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The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition of faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls.\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      ,\n                      <jats:italic>Clostridium histolyticum<\/jats:italic>\n                      ,\n                      <jats:italic>C. lituseburense<\/jats:italic>\n                      and\n                      <jats:italic>Faecalibacterium prausnitzii<\/jats:italic>\n                      group proportions were less abundant (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.050) in untreated CD patients than in healthy controls.\n                      <jats:italic>Bacteroides-Prevotella<\/jats:italic>\n                      group proportions were more abundant (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.050) in untreated CD patients than in controls. Levels of IgA coating the\n                      <jats:italic>Bacteroides-Prevotella<\/jats:italic>\n                      group were significantly reduced (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.050) in both CD patients in comparison with healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In CD patients, reduced IgA-coated bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2180-10-63","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T14:16:48Z","timestamp":1267021008000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":288,"title":["Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children"],"prefix":"10.1186","volume":"10","author":[{"given":"Giada","family":"De Palma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Nadal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Donat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ribes-Koninckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Calabuig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"1019_CR1","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1080\/00365520500235334","volume":"41","author":"S Drago","year":"2006","unstructured":"Drago S, El Asmar R, Di Pierro M, Grazia Clemente M, Tripathi A, Sapone A, Thakar M, Iacono G, Carroccio A, D'Agate C, Not T, Zampini L, Catassi C, Fasano A: Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. 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