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The presence of \"dark\" neurons in the PRF was investigated by the sensitive silver method of Gallyas in rats sacrificed at 3 h after focal 4-AP crystal or systemic 4-AP, pilocarpine, or kainic acid application. The behavioral signs of the developing epileptic seizures were scored in all rats. The EEG activity was recorded in eight rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regardless of the initiating drug or method of administration, \"dark\" neurons were consistently found in the PRF of animals entered the later phases of<jats:italic>status epilepticus<\/jats:italic>. EEG recordings demonstrated the presence of slow oscillations (1.5-2.5 Hz) simultaneously with the appearance of giant \"dark\" neurons in the PRF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We argue that the observed slow oscillation corresponds to the late periodic epileptiform discharge phase of<jats:italic>status epilepticus<\/jats:italic>, and that the PRF may be involved in the progression of<jats:italic>status epilepticus<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2202-10-133","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T19:15:06Z","timestamp":1258139706000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Status epilepticus affects the gigantocellular network of the pontine reticular formation"],"prefix":"10.1186","volume":"10","author":[{"given":"P\u00e9ter","family":"Baracskay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viola","family":"Kiglics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin A","family":"K\u00e9kesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Juh\u00e1sz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Czurk\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,11,13]]},"reference":[{"issue":"1","key":"1137_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1528-1167.2006.00363.x","volume":"47","author":"FW Drislane","year":"2006","unstructured":"Drislane FW: Who's afraid of status epilepticus?. 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