth DA, Longaker MT, McCarthy JG, Rosen DM, McMullen HF, Levine JP, Sung J, Gold LI: Studies in cranial suture biology: Part I. Increased immunoreactivity for TGF-beta isoforms (beta 1, beta 2, and beta 3) during rat cranial suture fusion. J Bone Miner Res. 1997, 12: 311-321. 10.1359\/jbmr.1997.12.3.311.","journal-title":"J Bone Miner Res"},{"key":"1171_CR9","first-page":"164","volume":"19","author":"LA Opperman","year":"1999","unstructured":"Opperman LA, Chhabra A, Cho RW, Ogle RC: Cranial suture obliteration is induced by removal of transforming growth factor (TGF)-beta 3 activity and prevented by removal of TGF-beta 2 activity from fetal rat calvaria in vitro. J Craniofac Genet Dev Biol. 1999, 19: 164-173.","journal-title":"J Craniofac Genet Dev Biol"},{"key":"1171_CR10","doi-asserted-by":"publisher","first-page":"34387","DOI":"10.1074\/jbc.M211386200","volume":"278","author":"MH Lee","year":"2003","unstructured":"Lee MH, Kim YJ, Kim HJ, Park HD, Kang AR, Kyung HM, Sung JH, Wozney JM, Ryoo HM: BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. J Biol Chem. 2003, 278: 34387-34394. 10.1074\/jbc.M211386200.","journal-title":"J Biol Chem"},{"key":"1171_CR11","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1242\/dev.125.7.1241","volume":"125","author":"HJ Kim","year":"1998","unstructured":"Kim HJ, Rice DP, Kettunen PJ, Thesleff I: FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development. 1998, 125: 1241-1251.","journal-title":"Development"},{"key":"1171_CR12","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1006\/dbio.2001.0487","volume":"241","author":"X Jiang","year":"2002","unstructured":"Jiang X, Iseki S, Maxson RE, Sucov HM, Morriss-Kay GM: Tissue origins and interactions in the mammalian skull vault. Dev Biol. 2002, 241: 106-116. 10.1006\/dbio.2001.0487.","journal-title":"Dev Biol"},{"key":"1171_CR13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1242\/dev.117.2.409","volume":"117","author":"GF Couly","year":"1993","unstructured":"Couly GF, Coltey PM, Le Douarin NM: The triple origin of skull in higher vertebrates: a study in quail-chick chimeras. Development. 1993, 117: 409-429.","journal-title":"Development"},{"key":"1171_CR14","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1111\/j.1469-7580.2005.00475.x","volume":"207","author":"GM Morriss-Kay","year":"2005","unstructured":"Morriss-Kay GM, Wilkie AO: Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies. J Anat. 2005, 207: 637-653.","journal-title":"J Anat"},{"key":"1171_CR15","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1097\/00006534-200009020-00017","volume":"106","author":"JA Spector","year":"2000","unstructured":"Spector JA, Mehrara BJ, Greenwald JA, Saadeh PB, Steinbrech DS, Smith LP, Longaker MT: A molecular analysis of the isolated rat posterior frontal and sagittal sutures: differences in gene expression. Plast Reconstr Surg. 2000, 106: 852-861; discussion 862-867. 10.1097\/00006534-200009040-00017.","journal-title":"Plast Reconstr Surg"},{"key":"1171_CR16","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1097\/01.PRS.0000110203.90911.63","volume":"113","author":"HM Song","year":"2004","unstructured":"Song HM, Sahar DE, Fong KD, Nacamuli RP, Fang TD, Mathy JA, Aalami OO, Warren SM, Longaker MT: In vitro murine posterior frontal suture fate is age-dependent: implications for cranial suture biology. Plast Reconstr Surg. 2004, 113: 1192-1204. 10.1097\/01.PRS.0000110203.90911.63.","journal-title":"Plast Reconstr Surg"},{"key":"1171_CR17","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1097\/01.PRS.0000079826.24086.CD","volume":"112","author":"RP Nacamuli","year":"2003","unstructured":"Nacamuli RP, Fong KD, Warren SM, Fang TD, Song HM, Helms JA, Longaker MT: Markers of osteoblast differentiation in fusing and nonfusing cranial sutures. Plast Reconstr Surg. 2003, 112: 1328-1335. 