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Proteomic studies on temperature regulation in <jats:italic>C. jejuni<\/jats:italic> strain 81\u2013176 revealed the upregulation at 37\u00b0C of Cj0596, a predicted periplasmic chaperone that is similar to proteins involved in outer membrane protein folding and virulence in other bacteria.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The <jats:italic>cj0596<\/jats:italic> gene was highly conserved in 24 strains and species of <jats:italic>Campylobacter<\/jats:italic>, implying the importance of this gene. To study the role that Cj0596 plays in <jats:italic>C. jejuni<\/jats:italic> pathogenesis, a mutant derivative of strain 81\u2013176 was constructed in which the <jats:italic>cj0596<\/jats:italic> gene was precisely deleted. A revertant of this mutant was isolated by restoring the gene to its original chromosomal location using streptomycin counterselection. The <jats:italic>cj0596<\/jats:italic> mutant strain demonstrated a slightly decreased growth rate and lower final growth yield, yet was more motile and more invasive of human intestinal epithelial cells than wild-type. In either single or mixed infections, the mutant was less able to colonize mice than 81\u2013176. The <jats:italic>cj0596<\/jats:italic> mutant also expressed altered levels of several proteins.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Mutation of <jats:italic>cj0596<\/jats:italic> has an effect on phenotypes related to <jats:italic>C. jejuni<\/jats:italic> pathogenesis, probably due to its role in the proper folding of critical outer membrane proteins.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2180-9-160","type":"journal-article","created":{"date-parts":[[2009,8,8]],"date-time":"2009-08-08T18:13:28Z","timestamp":1249755208000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cj0596 is a periplasmic peptidyl prolyl cis-trans isomerase involved in Campylobacter jejuni motility, invasion, and colonization"],"prefix":"10.1186","volume":"9","author":[{"given":"Kimberly M","family":"Rathbun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna E","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,8,8]]},"reference":[{"key":"831_CR1","first-page":"121","volume-title":"Campylobacter","author":"CR Friedman","year":"2000","unstructured":"Friedman CR, Neimann J, Wegener HC, Tauxe RV: Epidemiology of Campylobacter jejuni infections in the United States and other industrialized nations. 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