{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:49:29Z","timestamp":1782172169121,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T00:00:00Z","timestamp":1337558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Immunol"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1186\/1471-2172-13-26","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T00:33:16Z","timestamp":1337560396000},"source":"Crossref","is-referenced-by-count":19,"title":["Immune Mediators of protective and pathogenic immune responses in patients with mild and fatal human monocytotropic ehrlichiosis"],"prefix":"10.1186","volume":"13","author":[{"given":"Nahed","family":"Ismail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnima","family":"Ghose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,5,21]]},"reference":[{"key":"470_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S1473-3099(09)70296-8","volume":"121","author":"JS Dumler","year":"2001","unstructured":"Dumler JS, Walker DH: Tick-borne Ehrlichiosis. Lancet Infectious disease. 2001, 121: 21-28.","journal-title":"Lancet Infectious disease"},{"key":"470_CR2","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/0046-8177(93)90087-W","volume":"24","author":"JS Dumler","year":"1993","unstructured":"Dumler JS, Dawson JE, Walker DH: Human Ehrlichiosis: Hematopathology and immunohistologic detection of Ehrlichia chaffeensis. Hum Pathol. 1993, 24: 391-396. 10.1016\/0046-8177(93)90087-W.","journal-title":"Hum Pathol"},{"key":"470_CR3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1128\/CMR.16.1.37-64.2003","volume":"16","author":"CD Paddock","year":"2003","unstructured":"Paddock CD, Childs JE: Ehrlichia chaffeensis: a prototypical emerging pathogen. Clin Microbiol Rev. 2003, 16: 37-64. 10.1128\/CMR.16.1.37-64.2003.","journal-title":"Clin Microbiol Rev"},{"key":"470_CR4","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0002-9343(93)90302-6","volume":"95","author":"CJ Fichtenbaum","year":"1993","unstructured":"Fichtenbaum CJ, Peterson LR, Weil GJ: Ehrlichiosis presenting as a life- threatening illness with features of the toxic shock syndrome. Am J Med. 1993, 95: 351-357. 10.1016\/0002-9343(93)90302-6.","journal-title":"Am J Med"},{"key":"470_CR5","first-page":"262","volume-title":"Rickettsiae and Rickettsial Diseases at the Turn of the Third Millenium","author":"JP Olano","year":"1999","unstructured":"Olano JP, Masters E, Cullman L, Hogrefe W, Yu X-J, Walker DH: Human monocytotrophic Ehrlichiosis (HME): Epidemiological, clinical and laboratory diagnosis of a newly emergent infection in the United States. Rickettsiae and Rickettsial Diseases at the Turn of the Third Millenium. Edited by: Raoult D, Brouqui P. 1999, Paris: Elsevier, 262-268."},{"key":"470_CR6","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1309\/F7EAB5P7321716LJ","volume":"119","author":"AE Sehdev","year":"2003","unstructured":"Sehdev AE, Dumler JS: Hepatic pathology in human monocytic Ehrlichiosis. Ehrlichia chaffeensis infection. Am J Clin Pathol. 2003, 119: 859-865. 10.1309\/F7EAB5P7321716LJ.","journal-title":"Am J Clin Pathol"},{"key":"470_CR7","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.4049\/jimmunol.172.3.1786","volume":"172","author":"N Ismail","year":"2004","unstructured":"Ismail N, Soong L, McBride JW, Valbuena G, Olano JP, Feng HM, Walker DH: Overproduction of TNF-alpha by CD8+ type 1 cells and down-regulation of IFN-gamma production by CD4+ Th1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic Ehrlichiosis. J Immunol. 2004, 172: 1786-1800.","journal-title":"J Immunol"},{"key":"470_CR8","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1093\/clinids\/23.2.314","volume":"23","author":"N Ratnasamy","year":"1996","unstructured":"Ratnasamy N, Everett ED, Roland WE, McDonald G, Caldwell CW: Central nervous system manifestations of human Ehrlichiosis. Clin Infect Dis. 1996, 23: 314-319. 10.1093\/clinids\/23.2.314.","journal-title":"Clin Infect Dis"},{"key":"470_CR9","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1111\/j.1600-6143.2007.01821.x","volume":"7","author":"LD Thomas","year":"2007","unstructured":"Thomas LD, Hongo I, Bloch KC, Tang YW, Dummer S: Human ehrlichiosis in transplant recipients. Am J Transplant. 2007, 7: 1641-1647. 10.1111\/j.1600-6143.2007.01821.x.","journal-title":"Am J Transplant"},{"key":"470_CR10","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1128\/IAI.74.3.1846-1856.2006","volume":"74","author":"N Ismail","year":"2006","unstructured":"Ismail N, Stevenson HL, Walker DH: Role of tumor necrosis factor alpha and interleukin-10 in the pathogenesis of severe murine monocytotropic Ehrlichiosis: increased resistance of TNF receptor p55- and p75-deficient mice to fatal ehrlichial infection. Infect Immun. 