{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:38:57Z","timestamp":1790145537742,"version":"4.0.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Immunol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Backgroud<\/jats:title>\n            <jats:p>IL-17<jats:sup>+<\/jats:sup> T helper cells and Foxp3<jats:sup>+<\/jats:sup> regulatory T cells are CD4<jats:sup>+<\/jats:sup> T helper cells with reciprocally regulated differentiation and function. Their frequency and function vary in patients with chronic hepatitis B. In this study, we investigated the balance between IL-17<jats:sup>+<\/jats:sup> T cells and Foxp3<jats:sup>+<\/jats:sup> regulatory T cells and illustrated their function in the aggravation of chronic hepatitis B (CHB).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Twenty-six patients with chronic HBV -related liver failure (CLF), thirty-one patients with acute on chronic HBV-related liver failure (ACLF) and twelve normal controls were enrolled in our study. The expressions of IL-17, Foxp3, CD4, CD8 and perforin in liver tissue were measured by immunochemistry for the evaluation of liver-infiltrating lymphocytes. The frequency of liver IL-17<jats:sup>+<\/jats:sup> T cells on liver inflammatory cells and their proportion in the total CD4<jats:sup>+<\/jats:sup> T cell population increased markedly in the ACLF group, while the frquency of Foxp3<jats:sup>+<\/jats:sup> T cells and their proportion in the total CD4<jats:sup>+<\/jats:sup> T cell population did not show a significant difference in the two HBV infection groups. In addition, the ACLF group showed a dramatically higher IL-17<jats:sup>+<\/jats:sup> \/Foxp3<jats:sup>+<\/jats:sup> ratio than the CLF group. CD4<jats:sup>+<\/jats:sup> T cells increased significantly in the liver of patients with ACLF, compared with those in the liver of patients with CLF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our findings suggest that intrahepatic IL-17<jats:sup>+<\/jats:sup> T cells play an important role in the development of chronic HBV and that the imbalance between IL-17<jats:sup>+<\/jats:sup> and Foxp3<jats:sup>+<\/jats:sup> T cells in the liver may lead to progression of the disease but the mechanism should be further explored.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2172-12-47","type":"journal-article","created":{"date-parts":[[2011,8,19]],"date-time":"2011-08-19T06:17:14Z","timestamp":1313734634000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["The balance between intrahepatic IL-17+ T cells and Foxp3+ regulatory T cells plays an important role in HBV-related end-stage liver disease"],"prefix":"10.1186","volume":"12","author":[{"given":"Yinghua","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruitian","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong'an","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingren","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,19]]},"reference":[{"key":"395_CR1","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S1473-3099(02)00315-8","volume":"2","author":"JH Kao","year":"2002","unstructured":"Kao JH, Chen DS: Global control of hepatitis B virus infection. 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