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Besides being a human pathogen, it is able to infect and cause disease in many different animals and alternative hosts such as <jats:italic>C. elegans<\/jats:italic>.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Its host range is further extended to include plants as we demonstrated the ability of <jats:italic>B. pseudomallei<\/jats:italic> and the closely related species <jats:italic>B. thailandensis<\/jats:italic> to infect susceptible tomato but not rice plants. Bacteria were found to multiply intercellularly and were found in the xylem vessels of the vascular bundle. Disease is substantially attenuated upon infection with bacterial mutants deficient in T3SS1 or T3SS2 and slightly attenuated upon infection with the T3SS3 mutant. This shows the importance of both T3SS1 and T3SS2 in bacterial pathogenesis in susceptible plants.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The potential of <jats:italic>B. pseudomallei<\/jats:italic> as a plant pathogen raises new possibilities of exploiting plant as an alternative host for novel anti-infectives or virulence factor discovery. It also raises issues of biosecurity due to its classification as a potential bioterrorism agent.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2180-10-28","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T07:14:46Z","timestamp":1264749286000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Identification of tomato plant as a novel host model for Burkholderia pseudomallei"],"prefix":"10.1186","volume":"10","author":[{"given":"Yian Hoon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhi","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunn-Hwen","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,1,29]]},"reference":[{"key":"984_CR1","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1086\/318116","volume":"31","author":"BJ Currie","year":"2000","unstructured":"Currie BJ, Fisher DA, Howard DM, Burrow JNC, Lo D, Selva-nayagam S, Anstey NM, Huffam SE, Snelling PL, Marks PJ, Stephens DP, Lum GD, Jacups SP, Krause VL: Endemic melioidosis in tropical northern Australia: A 10-year prospective study and review of literature. 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