{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:13:51Z","timestamp":1791810831027,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurosci"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Voltage gated sodium channels Na<jats:sub>v<\/jats:sub>1.7 are involved in nociceptor nerve action potentials and are known to affect pain sensitivity in clinical genetic disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims and Objectives<\/jats:title><jats:p>To study Na<jats:sub>v<\/jats:sub>1.7 levels in dental pulpitis pain, an inflammatory condition, and burning mouth syndrome (BMS), considered a neuropathic orofacial pain disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two groups of patients were recruited for this study. One group consisted of patients with dental pulpitis pain (n = 5) and controls (n = 12), and the other patients with BMS (n = 7) and controls (n = 10). BMS patients were diagnosed according to the International Association for the Study of Pain criteria; a pain history was collected, including the visual analogue scale (VAS). Immunohistochemistry with visual intensity and computer image analysis were used to evaluate levels of Na<jats:sub>v<\/jats:sub>1.7 in dental pulp tissue samples from the dental pulpitis group, and tongue biopsies from the BMS group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significantly increased visual intensity score for Na<jats:sub>v<\/jats:sub>1.7 in nerve fibres in the painful dental pulp specimens, compared to controls. Image analysis showed a trend for an increase of the Na<jats:sub>v<\/jats:sub>1.7 immunoreactive % area in the painful pulp group, but this was not statistically significant. When expressed as a ratio of the neurofilament % area, there was a strong trend for an increase of Na<jats:sub>v<\/jats:sub>1.7 in the painful pulp group. Na<jats:sub>v<\/jats:sub>1.7 immunoreactive fibres were seen in abundance in the sub-mucosal layer of tongue biopsies, with no significant difference between BMS and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Na<jats:sub>v<\/jats:sub>1.7 sodium channel may play a significant role in inflammatory dental pain. Clinical trials with selective Na<jats:sub>v<\/jats:sub>1.7 channel blockers should prioritise dental pulp pain rather than BMS.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2202-11-71","type":"journal-article","created":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T18:16:31Z","timestamp":1277230591000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Sodium channel Nav1.7 immunoreactivity in painful human dental pulp and burning mouth syndrome"],"prefix":"10.1186","volume":"11","author":[{"given":"Kiran","family":"Beneng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Renton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiangos","family":"Yiangou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,8]]},"reference":[{"issue":"10","key":"1630_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.14219\/jada.archive.1993.0200","volume":"124","author":"JA Lipton","year":"1993","unstructured":"Lipton JA, Ship JA, Larach-Robinson D: Estimated prevalence and distribution of reported orofacial pain in the United States. 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