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The clitellate annelid\n                      <jats:italic>Lumbricus rubellus<\/jats:italic>\n                      is a model organism for soil health testing, but genetic data have been lacking.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We generated a 17,000 sequence expressed sequence tag dataset, defining ~8,100 different putative genes, and built an 8,000-element transcriptome microarray for\n                      <jats:italic>L. rubellus<\/jats:italic>\n                      . Strikingly, less than half the putative genes (43%) were assigned annotations from the gene ontology (GO) system; this reflects the phylogenetic uniqueness of earthworms compared to the well-annotated model animals. The microarray was used to identify adult- and juvenile-specific transcript profiles in untreated animals and to determine dose-response transcription profiles following exposure to three xenobiotics from different chemical classes: inorganic (the metal cadmium), organic (the polycyclic aromatic hydrocarbon fluoranthene), and agrochemical (the herbicide atrazine). Analysis of these profiles revealed compound-specific fingerprints which identify the molecular responses of this annelid to each contaminant. The data and analyses are available in an integrated database, LumbriBASE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>L. rubellus<\/jats:italic>\n                      has a complex response to contaminant exposure, but this can be efficiently analysed using molecular methods, revealing unique response profiles for different classes of effector. These profiles may assist in the development of novel monitoring or bioremediation protocols, as well as in understanding the ecosystem effects of exposure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2164-9-266","type":"journal-article","created":{"date-parts":[[2008,6,24]],"date-time":"2008-06-24T14:14:06Z","timestamp":1214316846000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Transcriptome profiling of developmental and xenobiotic responses in a keystone soil animal, the oligochaete annelid Lumbricus rubellus"],"prefix":"10.1186","volume":"9","author":[{"given":"Jennifer","family":"Owen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Ann","family":"Hedley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Wren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijs J","family":"Jonker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K","family":"Hankard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linsey J","family":"Lister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R","family":"St\u00fcrzenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A John","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Spurgeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L","family":"Blaxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,3]]},"reference":[{"key":"1459_CR1","volume-title":"The formation of vegtable Mould through the action of Worms with observations on their habitats","author":"C Darwin","year":"1883","unstructured":"Darwin C: The formation of vegtable Mould through the action of Worms with observations on their habitats. 1883, London: John Murray"},{"key":"1459_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-5279-4","volume-title":"Soil Ecology","author":"P Lavelle","year":"2001","unstructured":"Lavelle P, Spain A: Soil Ecology. 2001, Amsterdam: Kluwer Academic Publishers, 1","edition":"1"},{"issue":"5\u20136","key":"1459_CR3","first-page":"588","volume":"47","author":"DJ Spurgeon","year":"2003","unstructured":"Spurgeon DJ, Weeks JM, Van Gestel CAM: A summary of eleven years progress in earthworm ecotoxicology. 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