{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:46:26Z","timestamp":1778121986540,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,10,12]],"date-time":"2011-10-12T00:00:00Z","timestamp":1318377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Neurosci"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1186\/1471-2202-12-102","type":"journal-article","created":{"date-parts":[[2011,10,12]],"date-time":"2011-10-12T06:26:55Z","timestamp":1318400815000},"source":"Crossref","is-referenced-by-count":29,"title":["Inner ear dysfunction in caspase-3 deficient mice"],"prefix":"10.1186","volume":"12","author":[{"given":"Tomoko","family":"Makishima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Hochman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Rosenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Ridley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minna","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Perachio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,10,12]]},"reference":[{"issue":"3","key":"2442_CR1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1023\/B:APPT.0000025802.07676.a5","volume":"9","author":"Y Leon","year":"2004","unstructured":"Leon Y, Sanchez-Galiano S, Gorospe I: Programmed cell death in the development of the vertebrate inner ear. Apoptosis. 2004, 9 (3): 255-264.","journal-title":"Apoptosis"},{"issue":"1","key":"2442_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s004290050255","volume":"200","author":"T Nishikori","year":"1999","unstructured":"Nishikori T, Hatta T, Kawauchi H, Otani H: Apoptosis during inner ear development in human and mouse embryos: an analysis by computer-assisted three-dimensional reconstruction. Anat Embryol (Berl). 1999, 200 (1): 19-26. 10.1007\/s004290050255.","journal-title":"Anat Embryol (Berl)"},{"issue":"6","key":"2442_CR3","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/01.moo.0000186799.45377.63","volume":"13","author":"AG Cheng","year":"2005","unstructured":"Cheng AG, Cunningham LL, Rubel EW: Mechanisms of hair cell death and protection. Curr Opin Otolaryngol Head Neck Surg. 2005, 13 (6): 343-348. 10.1097\/01.moo.0000186799.45377.63.","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"issue":"4","key":"2442_CR4","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1097\/00129492-200407000-00035","volume":"25","author":"TR Van De Water","year":"2004","unstructured":"Van De Water TR, Lallemend F, Eshraghi AA, Ahsan S, He J, Guzman J, Polak M, Malgrange B, Lefebvre PP, Staecker H, et al.: Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells. Otol Neurotol. 2004, 25 (4): 627-632. 10.1097\/00129492-200407000-00035.","journal-title":"Otol Neurotol"},{"issue":"6607","key":"2442_CR5","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/384368a0","volume":"384","author":"K Kuida","year":"1996","unstructured":"Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA: Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 1996, 384 (6607): 368-372. 10.1038\/384368a0.","journal-title":"Nature"},{"issue":"6","key":"2442_CR6","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1101\/gad.12.6.806","volume":"12","author":"M Woo","year":"1998","unstructured":"Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kagi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, et al.: Essential contribution of caspase 3\/CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 1998, 12 (6): 806-819. 10.1101\/gad.12.6.806.","journal-title":"Genes Dev"},{"issue":"1","key":"2442_CR7","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1006\/bbrc.2001.4939","volume":"284","author":"H Morishita","year":"2001","unstructured":"Morishita H, Makishima T, Kaneko C, Lee YS, Segil N, Takahashi K, Kuraoka A, Nakagawa T, Nabekura J, Nakayama K, et al.: Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochem Biophys Res Commun. 2001, 284 (1): 142-149. 10.1006\/bbrc.2001.4939.","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"2442_CR8","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S0006-8993(01)02123-0","volume":"894","author":"K Takahashi","year":"2001","unstructured":"Takahashi K, Kamiya K, Urase K, Suga M, Takizawa T, Mori H, Yoshikawa Y, Ichimura K, Kuida K, Momoi T: Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss. Brain Res. 2001, 894 (2): 359-367. 10.1016\/S0006-8993(01)02123-0.","journal-title":"Brain Res"},{"key":"2442_CR9","doi-asserted-by":"crossref","unstructured":"Parker A, Hardisty-Hughes RE, Wisby L, Joyce S, Brown SD: Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice. Mamm Genome. 