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This study aimed at characterizing the meningococcal Fpg and its role in DNA repair.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The deduced <jats:italic>N. meningitidis<\/jats:italic> Fpg amino acid sequence was highly homologous to other Fpg orthologues, with particularly high conservation of functional domains. As for most <jats:italic>N. meningitidis<\/jats:italic> DNA repair genes, the <jats:italic>fpg<\/jats:italic> gene contained a DNA uptake sequence mediating efficient transformation of DNA. The recombinant <jats:italic>N. meningitidis<\/jats:italic> Fpg protein was over-expressed, purified to homogeneity and assessed for enzymatic activity. <jats:italic>N. meningitidis<\/jats:italic> Fpg was found to remove 2,6-diamino-4-hydroxy-5-formamidopyrimidine (faPy) lesions and 7,8-dihydro-8-oxo-2'-deoxyguanosine (8oxoG) opposite of C, T and G and to a lesser extent opposite of A. Moreover, the <jats:italic>N. meningitidis fpg<\/jats:italic> single mutant was only slightly affected in terms of an increase in the frequency of phase variation as compared to a mismatch repair mutant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Collectively, these findings show that meningococcal Fpg functions are similar to those of prototype Fpg orthologues in other bacterial species.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2180-9-7","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T19:14:51Z","timestamp":1231528491000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characterization of the meningococcal DNA glycosylase Fpg involved in base excision repair"],"prefix":"10.1186","volume":"9","author":[{"given":"Katrina L","family":"Tibballs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole Herman","family":"Ambur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Alfsnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5vard","family":"Homberset","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan A","family":"Frye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonje","family":"Davidsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tone","family":"T\u00f8njum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,1,9]]},"reference":[{"key":"678_CR1","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1099\/jmm.0.45529-0","volume":"53","author":"SP Yazdankhah","year":"2004","unstructured":"Yazdankhah SP, Caugant DA: Neisseria meningitidis: an overview of the carriage state. 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