{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:02:58Z","timestamp":1761487378086},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T00:00:00Z","timestamp":1113782400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T00:00:00Z","timestamp":1113782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Immunol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>Marginal zone (MZ) B cells play important roles in the early phases of humoral immune responses. In addition to possessing an inherent capacity to rapidly differentiate into antibody secreting cells, MZ B cells also help to regulate the fate of both T-independent and T-dependent blood-borne antigens in the spleen. For T-dependent antigens, MZ B cells bind IgM-antigen complexes in a complement-dependent manner. Once MZ B cells bind IgM-containing immune complexes (IgM-IC), they transport them into B cell follicles for deposition onto follicular dendritic cells (FDCs), an important component of secreted IgM's ability to enhance adaptive immune responses. To further define the requirement for MZ B cells in IgM-IC deposition, mice deficient in the NF-\u03baB protein p50, which have been reported to lack MZ B cells, were analyzed for their ability to trap IgM-IC onto FDCs.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Mice (2 months of age) deficient in p50 (p50<jats:sup>-\/-<\/jats:sup>) had small numbers of MZ B cells, as determined by cell surface phenotype and localization in the splenic MZ. These cells bound high levels of IgM-IC both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Subsequent to the binding of IgM-IC by the MZ B cells in p50<jats:sup>-\/-<\/jats:sup> mice, small amounts of IgM-IC were found localized on FDCs, suggesting that the MZ B cells retained their ability to transport these complexes into splenic follicles. Strikingly, MZ B cells accumulated with age in p50<jats:sup>-\/-<\/jats:sup> mice. By 6 months of age, p50<jats:sup>-\/-<\/jats:sup> mice contained normal numbers of these cells as defined by CD21\/CD23 profile and high level expression of CD1d, CD9, and IgM, and by their positioning around the marginal sinus. However, FDCs from these older p50<jats:sup>-\/-<\/jats:sup> mice exhibited a reduced capacity to trap IgM-IC and retain complement components.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>These results demonstrate that while the p50 component of the NF-\u03baB transcription complex plays an important role in the early development of MZ B cells, MZ B cells can develop and accumulate in mice lacking this protein. These results highlight the interface between genetic deficiencies and age, and suggest that different transcription factors may play distinct roles in the development and maintenance of cell populations at different ages.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1471-2172-6-8","type":"journal-article","created":{"date-parts":[[2005,4,19]],"date-time":"2005-04-19T06:14:05Z","timestamp":1113891245000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Accumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-\u03baB p50-deficient mice"],"prefix":"10.1186","volume":"6","author":[{"given":"Andrew R","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald B","family":"Corley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,4,18]]},"reference":[{"key":"69_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1084\/jem.128.1.133","volume":"128","author":"C Henry","year":"1968","unstructured":"Henry C, Jerne NK: Competition of 19S and 7S antigen receptors in the regulation of the primary immune response. 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