21 (11-12): 565-576.","DOI":"10.1007\/s00335-010-9306-2"},{"key":"2442_CR10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/bmb\/66.1.43","volume":"66","author":"C Weissmann","year":"2003","unstructured":"Weissmann C, Flechsig E: PrP knock-out and PrP transgenic mice in prion research. Br Med Bull. 2003, 66: 43-60. 10.1093\/bmb\/66.1.43.","journal-title":"Br Med Bull"},{"issue":"10","key":"2442_CR11","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0168-9525(02)02753-1","volume":"18","author":"AV Anagnostopoulos","year":"2002","unstructured":"Anagnostopoulos AV: A compendium of mouse knockouts with inner ear defects. Trends Genet. 2002, 18 (10): 499.","journal-title":"Trends Genet"},{"issue":"6","key":"2442_CR12","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0166-2236(98)01366-6","volume":"22","author":"DM Fekete","year":"1999","unstructured":"Fekete DM: Development of the vertebrate ear: insights from knockouts and mutants. Trends Neurosci. 1999, 22 (6): 263-269. 10.1016\/S0166-2236(98)01366-6.","journal-title":"Trends Neurosci"},{"issue":"9","key":"2442_CR13","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1242\/dev.01082","volume":"131","author":"F Cecconi","year":"2004","unstructured":"Cecconi F, Roth KA, Dolgov O, Munarriz E, Anokhin K, Gruss P, Salminen M: Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth. Development. 2004, 131 (9): 2125-2135. 10.1242\/dev.01082.","journal-title":"Development"},{"issue":"11","key":"2442_CR14","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1007\/PL00000806","volume":"58","author":"F Cecconi","year":"2001","unstructured":"Cecconi F, Gruss P: Apaf1 in developmental apoptosis and cancer: how many ways to die?. Cell Mol Life Sci. 2001, 58 (11): 1688-1697. 10.1007\/PL00000806.","journal-title":"Cell Mol Life Sci"},{"key":"2442_CR15","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0074-7696(08)62210-X","volume":"163","author":"EJ Sanders","year":"1995","unstructured":"Sanders EJ, Wride MA: Programmed cell death in development. Int Rev Cytol. 1995, 163: 105-173.","journal-title":"Int Rev Cytol"},{"issue":"6-7","key":"2442_CR16","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1387\/ijdb.072381jb","volume":"51","author":"J Bok","year":"2007","unstructured":"Bok J, Chang W, Wu DK: Patterning and morphogenesis of the vertebrate inner ear. Int J Dev Biol. 2007, 51 (6-7): 521-533. 10.1387\/ijdb.072381jb.","journal-title":"Int J Dev Biol"},{"issue":"6","key":"2442_CR17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3233\/VES-1999-9601","volume":"9","author":"A Maklad","year":"1999","unstructured":"Maklad A, Fritzsch B: Incomplete segregation of endorgan-specific vestibular ganglion cells in mice and rats. J Vestib Res. 1999, 9 (6): 387-399.","journal-title":"J Vestib Res"},{"issue":"1-2","key":"2442_CR18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0006-8993(03)02505-8","volume":"972","author":"CG Harrod","year":"2003","unstructured":"Harrod CG, Baker JF: The vestibulo ocular reflex (VOR) in otoconia deficient head tilt (het) mutant mice versus wild type C57BL\/6 mice. Brain Res. 2003, 972 (1-2): 75-83. 10.1016\/S0006-8993(03)02505-8.","journal-title":"Brain Res"},{"issue":"3-4","key":"2442_CR19","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00221-010-2521-y","volume":"210","author":"AA Migliaccio","year":"2011","unstructured":"Migliaccio AA, Meierhofer R, Della Santina CC: Characterization of the 3D angular vestibulo-ocular reflex in C57BL6 mice. Exp Brain Res. 2011, 210 (3-4): 489-501. 10.1007\/s00221-010-2521-y.","journal-title":"Exp Brain Res"},{"issue":"Pt 2","key":"2442_CR20","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1113\/jphysiol.2004.063883","volume":"559","author":"PP Vidal","year":"2004","unstructured":"Vidal PP, Degallaix L, Josset P, Gasc JP, Cullen KE: Postural and locomotor control in normal and vestibularly deficient mice. J Physiol. 2004, 559 (Pt 2): 625-638.","journal-title":"J Physiol"},{"key":"2442_CR21","doi-asserted-by":"crossref","unstructured":"Groves AK: The challenge of hair cell regeneration. Exp Biol Med (Maywood). 235 (4): 434-446.","DOI":"10.1258\/ebm.2009.009281"},{"issue":"5101","key":"2442_CR22","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1126\/science.8456284","volume":"259","author":"A Forge","year":"1993","unstructured":"Forge A, Li L, Corwin JT, Nevill G: Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science. 