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The second aim is to examine the relationship between specific IgG\/IgG subclasses and early onset sepsis (EOS) infection among these newborns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>S<jats:italic>taphylococcus aureus<\/jats:italic>(<jats:italic>S. aureus<\/jats:italic>) is one of the most common organisms related to sepsis infection in the newborn at King Abdel Aziz Specialist Hospital (KAASH). This study was conducted in Taif city, at KAASH\u2019s neonatal intensive care unit between March and August 2012. Neonates were consecutively enrolled onto the study having met our inclusion criteria (as per our research protocol).<\/jats:p><jats:p>The CRP concentration level was analysed using NycoCard\u00ae CRP Single Test.<jats:italic>CRP -286 (C&gt;T&gt;A) A<\/jats:italic>polymorphisms were analyzed using Pyrosequencing technology for<jats:italic>CRP<\/jats:italic>genotyping. IgG subclasses were analysed in the study population using ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Logistic regression analyses showed that the AA and AC genotypes were negatively associated amongst EOS neonates compared to suspected neonates. The frequency of CC and CT were significantly associated with the EOS neonates compared to the suspected group. The levels of specific IgG1, IgG2 and IgG3 antibodies were significantly lower amongst EOS compared to the suspected group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Taken together, the<jats:italic>CRP-286 (C&gt;T&gt;A) A<\/jats:italic>genotype polymorphism and specific IgG antibodies isotype levels can contribute to a reduced risk of EOS. Furthermore, CRP has a potential use in detecting EOS in neonates, which may mean earlier detection and management of EOS and subsequently better clinical outcome.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2172-14-38","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T00:15:39Z","timestamp":1376439339000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neonatal infections in Saudi Arabia: association with C-reactive protein, CRP -286 (C&gt;T&gt;A) gene polymorphism and IgG antibodies"],"prefix":"10.1186","volume":"14","author":[{"given":"Amre","family":"Nasr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal","family":"Allam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Al-Zahrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Alsulaimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,8,13]]},"reference":[{"key":"543_CR1","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.jpag.2004.06.002","volume":"17","author":"C Nelson","year":"2004","unstructured":"Nelson C: Early recognition and treatment of staphylococcal and streptococcal toxic shock. 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