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The 181 collected <jats:italic>H. pylori<\/jats:italic> isolates were detected for the <jats:italic>dupA<\/jats:italic> genotype by PCR. The rates of <jats:italic>dupA<\/jats:italic>-positive <jats:italic>H. pylori<\/jats:italic> infection were similar among patients with duodenal ulcer (22.8%), gastric ulcer (20.0%), and gastritis (25.5%) (<jats:italic>p<\/jats:italic> &gt; 0.05). Males had higher rates of duodenal ulcer and gastric ulcer than females (<jats:italic>p<\/jats:italic> &lt; 0.01). Of <jats:italic>H. pylori<\/jats:italic>-infected patients, the MMP-3 6A6A genotype were more common in patients with duodenal ulcers than in those with gastritis (87.7% <jats:italic>vs<\/jats:italic>. 74.9%, <jats:italic>p<\/jats:italic> &lt; 0.05) in females. This genotype had a 2.4-fold (95% CI: 1.02-5.66) increased risk of duodenal ulcer, compared to those with the 5A carrier. Combining the MMP-3\/TIMP-1 genotype as 6A6A\/CC, the risk of duodenal ulcer increased up to 3.6 fold (<jats:italic>p<\/jats:italic> &lt; 0.05) in <jats:italic>H. pylori-<\/jats:italic> infected females.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The MMP-3 promoter polymorphism, but not the <jats:italic>dupA<\/jats:italic>-status, may correlate with susceptibility to duodenal ulcer after <jats:italic>H. pylori<\/jats:italic> infection in Taiwanese females.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2180-10-218","type":"journal-article","created":{"date-parts":[[2010,8,14]],"date-time":"2010-08-14T06:18:15Z","timestamp":1281766695000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females"],"prefix":"10.1186","volume":"10","author":[{"given":"Yi-Chun","family":"Yeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Chi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Lun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao-Bai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bor-Shyang","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,8,13]]},"reference":[{"issue":"4","key":"1174_CR1","first-page":"191","volume":"5","author":"A Labigne","year":"1996","unstructured":"Labigne A, de Reuse H: Determinants of Helicobacter pylori pathogenicity. 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