10.1097\/01.PRS.0000079826.24086.CD.","journal-title":"Plast Reconstr Surg"},{"key":"1171_CR18","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1097\/00006534-199811000-00001","volume":"102","author":"BJ Mehrara","year":"1998","unstructured":"Mehrara BJ, Mackool RJ, McCarthy JG, Gittes GK, Longaker MT: Immunolocalization of basic fibroblast growth factor and fibroblast growth factor receptor-1 and receptor-2 in rat cranial sutures. Plast Reconstr Surg. 1998, 102: 1805-1817; discussion 1818-1820. 10.1097\/00006534-199811000-00001.","journal-title":"Plast Reconstr Surg"},{"key":"1171_CR19","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1097\/01.PRS.0000117362.33347.43","volume":"113","author":"AK Gosain","year":"2004","unstructured":"Gosain AK, Recinos RF, Agresti M, Khanna AK: TGF-beta1, FGF-2, and receptor mRNA expression in suture mesenchyme and dura versus underlying brain in fusing and nonfusing mouse cranial sutures. Plast Reconstr Surg. 2004, 113: 1675-1684. 10.1097\/01.PRS.0000117362.33347.43.","journal-title":"Plast Reconstr Surg"},{"key":"1171_CR20","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/00006534-199907000-00019","volume":"104","author":"JP Bradley","year":"1999","unstructured":"Bradley JP, Han VK, Roth DA, Levine JP, McCarthy JG, Longaker MT: Increased IGF-I and IGF-II mRNA and IGF-I peptide in fusing rat cranial sutures suggest evidence for a paracrine role of insulin-like growth factors in suture fusion. Plast Reconstr Surg. 1999, 104: 129-138. 10.1097\/00006534-199907000-00018.","journal-title":"Plast Reconstr Surg"},{"key":"1171_CR21","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1093\/hmg\/9.13.2001","volume":"9","author":"YX Zhou","year":"2000","unstructured":"Zhou YX, Xu X, Chen L, Li C, Brodie SG, Deng CX: A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Hum Mol Genet. 2000, 9: 2001-2008. 10.1093\/hmg\/9.13.2001.","journal-title":"Hum Mol Genet"},{"key":"1171_CR22","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1002\/jcb.20582","volume":"96","author":"PJ Marie","year":"2005","unstructured":"Marie PJ, Coffin JD, Hurley MM: FGF and FGFR signalling in chondrodysplasias and craniosynostosis. J Cell Biochem. 2005, 96: 888-896. 10.1002\/jcb.20582.","journal-title":"J Cell Biochem"},{"key":"1171_CR23","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/ng1194-275","volume":"8","author":"EW Jabs","year":"1994","unstructured":"Jabs EW, Li X, Scott AF, Meyers G, Chen W, Eccles M, Mao JI, Charnas LR, Jackson CE, Jaye M: Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Nat Genet. 1994, 8: 275-279. 10.1038\/ng1194-275.","journal-title":"Nat Genet"},{"key":"1171_CR24","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1242\/dev.126.24.5611","volume":"126","author":"S Iseki","year":"1999","unstructured":"Iseki S, Wilkie AO, Morriss-Kay GM: Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault. Development. 1999, 126: 5611-5620.","journal-title":"Development"},{"key":"1171_CR25","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1242\/dev.127.9.1845","volume":"127","author":"DP Rice","year":"2000","unstructured":"Rice DP, Aberg T, Chan Y, Tang Z, Kettunen PJ, Pakarinen L, Maxson RE, Thesleff I: Integration of FGF and TWIST in calvarial bone and suture development. Development. 2000, 127: 1845-1855.","journal-title":"Development"},{"key":"1171_CR26","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1002\/ar.a.10113","volume":"274A","author":"S Lyn Chong","year":"2003","unstructured":"Lyn Chong S, Mitchell R, Moursi AM, Winnard P, Losken HW, Bradley J, Ozerdem OR, Azari K, Acarturk O, Opperman LA, Siegel MI, Mooney MP: Rescue of coronal suture fusion using transforming growth factor-beta 3 (Tgf-beta 3) in rabbits with delayed-onset craniosynostosis. Anat Rec. 2003, 274A: 962-971. 