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To study these, the gene expression profile of VEEV infected mouse brains was investigated. Changes in gene expression were correlated with histological changes in the brain. In addition, a molecular framework of changes in gene expression associated with progression of the disease was studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our results demonstrate that genes related to important immune pathways such as antigen presentation, inflammation, apoptosis and response to virus (\n                      <jats:italic>Cxcl10<\/jats:italic>\n                      ,\n                      <jats:italic>CxCl11<\/jats:italic>\n                      ,\n                      <jats:italic>Ccl5<\/jats:italic>\n                      ,\n                      <jats:italic>Ifr7<\/jats:italic>\n                      ,\n                      <jats:italic>Ifi27 Oas1b<\/jats:italic>\n                      ,\n                      <jats:italic>Fcerg1<\/jats:italic>\n                      ,\n                      <jats:italic>Mif<\/jats:italic>\n                      ,\n                      <jats:italic>Clusterin and MHC class II)<\/jats:italic>\n                      were upregulated as a result of virus infection. The number of over-expressed genes (&gt;1.5-fold level) increased as the disease progressed (from 197, 296, 400, to 1086 at 24, 48, 72 and 96 hours post infection, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Identification of differentially expressed genes in brain will help in the understanding of VEEV-induced pathogenesis and selection of biomarkers for diagnosis and targeted therapy of VEEV-induced neurodegeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2164-9-289","type":"journal-article","created":{"date-parts":[[2008,6,17]],"date-time":"2008-06-17T02:14:20Z","timestamp":1213668860000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Venezuelan equine encephalitis virus infection causes modulation of inflammatory and immune response genes in mouse brain"],"prefix":"10.1186","volume":"9","author":[{"given":"Anuj","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj K","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha K","family":"Maheshwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,16]]},"reference":[{"key":"1482_CR1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1146\/annurev.ento.49.061802.123422","volume":"49","author":"SC Weaver","year":"2004","unstructured":"Weaver SC, Ferro C, Barrera R, Boshell J, Navarro JC: Venezuelan equine encephalitis. 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