{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:08:34Z","timestamp":1790881714306,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/1471-2180-2-16","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:42:27Z","timestamp":1034361747000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Interaction of the Yersinia pestis type III regulatory proteins LcrG and LcrV occurs at a hydrophobic interface"],"prefix":"10.1186","volume":"2","author":[{"given":"Jyl S","family":"Matson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L","family":"Nilles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,6,28]]},"reference":[{"key":"50_CR1","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1128\/IAI.66.10.4611-4623.1998","volume":"66","author":"RD Perry","year":"1998","unstructured":"Perry RD, Straley SC, Fetherston JD, Rose DJ, Gregor J, Blattner FR: DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of Yersinia pestis KIM5. Infect Immun. 1998, 66: 4611-4623.","journal-title":"Infect Immun"},{"key":"50_CR2","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1128\/MMBR.62.4.1315-1352.1998","volume":"62","author":"GR Cornelis","year":"1998","unstructured":"Cornelis GR, Boland A, Boyd AP, Geuijen C, Iriarte M, Neyt C, Sory M-P, Stainier I: The Virulence plasmid of Yersinia, an antihost genome. Microbiol Mol Biol Rev. 1998, 62: 1315-1352.","journal-title":"Microbiol Mol Biol Rev"},{"key":"50_CR3","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S0966-842X(00)88960-X","volume":"3","author":"SC Straley","year":"1995","unstructured":"Straley SC, Perry RD: Environmental modulation of gene expression and pathogenesis in Yersinia. Trends Microbiol. 1995, 3: 310-317. 10.1016\/S0966-842X(00)88960-X.","journal-title":"Trends Microbiol"},{"key":"50_CR4","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1128\/jb.179.4.1307-1316.1997","volume":"179","author":"ML Nilles","year":"1997","unstructured":"Nilles ML, Williams AW, Skrzypek E, Straley SC: Yersinia pestis LcrV forms a stable complex with LcrG and may have a secretion-related regulatory role in the low-Ca2+ response. J Bacteriol. 1997, 179: 1307-1316.","journal-title":"J Bacteriol"},{"key":"50_CR5","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1128\/jb.175.11.3520-3528.1993","volume":"175","author":"E Skrzypek","year":"1993","unstructured":"Skrzypek E, Straley SC: LcrG, a secreted protein involved in negative regulation of the low-calcium response in Yersinia pestis. J Bacteriol. 1993, 175: 3520-3528.","journal-title":"J Bacteriol"},{"key":"50_CR6","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1002\/j.1460-2075.1996.tb00904.x","volume":"15","author":"A Boland","year":"1996","unstructured":"Boland A, Sory M-P, Iriarte M, Kerbourch C, Wattiau P, Cornelis GR: Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y. enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus. EMBO J. 1996, 15: 5191-5201.","journal-title":"EMBO J"},{"key":"50_CR7","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1046\/j.1365-2958.2000.01974.x","volume":"37","author":"ED Cambronne","year":"2000","unstructured":"Cambronne ED, Cheng LW, Schneewind O: LcrQ\/YscM1, regulators of the Yersinia yop virulon, are injected into host cells by a chaperone-dependent mechanism. Mol Microbiol. 2000, 37: 263-273. 10.1046\/j.1365-2958.2000.01974.x.","journal-title":"Mol Microbiol"},{"key":"50_CR8","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1128\/JB.182.11.3183-3190.2000","volume":"182","author":"LW Cheng","year":"2000","unstructured":"Cheng LW, Schneewind O: Yersinia enterocolitica TyeA, an intracellular regulator of the type III macinery, is required for specific targeting of YopE, YopH, YopM, and YopN into the cytosol of eukaryotic cells. J Bacteriol. 2000, 182: 3183-3190. 10.1128\/JB.182.11.3183-3190.2000.","journal-title":"J Bacteriol"},{"key":"50_CR9","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1046\/j.1365-2958.1998.01110.x","volume":"30","author":"JB Day","year":"1998","unstructured":"Day JB, Plano GV: A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis. Mol Microbiol. 