10.1002\/ar.a.10113.","journal-title":"Anat Rec"},{"key":"1171_CR27","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1359\/jbmr.1997.12.3.301","volume":"12","author":"LA Opperman","year":"1997","unstructured":"Opperman LA, Nolen AA, Ogle RC: TGF-beta 1, TGF-beta 2, and TGF-beta 3 exhibit distinct patterns of expression during cranial suture formation and obliteration in vivo and in vitro. J Bone Miner Res. 1997, 12: 301-310. 10.1359\/jbmr.1997.12.3.301.","journal-title":"J Bone Miner Res"},{"key":"1171_CR28","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00223001128","volume":"67","author":"HH Chien","year":"2000","unstructured":"Chien HH, Lin WL, Cho MI: Down-regulation of osteoblastic cell differentiation by epidermal growth factor receptor. Calcif Tissue Int. 2000, 67: 141-150. 10.1007\/s00223001128.","journal-title":"Calcif Tissue Int"},{"key":"1171_CR29","volume-title":"Differentiation","author":"AK Coussens","year":"2007","unstructured":"Coussens AK, Hughes IP, Wilkinson CR, Morris CP, Anderson PJ, Powell BC, van Daal A: Identification of genes differentially expressed by prematurely fused human sutures using a novel in vivo - in vitro approach. Differentiation. 2007, [Epub ahead of print],"},{"key":"1171_CR30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1146\/annurev.immunol.24.021605.090646","volume":"24","author":"MC Walsh","year":"2006","unstructured":"Walsh MC, Kim N, Kadono Y, Rho J, Lee SY, Lorenzo J, Choi Y: Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol. 2006, 24: 33-63. 10.1146\/annurev.immunol.24.021605.090646.","journal-title":"Annu Rev Immunol"},{"key":"1171_CR31","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1385\/IR:30:3:291","volume":"30","author":"I Marriott","year":"2004","unstructured":"Marriott I: Osteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progression. Immunol Res. 2004, 30: 291-308. 10.1385\/IR:30:3:291.","journal-title":"Immunol Res"},{"key":"1171_CR32","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1093\/hmg\/ddl052","volume":"15","author":"AE Merrill","year":"2006","unstructured":"Merrill AE, Bochukova EG, Brugger SM, Ishii M, Pilz DT, Wall SA, Lyons KM, Wilkie AO, Maxson RE: Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis. Hum Mol Genet. 2006, 15: 1319-1328. 10.1093\/hmg\/ddl052.","journal-title":"Hum Mol Genet"},{"key":"1171_CR33","doi-asserted-by":"publisher","first-page":"8652","DOI":"10.1073\/pnas.0402819101","volume":"101","author":"SR Twigg","year":"2004","unstructured":"Twigg SR, Kan R, Babbs C, Bochukova EG, Robertson SP, Wall SA, Morriss-Kay GM, Wilkie AO: Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome. Proc Natl Acad Sci U S A. 2004, 101: 8652-8657. 10.1073\/pnas.0402819101.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1171_CR34","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1359\/jbmr.2000.15.11.2187","volume":"15","author":"M Wilda","year":"2000","unstructured":"Wilda M, Bachner D, Just W, Geerkens C, Kraus P, Vogel W, Hameister H: A comparison of the expression pattern of five genes of the family of small leucine-rich proteoglycans during mouse development. J Bone Miner Res. 2000, 15: 2187-2196. 10.1359\/jbmr.2000.15.11.2187.","journal-title":"J Bone Miner Res"},{"key":"1171_CR35","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S0014-5793(00)01314-4","volume":"470","author":"L Svensson","year":"2000","unstructured":"Svensson L, Narlid I, Oldberg A: Fibromodulin and lumican bind to the same region on collagen type I fibrils. FEBS Lett. 2000, 470: 178-182. 