{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:19:37Z","timestamp":1774574377674,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The ability to use erythritol as a sole carbon source is not universal amongthe Rhizobiaceae. Based on the relatedness to the catabolic genes in<jats:italic>Brucella<\/jats:italic> it has been suggested that the <jats:italic>eryABCD<\/jats:italic> operonmay have been horizontally transferred into <jats:italic>Rhizobium<\/jats:italic>. During workcharacterizing a locus necessary for the transport and catabolism oferythritol, adonitol and L-arabitol in <jats:italic>Sinorhizobium meliloti,<\/jats:italic> webecame interested in the differences between the erythritol loci of <jats:italic>S.meliloti<\/jats:italic> and <jats:italic>R. leguminosarum.<\/jats:italic> Utilizing the OrthologNeighborhood Viewer from the DOE Joint Genome Institute database it appearedthat loci for erythritol and polyol utilization had distinct arrangementsthat suggested these loci may have undergone genetic rearrangements.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A data set was established of genetic loci containing erythritol\/polyolorthologs for 19 different proteobacterial species. These loci were analyzedfor genetic content and arrangement of genes associated with erythritol,adonitol and L-arabitol catabolism. Phylogenetic trees were constructed forcore erythritol catabolic genes and contrasted with the species phylogeny.Additionally, phylogenetic trees were constructed for genes that showeddifferences in arrangement among the putative erythritol loci in thesespecies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Three distinct erythritol\/polyol loci arrangements have been identified thatreflect metabolic need or specialization. Comparison of the phylogenetictrees of core erythritol catabolic genes with species phylogeny providesevidence that is consistent with these loci having been horizontallytransferred from the alpha-proteobacteria into both the beta andgamma-proteobacteria. ABC transporters within these loci adopt 2 uniquegenetic arrangements, and although biological data suggests they arefunctional erythritol transporters, phylogenetic analysis suggests they maynot be orthologs and probably should be considered analogs. Finally,evidence for the presence of paralogs, and xenologs of erythritol catabolicgenes in some of the genomes included in the analysis is provided.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2180-13-46","type":"journal-article","created":{"date-parts":[[2013,2,23]],"date-time":"2013-02-23T23:14:49Z","timestamp":1361661289000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Phylogenetic analysis of erythritol catabolic loci within theRhizobiales and Proteobacteria"],"prefix":"10.1186","volume":"13","author":[{"given":"Barney A","family":"Geddes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Hausner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan J","family":"Oresnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,23]]},"reference":[{"key":"1914_CR1","doi-asserted-by":"publisher","first-page":"13571","DOI":"10.1073\/pnas.96.23.13571","volume":"96","author":"T Omata","year":"1999","unstructured":"Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T: Identification of an ATP-binding cassette transporter involved in bicarbonateuptake in the cyanobacterium Synechoccus sp. strain PCC 7942. 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