{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T04:59:07Z","timestamp":1794373147276,"version":"4.9.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The anaerobic Gram-positive bacterium <jats:italic>Propionibacterium acnes<\/jats:italic> is a human skin commensal that resides preferentially within sebaceous follicles; however, it also exhibits many traits of an opportunistic pathogen, playing roles in a variety of inflammatory diseases such as <jats:italic>acne vulgaris<\/jats:italic>. To date, the underlying disease-causing mechanisms remain ill-defined and knowledge of <jats:italic>P. acnes<\/jats:italic> virulence factors remains scarce. Here, we identified proteins secreted during anaerobic cultivation of a range of skin and clinical <jats:italic>P. acnes<\/jats:italic> isolates, spanning the four known phylogenetic groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Culture supernatant proteins of <jats:italic>P. acnes<\/jats:italic> were separated by two-dimensional electrophoresis (2-DE) and all Coomassie-stained spots were subsequently identified by MALDI mass spectrometry (MALDI-MS). A set of 20 proteins was secreted in the mid-exponential growth phase by the majority of strains tested. Functional annotation revealed that many of these common proteins possess degrading activities, including glycoside hydrolases with similarities to endoglycoceramidase, \u03b2-N-acetylglucosaminidase and muramidase; esterases such as lysophospholipase and triacylglycerol lipase; and several proteases. Other secreted factors included Christie-Atkins-Munch-Petersen (CAMP) factors, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and several hypothetical proteins, a few of which are unique to <jats:italic>P. acnes<\/jats:italic>. Strain-specific differences were apparent, mostly in the secretion of putative adhesins, whose genes exhibit variable phase variation-like sequence signatures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our proteomic investigations have revealed that the <jats:italic>P. acnes<\/jats:italic> secretome harbors several proteins likely to play a role in host-tissue degradation and inflammation. Despite a large overlap between the secretomes of all four <jats:italic>P. acnes<\/jats:italic> phylotypes, distinct differences between predicted host-tissue interacting proteins were identified, providing potential insight into the differential virulence properties of <jats:italic>P. acnes<\/jats:italic> isolates. Thus, our data presents a rich resource for guiding much-needed investigations on <jats:italic>P. acnes<\/jats:italic> virulence factors and host interacting properties.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2180-10-230","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T18:14:40Z","timestamp":1282932880000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":164,"title":["Proteomic identification of secreted proteins of Propionibacterium acnes"],"prefix":"10.1186","volume":"10","author":[{"given":"Carsten","family":"Holland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim N","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Zimny-Arndt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R","family":"Jungblut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Br\u00fcggemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,8,27]]},"reference":[{"key":"1186_CR1","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/j.1365-2133.2008.08437.x","volume":"158","author":"AL Cogen","year":"2008","unstructured":"Cogen AL, Nizet V, Gallo RL: Skin microbiota: a source of disease or defence?. 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