10.1016\/S0014-5793(00)01314-4.","journal-title":"FEBS Lett"},{"key":"1171_CR36","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1042\/bj3020527","volume":"302 (Pt 2)","author":"A Hildebrand","year":"1994","unstructured":"Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E: Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J. 1994, 302 (Pt 2): 527-534.","journal-title":"Biochem J"},{"key":"1171_CR37","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00223-004-0145-6","volume":"76","author":"G Li","year":"2005","unstructured":"Li G, Bunn JR, Mushipe MT, He Q, Chen X: Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair. Calcif Tissue Int. 2005, 76: 299-306. 10.1007\/s00223-004-0145-6.","journal-title":"Calcif Tissue Int"},{"key":"1171_CR38","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/jcb.10272","volume":"86","author":"A Oshima","year":"2002","unstructured":"Oshima A, Tanabe H, Yan T, Lowe GN, Glackin CA, Kudo A: A novel mechanism for the regulation of osteoblast differentiation: transcription of periostin, a member of the fasciclin I family, is regulated by the bHLH transcription factor, twist. J Cell Biochem. 2002, 86: 792-804. 10.1002\/jcb.10272.","journal-title":"J Cell Biochem"},{"key":"1171_CR39","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1172\/JCI28551","volume":"116","author":"V Krishnan","year":"2006","unstructured":"Krishnan V, Bryant HU, Macdougald OA: Regulation of bone mass by Wnt signaling. J Clin Invest. 2006, 116: 1202-1209. 10.1172\/JCI28551.","journal-title":"J Clin Invest"},{"key":"1171_CR40","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.bone.2005.02.001","volume":"36","author":"BL Vaes","year":"2005","unstructured":"Vaes BL, Dechering KJ, van Someren EP, Hendriks JM, van de Ven CJ, Feijen A, Mummery CL, Reinders MJ, Olijve W, van Zoelen EJ, Steegenga WT: Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts. Bone. 2005, 36: 803-811. 10.1016\/j.bone.2005.02.001.","journal-title":"Bone"},{"key":"1171_CR41","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000157085","volume":"7","author":"TF Linsenmayer","year":"1988","unstructured":"Linsenmayer TF, Eavey RD, Schmid TM: Type X collagen: a hypertrophic cartilage-specific molecule. Pathol Immunopathol Res. 1988, 7: 14-19.","journal-title":"Pathol Immunopathol Res"},{"key":"1171_CR42","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/S0092-8674(01)00571-2","volume":"107","author":"Y Gong","year":"2001","unstructured":"Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Juppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML: LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001, 107: 513-523. 10.1016\/S0092-8674(01)00571-2.","journal-title":"Cell"},{"key":"1171_CR43","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1083\/jcb.200409182","volume":"168","author":"A Mansukhani","year":"2005","unstructured":"Mansukhani A, Ambrosetti D, Holmes G, Cornivelli L, Basilico C: Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J Cell Biol. 2005, 168: 1065-1076. 10.1083\/jcb.200409182.","journal-title":"J Cell Biol"},{"key":"1171_CR44","doi-asserted-by":"publisher","first-page":"4633","DOI":"10.1093\/emboj\/18.17.4633","volume":"18","author":"L Quadro","year":"1999","unstructured":"Quadro L, Blaner WS, Salchow DJ, Vogel S, Piantedosi R, Gouras P, Freeman S, Cosma MP, Colantuoni V, Gottesman ME: Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. Embo J. 1999, 18: 4633-4644. 