1993, 259 (5101): 1616-1619. 10.1126\/science.8456284.","journal-title":"Science"},{"issue":"5101","key":"2442_CR23","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1126\/science.8456285","volume":"259","author":"ME Warchol","year":"1993","unstructured":"Warchol ME, Lambert PR, Goldstein BJ, Forge A, Corwin JT: Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. Science. 1993, 259 (5101): 1619-1622. 10.1126\/science.8456285.","journal-title":"Science"},{"issue":"2","key":"2442_CR24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1159\/000083365","volume":"10","author":"A Shiga","year":"2005","unstructured":"Shiga A, Nakagawa T, Nakayama M, Endo T, Iguchi F, Kim TS, Naito Y, Ito J: Aging effects on vestibulo-ocular responses in C57BL\/6 mice: comparison with alteration in auditory function. Audiol Neurootol. 2005, 10 (2): 97-104. 10.1159\/000083365.","journal-title":"Audiol Neurootol"},{"issue":"2","key":"2442_CR25","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/S0006-8993(02)03557-6","volume":"958","author":"GD Kaufman","year":"2002","unstructured":"Kaufman GD: Video-oculography in the gerbil. Brain Res. 2002, 958 (2): 472-487. 10.1016\/S0006-8993(02)03557-6.","journal-title":"Brain Res"},{"key":"2442_CR26","volume-title":"A model-based approach for the measurement of eye movements using image processing","author":"K Sung","year":"1997","unstructured":"Sung K, Reschke MF: A model-based approach for the measurement of eye movements using image processing. 1997, Houston, TX: NASA Johnson Space Center"},{"issue":"3","key":"2442_CR27","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1080\/14992020500057434","volume":"44","author":"K Hawker","year":"2005","unstructured":"Hawker K, Fuchs H, Angelis MH, Steel KP: Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4. Int J Audiol. 2005, 44 (3): 171-177. 10.1080\/14992020500057434.","journal-title":"Int J Audiol"},{"issue":"4","key":"2442_CR28","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1002\/cne.10975","volume":"468","author":"K Cryns","year":"2004","unstructured":"Cryns K, van Alphen AM, van Spaendonck MP, van de Heyning PH, Timmermans JP, de Zeeuw CI, van Camp G: Circling behavior in the Ecl mouse is caused by lateral semicircular canal defects. J Comp Neurol. 2004, 468 (4): 587-595. 10.1002\/cne.10975.","journal-title":"J Comp Neurol"},{"issue":"5","key":"2442_CR29","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1097\/00129492-200409000-00010","volume":"25","author":"H Pau","year":"2004","unstructured":"Pau H, Hawker K, Fuchs H, De Angelis MH, Steel KP: Characterization of a new mouse mutant, flouncer, with a balance defect and inner ear malformation. Otol Neurotol. 2004, 25 (5): 707-713. 10.1097\/00129492-200409000-00010.","journal-title":"Otol Neurotol"},{"issue":"3","key":"2442_CR30","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s0033501-2088-9","volume":"13","author":"AE Kiernan","year":"2002","unstructured":"Kiernan AE, Erven A, Voegeling S, Peters J, Nolan P, Hunter J, Bacon Y, Steel KP, Brown SD, Guenet JL: ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis. Mamm Genome. 2002, 13 (3): 142-148. 10.1007\/s0033501-2088-9.","journal-title":"Mamm Genome"},{"issue":"11","key":"2442_CR31","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1242\/dev.126.11.2335","volume":"126","author":"H Morsli","year":"1999","unstructured":"Morsli H, Tuorto F, Choo D, Postiglione MP, Simeone A, Wu DK: Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. Development. 1999, 126 (11): 2335-2343.","journal-title":"Development"},{"issue":"19","key":"2442_CR32","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1242\/dev.125.19.3831","volume":"125","author":"D ten Berge","year":"1998","unstructured":"ten Berge D, Brouwer A, Korving J, Martin JF, Meijlink F: Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs. Development. 1998, 125 (19): 3831-3842.","journal-title":"Development"},{"issue":"1","key":"2442_CR33","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1006\/dbio.2001.0241","volume":"234","author":"A Alavizadeh","year":"2001","unstructured":"Alavizadeh A, Kiernan AE, Nolan P, Lo C, Steel KP, Bucan M: The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects. Dev Biol. 2001, 234 (1): 244-260. 10.1006\/dbio.2001.0241.","journal-title":"Dev Biol"},{"issue":"1","key":"2442_CR34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1001\/archotol.131.1.41","volume":"131","author":"SE Sobol","year":"2005","unstructured":"Sobol SE, Teng X, Crenshaw EB: Abnormal mesenchymal differentiation in the superior semicircular canal of brn4\/pou3f4 knockout mice. Arch Otolaryngol Head Neck Surg. 2005, 131 (1): 41-45. 