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Neutrophil depletion in H99\u03b3-immunized mice did not affect pulmonary fungal burden, indicating that neutrophils are not required for clearance. However, we observed an increase in IL-17A in the lungs of neutrophil-depleted H99\u03b3 infected mice, which corresponded to an increase in IL-17A\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Moreover, we observed increased IL-17A\n                    <jats:sup>+<\/jats:sup>\n                    \/ CD3\n                    <jats:sup>+<\/jats:sup>\n                    cells and IL-17A\n                    <jats:sup>+<\/jats:sup>\n                    \/\u03b3\u03b4\n                    <jats:sup>+<\/jats:sup>\n                    cells, but decreased IL-17A\n                    <jats:sup>+<\/jats:sup>\n                    \/Ly6G\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils in the lungs of IL-17 receptor (R)A deficient mice compared to wild-type mice. Increased production of IL-17A in neutropenic mice coincided with increased IL-6 and CXCL1, but not Th17 inducing cytokines TGF-\u03b2, IL-21 and IL-23. Concurrent depletion of neutrophils and \u03b3\u03b4\n                    <jats:sup>+<\/jats:sup>\n                    T cells reduced IL-17A levels. Our results suggest that \u03b3\u03b4\n                    <jats:sup>+<\/jats:sup>\n                    T cells mediate significant IL-17A production in neutropenic mice during the protective response to\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>neoformans<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1186\/1471-2172-13-65","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T08:14:31Z","timestamp":1354868071000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Depletion of neutrophils in a protective model of pulmonary cryptococcosis results in increased IL-17A production by gamma\/delta T cells"],"prefix":"10.1186","volume":"13","author":[{"given":"Karen L","family":"Wozniak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay K","family":"Kolls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Floyd L","family":"Wormley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,7]]},"reference":[{"key":"483_CR1","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1093\/clinids\/13.6.1163","volume":"13","author":"SM Levitz","year":"1991","unstructured":"Levitz SM: The ecology of cryptococcus neoformans and the epidemiology of cryptococcosis. 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