10.1093\/emboj\/18.17.4633.","journal-title":"Embo J"},{"key":"1171_CR45","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1002\/bdra.20095","volume":"70","author":"P Mukhopadhyay","year":"2004","unstructured":"Mukhopadhyay P, Greene RM, Zacharias W, Weinrich MC, Singh S, Young WW, Pisano MM: Developmental gene expression profiling of mammalian, fetal orofacial tissue. Birth Defects Res A Clin Mol Teratol. 2004, 70: 912-926. 10.1002\/bdra.20095.","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"1171_CR46","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1210\/endo.140.3.6564","volume":"140","author":"Y Kawashima-Ohya","year":"1999","unstructured":"Kawashima-Ohya Y, Kuruta Y, Yan W, Kawamoto T, Noshiro M, Kato Y: Retinol-binding protein is produced by rabbit chondrocytes and responds to parathyroid hormone (PTH)\/PTH-related peptide-cyclic adenosine monophosphate pathway. Endocrinology. 1999, 140: 1075-1081. 10.1210\/en.140.3.1075.","journal-title":"Endocrinology"},{"key":"1171_CR47","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1093\/cercor\/bhh112","volume":"15","author":"Y Komatsu","year":"2005","unstructured":"Komatsu Y, Watakabe A, Hashikawa T, Tochitani S, Yamamori T: Retinol-binding protein gene is highly expressed in higher-order association areas of the primate neocortex. Cereb Cortex. 2005, 15: 96-108. 10.1093\/cercor\/bhh112.","journal-title":"Cereb Cortex"},{"key":"1171_CR48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0022-2275(20)38373-5","volume":"30","author":"A Makover","year":"1989","unstructured":"Makover A, Soprano DR, Wyatt ML, Goodman DS: Localization of retinol-binding protein messenger RNA in the rat kidney and in perinephric fat tissue. J Lipid Res. 1989, 30: 171-180.","journal-title":"J Lipid Res"},{"key":"1171_CR49","doi-asserted-by":"publisher","first-page":"30191","DOI":"10.1074\/jbc.M205046200","volume":"277","author":"L Quadro","year":"2002","unstructured":"Quadro L, Blaner WS, Hamberger L, Van Gelder RN, Vogel S, Piantedosi R, Gouras P, Colantuoni V, Gottesman ME: Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice. J Biol Chem. 2002, 277: 30191-30197. 10.1074\/jbc.M205046200.","journal-title":"J Biol Chem"},{"key":"1171_CR50","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1194\/jlr.M400137-JLR200","volume":"45","author":"L Quadro","year":"2004","unstructured":"Quadro L, Blaner WS, Hamberger L, Novikoff PM, Vogel S, Piantedosi R, Gottesman ME, Colantuoni V: The role of extrahepatic retinol binding protein in the mobilization of retinoid stores. J Lipid Res. 2004, 45: 1975-1982. 10.1194\/jlr.M400137-JLR200.","journal-title":"J Lipid Res"},{"key":"1171_CR51","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1177\/10454411000110030201","volume":"11","author":"DL Young","year":"2000","unstructured":"Young DL, Schneider RA, Hu D, Helms JA: Genetic and teratogenic approaches to craniofacial development. Crit Rev Oral Biol Med. 2000, 11: 304-317.","journal-title":"Crit Rev Oral Biol Med"},{"key":"1171_CR52","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/bies.950150103","volume":"15","author":"G Morriss-Kay","year":"1993","unstructured":"Morriss-Kay G: Retinoic acid and craniofacial development: molecules and morphogenesis. Bioessays. 1993, 15: 9-15. 10.1002\/bies.950150103.","journal-title":"Bioessays"},{"key":"1171_CR53","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3177\/jnsv.43.281","volume":"43","author":"CK Park","year":"1997","unstructured":"Park CK, Ishimi Y, Ohmura M, Yamaguchi M, Ikegami S: Vitamin A and carotenoids stimulate differentiation of mouse osteoblastic cells. J Nutr Sci Vitaminol (Tokyo). 1997, 43: 281-296.","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"1171_CR54","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1083\/jcb.200106147","volume":"155","author":"MJ Jimenez","year":"2001","unstructured":"Jimenez MJ, Balbin M, Alvarez J, Komori T, Bianco P, Holmbeck K, Birkedal-Hansen H, Lopez JM, Lopez-Otin C: A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation. J Cell Biol. 2001, 155: 1333-1344. 