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Of these, nisin V (containing a Met21Val change) is noteworthy by virtue of exhibiting enhanced antimicrobial efficacy against a wide range of clinical and food-borne pathogens, including <jats:italic>Listeria monocytogenes.<\/jats:italic> However, this increased potency has not been tested <jats:italic>in vivo<\/jats:italic>.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Here we address this issue by assessing the ability of nisin A and nisin V to control a bioluminescent strain of <jats:italic>Listeria monocytogenes<\/jats:italic> EGDe in a murine infection model.<\/jats:p>\n            <jats:p>More specifically, Balb\/c mice were infected <jats:italic>via<\/jats:italic> the intraperitoneal route at a dose of 1\u2009\u00d7\u200910<jats:sup>5<\/jats:sup> cfu\/animal and subsequently treated intraperitoneally with either nisin V, nisin A or a PBS control. Bioimaging of the mice was carried out on day 3 of the trial. Animals were then sacrificed and levels of infection were quantified in the liver and spleen.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This analysis revealed that nisin V was more effective than Nisin A with respect to controlling infection and therefore merits further investigation with a view to potential chemotherapeutic applications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2180-13-23","type":"journal-article","created":{"date-parts":[[2013,2,2]],"date-time":"2013-02-02T00:34:09Z","timestamp":1359765249000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["In vivo activity of Nisin A and Nisin V against Listeria monocytogenesin mice"],"prefix":"10.1186","volume":"13","author":[{"given":"Alicia","family":"Campion","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat G","family":"Casey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Des","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D","family":"Cotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Paul","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"1926_CR1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1128\/jb.16.4.211-229.1928","volume":"16","author":"LA Rogers","year":"1928","unstructured":"Rogers LA, Whittier EO: Limiting factors in the lactic fermentation. 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