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Evidence exists from other organisms that these repeats can be involved in the evolution of new genes, gene regulation, adaptation, resistance to environmental stresses, and avoidance of the immune system.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In this study, we have investigated the presence and variability in copy number of intragenic tandemly repeated sequences in the genome of <jats:italic>Legionella pneumophila<\/jats:italic>, the etiological agent of a severe pneumonia known as Legionnaires' disease. Within the genome of the Philadelphia strain, we have identified 26 intragenic tandem repeat sequences using conservative selection criteria. Of these, seven were \"polymorphic\" in terms of repeat copy number between a large number of <jats:italic>L. pneumophila<\/jats:italic> serogroup 1 strains. These strains were collected from a wide variety of environments and patients in several geographical regions. Within this panel of strains, all but one of these seven genes exhibited statistically different patterns in repeat copy number between samples from different origins (environmental, clinical, and hot springs).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These results support the hypothesis that intragenic tandem repeats could play a role in virulence and adaptation to different environments. While tandem repeats are an increasingly popular focus of molecular typing studies in prokaryotes, including in <jats:italic>L. pneumophila<\/jats:italic>, this study is the first examining the difference in tandem repeat distribution as a function of clinical or environmental origin.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2180-8-218","type":"journal-article","created":{"date-parts":[[2008,12,10]],"date-time":"2008-12-10T19:13:22Z","timestamp":1228936402000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Intragenic tandem repeat variation between Legionella pneumophila strains"],"prefix":"10.1186","volume":"8","author":[{"given":"David A","family":"Coil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Vandersmissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Ginevra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Jarraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Lammertyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Ann\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,12,10]]},"reference":[{"issue":"6","key":"651_CR1","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1172\/JCI12557","volume":"107","author":"CD Bayliss","year":"2001","unstructured":"Bayliss CD, Field D, Moxon ER: The simple sequence contingency loci of Haemophilus influenzae and Neisseria meningitidis. 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