10.1083\/jcb.200106147.","journal-title":"J Cell Biol"},{"key":"1171_CR55","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1210\/me.7.2.189","volume":"7","author":"D Gazit","year":"1993","unstructured":"Gazit D, Ebner R, Kahn AJ, Derynck R: Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Mol Endocrinol. 1993, 7: 189-198. 10.1210\/me.7.2.189.","journal-title":"Mol Endocrinol"},{"key":"1171_CR56","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/jcp.20115","volume":"202","author":"HM Song","year":"2005","unstructured":"Song HM, Nacamuli RP, Xia W, Bari AS, Shi YY, Fang TD, Longaker MT: High-dose retinoic acid modulates rat calvarial osteoblast biology. J Cell Physiol. 2005, 202: 255-262. 10.1002\/jcp.20115.","journal-title":"J Cell Physiol"},{"key":"1171_CR57","doi-asserted-by":"publisher","first-page":"4479","DOI":"10.1210\/en.2005-0158","volume":"146","author":"L Quadro","year":"2005","unstructured":"Quadro L, Hamberger L, Gottesman ME, Wang F, Colantuoni V, Blaner WS, Mendelsohn CL: Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency. Endocrinology. 2005, 146: 4479-4490. 10.1210\/en.2005-0158.","journal-title":"Endocrinology"},{"key":"1171_CR58","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/ije\/27.1.64","volume":"27","author":"JS Gardner","year":"1998","unstructured":"Gardner JS, Guyard-Boileau B, Alderman BW, Fernbach SK, Greene C, Mangione EJ: Maternal exposure to prescription and non-prescription pharmaceuticals or drugs of abuse and risk of craniosynostosis. Int J Epidemiol. 1998, 27: 64-67. 10.1093\/ije\/27.1.64.","journal-title":"Int J Epidemiol"},{"key":"1171_CR59","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ng0396-241","volume":"12","author":"G Pilia","year":"1996","unstructured":"Pilia G, Hughes-Benzie RM, MacKenzie A, Baybayan P, Chen EY, Huber R, Neri G, Cao A, Forabosco A, Schlessinger D: Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. Nat Genet. 1996, 12: 241-247. 10.1038\/ng0396-241.","journal-title":"Nat Genet"},{"key":"1171_CR60","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1083\/jcb.200302152","volume":"163","author":"B De Cat","year":"2003","unstructured":"De Cat B, Muyldermans SY, Coomans C, Degeest G, Vanderschueren B, Creemers J, Biemar F, Peers B, David G: Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. J Cell Biol. 2003, 163: 625-635. 10.1083\/jcb.200302152.","journal-title":"J Cell Biol"},{"key":"1171_CR61","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/ijc.10856","volume":"103","author":"Y Midorikawa","year":"2003","unstructured":"Midorikawa Y, Ishikawa S, Iwanari H, Imamura T, Sakamoto H, Miyazono K, Kodama T, Makuuchi M, Aburatani H: Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling. Int J Cancer. 2003, 103: 455-465. 10.1002\/ijc.10856.","journal-title":"Int J Cancer"},{"key":"1171_CR62","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/dbio.2000.9831","volume":"225","author":"S Paine-Saunders","year":"2000","unstructured":"Paine-Saunders S, Viviano BL, Zupicich J, Skarnes WC, Saunders S: glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev Biol. 2000, 225: 179-187. 10.1006\/dbio.2000.9831.","journal-title":"Dev Biol"},{"key":"1171_CR63","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1074\/jbc.M410090200","volume":"280","author":"HH Song","year":"2005","unstructured":"Song HH, Shi W, Xiang YY, Filmus J: The loss of glypican-3 induces alterations in Wnt signaling. J Biol Chem. 2005, 280: 2116-2125. 