2006, 74: 1846-1856. 10.1128\/IAI.74.3.1846-1856.2006.","journal-title":"Infect Immun"},{"key":"470_CR11","doi-asserted-by":"publisher","first-page":"4856","DOI":"10.1128\/IAI.00246-06","volume":"74","author":"HL Stevenson","year":"2006","unstructured":"Stevenson HL, Jordan JM, Peerwani Z, Wang HQ, Walker DH, Ismail N: An intradermal environment promotes a protective type-1 response against lethal systemic monocytotropic Ehrlichial infection. Infect Immun. 2006, 74: 4856-4864. 10.1128\/IAI.00246-06.","journal-title":"Infect Immun"},{"issue":"75","key":"470_CR12","doi-asserted-by":"publisher","first-page":"4608","DOI":"10.1128\/IAI.00198-07","volume":"2007","author":"N Ismail","year":"2007","unstructured":"Ismail N, Crossely EC, Stevenson HL, Walker DH: Relative importance of T-cell subsets in monocytotropic Ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine Ehrlichiosis. Infect Immun. 2007, 2007 (75): 4608-4620.","journal-title":"Infect Immun"},{"key":"470_CR13","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1128\/IAI.01242-07","volume":"76","author":"HL Stevenson","year":"2006","unstructured":"Stevenson HL, Crossely EC, Walker DH, Ismail N: Regulatory roles of CD1d-restricted NKT cells in the induction of toxic shock-like syndrome in an animal model of fatal Ehrlichiosis. Infec Immun. 2006, 76: 1434-1444.","journal-title":"Infec Immun"},{"key":"470_CR14","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nature03408","volume":"434","author":"J Mattner","year":"2005","unstructured":"Mattner J, Debord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, Savage PB, Bendelac A: Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature. 2005, 434: 525-529. 10.1038\/nature03408.","journal-title":"Nature"},{"key":"470_CR15","doi-asserted-by":"publisher","first-page":"6894","DOI":"10.4049\/jimmunol.172.11.6894","volume":"172","author":"C Bitsaktsis","year":"2004","unstructured":"Bitsaktsis C, Huntington J, Winslow G: Production of IFN-\u03b3 by CD4 T cells is essential for resolving Ehrlichia infection. J Immunol. 2004, 172: 6894-6901.","journal-title":"J Immunol"},{"key":"470_CR16","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1128\/IAI.70.1.380-388.2002","volume":"70","author":"RR Ganta","year":"2002","unstructured":"Ganta RR, Wilkerson MJ, Cheng C, Rokey AM, Chapes SK: Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes. Infect Immun. 2002, 70: 380-388. 10.1128\/IAI.70.1.380-388.2002.","journal-title":"Infect Immun"},{"key":"470_CR17","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1128\/IAI.72.2.966-971.2004","volume":"72","author":"HM Feng","year":"2004","unstructured":"Feng HM, Walker DH: Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic Ehrlichiosis. Infect Immun. 2004, 72: 966-971. 10.1128\/IAI.72.2.966-971.2004.","journal-title":"Infect Immun"},{"key":"470_CR18","doi-asserted-by":"publisher","first-page":"766","DOI":"10.2353\/ajpath.2010.091110","volume":"177","author":"HL Stevenson","year":"2010","unstructured":"Stevenson HL, Estes DM, Thirumalapura RN, Walker DH, Ismail N: Natural killer cells promote tissue injury and systemic inflammatory responses during fatal Ehrlichia-induced toxic shock-like syndrome. Am J Pathology. 2010, 177: 766-776. 10.2353\/ajpath.2010.091110.","journal-title":"Am J Pathology"},{"key":"470_CR19","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/S1525-1578(10)60581-8","volume":"7","author":"CK Doyle","year":"2005","unstructured":"Doyle CK, Labruna MB, Breitschwerdt EB, Tang YW, Corstvet RE, Hegarty BC, Mcbride JW: Detection of medically important Ehrlichia by quantitative multicolor TaqMan real-time polymerase chain reaction of the dsb gene. J Mol Diag. 2005, 7: 504-510. 10.1016\/S1525-1578(10)60581-8.","journal-title":"J Mol Diag"},{"key":"470_CR20","doi-asserted-by":"publisher","first-page":"4830","DOI":"10.1128\/JCM.43.9.4830-4833.2005","volume":"43","author":"YW Tang","year":"2005","unstructured":"Tang YW, Sefers SE, Li H, Kohn DJ, Procop GW: Comparative evaluation of three commercial systems for nucleic acid extraction from urine specimens. J Clin Microbiol. 2005, 43: 4830-4833. 10.1128\/JCM.43.9.4830-4833.2005.","journal-title":"J Clin Microbiol"},{"key":"470_CR21","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.4049\/jimmunol.1002971","volume":"186","author":"CJ Greenhill","year":"2011","unstructured":"Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, Mansell A, Jenkins BJ: IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. J Immunol. 