1998, 30: 777-788. 10.1046\/j.1365-2958.1998.01110.x.","journal-title":"Mol Microbiol"},{"key":"50_CR10","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1111\/j.1365-2958.1991.tb00773.x","volume":"5","author":"\u00c5 Forsberg","year":"1991","unstructured":"Forsberg \u00c5, Viitanen A-M, Skurnik M, Wolf-Watz H: The surface-located YopN protein is involved in calcium signal transduction in Yersinia pseudotuberculosis. Mol Microbiol. 1991, 5: 977-986.","journal-title":"Mol Microbiol"},{"key":"50_CR11","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1046\/j.1365-2958.2001.02702.x","volume":"42","author":"MS Francis","year":"2001","unstructured":"Francis MS, Lloyd SA, Wolf-Watz H: The type III secretion chaperone LcrH co-operates with YopD to establish a negative, regulatory loop for control of Yop synthesis in Yersinia pseudotuberculosis. Mol Microbiol. 2001, 42: 1075-1093. 10.1046\/j.1365-2958.2001.02702.x.","journal-title":"Mol Microbiol"},{"key":"50_CR12","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1093\/emboj\/17.7.1907","volume":"17","author":"M Iriarte","year":"1998","unstructured":"Iriarte M, Sory M-P, Boland A, Boyd AP, Mills SD, Lambermont I, Cornelis GR: TyeA, a protein involved in control of Yop release and in translocation of Yersinia Yop effectors. EMBO J. 1998, 17: 1907-1918. 10.1093\/emboj\/17.7.1907.","journal-title":"EMBO J"},{"key":"50_CR13","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1128\/JB.180.18.4912-4921.1998","volume":"180","author":"MW Jackson","year":"1998","unstructured":"Jackson MW, Day JB, Plano GV: YscB of Yersinia pestis functions as a specific chaperone for YopN. J Bacteriol. 1998, 180: 4912-4921.","journal-title":"J Bacteriol"},{"key":"50_CR14","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1128\/iai.57.5.1491-1498.1989","volume":"57","author":"SB Price","year":"1989","unstructured":"Price SB, Straley SC: lcrH, a gene necessary for virulence of Yersinia pestis and for the normal response of Y. pestis to ATP and calcium. Infect Immun. 1989, 57: 1491-1498.","journal-title":"Infect Immun"},{"key":"50_CR15","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1128\/jb.174.10.3355-3363.1992","volume":"174","author":"M Rimpil\u00e4inen","year":"1992","unstructured":"Rimpil\u00e4inen M, Forsberg \u00c5, Wolf-watz H: A novel protein, LcrQ, involved in the low-calcium response of Yersinia pseudotuberculosis, shows extensive homology to YopH. J Bacteriol. 1992, 174: 3355-3363.","journal-title":"J Bacteriol"},{"key":"50_CR16","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1128\/JB.180.2.350-358.1998","volume":"180","author":"AW Williams","year":"1998","unstructured":"Williams AW, Straley SC: YopD of Yersinia pestis plays a role in the negative regulation of the low-calcium response in addition to its role in the translocation of Yops. J Bacteriol. 1998, 180: 350-358.","journal-title":"J Bacteriol"},{"key":"50_CR17","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1046\/j.1365-2958.2002.02752.x","volume":"43","author":"CR Wulff-Strobel","year":"2002","unstructured":"Wulff-Strobel CR, Williams AW, Straley SC: LcrQ and SycH function together at the Ysc type III secretion system in Yersinia pestis to impose a hierarchy of secretion. Mol Microbiol. 2002, 43: 411-423. 10.1046\/j.1365-2958.2002.02752.x.","journal-title":"Mol Microbiol"},{"key":"50_CR18","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1128\/JB.180.13.3410-3420.1998","volume":"180","author":"ML Nilles","year":"1998","unstructured":"Nilles ML, Fields KA, Straley SC: The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG. J Bacteriol. 1998, 180: 3410-3420.","journal-title":"J Bacteriol"},{"key":"50_CR19","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1128\/jb.177.9.2530-2542.1995","volume":"177","author":"E Skrzypek","year":"1995","unstructured":"Skrzypek E, Straley SC: Differential effects of deletions in lcrV on secretion of V antigen, regulation of the low-Ca2+ response, and virulence of Yersinia pestis. J Bacteriol. 