10.1001\/archotol.131.1.41.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"14","key":"2442_CR35","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1523\/JNEUROSCI.19-14-05980.1999","volume":"19","author":"D Phippard","year":"1999","unstructured":"Phippard D, Lu L, Lee D, Saunders JC, Crenshaw EB: Targeted mutagenesis of the POU-domain gene Brn4\/Pou3f4 causes developmental defects in the inner ear. J Neurosci. 1999, 19 (14): 5980-5989.","journal-title":"J Neurosci"},{"issue":"5","key":"2442_CR36","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/cne.21460","volume":"504","author":"ME Adams","year":"2007","unstructured":"Adams ME, Hurd EA, Beyer LA, Swiderski DL, Raphael Y, Martin DM: Defects in vestibular sensory epithelia and innervation in mice with loss of Chd7 function: implications for human CHARGE syndrome. J Comp Neurol. 2007, 504 (5): 519-532. 10.1002\/cne.21460.","journal-title":"J Comp Neurol"},{"issue":"10","key":"2442_CR37","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1242\/dev.01804","volume":"132","author":"Z Lin","year":"2005","unstructured":"Lin Z, Cantos R, Patente M, Wu DK: Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling. Development. 2005, 132 (10): 2309-2318. 10.1242\/dev.01804.","journal-title":"Development"},{"issue":"17","key":"2442_CR38","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1242\/dev.126.17.3795","volume":"126","author":"D Acampora","year":"1999","unstructured":"Acampora D, Merlo GR, Paleari L, Zerega B, Postiglione MP, Mantero S, Bober E, Barbieri O, Simeone A, Levi G: Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development. 1999, 126 (17): 3795-3809.","journal-title":"Development"},{"issue":"1","key":"2442_CR39","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/dvdy.20319","volume":"233","author":"H Ohuchi","year":"2005","unstructured":"Ohuchi H, Yasue A, Ono K, Sasaoka S, Tomonari S, Takagi A, Itakura M, Moriyama K, Noji S, Nohno T: Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development. Dev Dyn. 2005, 233 (1): 177-187. 10.1002\/dvdy.20319.","journal-title":"Dev Dyn"},{"issue":"24","key":"2442_CR40","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1242\/dev.128.24.5017","volume":"128","author":"W Wang","year":"2001","unstructured":"Wang W, Chan EK, Baron S, Van de Water T, Lufkin T: Hmx2 homeobox gene control of murine vestibular morphogenesis. Development. 2001, 128 (24): 5017-5029.","journal-title":"Development"},{"issue":"6","key":"2442_CR41","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1242\/dev.125.6.1123","volume":"125","author":"A Gavalas","year":"1998","unstructured":"Gavalas A, Studer M, Lumsden A, Rijli FM, Krumlauf R, Chambon P: Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch. Development. 1998, 125 (6): 1123-1136.","journal-title":"Development"},{"issue":"1","key":"2442_CR42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1242\/dev.127.1.13","volume":"127","author":"M Salminen","year":"2000","unstructured":"Salminen M, Meyer BI, Bober E, Gruss P: Netrin 1 is required for semicircular canal formation in the mouse inner ear. Development. 2000, 127 (1): 13-22.","journal-title":"Development"},{"issue":"3","key":"2442_CR43","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1128\/MCB.22.3.935-945.2002","volume":"22","author":"T Ponnio","year":"2002","unstructured":"Ponnio T, Burton Q, Pereira FA, Wu DK, Conneely OM: The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear. Mol Cell Biol. 2002, 22 (3): 935-945. 10.1128\/MCB.22.3.935-945.2002.","journal-title":"Mol Cell Biol"}],"container-title":["BMC Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2202-12-102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2202-12-102\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2202-12-102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T04:56:55Z","timestamp":1639112215000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurosci.biomedcentral.com\/articles\/10.1186\/1471-2202-12-102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,12]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["2442"],"URL":"https:\/\/doi.org\/10.1186\/1471-2202-12-102","relation":{},"ISSN":["1471-2202"],"issn-type":[{"value":"1471-2202","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,12]]},"article-number":"102"}}