2011, 186: 1199-1208. 10.4049\/jimmunol.1002971.","journal-title":"J Immunol"},{"key":"470_CR22","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1146\/annurev.immunol.021908.132603","volume":"28","author":"GP Sims","year":"2010","unstructured":"Sims GP, Rowe DC, Rietdijk ST, Herbst R, Coyle AJ: HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol. 2010, 28: 367-388. 10.1146\/annurev.immunol.021908.132603.","journal-title":"Annu Rev Immunol"},{"key":"470_CR23","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1586\/17474086.1.2.217","volume":"1","author":"HA Papadaki","year":"2008","unstructured":"Papadaki HA, Pontikoglou C: Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia. Expert Rev Hematol. 2008, 1: 217-229. 10.1586\/17474086.1.2.217.","journal-title":"Expert Rev Hematol"},{"key":"470_CR24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/SHK.0b013e3181818466","volume":"1","author":"JC Alves-Filho","year":"2008","unstructured":"Alves-Filho JC, de Freitas A, Spiller F, Souto FO, Cunha FQ: The role of neutrophils in severe sepsis. Shock. 2008, 1: 3-9.","journal-title":"Shock"},{"key":"470_CR25","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/BF03257159","volume":"1","author":"JE Pease","year":"2002","unstructured":"Pease JE, Sabroe I: The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy. Am J Respir Med. 2002, 1: 19-25.","journal-title":"Am J Respir Med"},{"key":"470_CR26","doi-asserted-by":"publisher","first-page":"e8791","DOI":"10.1371\/journal.pone.0008791","volume":"5","author":"E Glattard","year":"2010","unstructured":"Glattard E, Welters ID, Lavaux T, Muller AH, Laux A, Zhang D, Schmidt AR, Delalande F, Laventie BJ, Dirrig-Grosch S, Colin DA, Van Dorsselaer A, Aunis D, Metz-Boutigue MH, Schneider F, Goumon Y: Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils. PLoS One. 2010, 5: e8791-10.1371\/journal.pone.0008791.","journal-title":"PLoS One"},{"key":"470_CR27","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.4049\/jimmunol.1100092","volume":"187","author":"P Ghose","year":"2011","unstructured":"Ghose P, Ali A, Forbes D, Ballard B, Ismail N: The interaction between IL-18 and IL-18R limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria. J Immunol. 2011, 187: 1333-1346. 10.4049\/jimmunol.1100092.","journal-title":"J Immunol"},{"key":"470_CR28","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.4049\/jimmunol.167.7.3919","volume":"167","author":"K Emmanuilidis","year":"2001","unstructured":"Emmanuilidis K, Weighardt H, Maier S, Gerauer K, Fleischmann T, Zheng XX, Hancock WW, Holzmann B, Heidecke CD: Critical role of Kupffer cell-derived IL-10 for host defense in septic peritonitis. J Immunol. 2001, 167: 3919-3927.","journal-title":"J Immunol"},{"key":"470_CR29","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.4049\/jimmunol.1002952","volume":"186","author":"H Yu","year":"2011","unstructured":"Yu H, Karunakaran KP, Kelly I, Shen C, Jiang X, Foster LJ, Brunham RC: Immunization with live and dead Chlamydia muridarum induces different levels of protective immunity in a murine genital tract model: correlation with MHC class II peptide presentation and multifunctional Th1 cells. J Immunol. 2011, 186: 3615-3621. 10.4049\/jimmunol.1002952.","journal-title":"J Immunol"},{"key":"470_CR30","doi-asserted-by":"publisher","first-page":"533","DOI":"10.4049\/jimmunol.0802189","volume":"183","author":"AF de Vos","year":"2009","unstructured":"de Vos AF, Pater JM, van den Pangaart PS, de Kruif MD, van Veer C, Van\u2019t der Poll T: In vivo lipopolysaccharide exposure of human blood leukocytes induces cross-tolerance to multiple TLR ligands. J Immunol. 2009, 183: 533-542. 10.4049\/jimmunol.0802189.","journal-title":"J Immunol"}],"container-title":["BMC Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2172-13-26.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2172-13-26\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2172-13-26.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T21:19:07Z","timestamp":1548105547000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcimmunol.biomedcentral.com\/articles\/10.1186\/1471-2172-13-26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,21]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["470"],"URL":"https:\/\/doi.org\/10.1186\/1471-2172-13-26","relation":{},"ISSN":["1471-2172"],"issn-type":[{"value":"1471-2172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,21]]},"article-number":"26"}}