{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:30:17Z","timestamp":1790836217029,"version":"4.1.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurosci"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The mammalian suprachiasmatic nucleus (SCN), located in the ventral hypothalamus, is a major regulator of circadian rhythms in mammals and birds. However, the role of the SCN in lower vertebrates remains poorly understood. Zebrafish <jats:italic>cyclops<\/jats:italic> (<jats:italic>cyc<\/jats:italic>) mutants lack ventral brain, including the region that gives rise to the SCN. We have used <jats:italic>cyc<\/jats:italic> embryos to define the function of the zebrafish SCN in regulating circadian rhythms in the developing pineal organ. The pineal organ is the major source of the circadian hormone melatonin, which regulates rhythms such as daily rest\/activity cycles. Mammalian pineal rhythms are controlled almost exclusively by the SCN. In zebrafish and many other lower vertebrates, the pineal has an endogenous clock that is responsible in part for cyclic melatonin biosynthesis and gene expression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We find that pineal rhythms are present in <jats:italic>cyc<\/jats:italic> mutants despite the absence of an SCN. The arginine vasopressin-like protein (Avpl, formerly called Vasotocin) is a peptide hormone expressed in and around the SCN. We find <jats:italic>avpl<\/jats:italic> mRNA is absent in <jats:italic>cyc<\/jats:italic> mutants, supporting previous work suggesting the SCN is missing. In contrast, expression of the putative circadian clock genes, <jats:italic>cryptochrome 1b (cry1b)<\/jats:italic> and <jats:italic>cryptochrome 3 (cry3)<\/jats:italic>, in the brain of the developing fish is unaltered. Expression of two pineal rhythmic genes, <jats:italic>exo-rhodopsin<\/jats:italic> (<jats:italic>exorh)<\/jats:italic> and <jats:italic>serotonin-N-acetyltransferase<\/jats:italic> (<jats:italic>aanat2<\/jats:italic>), involved in photoreception and melatonin synthesis, respectively, is also similar between <jats:italic>cyc<\/jats:italic> embryos and their wildtype (WT) siblings. The timing of the peaks and troughs of expression are the same, although the amplitude of expression is slightly decreased in the mutants. Cyclic gene expression persists for two days in <jats:italic>cyc<\/jats:italic> embryos transferred to constant light or constant dark, suggesting a circadian clock is driving the rhythms. However, the amplitude of rhythms in <jats:italic>cyc<\/jats:italic> mutants kept in constant conditions decreased more quickly than in their WT siblings.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our data suggests that circadian rhythms can be initiated and maintained in the absence of SCN and other tissues in the ventral brain. However, the SCN may have a role in regulating the amplitude of rhythms when environmental cues are absent. This provides some of the first evidence that the SCN of teleosts is not essential for establishing circadian rhythms during development. Several SCN-independent circadian rhythms have also been found in mammalian species. Thus, zebrafish may serve as a model system for understanding how vertebrate embryos coordinate rhythms that are controlled by different circadian clocks.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2202-12-7","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T11:10:53Z","timestamp":1295435453000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Circadian rhythms in the pineal organ persist in zebrafish larvae that lack ventral brain"],"prefix":"10.1186","volume":"12","author":[{"given":"Ramil R","family":"Noche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Nien","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Goldstein-Kral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Glasgow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer O","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,1,13]]},"reference":[{"issue":"5","key":"1940_CR1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/bies.10091","volume":"24","author":"MP Pando","year":"2002","unstructured":"Pando MP, Sassone-Corsi P: Unraveling the mechanisms of the vertebrate circadian clock: zebrafish may light the way. 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