1995, 177: 2530-2542.","journal-title":"J Bacteriol"},{"key":"50_CR20","doi-asserted-by":"publisher","first-page":"5082","DOI":"10.1128\/JB.183.17.5082-5091.2001","volume":"183","author":"JS Matson","year":"2001","unstructured":"Matson JS, Nilles ML: LcrG-LcrV Interaction Is Required for Control of Yops Secretion in Yersinia pestis. J Bacteriol. 2001, 183: 5082-5091. 10.1128\/JB.183.17.5082-5091.2001.","journal-title":"J Bacteriol"},{"key":"50_CR21","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1046\/j.1365-2958.1997.6251991.x","volume":"26","author":"DW Frank","year":"1997","unstructured":"Frank DW: The exoenzyme S regulon of Pseudomonas aeruginosa. Mol Microbiol. 1997, 26: 621-629. 10.1046\/j.1365-2958.1997.6251991.x.","journal-title":"Mol Microbiol"},{"key":"50_CR22","doi-asserted-by":"crossref","first-page":"7165","DOI":"10.1128\/jb.179.22.7165-7168.1997","volume":"179","author":"TL Yahr","year":"1997","unstructured":"Yahr TL, Mende-Mueller LM, Friese MB, Frank DW: Identification of type III secreted products of the Pseudomonas aeruginosa Exoenzyme S regulon. J Bacteriol. 1997, 179: 7165-7168.","journal-title":"J Bacteriol"},{"key":"50_CR23","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1046\/j.1365-2958.1996.01554.x","volume":"22","author":"TL Yahr","year":"1996","unstructured":"Yahr TL, Goranson J, Frank DW: Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway. Mol Microbiol. 1996, 22: 991-1003. 10.1046\/j.1365-2958.1996.01554.x.","journal-title":"Mol Microbiol"},{"key":"50_CR24","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1046\/j.1365-2958.1999.01408.x","volume":"32","author":"J Pettersson","year":"1999","unstructured":"Pettersson J, Holmstr\u00f6m A, Hill J, Leary S, Frithz-Lindsten E, von Euler-Matell A, Carlsson E, Titball R, Forsberg \u00c5, Wolf-Watz H: The V-antigen of Yersinia is surface-exposed before targent cell contact and involved in virulence protein translocation. Mol Microbiol. 1999, 32: 961-976. 10.1046\/j.1365-2958.1999.01408.x.","journal-title":"Mol Microbiol"},{"key":"50_CR25","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1046\/j.1365-2958.1998.00994.x","volume":"29","author":"E Frithz-Lindsten","year":"1998","unstructured":"Frithz-Lindsten E, Holmstr\u00f6m A, Jacobsson L, Soltani M, Olsson J, Rosqvist R, Forsberg \u00c5: Functional conservation of the effector protein translocators PopB\/YopB and PopD\/YopD of Pserudomonas aeruginosa and Yersinia pseudotuberculosis. Mol Microbiol. 1998, 29: 1155-1165. 10.1046\/j.1365-2958.1998.00994.x.","journal-title":"Mol Microbiol"},{"key":"50_CR26","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1126\/science.252.5009.1162","volume":"252","author":"A Lupas","year":"1991","unstructured":"Lupas A, Van Dyke M, Stock J: Predicting coiled coils from protein sequences. Science. 1991, 252: 1162-1164.","journal-title":"Science"},{"key":"50_CR27","doi-asserted-by":"publisher","first-page":"4498","DOI":"10.1073\/pnas.88.10.4498","volume":"88","author":"PD Bass","year":"1991","unstructured":"Bass PD, Mulkerrin MG, Wells JA: A systematic mutational analysis of hormone-binding determinants in the human growth-hormone receptor. Proc Natl Acad Sci USA. 1991, 88: 4498-4502.","journal-title":"Proc Natl Acad Sci USA"},{"key":"50_CR28","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1046\/j.1365-2958.2000.02112.x","volume":"38","author":"MS Francis","year":"2000","unstructured":"Francis MS, Aili M, Wiklund M-L, Wolf-Watz H: A study of the YopD-LcrH interaction from Yersinia pseudotuberculosis reveals a role for hydrophobic residues within the amphipathic domain of YopD. Mol Microbiol. 2000, 38: 85-102. 