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In this study, we assess the role of CA1 hippocampus (structure highly affected in Alzheimer disease) subfield in the rats\u2019 olfactory behavior, and the neuroprotective effect of 17 beta estradiol (E<jats:sub>2<\/jats:sub>) against the oxidative stress produced by the injection of amyloid beta 25\u201335.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>162 Wistar rats were ovariectomized and two weeks after injected with 2\u00a0\u03bcl of amyloid beta 25\u201335 (A-\u03b2<jats:sub>25\u201335<\/jats:sub>) in CA1 subfield. Olfactory behavior was evaluated with a social recognition test, odor discrimination, and search tests. Oxidative stress was evaluated with FOX assay and Western Blot against 4-HNE, Fluoro Jade staining was made to quantify degenerated neurons; all these evaluations were performed 24\u00a0h, 8 or 15\u00a0days after A-\u03b2<jats:sub>25\u201335<\/jats:sub> injection. Three additional groups treated with 17 beta estradiol (E<jats:sub>2<\/jats:sub>) were also evaluated. The injection of A-\u03b2<jats:sub>25\u201335<\/jats:sub> produced an olfactory impairment 24\u00a0h and 8\u00a0days after, whereas a partial recovery of the olfactory behavior was observed at 15\u00a0days. A complete prevention of the olfactory impairment was observed with the administration of E<jats:sub>2<\/jats:sub> two weeks before the amyloid injection (A-\u03b2<jats:sub>25\u201335<\/jats:sub> 24\u00a0h\u2009+\u2009E<jats:sub>2<\/jats:sub>) and one or two weeks after (groups 8 A-\u03b2 +E<jats:sub>2<\/jats:sub> and 15 A-\u03b2 +E<jats:sub>2<\/jats:sub> days, respectively); a decrease of the oxidative stress and neurodegeneration were also observed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our finding shows that CA1 hippocampus subfield plays an important role in the olfactory behavior of the rat. The oxidative stress generated by the administration of A-\u03b2<jats:sub>25\u201335<\/jats:sub> is enough to produce an olfactory impairment. This can be prevented with the administration of E<jats:sub>2<\/jats:sub> before and after amyloid injection. This suggests a possible therapeutic use of estradiol in Alzheimer\u2019s disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2202-14-104","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T07:45:04Z","timestamp":1380008704000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Estradiol prevents olfactory dysfunction induced by A-\u03b2 25\u201335 injection in hippocampus"],"prefix":"10.1186","volume":"14","author":[{"given":"Carlos","family":"Bernal-Mondrag\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selva","family":"Rivas-Arancibia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith M","family":"Kendrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalinda","family":"Guevara-Guzm\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,9,24]]},"reference":[{"issue":"7\u20138","key":"3406_CR1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2119\/2007-00100.Irvine","volume":"14","author":"GB Irvine","year":"2008","unstructured":"Irvine GB, El-Agnaf OM, Shankar GM, Walsh DM: Protein aggregation in the brain: the molecular basis for Alzheimer\u2019s and Parkinson\u2019s diseases. 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