10.1074\/jbc.M410090200.","journal-title":"J Biol Chem"},{"key":"1171_CR64","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/jcp.20493","volume":"206","author":"T Maeda","year":"2006","unstructured":"Maeda T, Jikko A, Abe M, Yokohama-Tamaki T, Akiyama H, Furukawa S, Takigawa M, Wakisaka S: Cartducin, a paralog of Acrp30\/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes. J Cell Physiol. 2006, 206: 537-544. 10.1002\/jcp.20493.","journal-title":"J Cell Physiol"},{"key":"1171_CR65","volume-title":"Mol Cell Biochem","author":"H Akiyama","year":"2007","unstructured":"Akiyama H, Furukawa S, Wakisaka S, Maeda T: CTRP3\/cartducin promotes proliferation and migration of endothelial cells. Mol Cell Biochem. 2007"},{"key":"1171_CR66","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3171\/jns.1984.61.2.0333","volume":"61","author":"DR Hinton","year":"1984","unstructured":"Hinton DR, Becker LE, Muakkassa KF, Hoffman HJ: Lambdoid synostosis. Part 1: The lambdoid suture: Normal development and pathology of \"synostosis\". J Neurosurg. 1984, 61: 333-339.","journal-title":"J Neurosurg"},{"key":"1171_CR67","first-page":"73","volume":"90","author":"JJ Pritchard","year":"1956","unstructured":"Pritchard JJ, Scott JH, Girgis FG: The structure and development of cranial and facial sutures. Journal of anatomy. 1956, 90: 73-86.","journal-title":"Journal of anatomy"},{"key":"1171_CR68","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1242\/dev.01914","volume":"132","author":"Y Wang","year":"2005","unstructured":"Wang Y, Xiao R, Yang F, Karim BO, Iacovelli AJ, Cai J, Lerner CP, Richtsmeier JT, Leszl JM, Hill CA, Yu K, Ornitz DM, Elisseeff J, Huso DL, Jabs EW: Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+\/S252W) mouse. Development. 2005, 132: 3537-3548. 10.1242\/dev.01914.","journal-title":"Development"},{"key":"1171_CR69","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.ydbio.2005.01.022","volume":"280","author":"DE Sahar","year":"2005","unstructured":"Sahar DE, Longaker MT, Quarto N: Sox9 neural crest determinant gene controls patterning and closure of the posterior frontal cranial suture. Dev Biol. 2005, 280: 344-361. 10.1016\/j.ydbio.2005.01.022.","journal-title":"Dev Biol"},{"key":"1171_CR70","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1359\/jbmr.2000.15.3.522","volume":"15","author":"HD Nah","year":"2000","unstructured":"Nah HD, Pacifici M, Gerstenfeld LC, Adams SL, Kirsch T: Transient chondrogenic phase in the intramembranous pathway during normal skeletal development. J Bone Miner Res. 2000, 15: 522-533. 10.1359\/jbmr.2000.15.3.522.","journal-title":"J Bone Miner Res"},{"key":"1171_CR71","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/dvdy.10319","volume":"227","author":"HJ Kim","year":"2003","unstructured":"Kim HJ, Lee MH, Park HS, Park MH, Lee SW, Kim SY, Choi JY, Shin HI, Ryoo HM: Erk pathway and activator protein 1 play crucial roles in FGF2-stimulated premature cranial suture closure. Dev Dyn. 2003, 227: 335-346. 10.1002\/dvdy.10319.","journal-title":"Dev Dyn"},{"key":"1171_CR72","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1097\/scs.0b013e31802d6e76","volume":"18","author":"PJ Anderson","year":"2007","unstructured":"Anderson PJ, Cox TC, Roscioli T, Elakis G, Smithers L, David DJ, Powell BC: Somatic FGFR and TWIST mutations are not a common cause of isolated non-syndromic single suture craniosynostosis. J Craniofac Surg. 2007, 18: 312-314. 10.1097\/scs.0b013e31802d6e76.","journal-title":"J Craniofac Surg"},{"key":"1171_CR73","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1097\/01.scs.0000230019.46896.b0","volume":"17","author":"PJ Anderson","year":"2006","unstructured":"Anderson PJ, Netherway DJ, David DJ, Self P: Scanning electron microscope and micro-CT evaluation of cranial sutures in health and disease. J Craniofac Surg. 2006, 17: 909-919. 