10.1046\/j.1365-2958.2000.02112.x.","journal-title":"Mol Microbiol"},{"key":"50_CR29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1128\/iai.51.2.445-454.1986","volume":"51","author":"SC Straley","year":"1986","unstructured":"Straley SC, Bowmer WS: Virulence genes regulated at the transcriptional level by Ca2+ in Yersinia pestis include structural genes for outer membrane proteins. Infect Immun. 1986, 51: 445-454.","journal-title":"Infect Immun"},{"key":"50_CR30","volume-title":"Plainview, NY: Cold Spring Harbor Laboratory Press;","author":"JH Miller","year":"1992","unstructured":"Miller JH: A short course in bacterial genetics: A laboratory manual and handbook for Escherichia coli and related bacteria. Plainview, NY: Cold Spring Harbor Laboratory Press;. 1992"},{"key":"50_CR31","volume-title":"Molecular cloning: a laboratory manual, Second edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press;","author":"J Sambrook","year":"1989","unstructured":"Sambrook J, Fritsch EF, Maniatis T: Molecular cloning: a laboratory manual, Second edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press;. 1989"},{"key":"50_CR32","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1128\/jb.172.10.5929-5937.1990","volume":"172","author":"RD Perry","year":"1990","unstructured":"Perry RD, Pendrak M, Schuetze P: Identification and cloning of a hemin storage locus involved in the pigmentation phenotype of Yersinia pestis. J Bacteriol. 1990, 172: 5929-5937.","journal-title":"J Bacteriol"},{"key":"50_CR33","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1128\/jb.177.14.4121-4130.1995","volume":"177","author":"L-M Guzman","year":"1995","unstructured":"Guzman L-M, Belin D, Carson MJ, Beckwith J: Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol. 1995, 177: 4121-4130.","journal-title":"J Bacteriol"},{"key":"50_CR34","volume-title":"Current Protocols in Molecular Biology. New York: John Wiley & Sons;","year":"1998","unstructured":"Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K, eds: Current Protocols in Molecular Biology. New York: John Wiley & Sons;. 1998"},{"key":"50_CR35","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970, 227: 680-685.","journal-title":"Nature"},{"key":"50_CR36","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1128\/iai.65.3.924-930.1997","volume":"65","author":"J Nemeth","year":"1997","unstructured":"Nemeth J, Straley SC: Effect of Yersinia pestis YopM on experimental plague. Infect Immun. 1997, 65: 924-930.","journal-title":"Infect Immun"},{"key":"50_CR37","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1574-6968.1999.tb13575.x","volume":"174","author":"TA Tatusova","year":"1999","unstructured":"Tatusova TA, Madden TL: BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences. FEMS Microbiol Lett. 1999, 174: 247-250. 10.1016\/S0378-1097(99)00149-4.","journal-title":"FEMS Microbiol Lett"},{"key":"50_CR38","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1128\/IAI.67.10.5395-5408.1999","volume":"67","author":"KA Fields","year":"1999","unstructured":"Fields KA, Nilles ML, Cowan C, Straley SC: Virulence role of V antigen of Yersinia pestis at the bacterial surface. Infect Immun. 1999, 67: 5395-5408.","journal-title":"Infect Immun"}],"updated-by":[{"DOI":"10.1186\/1471-2180-2-25","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T00:00:00Z","timestamp":1031184000000}}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2180-2-16.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T15:29:39Z","timestamp":1726241379000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmicrobiol.biomedcentral.com\/articles\/10.1186\/1471-2180-2-16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,28]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2002,12]]}},"alternative-id":["50"],"URL":"https:\/\/doi.org\/10.1186\/1471-2180-2-16","relation":{"erratum":[{"id-type":"doi","id":"10.1186\/1471-2180-2-25","asserted-by":"object"}]},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,28]]},"assertion":[{"value":"1 May 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2002","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"16"}}