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In contrast to TAF6\u03b1, TAF6\u03b4 is a pro-apoptotic isoform with a 10 amino acid deletion in its histone fold domain that abolishes its interaction with TAF9. TAF6\u03b4 expression can dictate life versus death decisions of human cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Here we define the impact of endogenous TAF6\u03b4 expression on the global transcriptome landscape. TAF6\u03b4 was found to orchestrate a transcription profile that included statistically significant enrichment of genes of apoptotic function. Interestingly, gene expression patterns controlled by TAF6\u03b4 share similarities with, but are not equivalent to, those reported to change following TAF9 and\/or TAF9b depletion. Finally, because TAF6\u03b4 regulates certain p53 target genes, we tested and demonstrated a physical and functional interaction between TAF6\u03b4 and p53.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Together our data define a TAF6\u03b4-driven apoptotic gene expression program and show crosstalk between the p53 and TAF6\u03b4 pathways.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2199-11-10","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T07:14:59Z","timestamp":1266995699000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["TAF6\u03b4 orchestrates an apoptotic transcriptome profile and interacts functionally with p53"],"prefix":"10.1186","volume":"11","author":[{"given":"Emmanuelle","family":"Wilhelm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Kornete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Targat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Vigneault-Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Frontini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Tora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Benecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,1,22]]},"reference":[{"issue":"6805","key":"491_CR1","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/35037710","volume":"407","author":"MO Hengartner","year":"2000","unstructured":"Hengartner MO: The biochemistry of apoptosis. 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