10.1097\/01.scs.0000230019.46896.b0.","journal-title":"J Craniofac Surg"},{"key":"1171_CR74","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2164-5-9","volume":"5","author":"A Naderi","year":"2004","unstructured":"Naderi A, Ahmed AA, Barbosa-Morais NL, Aparicio S, Brenton JD, Caldas C: Expression microarray reproducibility is improved by optimising purification steps in RNA amplification and labelling. BMC Genomics. 2004, 5: 9-10.1186\/1471-2164-5-9.","journal-title":"BMC Genomics"},{"key":"1171_CR75","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","author":"RC Gentleman","year":"2004","unstructured":"Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J: Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004, 5: R80-10.1186\/gb-2004-5-10-r80.","journal-title":"Genome Biol"},{"key":"1171_CR76","unstructured":"Bioconductor: open source software for bioinformatics. [http:\/\/www.bioconductor.org]"},{"key":"1171_CR77","volume-title":"Phd Thesis; Department of Biostatistics","author":"BM Bolstad","year":"2004","unstructured":"Bolstad BM: Low Level Analysis of High-density Oligonucleotide Array Data: Background, Normalization and Summarization. Phd Thesis; Department of Biostatistics. 2004, Berkeley, University of California, [http:\/\/bmbolstad.com\/Dissertation\/Bolstad_2004_Dissertation.pdf]"},{"key":"1171_CR78","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1198\/016214504000000683","volume":"99","author":"Z Wu","year":"2004","unstructured":"Wu Z, Irizarry R, Gentleman R, Murillo F, Spencer F: A model based background adjustment for oligonucleotide expression arrays. Journal of the American Statistical Association. 2004, 99: 909-917. 10.1198\/016214504000000683.","journal-title":"Journal of the American Statistical Association"},{"key":"1171_CR79","doi-asserted-by":"publisher","first-page":"Article 3","DOI":"10.2202\/1544-6115.1027","volume":"3","author":"GK Smyth","year":"2004","unstructured":"Smyth GK: Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Statistical Applications in Genetics and Molecular Biology. 2004, 3: Article 3-10.2202\/1544-6115.1027.","journal-title":"Statistical Applications in Genetics and Molecular Biology"},{"key":"1171_CR80","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"B 57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful appraoch to multiple testing. J R Statis Soc. 1995, B 57: 289-300.","journal-title":"J R Statis Soc"},{"key":"1171_CR81","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-2105-5-16","volume":"5","author":"B Zhang","year":"2004","unstructured":"Zhang B, Schmoyer D, Kirov S, Snoddy J: GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies. BMC Bioinformatics. 2004, 5: 16-10.1186\/1471-2105-5-16.","journal-title":"BMC Bioinformatics"},{"key":"1171_CR82","unstructured":"Gene Ontology Tree Machine. [http:\/\/bioinfo.vanderbilt.edu\/gotm\/]"},{"key":"1171_CR83","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005, 102: 15545-15550. 10.1073\/pnas.0506580102.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1171_CR84","unstructured":"Gene Set Enrichment Analysis. [http:\/\/www.broad.mit.edu\/gsea]"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2164-8-458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T11:19:53Z","timestamp":1737631193000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/1471-2164-8-458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["1171"],"URL":"https:\/\/doi.org\/10.1186\/1471-2164-8-458","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"11 September 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"458"}}