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Here, we examined the<jats:italic>in vivo<\/jats:italic>effects of enterohepatic bacterial infection over the FGF15 endocrine axis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Infection triggered significant reductions in the intestinal expression of<jats:italic>Fgf15<\/jats:italic>and its hepatic receptor components (<jats:italic>Fgfr4<\/jats:italic>and<jats:italic>Klb<\/jats:italic>(\u03b2Klotho)). Infection also resulted in alterations of the expression pattern of genes involved in hepatobiliary function, marked reduction in gallbladder bile volumes and accumulation of hepatic cholesterol and triglycerides. The decrease in ileal<jats:italic>Fgf15<\/jats:italic>expression was associated with liver bacterial colonization and hepatobiliary pathophysiology rather than with direct intestinal bacterial pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bacterial pathogens of the enterohepatic system can disturb the homeostasis of the FGF15\/19-FGFR4 endocrine axis. These results open up a possible link between FGF15\/19-FGFR4 disruptions and the metabolic and nutritional disorders observed in infectious diseases.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2180-13-238","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T02:01:25Z","timestamp":1383012085000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Enterohepatic bacterial infections dysregulate the FGF15-FGFR4 endocrine axis"],"prefix":"10.1186","volume":"13","author":[{"given":"Guillaume","family":"Romain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen T","family":"Arena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L Caetano M","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Covey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B Brett","family":"Finlay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Menendez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"issue":"1","key":"2110_CR1","doi-asserted-by":"crossref","first-page":"322S","DOI":"10.1093\/jn\/133.1.322S","volume":"133","author":"MC Powanda","year":"2003","unstructured":"Powanda MC, Beisel WR: Metabolic effects of infection on protein and energy status. 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